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Select item 106538791.

Phosphoprotein phosphatase activity positively regulates oligomeric pyrin to trigger inflammasome assembly in phagocytes

Haleema S. Malik, Flora Magnotti, Nicole A. Loeven, Jose M. Delgado, Arminja N. Kettenbach, Thomas Henry, James B. Bliska

mBio. 2023 Sep-Oct; 14(5): e02066-23. Published online 2023 Oct 3. doi: 10.1128/mbio.02066-23

PMCID:: PMC10653879

Abstract Article PDF–1.6M

Select item 100833952.

Alpha-linolenic acid pretreatment alleviates NETs-induced alveolar macrophage pyroptosis by inhibiting pyrin inflammasome activation in a mouse model of sepsis-induced ALI/ARDS

Chenchen Liu, Yu Zhou, Qing Tu, Liangfang Yao, Jinbao Li, Zhongwei Yang

Front Immunol. 2023; 14: 1146612. Published online 2023 Mar 27. doi: 10.3389/fimmu.2023.1146612

PMCID:: PMC10083395

Abstract Article PDF–12M

Select item 98276173.

Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins

Changhoon Oh, Lupeng Li, Ambika Verma, Arianna D. Reuven, Edward A. Miao, James B. Bliska, Youssef Aachoui

Cell Rep. Author manuscript; available in PMC 2023 Jan 9.

Published in final edited form as: Cell Rep. 2022 Nov 22; 41(8): 111688. doi: 10.1016/j.celrep.2022.111688

PMCID:: PMC9827617

Abstract Article PDF–1.1M

Select item 94470074.

RIPK3 promotes Mefv expression and pyrin inflammasome activation via modulation of mTOR signaling

Deepika Sharma, Ankit Malik, Arjun Balakrishnan, R.K. Subbarao Malireddi, Thirumala-Devi Kanneganti

J Immunol. Author manuscript; available in PMC 2022 Sep 6.

Published in final edited form as: J Immunol. 2020 Nov 15; 205(10): 2778–2785. Published online 2020 Sep 28. doi: 10.4049/jimmunol.2000244

PMCID:: PMC9447007

Abstract Article PDF–1.7M

Select item 93382655.

Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling

Shouya Feng, Daniel Enosi Tuipulotu, Abhimanu Pandey, Weidong Jing, Cheng Shen, Chinh Ngo, Melkamu B. Tessema, Fei-Ju Li, Daniel Fox, Anukriti Mathur, Anyang Zhao, Runli Wang, Klaus Pfeffer, Daniel Degrandi, Masahiro Yamamoto, Patrick C. Reading, Gaetan Burgio, Si Ming Man

Nat Commun. 2022; 13: 4395. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32127-0

PMCID:: PMC9338265

Abstract Article PDF–3.0M

Select item 88536346.

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

Rajendra Karki, Balamurugan Sundaram, Bhesh Raj Sharma, SangJoon Lee, R.K. Subbarao Malireddi, Lam Nhat Nguyen, Shelbi Christgen, Min Zheng, Yaqiu Wang, Parimal Samir, Geoffrey Neale, Peter Vogel, Thirumala-Devi Kanneganti

Cell Rep. Author manuscript; available in PMC 2022 Feb 17.

Published in final edited form as: Cell Rep. 2021 Oct 19; 37(3): 109858. doi: 10.1016/j.celrep.2021.109858

PMCID:: PMC8853634

Abstract Article PDF–2.8M

Select item 87441417.

Succination inactivates gasdermin D and blocks pyroptosis

Fiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Sheng Li, Bingwei Wang, Venkatesh V. Nemmara, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin, Scott A. Shaffer, Ranjan Dutta, Carolina Ionete, Scott Pesiridis, Shuo Yang, Paul R. Thompson, Katherine A. Fitzgerald

Science. Author manuscript; available in PMC 2022 Jan 10.

Published in final edited form as: Science. 2020 Sep 25; 369(6511): 1633–1637. Published online 2020 Aug 20. doi: 10.1126/science.abb9818

PMCID:: PMC8744141

Abstract Article PDF–1.3M

Select item 86039428.

AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense

SangJoon Lee, Rajendra Karki, Yaqiu Wang, Lam Nhat Nguyen, Ravi C. Kalathur, Thirumala-Devi Kanneganti

Nature. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Nature. 2021 Sep; 597(7876): 415–419. Published online 2021 Sep 1. doi: 10.1038/s41586-021-03875-8

PMCID:: PMC8603942

Abstract Article PDF–7.4M

Select item 85468629.

The Burkholderia cenocepacia Type VI Secretion System Effector TecA Is a Virulence Factor in Mouse Models of Lung Infection

Nicole A. Loeven, Andrew I. Perault, Peggy A. Cotter, Craig A. Hodges, Joseph D. Schwartzman, Thomas H. Hampton, James B. Bliska

mBio. 2021 Sep-Oct; 12(5): e02098-21. Published online 2021 Sep 28. doi: 10.1128/mBio.02098-21

PMCID:: PMC8546862

Abstract Article PDF–5.1M

Select item 793877010.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 742520811.

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

Min Zheng, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti

Cell. Author manuscript; available in PMC 2021 Apr 30.

