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Select item 114252011.

Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense

Zhen Tong, Jia‐Peng Zou, Su‐Yun Wang, Wei‐Wei Luo, Yan‐Yi Wang

Adv Sci (Weinh) 2024 Sep; 11(35): 2308890. Published online 2024 Jul 14. doi: 10.1002/advs.202308890

PMCID:: PMC11425201

Abstract Article PDF–5.4M

Select item 113343392.

Expression of human Interferon Regulatory Factor 3 (IRF-3) in alveolar macrophages relates to clinical and functional traits in COPD.

Simonetta Baraldo, Matteo Bonato, Sebastiano Cassia, Paolo Casolari, Laura De Ferrari, Mariaenrica Tiné, Federico Baraldi, Tommaso Bigoni, Anna Maria Riccio, Fulvio Braido, Marina Saetta, Alberto Papi, Marco Contoli

Respir Res. 2024; 25: 315. Published online 2024 Aug 19. doi: 10.1186/s12931-024-02952-6

PMCID:: PMC11334339

Abstract Article PDF–1.3M

Select item 111137523.

Interferon regulatory factor 3 in adaptive immune responses

Laure Ysebrant de Lendonck, Valerie Martinet, Stanislas Goriely

Cell Mol Life Sci. 2014 Oct; 71(20): 3873–3883. Published online 2014 May 31. doi: 10.1007/s00018-014-1653-9

PMCID:: PMC11113752

Abstract Article PDF–687K

Select item 110309434.

Regulation of immunity and oncogenesis by the IRF transcription factor family

David Savitsky, Tomohiko Tamura, Hideyuki Yanai, Tadatsugu Taniguchi

Cancer Immunol Immunother. 2010 Apr; 59(4): 489–510. Published online 2010 Jan 5. doi: 10.1007/s00262-009-0804-6

PMCID:: PMC11030943

Abstract Article PDF–668K

Select item 109076045.

Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer

Alessandro Alaimo, Sacha Genovesi, Nicole Annesi, Dario De Felice, Saurav Subedi, Alice Macchia, Federico La Manna, Yari Ciani, Federico Vannuccini, Vera Mugoni, Michela Notarangelo, Michela Libergoli, Francesca Broso, Riccardo Taulli, Ugo Ala, Aurora Savino, Martina Cortese, Somayeh Mirzaaghaei, Valeria Poli, Ian Marc Bonapace, Mauro Giulio Papotti, Luca Molinaro, Claudio Doglioni, Orazio Caffo, Adriano Anesi, Michael Nagler, Giovanni Bertalot, Francesco Giuseppe Carbone, Mattia Barbareschi, Umberto Basso, Erik Dassi, Massimo Pizzato, Alessandro Romanel, Francesca Demichelis, Marianna Kruithof-de Julio, Andrea Lunardi

EMBO J. 2024 Mar; 43(5): 780–805. Published online 2024 Feb 5. doi: 10.1038/s44318-024-00040-5

PMCID:: PMC10907604

Abstract Article PDF–5.4M

Select item 108890056.

The African Swine Fever Virus Virulence Determinant DP96R Suppresses Type I IFN Production Targeting IRF3

Niranjan Dodantenna, Ji-Won Cha, Kiramage Chathuranga, W. A. Gayan Chathuranga, Asela Weerawardhana, Lakmal Ranathunga, Yongkwan Kim, Weonhwa Jheong, Jong-Soo Lee

Int J Mol Sci. 2024 Feb; 25(4): 2099. Published online 2024 Feb 8. doi: 10.3390/ijms25042099

PMCID:: PMC10889005

Abstract Article PDF–3.4M

Select item 108749987.

IRF3 function and immunological gaps in sepsis

Bristy Basak, Sachiko Akashi-Takamura

Front Immunol. 2024; 15: 1336813. Published online 2024 Feb 5. doi: 10.3389/fimmu.2024.1336813

PMCID:: PMC10874998

Abstract Article PDF–1.1M

Select item 107953438.

Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation

Jae-Hyun Yu, Myeung Gi Choi, Na Young Lee, Ari Kwon, Euijin Lee, Ja Hyun Koo

Cell Commun Signal. 2024; 22: 48. Published online 2024 Jan 17. doi: 10.1186/s12964-023-01416-6

PMCID:: PMC10795343

Abstract Article PDF–8.0M

Select item 107785859.

FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3

Zhiqiang Xu, Mingyao Tian, Qihan Tan, Pengfei Hao, Zihan Gao, Chang Li, Ningyi Jin

Int J Mol Sci. 2024 Jan; 25(1): 353. Published online 2023 Dec 26. doi: 10.3390/ijms25010353

PMCID:: PMC10778585

Abstract Article PDF–2.7M

Select item 1073384110.

