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Select item 114130211.

GPX4 restricts ferroptosis of NKp46⁺ILC3s to control intestinal inflammation

Xinyao Li, Junyu He, Xiang Gao, Guilang Zheng, Chunling Chen, Yimin Chen, Zhe Xing, Tianci Wang, Jian Tang, Yuxiong Guo, Yumei He

Cell Death Dis. 2024 Sep; 15(9): 687. Published online 2024 Sep 19. doi: 10.1038/s41419-024-07060-3

PMCID:: PMC11413021

Abstract Article PDF–7.8M

Select item 110324642.

USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy

Haiou Li, Yishuang Sun, Yingmeng Yao, Shanwen Ke, Nannan Zhang, Wenjun Xiong, Jie Shi, Chuan He, Xiangling Xiao, Haisheng Yu, Panpan Dai, Bolin Xiang, Xixin Xing, Gaoshan Xu, Wenjing Song, Jiquan Song, Jinfang Zhang

Proc Natl Acad Sci U S A. 2024 Apr 16; 121(16): e2315541121. Published online 2024 Apr 10. doi: 10.1073/pnas.2315541121

Correction in:: Proc Natl Acad Sci U S A. 2024 Jun 18; 121(25): e2409669121.

PMCID:: PMC11032464

Abstract Article PDF–2.1M

Select item 110084183.

Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis

Xing-Nian Zhou, Quan Zhang, Hong Peng, Yu-Jie Qin, Yu-Hong Liu, Lu Wang, Ming-Liang Cheng, Xin-Hua Luo, Hong Li

World J Gastroenterol. 2024 Mar 21; 30(11): 1588–1608. Published online 2024 Mar 21. doi: 10.3748/wjg.v30.i11.1588

PMCID:: PMC11008418

Abstract Article PDF–18M

Select item 109450844.

GPX4‐mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP‐TEAD signalling pathway

Wang Mengjia, Ji Jun, Zhang Xin, Zhang Jiahao, Guo Jie

J Cell Mol Med. 2024 Apr; 28(7): e18231. Published online 2024 Mar 17. doi: 10.1111/jcmm.18231

PMCID:: PMC10945084

Abstract Article PDF–16M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109002726.

Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8⁺T cell function and its impact against pancreatic ductal adenocarcinoma

Wei Wei, Linqing Tian, Xiaoyan Zheng, Lei Zhong, Yuan Chen, Hui Dong, Guibing Zhang, Shibing Wang, Xiangmin Tong

Oncoimmunology. 2024; 13(1): 2322173. Published online 2024 Feb 27. doi: 10.1080/2162402X.2024.2322173

PMCID:: PMC10900272

Abstract Article PDF–7.5M

Select item 108711527.

Modulation of sarcopenia phenotypes by glutathione peroxidase 4 overexpression in mice

Hongyang Xu, Agnieszka Czyżowska, Holly Van Remmen, Jacob L. Brown

J Physiol. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: J Physiol. 2023 Dec; 601(23): 5277–5293. Published online 2023 Oct 25. doi: 10.1113/JP285259

PMCID:: PMC10871152

Abstract Article PDF–1.7M

Select item 108598748.

Iron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity

Islam A. Berdaweel, T. Blake Monroe, Amany A. Alowaisi, Jolonda C. Mahoney, I-Chau Liang, Kaitlyn A. Berns, Dylan Gao, Jared M. McLendon, Ethan J. Anderson

Front Pharmacol. 2023; 14: 1275388. Published online 2024 Jan 3. doi: 10.3389/fphar.2023.1275388

PMCID:: PMC10859874

Abstract Article PDF–2.1M

Select item 108401849.

Microglial ferroptotic stress causes non-cell autonomous neuronal death

Jeffrey R. Liddell, James B. W. Hilton, Kai Kysenius, Jessica L. Billings, Sara Nikseresht, Lachlan E. McInnes, Dominic J. Hare, Bence Paul, Stephen W. Mercer, Abdel A. Belaidi, Scott Ayton, Blaine R. Roberts, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Peter J. Crouch

Mol Neurodegener. 2024; 19: 14. Published online 2024 Feb 5. doi: 10.1186/s13024-023-00691-8

PMCID:: PMC10840184

Abstract Article PDF–4.8M

Select item 1077757210.

Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice

Xue Bai, Bing Wang, Yiduo Cui, Siqi Tian, Yi Zhang, Linhao You, Yan-Zhong Chang, Guofen Gao

J Neuroinflammation. 2024; 21: 15. Published online 2024 Jan 9. doi: 10.1186/s12974-023-03008-0

PMCID:: PMC10777572

Abstract Article PDF–8.2M

Select item 1077012011.

FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner

Yaguang Bi, Shuolin Liu, Xing Qin, Miyesaier Abudureyimu, Lu Wang, Rongjun Zou, Amir Ajoolabady, Wenjing Zhang, Hu Peng, Jun Ren, Yingmei Zhang

J Adv Res. 2024 Jan; 55: 45–60. Published online 2023 Feb 23. doi: 10.1016/j.jare.2023.02.012

PMCID:: PMC10770120

Abstract Article PDF–5.8M

Select item 1063861012.

HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression

Lijun Zhang, Fang Chen, Jian Dong, Rong Wang, Guangyu Bi, Daoliang Xu, Yingwei Zhang, Yijun Deng, Wenjun Lin, Zhongzhou Yang, Wangsen Cao

Redox Biol. 2023 Dec; 68: 102939. Published online 2023 Oct 20. doi: 10.1016/j.redox.2023.102939

PMCID:: PMC10638610

Abstract Article PDF–18M

Select item 1034513913.

GPX4 is a key ferroptosis biomarker and correlated with immune cell populations and immune checkpoints in childhood sepsis

Guoxin Qu, Hui Liu, Jin Li, Siyuan Huang, Nannan Zhao, Ling Zeng, Jin Deng

Sci Rep. 2023; 13: 11358. Published online 2023 Jul 13. doi: 10.1038/s41598-023-32992-9

PMCID:: PMC10345139

Abstract Article PDF–11M

Select item 1027614314.

Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness

Agnieszka Czyżowska, Jacob Brown, Hongyang Xu, Kavitha Sataranatarajan, Michael Kinter, Victoria J. Tyrell, Valerie B. O'Donnell, Holly Van Remmen

Redox Biol. 2023 Aug; 64: 102761. Published online 2023 Jun 1. doi: 10.1016/j.redox.2023.102761

PMCID:: PMC10276143

Abstract Article PDF–11M

Select item 981133015.

GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS

Long-Fang Tu, Tian-Ze Zhang, Yang-Fan Zhou, Qing-Qing Zhou, Hai-Biao Gong, Lei Liang, Lin-Na Hai, Nan-Xin You, Yang Su, Yong-Jun Chen, Xu-Kai Mo, Chang-Zheng Shi, Liang-Ping Luo, Wan-Yang Sun, Wen-Jun Duan, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He

J Adv Res. 2023 Jan; 43: 205–218. Published online 2022 Mar 4. doi: 10.1016/j.jare.2022.02.016

PMCID:: PMC9811330

Abstract Article PDF–4.2M

Select item 980408116.

Netrin‐1 upregulates GPX4 and prevents ferroptosis after traumatic brain injury via the UNC5B/Nrf2 signaling pathway

Yuanda Zhang, Jin Lan, Dongxu Zhao, Cijie Ruan, Jue Zhou, Haoyuan Tan, Yinghui Bao

CNS Neurosci Ther. 2023 Jan; 29(1): 216–227. Published online 2022 Dec 5. doi: 10.1111/cns.13997

PMCID:: PMC9804081

Abstract Article PDF–14M

Select item 979540917.

Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair

Shintaro Ide, Kana Ide, Koki Abe, Yoshihiko Kobayashi, Hiroki Kitai, Jennifer McKey, Sarah A. Strausser, Lori L. O’Brien, Aleksandra Tata, Purushothama Rao Tata, Tomokazu Souma

Cell Rep. Author manuscript; available in PMC 2022 Dec 28.

Published in final edited form as: Cell Rep. 2022 Nov 8; 41(6): 111610. doi: 10.1016/j.celrep.2022.111610

PMCID:: PMC9795409

Abstract Article PDF–3.1M

Select item 971225318.

The role of selenoproteins in neutrophils during inflammation

Tai-Jung Lee, Shaneice K. Nettleford, Allison McGlynn, Bradley A. Carlson, Girish S. Kirimanjeswara, K. Sandeep Prabhu

Arch Biochem Biophys. Author manuscript; available in PMC 2023 Dec 15.

Published in final edited form as: Arch Biochem Biophys. 2022 Dec 15; 732: 109452. Published online 2022 Nov 3. doi: 10.1016/j.abb.2022.109452

PMCID:: PMC9712253

Abstract Article PDF–821K

Select item 963748419.

Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx

Shaoyi Wang, Weiwei Li, Pengfei Zhang, Zihao Wang, Xiaoyuan Ma, Chuanju Liu, Krasimir Vasilev, Lei Zhang, Xiaocong Zhou, Liang Liu, John Hayball, Shuli Dong, Yuhua Li, Yuan Gao, Lei Cheng, Yunpeng Zhao

J Adv Res. 2022 Nov; 41: 63–75. Published online 2022 Jan 11. doi: 10.1016/j.jare.2022.01.004

PMCID:: PMC9637484

Abstract Article PDF–5.3M

Select item 945847120.

GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection

Eduardo P. Amaral, Taylor W. Foreman, Sivaranjani Namasivayam, Kerry L. Hilligan, Keith D. Kauffman, Caio Cesar Barbosa Bomfim, Diego L. Costa, Beatriz Barreto-Duarte, Clarissa Gurgel-Rocha, Monique Freire Santana, Marcelo Cordeiro-Santos, Elsa Du Bruyn, Catherine Riou, Kate Aberman, Robert John Wilkinson, Daniel L. Barber, Katrin D. Mayer-Barber, Bruno B. Andrade, Alan Sher

J Exp Med. 2022 Nov 7; 219(11): e20220504. Published online 2022 Sep 7. doi: 10.1084/jem.20220504

PMCID:: PMC9458471

Abstract Article PDF–7.5M

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