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Select item 115125641.

ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A Demethylation

Wei Wang, Hua Li, Yiyong Qian, Min Li, Manli Deng, Dexi Bi, Jun Zou

Invest Ophthalmol Vis Sci. 2024 Oct; 65(12): 34. Published online 2024 Oct 23. doi: 10.1167/iovs.65.12.34

PMCID:: PMC11512564

Abstract Article PDF–5.9M

Select item 114530472.

Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance

Yiting Mao, Yicong Meng, Kexin Zou, Ningxin Qin, Yinyu Wang, Jing Yan, PinJia Chen, Yi Cheng, Weihui Shi, Chengliang Zhou, Huixi Chen, Jianzhong Sheng, Xinmei Liu, Jiexue Pan, Hefeng Huang

J Neuroinflammation. 2024; 21: 249. Published online 2024 Oct 4. doi: 10.1186/s12974-024-03248-8

PMCID:: PMC11453047

Abstract Article PDF–8.9M

Select item 112586553.

ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction

Kun Yang, Yongchao Zhao, Jingjing Hu, Rifeng Gao, Jiaran Shi, Xiang Wei, Juntao Chen, Kai Hu, Aijun Sun, Junbo Ge

J Adv Res. 2024 Jul; 61: 193–209. Published online 2023 Sep 9. doi: 10.1016/j.jare.2023.09.004

PMCID:: PMC11258655

Abstract Article PDF–7.4M

Select item 111091954.

Astrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice

Fang Guo, Jun Fan, Jin-Ming Liu, Peng-Li Kong, Jing Ren, Jia-Wen Mo, Cheng-Lin Lu, Qiu-Ling Zhong, Liang-Yu Chen, Hao-Tian Jiang, Canyuan Zhang, You-Lu Wen, Ting-Ting Gu, Shu-Ji Li, Ying-Ying Fang, Bing-Xing Pan, Tian-Ming Gao, Xiong Cao

Nat Commun. 2024; 15: 4347. Published online 2024 May 21. doi: 10.1038/s41467-024-48730-2

PMCID:: PMC11109195

Abstract Article PDF–5.4M

Select item 110083685.

ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis

Tao Zhang, Shuai Zhu, Geng-Wen Huang

World J Gastroenterol. 2024 Mar 28; 30(12): 1764–1776. Published online 2024 Mar 28. doi: 10.3748/wjg.v30.i12.1764

PMCID:: PMC11008368

Abstract Article PDF–6.2M

Select item 109147606.

ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice

Tao Zhuang, Mei-Hua Chen, Ruo-Xi Wu, Jing Wang, Xi-De Hu, Ting Meng, Ai-Hua Wu, Yan Li, Yong-Feng Yang, Yu Lei, Dong-Hua Hu, Yan-Xiu Li, Li Zhang, Ai-Jun Sun, Wei Lu, Guan-Nan Zhang, Jun-Li Zuo, Cheng-Chao Ruan

Nat Commun. 2024; 15: 1995. Published online 2024 Mar 5. doi: 10.1038/s41467-024-46357-x

Correction in:: Nat Commun. 2024; 15: 5595.

PMCID:: PMC10914760

Abstract Article PDF–5.6M

Select item 108638167.

Aging‐Associated ALKBH5‐m⁶A Modification Exacerbates Doxorubicin‐Induced Cardiomyocyte Apoptosis Via AT‐Rich Interaction Domain 2

Runtai Chen, Guogang Zhang, Kun Sun, Alex F. Chen

J Am Heart Assoc. 2024 Jan 2; 13(1): e031353. Published online 2023 Dec 29. doi: 10.1161/JAHA.123.031353

PMCID:: PMC10863816

Abstract Article PDF–4.0M

Select item 108171758.

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome

Senko Tsukuda, James M. Harris, Andrea Magri, Peter Balfe, Aleem Siddiqui, Peter A.C. Wing, Jane A. McKeating

PLoS Pathog. 2024 Jan; 20(1): e1011917. Published online 2024 Jan 16. doi: 10.1371/journal.ppat.1011917

PMCID:: PMC10817175

Abstract Article PDF–2.5M

Select item 107577169.

The RNA m⁶A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression

Yang Liu, Renjie Song, Zhike Lu, Lu Zhao, Xinyi Zhan, Yini Li, Xuetao Cao

Cell Mol Immunol. 2024 Jan; 21(1): 6–18. Published online 2023 Dec 20. doi: 10.1038/s41423-023-01115-9

PMCID:: PMC10757716

Abstract Article PDF–5.3M

Select item 1063660910.

ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m⁶A modification-mediated RNA stability control

Yimeng Gao, Joshua T. Zimmer, Radovan Vasic, Chengyang Liu, Rana Gbyli, Shu-Jian Zheng, Amisha Patel, Wei Liu, Zhihong Qi, Yaping Li, Raman Nelakanti, Yuanbin Song, Giulia Biancon, Andrew Z. Xiao, Sarah Slavoff, Richard G. Kibbey, Richard A. Flavell, Matthew D. Simon, Toma Tebaldi, Hua-Bing Li, Stephanie Halene

Cell Rep. 2023 Oct 31; 42(10): 113163. Published online 2023 Sep 23. doi: 10.1016/j.celrep.2023.113163

PMCID:: PMC10636609

Abstract Article PDF–5.0M

Select item 1063456911.

