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Select item 114252171.

CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC

Qi Li, Qingzhou Chen, Tao Zheng, Fulin Wang, Junlin Teng, Haining Zhou, Jianguo Chen

Adv Sci (Weinh) 2024 Sep; 11(35): 2406009. Published online 2024 Jul 17. doi: 10.1002/advs.202406009

PMCID:: PMC11425217

Abstract Article PDF–6.2M

Select item 112099352.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111481843.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111094834.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 108698005.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett

Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4

PMCID:: PMC10869800

Abstract Article PDF–9.3M

Select item 108581916.

Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling

Yuqing Zhang, Rose Young, Dimitriya H. Garvanska, Chunlin Song, Yujing Zhai, Ying Wang, Hongfei Jiang, Jing Fang, Jakob Nilsson, Claudio Alfieri, Gang Zhang

Commun Biol. 2024; 7: 164. Published online 2024 Feb 9. doi: 10.1038/s42003-024-05859-6

PMCID:: PMC10858191

Abstract Article PDF–2.3M

Select item 106869827.

Functional analysis of recurrent CDC20 promoter variants in human melanoma

Paula M. Godoy, Abimbola Oyedeji, Jacqueline L. Mudd, Vasilios A. Morikis, Anna P. Zarov, Gregory D. Longmore, Ryan C. Fields, Charles K. Kaufman

Commun Biol. 2023; 6: 1216. Published online 2023 Nov 29. doi: 10.1038/s42003-023-05526-2

PMCID:: PMC10686982

Abstract Article PDF–1.9M

Select item 104895478.

The potential role of CDC20 in tumorigenesis, cancer progression and therapy: A narrative review

Feng Xian, Caixia Zhao, Chun Huang, Jun Bie, Guohui Xu

Medicine (Baltimore) 2023 Sep 8; 102(36): e35038. Published online 2023 Sep 8. doi: 10.1097/MD.0000000000035038

PMCID:: PMC10489547

Abstract Article PDF–972K

Select item 104610789.

Alternative Cdc20 translational isoforms tune mitotic arrest duration

Mary-Jane Tsang, Iain M. Cheeseman

Nature. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Nature. 2023 May; 617(7959): 154–161. Published online 2023 Apr 26. doi: 10.1038/s41586-023-05943-7

PMCID:: PMC10461078

Abstract Article PDF–5.8M

Select item 1031801110.

SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence

Sang Hyup Lee, Ji-Hye Yang, Ui-Hyun Park, Hanbyeul Choi, Yoo Sung Kim, Bo-Eun Yoon, Hye-Jeong Han, Hyun-Taek Kim, Soo-Jong Um, Eun-Joo Kim

Exp Mol Med. 2023 Jun; 55(6): 1232–1246. Published online 2023 Jun 1. doi: 10.1038/s12276-023-01012-1

PMCID:: PMC10318011

Abstract Article PDF–4.5M

Select item 1024855411.

The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity

Sahezeel Awadia, Merna Sitto, Sundaresh Ram, Wenbin Ji, Yajing Liu, Raheema Damani, Dipankar Ray, Theodore S. Lawrence, Craig J. Galban, Steven D. Cappell, Alnawaz Rehemtulla

J Biol Chem. 2023 Jun; 299(6): 104786. Published online 2023 May 4. doi: 10.1016/j.jbc.2023.104786

PMCID:: PMC10248554

Abstract Article PDF–6.8M

Select item 1023742212.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1007290613.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1006344714.

PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B

Ji Wang, Zongyu Xiao, Peng Li, Chunwang Wu, Yan Li, Qing Wang, Yanming Chen, Honglong Zhou, Zhi Li, Zhaotao Wang, Qing Lan, Yezhong Wang

Oncogene. 2023; 42(14): 1088–1100. Published online 2023 Feb 15. doi: 10.1038/s41388-023-02624-7

PMCID:: PMC10063447

Abstract Article PDF–8.8M

Select item 995044715.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 993386216.

Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor

Xiaofu Cao, Adnan Shami Shah, Ethan J. Sanford, Marcus B. Smolka, Jeremy M. Baskin

ACS Chem Biol. Author manuscript; available in PMC 2023 Sep 16.

Published in final edited form as: ACS Chem Biol. 2022 Sep 16; 17(9): 2605–2618. Published online 2022 Aug 11. doi: 10.1021/acschembio.2c00527

PMCID:: PMC9933862

Abstract Article PDF–2.5M

Select item 979798817.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 977255818.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 956995519.

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation

Yulemi Gonzalez Quesada, Luc DesGroseillers

Int J Mol Sci. 2022 Oct; 23(19): 11588. Published online 2022 Sep 30. doi: 10.3390/ijms231911588

PMCID:: PMC9569955

Abstract Article PDF–2.1M

Select item 949004320.

Impaired Cdc20 signaling promotes senescence in normal cells and apoptosis in non–small cell lung cancer cells

Daniela Volonte, Morgan Sedorovitz, Ferruccio Galbiati

J Biol Chem. 2022 Oct; 298(10): 102405. Published online 2022 Aug 19. doi: 10.1016/j.jbc.2022.102405

PMCID:: PMC9490043

Abstract Article PDF–3.2M

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