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Select item 108643631.

Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy

Yan Guo, Pan Xiang, Xiaojiao Sun, Wei Liu, Jiafeng Zhou, Bin Yin, Lin Hou, Boqin Qiang, Huiliang Li, Pengcheng Shu, Xiaozhong Peng

Signal Transduct Target Ther. 2024; 9: 32. Published online 2024 Feb 14. doi: 10.1038/s41392-024-01742-2

PMCID:: PMC10864363

Abstract Article PDF–9.9M

Select item 106897542.

PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III

Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Kim

Exp Mol Med. 2023 Nov; 55(11): 2357–2375. Published online 2023 Nov 1. doi: 10.1038/s12276-023-01104-y

PMCID:: PMC10689754

Abstract Article PDF–9.0M

Select item 105757333.

Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and antitumor immunity through eNOS/Src

Elin Sjöberg, Marit Melssen, Mark Richards, Yindi Ding, Catarina Chanoca, Dongying Chen, Emmanuel Nwadozi, Sagnik Pal, Dominic T. Love, Takeshi Ninchoji, Masabumi Shibuya, Michael Simons, Anna Dimberg, Lena Claesson-Welsh

J Clin Invest. 2023 Oct 16; 133(20): e161366. Published online 2023 Oct 16. doi: 10.1172/JCI161366

PMCID:: PMC10575733

Abstract Article PDF–7.1M

Select item 96594924.

Visuosocial Preference Memory, but Not Avoidance Memory, Requires PLCγ1 in the CA2 Hippocampus

Sunpil Kim, Jeongyeon Kim, Yongmin Mason Park, Pann-Ghill Suh, C. Justin Lee

Exp Neurobiol. 2022 Oct 31; 31(5): 332–342. Published online 2022 Oct 31. doi: 10.5607/en22033

PMCID:: PMC9659492

Abstract Article PDF–1.2M

Select item 95927685.

Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3‐mediated cancer development

Eun‐Bi Seo, Hyun‐Jun Jang, Sun‐Ho Kwon, Yong‐Jin Kwon, Seul‐Ki Kim, Song‐Hee Lee, Ae Jin Jeong, Hyun Mu Shin, Yong‐Nyun Kim, Stephanie Ma, Haeryoung Kim, Yun‐Han Lee, Pann‐Ghill Suh, Sang‐Kyu Ye

Hepatol Commun. 2022 Nov; 6(11): 3234–3246. Published online 2022 Sep 25. doi: 10.1002/hep4.2077

PMCID:: PMC9592768

Abstract Article PDF–48M

Select item 88546756.

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Tina M. Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H. Heidel

Blood. 2022 Feb 17; 139(7): 1080–1097. doi: 10.1182/blood.2021012778

PMCID:: PMC8854675

Abstract Article

Select item 87762477.

Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCγ1 Signal Transduction Pathway

Myun Soo Kim, Dongmin Park, Sora Lee, Sunyoung Park, Kyung Eun Kim, Tae Sung Kim, Hyun Jeong Park, Daeho Cho

Int J Mol Sci. 2022 Jan; 23(2): 844. Published online 2022 Jan 13. doi: 10.3390/ijms23020844

PMCID:: PMC8776247

Abstract Article PDF–1.9M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 78263479.

Prediction of Alzheimer’s disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening

Sung-Hyun Kim, Sumin Yang, Key-Hwan Lim, Euiseng Ko, Hyun-Jun Jang, Mingon Kang, Pann-Ghill Suh, Jae-Yeol Joo

Proc Natl Acad Sci U S A. 2021 Jan 19; 118(3): e2011250118. Published online 2021 Jan 4. doi: 10.1073/pnas.2011250118

Correction in:: Proc Natl Acad Sci U S A. 2021 Mar 2; 118(9): e2101727118.

PMCID:: PMC7826347

Abstract Article PDF–2.3M

Select item 776787710.

MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β₁-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration

Lisa Zondler, Sebastian Herich, Petra Kotte, Katharina Körner, Tilman Schneider-Hohendorf, Heinz Wiendl, Nicholas Schwab, Alexander Zarbock

Front Immunol. 2020; 11: 599936. Published online 2020 Dec 14. doi: 10.3389/fimmu.2020.599936

PMCID:: PMC7767877

Abstract Article PDF–2.5M

Select item 767933711.

Modulation of calcium signaling depends on the oligosaccharide of GM1 in Neuro2a mouse neuroblastoma cells

Giulia Lunghi, Maria Fazzari, Erika Di Biase, Laura Mauri, Sandro Sonnino, Elena Chiricozzi

Glycoconj J. 2020; 37(6): 713–727. Published online 2020 Nov 17. doi: 10.1007/s10719-020-09963-7

PMCID:: PMC7679337

Abstract Article PDF–2.8M

Select item 764197012.

Phosphorylation of PLCγ1 by EphA2 receptor tyrosine kinase promotes tumor growth in lung cancer

Wenqiang Song, Laura C. Kim, Wei Han, Yuan Hou, Deanna Edwards, Shan Wang, Timothy S. Blackwell, Feixiong Cheng, Dana M. Brantley-Sieders, Jin Chen

Mol Cancer Res. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Mol Cancer Res. 2020 Nov; 18(11): 1735–1743. Published online 2020 Aug 4. doi: 10.1158/1541-7786.MCR-20-0075

PMCID:: PMC7641970

Abstract Article PDF–2.1M

Select item 761041913.

PLCγ1 suppression promotes the adaptation of KRAS-mutant lung adenocarcinomas to hypoxia

Maria Saliakoura, Matteo Rossi Sebastiano, Chiara Pozzato, Florian H. Heidel, Tina M. Schnöder, Spasenija Savic Prince, Lukas Bubendorf, Paolo Pinton, Ralph Schmid, Johanna Baumgartner, Stefan Freigang, Sabina A. Berezowska, Alessandro Rimessi, Georgia Konstantinidou

Nat Cell Biol. Author manuscript; available in PMC 2021 Apr 19.

Published in final edited form as: Nat Cell Biol. 2020 Nov 1; 22(11): 1382–1395. Published online 2020 Oct 19. doi: 10.1038/s41556-020-00592-8

PMCID:: PMC7610419

Abstract Article PDF–8.7M

Select item 688288414.

Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice

Hye Yun Kim, Yong Ryoul Yang, Hongik Hwang, Ha-Eun Lee, Hyun-Jun Jang, Jeongyeon Kim, Esther Yang, Hyun Kim, Hyewhon Rhim, Pann-Ghill Suh, Jae-Ick Kim

Sci Rep. 2019; 9: 17761. Published online 2019 Nov 28. doi: 10.1038/s41598-019-54477-4

PMCID:: PMC6882884

Abstract Article PDF–1.8M

Select item 685906615.

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang, Odile Burlet-Schiltz, Hervé Luche, Frédéric Fiore, Marie Malissen, Anne Gonzalez de Peredo, Yinming Liang, Romain Roncagalli, Bernard Malissen

Nat Immunol. Author manuscript; available in PMC 2020 Apr 7.

Published in final edited form as: Nat Immunol. 2019 Nov 1; 20(11): 1530–1541. Published online 2019 Oct 7. doi: 10.1038/s41590-019-0489-8

PMCID:: PMC6859066

Abstract Article PDF–2.9M

Select item 667384516.

Hippocampal Long-Term Potentiation Is Supported by Presynaptic and Postsynaptic Tyrosine Receptor Kinase B-Mediated Phospholipase Cγ Signaling

Annette Gärtner, Dorit G. Polnau, Volker Staiger, Carla Sciarretta, Liliana Minichiello, Hans Thoenen, Tobias Bonhoeffer, Martin Korte

J Neurosci. 2006 Mar 29; 26(13): 3496–3504. doi: 10.1523/JNEUROSCI.3792-05.2006

PMCID:: PMC6673845

Abstract Article PDF–2.7M

Select item 626277717.

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher

J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214