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Select item 101476041.

USP7 controls NGN3 stability and pancreatic endocrine lineage development

Teodora Manea, Jessica Kristine Nelson, Cristina Maria Garrone, Karin Hansson, Ian Evans, Axel Behrens, Rocio Sancho

Nat Commun. 2023; 14: 2457. Published online 2023 Apr 28. doi: 10.1038/s41467-023-38146-9

PMCID:: PMC10147604

Abstract Article PDF–9.0M

Select item 84561252.

Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas

Hyo Jeong Yong, Gengqiang Xie, Chengyang Liu, Wei Wang, Ali Naji, Jerome Irianto, Yue J. Wang

Front Endocrinol (Lausanne) 2021; 12: 736286. Published online 2021 Sep 8. doi: 10.3389/fendo.2021.736286

PMCID:: PMC8456125

Abstract Article PDF–4.6M

Select item 83879193.

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

Valérie Schreiber, Reuben Mercier, Sara Jiménez, Tao Ye, Emmanuel García-Sánchez, Annabelle Klein, Aline Meunier, Sabitri Ghimire, Catherine Birck, Bernard Jost, Kristian Honnens de Lichtenberg, Christian Honoré, Palle Serup, Gérard Gradwohl

Mol Metab. 2021 Nov; 53: 101313. Published online 2021 Aug 3. doi: 10.1016/j.molmet.2021.101313

PMCID:: PMC8387919

Abstract Article PDF–4.4M

Select item 83529644.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80158246.

Recognition of maturity‐onset diabetes of the young in China

Hua Liang, Yanan Zhang, Maixinyue Li, Jinhua Yan, Daizhi Yang, Sihui Luo, Xueying Zheng, Guoqing Yang, Zhuo Li, Wen Xu, Leif Groop, Jianping Weng

J Diabetes Investig. 2021 Apr; 12(4): 501–509. Published online 2020 Sep 9. doi: 10.1111/jdi.13378

PMCID:: PMC8015824

Abstract Article PDF–281K

Select item 75668817.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 71699838.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 70828409.

A comprehensive structure-function study of Neurogenin3 disease causing alleles during human pancreas and intestinal organoid development.

Xinghao Zhang, Patrick S. McGrath, Joseph Salomone, Mohamed Rahal, Heather A. McCauley, Jamie Schweitzer, Rhett Kovall, Brian Gebelein, James Wells

Dev Cell. Author manuscript; available in PMC 2020 Aug 5.

Published in final edited form as: Dev Cell. 2019 Aug 5; 50(3): 367–380.e7. Published online 2019 Jun 6. doi: 10.1016/j.devcel.2019.05.017

PMCID:: PMC7082840

Abstract Article PDF–2.6M

Select item 703087310.

Null mutations of NEUROG3 are associated with delayed-onset diabetes mellitus

R. Sergio Solorzano-Vargas, Matthew Bjerknes, Jiafang Wang, S. Vincent Wu, Manuel G. Garcia-Careaga, Pisit Pitukcheewanont, Hazel Cheng, Michael S. German, Senta Georgia, Martín G. Martín

JCI Insight. 2020 Jan 16; 5(1): e127657. Published online 2020 Jan 16. doi: 10.1172/jci.insight.127657

PMCID:: PMC7030873

Abstract Article PDF–9.4M

Select item 679130711.

The cellular regulators PTEN and BMI1 help mediate NEUROGENIN-3–induced cell cycle arrest

R. Sergio Solorzano-Vargas, Matthew Bjerknes, S. Vincent Wu, Jiafang Wang, Matthias Stelzner, James C. Y. Dunn, Sangeeta Dhawan, Hazel Cheng, Senta Georgia, Martín G. Martín

J Biol Chem. 2019 Oct 11; 294(41): 15182–15192. Published online 2019 Jul 24. doi: 10.1074/jbc.RA119.008926

PMCID:: PMC6791307

Abstract Article PDF–3.2M

Select item 674264612.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 566746713.

PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration

Yaxi Zhu, Qian Liu, Zhiguang Zhou, Yasuhiro Ikeda

Stem Cell Res Ther. 2017; 8: 240. Published online 2017 Nov 2. doi: 10.1186/s13287-017-0694-z

PMCID:: PMC5667467

Abstract Article PDF–565K

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 551731515.

Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors

Nicole A.J. Krentz, Dennis van Hoof, Zhongmei Li, Akie Watanabe, Mei Tang, Cuilan Nian, Michael S. German, Francis C. Lynn

Dev Cell. Author manuscript; available in PMC 2018 Apr 24.

Published in final edited form as: Dev Cell. 2017 Apr 24; 41(2): 129–142.e6. doi: 10.1016/j.devcel.2017.02.006

PMCID:: PMC5517315

Abstract Article PDF–990K

Select item 542525116.

Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation

Roberta Azzarelli, Christopher Hurley, Magdalena K. Sznurkowska, Steffen Rulands, Laura Hardwick, Ivonne Gamper, Fahad Ali, Laura McCracken, Christopher Hindley, Fiona McDuff, Sonia Nestorowa, Richard Kemp, Kenneth Jones, Berthold Göttgens, Meritxell Huch, Gerard Evan, Benjamin D. Simons, Douglas Winton, Anna Philpott

Dev Cell. 2017 May 8; 41(3): 274–286.e5. doi: 10.1016/j.devcel.2017.04.004