Published in final edited form as: Cell. 2020 Apr 30; 181(3): 674–687.e13. Published online 2020 Apr 15. doi: 10.1016/j.cell.2020.03.040

PMCID:: PMC7425208

Abstract Article PDF–2.7M

Select item 698028412.

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

Parimal Samir, Sannula Kesavardhana, Deanna M. Patmore, Sebastien Gingras, R. K. Subbarao Malireddi, Rajendra Karki, Clifford S. Guy, Benoit Briard, David E. Place, Anannya Bhattacharya, Bhesh raj Sharma, Amanda Nourse, Sharon V. King, Aaron Pitre, Amanda R. Burton, Stephane Pelletier, Richard J. Gilbertson, Thirumala-Devi Kanneganti

Nature. Author manuscript; available in PMC 2020 Mar 11.

Published in final edited form as: Nature. 2019 Sep; 573(7775): 590–594. Published online 2019 Sep 11. doi: 10.1038/s41586-019-1551-2

PMCID:: PMC6980284

Abstract Article PDF–5.6M

Select item 674988713.

Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome

Takashi Orimo, Izumi Sasaki, Hiroaki Hemmi, Toshiya Ozasa, Yuri Fukuda-Ohta, Tomokazu Ohta, Mio Morinaka, Mariko Kitauchi, Takako Yamaguchi, Yayoi Sato, Takashi Tanaka, Katsuaki Hoshino, Kei-ichi Katayama, Shinji Fukuda, Kensuke Miyake, Masahiro Yamamoto, Takashi Satoh, Koichi Furukawa, Etsushi Kuroda, Ken J Ishii, Kiyoshi Takeda, Tsuneyasu Kaisho

Int Immunol. 2019 Oct; 31(10): 657–668. Published online 2019 Jan 25. doi: 10.1093/intimm/dxz004

PMCID:: PMC6749887

Abstract Article PDF–1.1M

Select item 630794614.

TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy

Deepika Sharma, Ankit Malik, Clifford Guy, Peter Vogel, Thirumala-Devi Kanneganti

J Clin Invest. 2019 Jan 2; 129(1): 150–162. Published online 2018 Nov 19. doi: 10.1172/JCI121372

PMCID:: PMC6307946

Abstract Article PDF–13M

Select item 624295415.

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

Pedro H. V. Saavedra, Linyan Huang, Farzaneh Ghazavi, Stephanie Kourula, Tom Vanden Berghe, Nozomi Takahashi, Peter Vandenabeele, Mohamed Lamkanfi

Nat Commun. 2018; 9: 4846. Published online 2018 Nov 19. doi: 10.1038/s41467-018-07386-5

PMCID:: PMC6242954

Abstract Article PDF–1.5M

Select item 593557716.

IRF8 regulates transcription of Naips for NLRC4 inflammasome activation

Rajendra Karki, Ein Lee, David Place, Parimal Samir, Jayadev Mavuluri, Bhesh Raj Sharma, Arjun Balakrishnan, R. K. Subbarao Malireddi, Rechel Geiger, Qifan Zhu, Geoffrey Neale, Thirumala-Devi Kanneganti

Cell. Author manuscript; available in PMC 2019 May 3.

Published in final edited form as: Cell. 2018 May 3; 173(4): 920–933.e13. Published online 2018 Mar 22. doi: 10.1016/j.cell.2018.02.055

PMCID:: PMC5935577

Abstract Article PDF–2.0M

Select item 587744317.

Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome

Eric S. Weiss, Charlotte Girard-Guyonvarc’h, Dirk Holzinger, Adriana A. de Jesus, Zeshan Tariq, Jennifer Picarsic, Eduardo J. Schiffrin, Dirk Foell, Alexei A. Grom, Sandra Ammann, Stephan Ehl, Tomoaki Hoshino, Raphaela Goldbach-Mansky, Cem Gabay, Scott W. Canna

Blood. 2018 Mar 29; 131(13): 1442–1455. Prepublished online 2018 Jan 11. doi: 10.1182/blood-2017-12-820852

PMCID:: PMC5877443

Abstract Article

Select item 584745618.

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis

Deepika Sharma, Ankit Malik, Clifford S. Guy, Rajendra Karki, Peter Vogel, Thirumala-Devi Kanneganti

Gastroenterology. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: Gastroenterology. 2018 Mar; 154(4): 948–964.e8. Published online 2017 Dec 2. doi: 10.1053/j.gastro.2017.11.276

PMCID:: PMC5847456

Abstract Article PDF–1.2M

Select item 576959119.

Inflammasome activation and assembly at a glance

Ankit Malik, Thirumala-Devi Kanneganti

J Cell Sci. 2017 Dec 1; 130(23): 3955–3963. doi: 10.1242/jcs.207365

PMCID:: PMC5769591

Abstract Article

Select item 538937220.

IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever

Deepika Sharma, Bhesh Raj Sharma, Peter Vogel, Thirumala-Devi Kanneganti

Am J Pathol. 2017 Feb; 187(2): 236–244. doi: 10.1016/j.ajpath.2016.10.015

PMCID:: PMC5389372

Abstract Article PDF–1.7M

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