The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes

Harald Husebye, Marie Hjelmseth Aune, Jørgen Stenvik, Eivind Samstad, Frode Skjeldal, Øyvind Halaas, Nadra J. Nilsen, Harald Stenmark, Eicke Latz, Egil Lien, Tom Eirik Mollnes, Oddmund Bakke, Terje Espevik

Immunity. Author manuscript; available in PMC 2023 Dec 21.

Published in final edited form as: Immunity. 2010 Oct 29; 33(4): 583–596. Published online 2010 Oct 7. doi: 10.1016/j.immuni.2010.09.010

PMCID:: PMC10733841

Abstract Article PDF–3.3M

Select item 1065390611.

Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3

Jian Wang, Hui Zheng, Chunsheng Dong, Sidong Xiong

mBio. 2023 Sep-Oct; 14(5): e00332-23. Published online 2023 Aug 31. doi: 10.1128/mbio.00332-23

PMCID:: PMC10653906

Abstract Article PDF–13M

Select item 1062943212.

Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma

Zhenyi Lv, Wenqi Gao, Zhiwei Du, Yi Zheng, Tianming Liu, Chenjun Hao, Dongbo Xue

Epigenetics. 2023; 18(1): 2276371. Published online 2023 Nov 5. doi: 10.1080/15592294.2023.2276371

PMCID:: PMC10629432

Abstract Article PDF–10M

Select item 1062199213.

Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response

Wei-Wei Li, Xu-Xu Fan, Zi-Xiang Zhu, Xue-Jing Cao, Zhao-Yu Zhu, Dan-Shi Pei, Yi-Zhuo Wang, Ji-Yan Zhang, Yan-Yi Wang, Hai-Xue Zheng

PLoS Pathog. 2023 Oct; 19(10): e1011742. Published online 2023 Oct 23. doi: 10.1371/journal.ppat.1011742

PMCID:: PMC10621992

Abstract Article PDF–3.9M

Select item 1055024214.

Human cytomegalovirus UL36 inhibits IRF3-dependent immune signaling to counterbalance its immunoenhancement as apoptotic inhibitor

Yujie Ren, An Wang, Bowen Zhang, Wenting Ji, Xiao-Xu Zhu, Jing Lou, Muhan Huang, Yang Qiu, Xi Zhou

Sci Adv. 2023 Oct 6; 9(40): eadi6586. Published online 2023 Oct 4. doi: 10.1126/sciadv.adi6586

PMCID:: PMC10550242

Abstract Article PDF–2.7M

Select item 1028146215.

Serine-arginine splicing factor 2 promotes oesophageal cancer progression by regulating alternative splicing of interferon regulatory factor 3

Ziqing Wei, Yuyao Wang, Wenyuan Ma, Wenqing Xing, Peng Lu, Zhijie Shang, Feng Li, Huiyu Li, Yuxuan Wang

RNA Biol. 2023; 20(1): 359–367. Published online 2023 Jun 19. doi: 10.1080/15476286.2023.2223939

PMCID:: PMC10281462

Abstract Article PDF–4.2M

Select item 1023742216.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1018358817.

Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection

Joseph K. Sampson Duncan, Danyang Xu, Maria Licursi, Michael A. Joyce, Holly A. Saffran, Kaiwen Liu, Jin Gohda, D. Lorne Tyrrell, Yasushi Kawaguchi, Kensuke Hirasawa

Front Immunol. 2023; 14: 930086. Published online 2023 May 1. doi: 10.3389/fimmu.2023.930086

PMCID:: PMC10183588

Abstract Article PDF–3.1M

Select item 1011280218.

Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1)

Jiale Shi, Xuemei Jia, Yujia He, Xinyue Ma, Xiaoyu Qi, Wan Li, Shou-Jiang Gao, Qin Yan, Chun Lu

PLoS Pathog. 2023 Apr; 19(4): e1011324. Published online 2023 Apr 6. doi: 10.1371/journal.ppat.1011324

PMCID:: PMC10112802

Abstract Article PDF–4.4M

Select item 960379619.

Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway

Nenavath Gopal Naik, See-Chi Lee, Beatriz H. S. Veronese, Zhe Ma, Zsolt Toth

Microbiol Spectr. 2022 Sep-Oct; 10(5): e02322-22. Published online 2022 Sep 29. doi: 10.1128/spectrum.02322-22

PMCID:: PMC9603796

Abstract Article PDF–1.9M

Select item 954241520.

OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity

Weihong Xie, Shuo Tian, Jiahui Yang, Sihui Cai, Shouheng Jin, Tao Zhou, Yaoxing Wu, Zhiyun Chen, Yanqin Ji, Jun Cui

Autophagy. 2022; 18(10): 2288–2302. Published online 2022 Jan 31. doi: 10.1080/15548627.2022.2026098

PMCID:: PMC9542415

Abstract Article PDF–3.2M

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