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Select item 111782681.

Polycystin-2-dependent transcriptome reveals early response of autosomal dominant polycystic kidney disease

Hyun Jun Jung, Eryn E. Dixon, Richard Coleman, Terry Watnick, Jeremy F. Reiter, Patricia Outeda, Valeriu Cebotaru, Owen M. Woodward, Paul A. Welling

Physiol Genomics. 2023 Nov 1; 55(11): 565–577. Published online 2023 Sep 18. doi: 10.1152/physiolgenomics.00040.2023

PMCID:: PMC11178268

Abstract Article

Select item 106356462.

CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease

Murali K. Yanda, Cristian Ciobanu, William B. Guggino, Liudmila Cebotaru

Am J Physiol Cell Physiol. 2023 Sep 1; 325(3): C682–C693. Published online 2023 Jul 31. doi: 10.1152/ajpcell.00197.2023

PMCID:: PMC10635646

Abstract Article

Select item 104820703.

Dnajb11-Kidney Disease Develops from Reduced Polycystin-1 Dosage but not Unfolded Protein Response in Mice

Sounak Ghosh Roy, Zhigui Li, Zi Guo, Kelly Tran Long, Sonja Rehrl, Xin Tian, Ke Dong, Whitney Besse

J Am Soc Nephrol. 2023 Sep; 34(9): 1521–1534. Published online 2023 Jun 19. doi: 10.1681/ASN.0000000000000164

PMCID:: PMC10482070

Abstract Article

Select item 101937824.

PKD2/polycystin-2 inhibits LPS-induced acute lung injury in vitro and in vivo by activating autophagy

Fan Pan, Lina Bu, Kaixuan Wu, Aizhong Wang, Xiaotao Xu

BMC Pulm Med. 2023; 23: 171. Published online 2023 May 18. doi: 10.1186/s12890-023-02449-w

PMCID:: PMC10193782

Abstract Article PDF–4.0M

Select item 101914415.

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities

Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji

Sci Adv. 2023 May; 9(20): eade3888. Published online 2023 May 17. doi: 10.1126/sciadv.ade3888

PMCID:: PMC10191441

Abstract Article PDF–2.4M

Select item 95291746.

KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency–Related Polycystic Kidney Disease

Gyuyeong Rah, Hwayeon Cha, Joohee Kim, Jieun Song, Hyunho Kim, Yun Kyu Oh, Curie Ahn, Minyong Kang, Jongmin Kim, Kyung Hyun Yoo, Min Jung Kim, Hyuk Wan Ko, Je Yeong Ko, Jong Hoon Park

J Am Soc Nephrol. 2022 Sep; 33(9): 1726–1741. Published online 2022 Sep. doi: 10.1681/ASN.2021111455

PMCID:: PMC9529174

Abstract Article

Select item 93761837.

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression

Ronak Lakhia, Harini Ramalingam, Chun-Mien Chang, Patricia Cobo-Stark, Laurence Biggers, Andrea Flaten, Jesus Alvarez, Tania Valencia, Darren P. Wallace, Edmund C. Lee, Vishal Patel

Nat Commun. 2022; 13: 4765. Published online 2022 Aug 15. doi: 10.1038/s41467-022-32543-2

PMCID:: PMC9376183

Abstract Article PDF–9.0M

Select item 93426408.

Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease

Biswajit Padhy, Jian Xie, Runping Wang, Fang Lin, Chou-Long Huang

J Am Soc Nephrol. 2022 Aug; 33(8): 1501–1516. Published online 2022 Aug. doi: 10.1681/ASN.2022010053

PMCID:: PMC9342640

Abstract Article

Select item 92914219.

Polycystin-2 (PC2) is a key determinant of in vitro myogenesis

Karla M. Márquez-Nogueras, Virdjinija Vuchkovska, Elisabeth DiNello, Sara Osorio-Valencia, Ivana Y. Kuo

Am J Physiol Cell Physiol. 2022 Aug 1; 323(2): C333–C346. Published online 2022 Jun 8. doi: 10.1152/ajpcell.00159.2021

PMCID:: PMC9291421

Abstract Article

Select item 927941410.

A SOX17-PDGFB signaling axis regulates aortic root development

Pengfei Lu, Ping Wang, Bingruo Wu, Yidong Wang, Yang Liu, Wei Cheng, Xuhui Feng, Xinchun Yuan, Miriam M. Atteya, Haleigh Ferro, Yukiko Sugi, Grant Rydquist, Mahdi Esmaily, Jonathan T. Butcher, Ching-Pin Chang, Jack Lenz, Deyou Zheng, Bin Zhou

Nat Commun. 2022; 13: 4065. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31815-1

PMCID:: PMC9279414

Abstract Article PDF–11M

Select item 893300311.

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation

Charles E MacKay, Miranda Floen, M Dennis Leo, Raquibul Hasan, Tessa AC Garrud, Carlos Fernández-Peña, Purnima Singh, Kafait U Malik, Jonathan H Jaggar

eLife. 2022; 11: e74765. Published online 2022 Mar 1. doi: 10.7554/eLife.74765

PMCID:: PMC8933003

Abstract Article PDF–8.9M

Select item 843529212.

A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts

Melanie Grosch, Katrin Brunner, Alexandr V. Ilyaskin, Michael Schober, Tobias Staudner, Denise Schmied, Tina Stumpp, Kerstin N. Schmidt, M. Gregor Madej, Thaissa D. Pessoa, Helga Othmen, Marion Kubitza, Larissa Osten, Uwe de Vries, Magdalena M. Mair, Stefan Somlo, Markus Moser, Karl Kunzelmann, Christine Ziegler, Silke Haerteis, Christoph Korbmacher, Ralph Witzgall

J Cell Sci. 2021 Aug 15; 134(16): jcs259013. Published online 2021 Aug 23. doi: 10.1242/jcs.259013

PMCID:: PMC8435292

Abstract Article

Select item 824938813.

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Katsura Minegishi, Benjamin Rothé, Kaoru R. Komatsu, Hiroki Ono, Yayoi Ikawa, Hiromi Nishimura, Takanobu A. Katoh, Eriko Kajikawa, Xiaorei Sai, Emi Miyashita, Katsuyoshi Takaoka, Kana Bando, Hiroshi Kiyonari, Tadashi Yamamoto, Hirohide Saito, Daniel B. Constam, Hiroshi Hamada

Nat Commun. 2021; 12: 4071. Published online 2021 Jul 1. doi: 10.1038/s41467-021-24295-2

PMCID:: PMC8249388

Abstract Article PDF–4.7M

Select item 819972014.

Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca²⁺ Signals

Khaoula Talbi, Inês Cabrita, Rainer Schreiber, Karl Kunzelmann

Int J Mol Sci. 2021 Jun; 22(11): 6019. Published online 2021 Jun 2. doi: 10.3390/ijms22116019

PMCID:: PMC8199720

Abstract Article PDF–5.9M

Select item 812647915.

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Leticia L. Niborski, Mélanie Paces-Fessy, Pierbruno Ricci, Adeline Bourgeois, Pedro Magalhães, Maria Kuzma-Kuzniarska, Celine Lesaulnier, Martin Reczko, Edwige Declercq, Petra Zürbig, Alain Doucet, Muriel Umbhauer, Silvia Cereghini

Dis Model Mech. 2021 May 1; 14(5): dmm047498. Published online 2021 May 4. doi: 10.1242/dmm.047498

PMCID:: PMC8126479

Abstract Article

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003