Cell Differentiation and Aging Lead To Up-Regulation of FTO, While the ALKBH5 Protein Level Was Stable During Aging but Up-Regulated During in vitro-Induced Cardiomyogenesis

Jana KREJČÍ, Orazio Angelo ARCIDIACONO, Radim ČEGAN, Katarzyna RADASZKIEWICZ, Jiří PACHERNÍK, Jan PIRK, Martin PEŠL, Petr FILA, Eva BÁRTOVÁ

Physiol Res. 2023 Aug; 72(4): 425–444. Published online 2023 Aug 31. doi: 10.33549/physiolres.935078

PMCID:: PMC10634569

Abstract Article PDF–3.8M

Select item 1058225712.

ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N ⁶-methyladenosine methylation

Long Bai, Yu Xiang, Minyue Tang, Shuangying Liu, Qingqing Chen, Qichao Chen, Min Zhang, Shan Wan, Yimiao Sang, Qingfang Li, Sisi Wang, Zhekun Li, Yang Song, Xiaoling Hu, Luna Mao, Guofang Feng, Long Cui, Yinghui Ye, Yimin Zhu

Nat Commun. 2023; 14: 6532. Published online 2023 Oct 17. doi: 10.1038/s41467-023-42302-6

PMCID:: PMC10582257

Abstract Article PDF–4.8M

Select item 1054364313.

Mettl14-mediated m⁶A modification ensures the cell-cycle progression of late-born retinal progenitor cells

Liang Li, Yue Sun, Alexander E. Davis, Sahil H. Shah, Lobna K. Hamed, Man-Ru Wu, Cheng-Hui Lin, Jun B. Ding, Sui Wang

Cell Rep. Author manuscript; available in PMC 2023 Oct 2.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112596. Published online 2023 Jun 1. doi: 10.1016/j.celrep.2023.112596

PMCID:: PMC10543643

Abstract Article PDF–3.9M

Select item 1047428814.

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

Guiwen Ye, Jinteng Li, Wenhui Yu, Zhongyu Xie, Guan Zheng, Wenjie Liu, Shan Wang, Qian Cao, Jiajie Lin, Zepeng Su, Dateng Li, Yunshu Che, Shuai Fan, Peng Wang, Yanfeng Wu, Huiyong Shen

Exp Mol Med. 2023 Aug; 55(8): 1743–1756. Published online 2023 Aug 1. doi: 10.1038/s12276-023-01059-0

PMCID:: PMC10474288

Abstract Article PDF–6.7M

Select item 1018317015.

m⁶A eraser ALKBH5 mitigates the apoptosis of cardiomyocytes in ischemia reperfusion injury through m⁶A/SIRT1 axis

Liangliang Liu, Zhen Liu

PeerJ. 2023; 11: e15269. Published online 2023 May 11. doi: 10.7717/peerj.15269

PMCID:: PMC10183170

Abstract Article PDF–4.7M

Select item 997786916.

Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment

Juntao Chen, Cuidi Xu, Kun Yang, Rifeng Gao, Yirui Cao, Lifei Liang, Siyue Chen, Shihao Xu, Ruiming Rong, Jina Wang, Tongyu Zhu

Nat Commun. 2023; 14: 1161. Published online 2023 Mar 1. doi: 10.1038/s41467-023-36747-y

PMCID:: PMC9977869

Abstract Article PDF–6.6M

Select item 993150017.

ALKBH5‐mediated m⁶A demethylation of TIRAP mRNA promotes radiation‐induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma

Yuhan Chen, Peitao Zhou, Yixun Deng, Xinni Cai, Mingrui Sun, Yining Sun, Dehua Wu

Clin Transl Med. 2023 Feb; 13(2): e1198. Published online 2023 Feb 15. doi: 10.1002/ctm2.1198

PMCID:: PMC9931500

Abstract Article PDF–5.6M

Select item 968275818.

ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity

Zhonglin Cai, Yao Zhang, Lin Yang, Chunhui Ma, Yi Fei, Jing Ding, Wei Song, Wei-Min Tong, Yamei Niu, Hongjun Li

Cell Mol Biol Lett. 2022; 27: 101. Published online 2022 Nov 22. doi: 10.1186/s11658-022-00404-x

Correction in:: Cell Mol Biol Lett. 2024; 29: 16.

PMCID:: PMC9682758

Abstract Article PDF–4.5M

Select item 938808619.

RNA m⁶A demethylase ALKBH5 regulates the development of γδ T cells

Chenbo Ding, Hao Xu, Zhibin Yu, Manolis Roulis, Rihao Qu, Jing Zhou, Joonseok Oh, Jason Crawford, Yimeng Gao, Ruaidhrí Jackson, Esen Sefik, Simiao Li, Zheng Wei, Mathias Skadow, Zhinan Yin, Xinshou Ouyang, Lei Wang, Qiang Zou, Bing Su, Weiguo Hu, Richard A. Flavell, Hua-Bing Li

Proc Natl Acad Sci U S A. 2022 Aug 16; 119(33): e2203318119. Published online 2022 Aug 8. doi: 10.1073/pnas.2203318119