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Select item 114062481.

Qki5 safeguards spinal motor neuron function by defining the motor neuron-specific transcriptome via pre-mRNA processing

Yoshika Hayakawa-Yano, Takako Furukawa, Tsuyoshi Matsuo, Takahisa Ogasawara, Masahiro Nogami, Kazumasa Yokoyama, Masato Yugami, Munehisa Shinozaki, Chihiro Nakamoto, Kenji Sakimura, Akihide Koyama, Kazuhiro Ogi, Osamu Onodera, Hirohide Takebayashi, Hideyuki Okano, Masato Yano

Proc Natl Acad Sci U S A. 2024 Sep 10; 121(37): e2401531121. Published online 2024 Sep 3. doi: 10.1073/pnas.2401531121

PMCID:: PMC11406248

Abstract Article PDF–5.2M

Select item 103232512.

Quaking regulates circular RNA production in cardiomyocytes

Pablo Montañés-Agudo, Ingeborg van der Made, Simona Aufiero, Anke J. Tijsen, Yigal M. Pinto, Esther E. Creemers

J Cell Sci. 2023 Jul 1; 136(13): jcs261120. Published online 2023 Jun 30. doi: 10.1242/jcs.261120

PMCID:: PMC10323251

Abstract Article

Select item 102026343.

The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes

Pablo Montañés-Agudo, Simona Aufiero, Eva N Schepers, Ingeborg van der Made, Lucia Cócera-Ortega, Auriane C Ernault, Stéphane Richard, Diederik W D Kuster, Vincent M Christoffels, Yigal M Pinto, Esther E Creemers

Cardiovasc Res. 2023 May; 119(5): 1161–1174. Published online 2023 Jan 11. doi: 10.1093/cvr/cvad007

PMCID:: PMC10202634

Abstract Article PDF–2.0M

Select item 94644124.

QKI degradation in macrophage by RNF6 protects mice from MRSA infection via enhancing PI3K p110β dependent autophagy

Dongsheng Zhai, Wenwen Wang, Zichen Ye, Ke Xue, Guo Chen, Sijun Hu, Zhao Yan, Yanhai Guo, Fang Wang, Xubo Li, An Xiang, Xia Li, Zifan Lu, Li Wang

Cell Biosci. 2022; 12: 154. Published online 2022 Sep 10. doi: 10.1186/s13578-022-00865-9

PMCID:: PMC9464412

Abstract Article PDF–12M

Select item 94249945.

Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma

Fatma Betul Aksoy Yasar, Takashi Shingu, Daniel B. Zamler, Mohammad Fayyad Zaman, Derek Lin Chien, Qiang Zhang, Jiangong Ren, Jian Hu

Front Cell Dev Biol. 2022; 10: 931387. Published online 2022 Aug 16. doi: 10.3389/fcell.2022.931387

PMCID:: PMC9424994

Abstract Article PDF–3.9M

Select item 90988576.

LncRNA CCAT1 enhances chemoresistance in hepatocellular carcinoma by targeting QKI-5

Chongsheng Xia, Yurui Sun, Yang Li, Junli Ma, Jing Shi

Sci Rep. 2022; 12: 7826. Published online 2022 May 12. doi: 10.1038/s41598-022-11644-4

PMCID:: PMC9098857

Abstract Article PDF–4.5M

Select item 88600927.

Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7)

Claudia Dominici, Stéphane Richard

Life Sci Alliance. 2022 May; 5(5): e202101192. Published online 2022 Feb 14. doi: 10.26508/lsa.202101192

PMCID:: PMC8860092

Abstract Article PDF–2.5M

Select item 83132398.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 81399809.

Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency

Seula Shin, Hao Zhou, Chenxi He, Yanjun Wei, Yunfei Wang, Takashi Shingu, Ailiang Zeng, Shaobo Wang, Xin Zhou, Hongtao Li, Qiang Zhang, Qinling Mo, Jiafu Long, Fei Lan, Yiwen Chen, Jian Hu

Nat Commun. 2021; 12: 3005. Published online 2021 May 21. doi: 10.1038/s41467-021-22782-0

PMCID:: PMC8139980

Abstract Article PDF–9.6M

Select item 813983410.

Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N Rasband, Jiangong Ren, Congxin Dai, Rocío I Zorrilla-Veloz, Takashi Shingu, Liang Yuan, Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu

eLife. 2021; 10: e60467. Published online 2021 May 4. doi: 10.7554/eLife.60467

PMCID:: PMC8139834

Abstract Article PDF–7.7M

Select item 794358211.

Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain

Kristina Sakers, Yating Liu, Lorida Llaci, Scott M. Lee, Michael J. Vasek, Michael A. Rieger, Sean Brophy, Eric Tycksen, Renate Lewis, Susan E. Maloney, Joseph D. Dougherty

Nat Commun. 2021; 12: 1537. Published online 2021 Mar 9. doi: 10.1038/s41467-021-21703-5

PMCID:: PMC7943582

Abstract Article PDF–4.0M

Select item 793877012.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 778258913.

QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function

Xinyun Chen, Ying Liu, Chen Xu, Lina Ba, Zhuo Liu, Xiuya Li, Jie Huang, Ed Simpson, Hongyu Gao, Dayan Cao, Wei Sheng, Hanping Qi, Hongrui Ji, Maria Sanderson, Chen-Leng Cai, Xiaohui Li, Lei Yang, Jie Na, Kenichi Yamamura, Yunlong Liu, Guoying Huang, Weinian Shou, Ning Sun

Nat Commun. 2021; 12: 89. Published online 2021 Jan 4. doi: 10.1038/s41467-020-20327-5

PMCID:: PMC7782589

Abstract Article PDF–8.6M

Select item 756294614.

Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage

Akihide Takeuchi, Yuji Takahashi, Kei Iida, Motoyasu Hosokawa, Koichiro Irie, Mikako Ito, J.B. Brown, Kinji Ohno, Kinichi Nakashima, Masatoshi Hagiwara

Stem Cell Reports. 2020 Oct 13; 15(4): 883–897. Published online 2020 Sep 24. doi: 10.1016/j.stemcr.2020.08.010

PMCID:: PMC7562946

Abstract Article PDF–6.7M

Select item 754309215.

Qki is an essential regulator of microglial phagocytosis in demyelination

Jiangong Ren, Congxin Dai, Xin Zhou, Joseph A. Barnes, Xi Chen, Yunfei Wang, Liang Yuan, Takashi Shingu, Amy B. Heimberger, Yiwen Chen, Jian Hu

J Exp Med. 2021 Jan 4; 218(1): e20190348. Published online 2020 Oct 6. doi: 10.1084/jem.20190348

PMCID:: PMC7543092

Abstract Article PDF–7.6M

Select item 739307216.

Targeting QKI-7 in vivo restores endothelial cell function in diabetes

Chunbo Yang, Magdalini Eleftheriadou, Sophia Kelaini, Thomas Morrison, Marta Vilà González, Rachel Caines, Nicola Edwards, Andrew Yacoub, Kevin Edgar, Arya Moez, Aleksandar Ivetic, Anna Zampetaki, Lingfang Zeng, Fiona L. Wilkinson, Noemi Lois, Alan W. Stitt, David J. Grieve, Andriana Margariti

Nat Commun. 2020; 11: 3812. Published online 2020 Jul 30. doi: 10.1038/s41467-020-17468-y

Correction in:: Nat Commun. 2020; 11: 4770.

PMCID:: PMC7393072

Abstract Article PDF–3.3M

Select item 720589217.

QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism

Tianshu Du, Zhao Yan, Shu Zhu, Guo Chen, Li Wang, Zichen Ye, Wenwen Wang, Qingsheng Zhu, Zifan Lu, Xiaorui Cao

Cell Death Dis. 2020 May; 11(5): 330. Published online 2020 May 7. doi: 10.1038/s41419-020-2548-3

PMCID:: PMC7205892

Abstract Article PDF–3.3M

Select item 719100018.

Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα–mediated lipid metabolism

Xin Zhou, Chenxi He, Jiangong Ren, Congxin Dai, Sharon R. Stevens, Qianghu Wang, Daniel Zamler, Takashi Shingu, Liang Yuan, Chythra R. Chandregowda, Yunfei Wang, Visweswaran Ravikumar, Arvind U.K. Rao, Feng Zhou, Hongwu Zheng, Matthew N. Rasband, Yiwen Chen, Fei Lan, Amy B. Heimberger, Benjamin M. Segal, Jian Hu

J Clin Invest. 2020 May 1; 130(5): 2220–2236. Published online 2020 Mar 23. doi: 10.1172/JCI131800

PMCID:: PMC7191000

Abstract Article PDF–16M

Select item 694495219.

QKI regulates adipose tissue metabolism by acting as a brake on thermogenesis and promoting obesity

Huanyu Lu, Zichen Ye, Yue Zhai, Li Wang, Ying Liu, Jiye Wang, Wenbin Zhang, Wenjing Luo, Zifan Lu, Jingyuan Chen

EMBO Rep. 2020 Jan 7; 21(1): e47929. Published online 2019 Dec 23. doi: 10.15252/embr.201947929

PMCID:: PMC6944952

Abstract Article PDF–3.8M

Select item 677230220.

Destabilization and Mislocalization of Myelin Basic Protein mRNAs in quaking Dysmyelination Lacking the QKI RNA-Binding Proteins

Zhenzhong Li, Youyi Zhang, Daqing Li, Yue Feng

J Neurosci. 2000 Jul 1; 20(13): 4944–4953. doi: 10.1523/JNEUROSCI.20-13-04944.2000

PMCID:: PMC6772302

Abstract Article PDF–449K

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