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Select item 114666551.

A regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-β signaling

Xiaoming Li, Sebastian Kempf, Fredy Delgado Lagos, Ürün Ukan, Rüdiger Popp, Jiong Hu, Timo Frömel, Stefan Günther, Andreas Weigert, Ingrid Fleming

iScience. 2024 Oct 18; 27(10): 110938. Published online 2024 Sep 16. doi: 10.1016/j.isci.2024.110938

PMCID:: PMC11466655

Abstract Article PDF–6.1M

Select item 106562262.

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder

Ami Oguro, Taichi Fujiyama, Yasuhiro Ishihara, Chisato Kataoka, Megumi Yamamoto, Komyo Eto, Yoshihiro Komohara, Susumu Imaoka, Toshihide Sakuragi, Mayumi Tsuji, Eiji Shibata, Yaichiro Kotake, Takeshi Yamazaki

J Lipid Res. 2023 Nov; 64(11): 100458. Published online 2023 Oct 12. doi: 10.1016/j.jlr.2023.100458

PMCID:: PMC10656226

Abstract Article PDF–2.6M

Select item 103342843.

Targeting soluble epoxide hydrolase promotes osteogenic–angiogenic coupling via activating SLIT3/HIF‐1α signalling pathway

Lu Gao, Weixian Chen, Lijun Li, Juanjuan Li, Wenyao Kongling, Yaoyang Zhang, Xueping Yang, Yanrong Zhao, Jie Bai, Fu Wang

Cell Prolif. 2023 Jul; 56(7): e13403. Published online 2023 Jan 13. doi: 10.1111/cpr.13403

PMCID:: PMC10334284

Abstract Article PDF–11M

Select item 100407344.

Disruption of Ephx2 in cardiomyocytes but not endothelial cells improves functional recovery after ischemia-reperfusion in isolated mouse hearts

Matthew L. Edin, Artiom Gruzdev, J. Alyce Bradbury, Joan P. Graves, Fred B. Lih, Laura M. DeGraff, Ingrid Fleming, Darryl C. Zeldin

J Biol Chem. 2023 Apr; 299(4): 103049. Published online 2023 Feb 22. doi: 10.1016/j.jbc.2023.103049

PMCID:: PMC10040734

Abstract Article PDF–1.9M

Select item 100035605.

Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon

Weicang Wang, Karen M. Wagner, Yuxin Wang, Nalin Singh, Jun Yang, Qiyi He, Christophe Morisseau, Bruce D. Hammock

Int J Mol Sci. 2023 Mar; 24(5): 4570. Published online 2023 Feb 26. doi: 10.3390/ijms24054570

PMCID:: PMC10003560

Abstract Article PDF–1.8M

Select item 100005446.

11,12-EET Regulates PPAR-γ Expression to Modulate TGF-β-Mediated Macrophage Polarization

Xiaoming Li, Sebastian Kempf, Stefan Günther, Jiong Hu, Ingrid Fleming

Cells. 2023 Mar; 12(5): 700. Published online 2023 Feb 23. doi: 10.3390/cells12050700

PMCID:: PMC10000544

Abstract Article PDF–2.1M

Select item 97790107.

Decreased Expression of Soluble Epoxide Hydrolase Suppresses Murine Choroidal Neovascularization

Bomina Park, Sheik Pran Babu Sardar Pasha, Kamakshi L. Sishtla, Gabriella D. Hartman, Xiaoping Qi, Michael E. Boulton, Timothy W. Corson

Int J Mol Sci. 2022 Dec; 23(24): 15595. Published online 2022 Dec 9. doi: 10.3390/ijms232415595

PMCID:: PMC9779010

Abstract Article PDF–11M

Select item 97604448.

Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury

Juan Zhang, Zhi-Lin Luan, Xiao-Kui Huo, Min Zhang, Christophe Morisseau, Cheng-Peng Sun, Bruce D. Hammock, Xiao-Chi Ma

Int J Biol Sci. 2023; 19(1): 294–310. Published online 2023 Jan 1. doi: 10.7150/ijbs.78097

PMCID:: PMC9760444

Abstract Article PDF–2.5M

Select item 95121179.

Cardiomyocyte-specific disruption of soluble epoxide hydrolase limits inflammation to preserve cardiac function

Deanna K. Sosnowski, K. Lockhart Jamieson, Artiom Gruzdev, Yingxi Li, Robert Valencia, Ala Yousef, Zamaneh Kassiri, Darryl C. Zeldin, John M. Seubert

Am J Physiol Heart Circ Physiol. 2022 Oct 1; 323(4): H670–H687. Published online 2022 Aug 19. doi: 10.1152/ajpheart.00217.2022

PMCID:: PMC9512117

Abstract Article

Select item 939312310.

Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth

Zumer Naeem, Sven Zukunft, Stephan Günther, Stefan Liebner, Andreas Weigert, Bruce D. Hammock, Timo Frömel, Ingrid Fleming

Pflugers Arch. 2022; 474(9): 1021–1035. Published online 2022 Jun 1. doi: 10.1007/s00424-022-02709-4

PMCID:: PMC9393123

Abstract Article PDF–6.5M

Select item 893660411.

