PMC Links for GEO Profiles (Select 4224875) - PMC

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 110730464.

Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma

Mankun Wei, Uli Nurjanah, Arin Herkilini, Can Huang, Yanjun Li, Makoto Miyagishi, Shourong Wu, Vivi Kasim

Cell Mol Life Sci. 2022 Sep; 79(9): 472. Published online 2022 Aug 6. doi: 10.1007/s00018-022-04504-x

PMCID:: PMC11073046

Abstract Article PDF–14M

Select item 110028935.

ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2

Yvonne Benatzy, Megan A. Palmer, Dieter Lütjohann, Rei-Ichi Ohno, Nadja Kampschulte, Nils Helge Schebb, Dominik C. Fuhrmann, Ryan G. Snodgrass, Bernhard Brüne

Redox Biol. 2024 Jun; 72: 103149. Published online 2024 Apr 3. doi: 10.1016/j.redox.2024.103149

PMCID:: PMC11002893

Abstract Article PDF–8.3M

Select item 109902776.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 108334727.

A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes

Shanshan Yang, Chengyu Liu, Mengmeng Jiang, Xiaoqian Liu, Lingling Geng, Yiyuan Zhang, Shuhui Sun, Kang Wang, Jian Yin, Shuai Ma, Si Wang, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu

Protein Cell. 2024 Feb; 15(2): 98–120. Published online 2023 Jun 28. doi: 10.1093/procel/pwad039

PMCID:: PMC10833472

Abstract Article PDF–31M

Select item 107193138.

Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis

Yu Muta, Juan F. Linares, Anxo Martinez-Ordoñez, Angeles Duran, Tania Cid-Diaz, Hiroto Kinoshita, Xiao Zhang, Qixiu Han, Yuki Nakanishi, Naoko Nakanishi, Thekla Cordes, Gurpreet K. Arora, Marc Ruiz-Martinez, Miguel Reina-Campos, Hiroaki Kasashima, Masakazu Yashiro, Kiyoshi Maeda, Ana Albaladejo-Gonzalez, Daniel Torres-Moreno, José García-Solano, Pablo Conesa-Zamora, Giorgio Inghirami, Christian M. Metallo, Timothy F. Osborne, Maria T. Diaz-Meco, Jorge Moscat

Nat Commun. 2023; 14: 8075. Published online 2023 Dec 13. doi: 10.1038/s41467-023-43690-5

PMCID:: PMC10719313

Abstract Article PDF–7.4M

Select item 106512069.

Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake

Danling Gu, Fengqi Zhou, Hao You, Jiancheng Gao, Tao Kang, Deobrat Dixit, Qiulian Wu, Kailin Yang, Shusheng Ci, Danyang Shan, Xiao Fan, Wei Yuan, Qian Zhang, Chenfei Lu, Daqi Li, Ningwei Zhao, Zhumei Shi, Wei Gao, Fan Lin, Jianghong Man, Qianghu Wang, Xu Qian, Stephen C Mack, Weiwei Tao, Sameer Agnihotri, Nu Zhang, Yongping You, Jeremy N Rich, Junxia Zhang, Xiuxing Wang

Neuro Oncol. 2023 Sep; 25(9): 1578–1591. Published online 2023 Mar 19. doi: 10.1093/neuonc/noad060

PMCID:: PMC10651206

Abstract Article PDF–11M

Select item 1046813010.

Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells

Weilian Bao, Yan You, Jiahui Ni, Hui Hou, Jiaren Lyu, Guize Feng, Yirui Wang, Keyuan You, Sulin Zhang, Lijie Zhang, Xinyue Cao, Xu Wang, Haidong Li, Hong Li, Jiake Xu, Chenying Liu, Xiaomin Luo, Peng Du, Daofeng Chen, Xiaoyan Shen

Sci Adv. 2023 Sep; 9(35): eadh5016. Published online 2023 Aug 30. doi: 10.1126/sciadv.adh5016

Correction in:: Sci Adv. 2024 Apr 12; 10(15): eadp3968.

PMCID:: PMC10468130

Abstract Article PDF–23M

Select item 1030777711.

USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer

Carina R. Maier, Oliver Hartmann, Cristian Prieto-Garcia, Kamal M. Al-Shami, Lisa Schlicker, Felix C. E. Vogel, Silke Haid, Kevin Klann, Viktoria Buck, Christian Münch, Werner Schmitz, Elias Einig, Bastian Krenz, Marco A. Calzado, Martin Eilers, Nikita Popov, Mathias T. Rosenfeldt, Markus E. Diefenbacher, Almut Schulze

Cell Death Differ. 2023 Jul; 30(7): 1710–1725. Published online 2023 May 18. doi: 10.1038/s41418-023-01173-6

PMCID:: PMC10307777

Abstract Article PDF–6.3M

Select item 1011716512.

Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway—implications for Parkinson’s disease

Willcyn Tang, John Thundyil, Grace Gui Yin Lim, Teddy J W Tng, Sean Qing Zhang Yeow, Aditya Nair, Chou Chai, Tso-Pang Yao, Kah-Leong Lim

Hum Mol Genet. 2023 May 1; 32(9): 1466–1482. Published online 2022 Nov 26. doi: 10.1093/hmg/ddac297

Correction in:: Hum Mol Genet. 2023 Jun 1; 32(11): 1943.

PMCID:: PMC10117165

Abstract Article PDF–2.3M

Select item 989960213.

SREBF2–STARD4 axis confers sorafenib resistance in hepatocellular carcinoma by regulating mitochondrial cholesterol homeostasis

Xuetian Yue, Youzi Kong, Yankun Zhang, Min Sun, Shuyue Liu, Zhuanchang Wu, Lifen Gao, Xiaohong Liang, Chunhong Ma

Cancer Sci. 2023 Feb; 114(2): 477–489. Published online 2022 Dec 1. doi: 10.1111/cas.15449

PMCID:: PMC9899602

Abstract Article PDF–17M

Select item 939519414.

Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells

Joseph Wayne M Fowler, Rong Zhang, Bo Tao, Nabil E Boutagy, William C Sessa

eLife. 2022; 11: e79529. Published online 2022 Aug 12. doi: 10.7554/eLife.79529

PMCID:: PMC9395194

Abstract Article PDF–4.6M

Select item 910747115.

TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2

Naohiro Egawa, Yuishin Izumi, Hidefumi Suzuki, Itaru Tsuge, Koji Fujita, Hitoshi Shimano, Keiichi Izumikawa, Nobuhiro Takahashi, Kayoko Tsukita, Takako Enami, Masahiro Nakamura, Akira Watanabe, Motoko Naitoh, Shigehiko Suzuki, Tsuneyoshi Seki, Kazuhiro Kobayashi, Tatsushi Toda, Ryuji Kaji, Ryosuke Takahashi, Haruhisa Inoue

Sci Rep. 2022; 12: 7988. Published online 2022 May 14. doi: 10.1038/s41598-022-12133-4

PMCID:: PMC9107471

Abstract Article PDF–5.8M

Select item 903755416.

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy

Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell

Autophagy. 2022; 18(4): 829–840. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1960116

PMCID:: PMC9037554

Abstract Article PDF–4.1M

Select item 897371617.

SREBP2 promotes the viability, proliferation, and migration and inhibits apoptosis in TGF-β1-induced airway smooth muscle cells by regulating TLR2/NF-κB/NFATc1/ABCA1 regulatory network

Yuebin Wang, Huike Yang, Xian Su, Anqiang Cao, Feng Chen, Peng Chen, Fangtao Yan, Huirong Hu

Bioengineered. 2022; 13(2): 3137–3147. Published online 2022 Jan 17. doi: 10.1080/21655979.2022.2026550

PMCID:: PMC8973716

Abstract Article PDF–3.8M

Select item 892365618.

LncCCAT1 interaction protein PKM2 upregulates SREBP2 phosphorylation to promote osteosarcoma tumorigenesis by enhancing the Warburg effect and lipogenesis

Feifei Pu, Jianxiang Liu, Doudou Jing, Fengxia Chen, Xin Huang, Deyao Shi, Wei Wu, Hui Lin, Lei Zhao, Zhenhao Zhang, Xiao Lv, Baichuan Wang, Zhicai Zhang, Zengwu Shao

Int J Oncol. 2022 Apr; 60(4): 44. Published online 2022 Mar 2. doi: 10.3892/ijo.2022.5334

PMCID:: PMC8923656

Abstract Article PDF–2.8M

Select item 880990319.

Knocking down Sterol regulatory element binding protein 2 (SREBF2) inhibits the Serine Protease 8 (PRSS8) /sodium channel epithelial 1alpha subunit (SCNN1A) axis to reduce the cell proliferation, migration and epithelial-mesenchymal transformation of ovarian cancer

Chunyan Cai, Yumei Zhang, Xing Peng

Bioengineered. 2021; 12(2): 9390–9400. Published online 2021 Nov 25. doi: 10.1080/21655979.2021.1978615

PMCID:: PMC8809903

Abstract Article PDF–2.9M

Select item 834837620.

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination

Wan Yun Ho, Jer-Cherng Chang, Kenneth Lim, Amaury Cazenave-Gassiot, Aivi T. Nguyen, Juat Chin Foo, Sneha Muralidharan, Ashley Viera-Ortiz, Sarah J.M. Ong, Jin Hui Hor, Ira Agrawal, Shawn Hoon, Olubankole Aladesuyi Arogundade, Maria J. Rodriguez, Su Min Lim, Seung Hyun Kim, John Ravits, Shi-Yan Ng, Markus R. Wenk, Edward B. Lee, Greg Tucker-Kellogg, Shuo-Chien Ling

J Cell Biol. 2021 Sep 6; 220(9): e201910213. Published online 2021 Aug 4. doi: 10.1083/jcb.201910213

PMCID:: PMC8348376

Abstract Article PDF–11M

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