PMC Links for GEO Profiles (Select 42252601) - PMC

Select item 112124251.

Platelet-derived exosomes alleviate tendon stem/progenitor cell senescence and ferroptosis by regulating AMPK/Nrf2/GPX4 signaling and improve tendon-bone junction regeneration in rats

Deheng Chen, Qian Tang, Wei Song, Yaohua He

J Orthop Surg Res. 2024; 19: 382. Published online 2024 Jun 28. doi: 10.1186/s13018-024-04869-8

PMCID:: PMC11212425

Abstract Article PDF–13M

Select item 110586122.

Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis

Chunyan Pang, Hongmei Zhang, Yi Liu, Na Tang, Kun Tian, Yandong Mu, Xue Li, Li Xiao

J Cell Mol Med. 2024 May; 28(9): e18377. Published online 2024 Apr 30. doi: 10.1111/jcmm.18377

PMCID:: PMC11058612

Abstract Article PDF–24M

Select item 109450843.

GPX4‐mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP‐TEAD signalling pathway

Wang Mengjia, Ji Jun, Zhang Xin, Zhang Jiahao, Guo Jie

J Cell Mol Med. 2024 Apr; 28(7): e18231. Published online 2024 Mar 17. doi: 10.1111/jcmm.18231

PMCID:: PMC10945084

Abstract Article PDF–16M

Select item 105009284.

Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis

Yun-xia Du, Yan-tao Zhao, Yong-xin Sun, Ai-hua Xu

Mol Med. 2023; 29: 125. Published online 2023 Sep 14. doi: 10.1186/s10020-023-00724-4

PMCID:: PMC10500928

Abstract Article PDF–16M

Select item 88099125.

Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis

Shujun Xu, Bingxin Wu, Biying Zhong, Luoqi Lin, Yining Ding, Xiao Jin, Zhiwei Huang, Miaoyang Lin, Huanlin Wu, Danping Xu

Bioengineered. 2021; 12(2): 10924–10934. Published online 2021 Nov 29. doi: 10.1080/21655979.2021.1995994

PMCID:: PMC8809912

Abstract Article PDF–1.7M

Select item 72530286.

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

Tomonori Tadokoro, Masataka Ikeda, Tomomi Ide, Hiroko Deguchi, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Shouji Matsushima, Tomoko Koumura, Ken-ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui

JCI Insight. 2020 May 7; 5(9): e132747. Published online 2020 May 7. doi: 10.1172/jci.insight.132747

Correction in:: JCI Insight. 2023 Mar 22; 8(6): e169756.

PMCID:: PMC7253028

Abstract Article PDF–15M

Select item 68287617.

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

Tae-Jun Park, Jei Hyoung Park, Ga Seul Lee, Ji-Yoon Lee, Ji Hye Shin, Min Wook Kim, Yong Sook Kim, Jeong-Yoon Kim, Kyoung-Jin Oh, Baek-Soo Han, Won-Kon Kim, Youngkeun Ahn, Jeong Hee Moon, Jaewhan Song, Kwang-Hee Bae, Do Han Kim, Eun-Woo Lee, Sang Chul Lee

Cell Death Dis. 2019 Nov; 10(11): 835. Published online 2019 Nov 4. doi: 10.1038/s41419-019-2061-8

PMCID:: PMC6828761

Abstract Article PDF–2.1M

Select item 48948468.

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli, Manuela Schneider, Bettina Proneth, Yulia Y. Tyurina, Vladimir A. Tyurin, Victoria J. Hammond, Nadja Herbach, Michaela Aichler, Axel Walch, Elke Eggenhofer, Devaraj Basavarajappa, Olof Rådmark, Sho Kobayashi, Tobias Seibt, Heike Beck, Frauke Neff, Irene Esposito, Rüdiger Wanke, Heidi Förster, Olena Yefremova, Marc Heinrichmeyer, Georg W. Bornkamm, Edward K. Geissler, Stephen B. Thomas, Brent R. Stockwell, Valerie B. O’Donnell, Valerian E. Kagan, Joel A. Schick, Marcus Conrad

Nat Cell Biol. Author manuscript; available in PMC 2016 Jun 6.

Published in final edited form as: Nat Cell Biol. 2014 Dec; 16(12): 1180–1191. Published online 2014 Nov 17. doi: 10.1038/ncb3064

PMCID:: PMC4894846

Abstract Article PDF–1.0M

Select item 45055339.

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

Irina Ingold, Michaela Aichler, Elena Yefremova, Antonella Roveri, Katalin Buday, Sebastian Doll, Adrianne Tasdemir, Nils Hoffard, Wolfgang Wurst, Axel Walch, Fulvio Ursini, José Pedro Friedmann Angeli, Marcus Conrad

J Biol Chem. 2015 Jun 5; 290(23): 14668–14678. Published online 2015 Apr 28. doi: 10.1074/jbc.M115.656363

PMCID:: PMC4505533

Abstract Article PDF–2.6M

Select item 404345410.

Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4

David N Hauser, April A Dukes, Amanda D Mortimer, Teresa G Hastings

Free Radic Biol Med. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Free Radic Biol Med. 2013 Dec; 65: 419–427. Published online 2013 Jun 28. doi: 10.1016/j.freeradbiomed.2013.06.030

PMCID:: PMC4043454

Abstract Article PDF–2.6M

Select item 317805911.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 283014012.

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

Eva K. Wirth, Marcus Conrad, Jochen Winterer, Christian Wozny, Bradley A. Carlson, Stephan Roth, Dietmar Schmitz, Georg W. Bornkamm, Vincenzo Coppola, Lino Tessarollo, Lutz Schomburg, Josef Köhrle, Dolph L. Hatfield, Ulrich Schweizer

FASEB J. 2010 Mar; 24(3): 844–852. doi: 10.1096/fj.09-143974

PMCID:: PMC2830140

Abstract Article

Select item 277884413.

A mitochondrial protein compendium elucidates complex I disease biology

David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha

Cell. Author manuscript; available in PMC 2009 Nov 18.

Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016