A Distinct Metabolically Defined Central Nucleus Circuit Bidirectionally Controls Anxiety-Related Behaviors

Jing Ren, Cheng-Lin Lu, Jie Huang, Jun Fan, Fang Guo, Jia-Wen Mo, Wei-Yuan Huang, Peng-Li Kong, Xiao-Wen Li, Li-Rong Sun, Xiang-Dong Sun, Xiong Cao

J Neurosci. 2022 Mar 16; 42(11): 2356–2370. doi: 10.1523/JNEUROSCI.1578-21.2022

PMCID:: PMC8936604

Abstract Article PDF–6.8M

Select item 859254512.

sEH promotes macrophage phagocytosis and lung clearance of Streptococcus pneumoniae

Hong Li, J. Alyce Bradbury, Matthew L. Edin, Joan P. Graves, Artiom Gruzdev, Jennifer Cheng, Samantha L. Hoopes, Laura M. DeGraff, Michael B. Fessler, Stavros Garantziotis, Shepherd H. Schurman, Darryl C. Zeldin

J Clin Invest. 2021 Nov 15; 131(22): e129679. Published online 2021 Nov 15. doi: 10.1172/JCI129679

PMCID:: PMC8592545

Abstract Article PDF–7.6M

Select item 826936213.

The Consequences of Soluble Epoxide Hydrolase Deletion on Tumorigenesis and Metastasis in a Mouse Model of Breast Cancer

Rushendhiran Kesavan, Timo Frömel, Sven Zukunft, Bernhard Brüne, Andreas Weigert, Ilka Wittig, Rüdiger Popp, Ingrid Fleming

Int J Mol Sci. 2021 Jul; 22(13): 7120. Published online 2021 Jul 1. doi: 10.3390/ijms22137120

PMCID:: PMC8269362

Abstract Article PDF–3.9M

Select item 806862314.

Soluble Epoxide Hydrolase Deficiency Attenuates Lipotoxic Cardiomyopathy via Upregulation of AMPK-mTORC Mediated Autophagy

Luyun Wang, Daqiang Zhao, Liangqiu Tang, Huihui Li, Zhaoyu Liu, Jingwei Gao, Matthew L. Edin, Huanji Zhang, Kun Zhang, Jie Chen, Xinhong Zhu, Daowen Wang, Darryl C. Zeldin, Bruce D. Hammock, Jingfeng Wang, Hui Huang

J Mol Cell Cardiol. Author manuscript; available in PMC 2022 May 1.

Published in final edited form as: J Mol Cell Cardiol. 2021 May; 154: 80–91. Published online 2020 Dec 27. doi: 10.1016/j.yjmcc.2020.12.013

PMCID:: PMC8068623

Abstract Article PDF–2.7M

Select item 794841715.

Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function

Matthew L. Edin, Haruto Yamanashi, William E. Boeglin, Joan P. Graves, Laura M. DeGraff, Fred B. Lih, Darryl C. Zeldin, Alan R. Brash

J Biol Chem. 2021 Jan-Jun; 296: 100198. Published online 2021 Jan 21. doi: 10.1074/jbc.RA120.016570

PMCID:: PMC7948417

Abstract Article PDF–738K

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 791530617.

Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury

K. Lockhart Jamieson, Ahmed M. Darwesh, Deanna K. Sosnowski, Hao Zhang, Saumya Shah, Pavel Zhabyeyev, Jun Yang, Bruce D. Hammock, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, Zamaneh Kassiri, John M. Seubert

Int J Mol Sci. 2021 Feb; 22(4): 1691. Published online 2021 Feb 8. doi: 10.3390/ijms22041691

PMCID:: PMC7915306

Abstract Article PDF–2.8M

Select item 788111218.

Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients

Thomas Duflot, Charlotte Laurent, Anne Soudey, Xavier Fonrose, Mouad Hamzaoui, Michèle Iacob, Dominique Bertrand, Julie Favre, Isabelle Etienne, Clothilde Roche, David Coquerel, Maëlle Le Besnerais, Safa Louhichi, Tracy Tarlet, Dongyang Li, Valéry Brunel, Christophe Morisseau, Vincent Richard, Robinson Joannidès, Françoise Stanke-Labesque, Fabien Lamoureux, Dominique Guerrot, Jérémy Bellien

Sci Rep. 2021; 11: 3739. Published online 2021 Feb 12. doi: 10.1038/s41598-021-83274-1

PMCID:: PMC7881112

Abstract Article PDF–3.6M

Select item 785118919.

Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease

Aline Mello, Ming-Fo Hsu, Shinichiro Koike, Bryan Chu, Jeff Cheng, Jun Yang, Christophe Morisseau, Natalie J. Torok, Bruce D. Hammock, Fawaz G. Haj

Cell Mol Gastroenterol Hepatol. 2021; 11(3): 815–830. Published online 2020 Oct 15. doi: 10.1016/j.jcmgh.2020.10.002

PMCID:: PMC7851189

Abstract Article PDF–4.3M

Select item 757465420.

14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease

Wenjun Chen, Mengyao Wang, Minzhen Zhu, Wenchao Xiong, Xihe Qin, Xinhong Zhu

J Neurosci. 2020 Oct 14; 40(42): 8188–8203. doi: 10.1523/JNEUROSCI.1246-20.2020

PMCID:: PMC7574654

Abstract Article PDF–7.3M

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