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Select item 115275281.

Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of Extreme Obesity

Cinthia Vila Nova Santana, Luiz Alexandre Viana Magno, Adauto Versiani Ramos, Maria Angélica Rios, Valéria Cristina Sandrim, Luiz Armando De Marco, Débora Marques de Miranda, Marco Aurélio Romano-Silva

J Obes. 2024; 2024: 3813621. Published online 2024 Oct 24. doi: 10.1155/2024/3813621

PMCID:: PMC11527528

Abstract Article PDF–433K

Select item 112379302.

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 112099353.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 110708494.

AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation

Xiaoming Dai, Cong Jiang, Qiwei Jiang, Lan Fang, Haihong Yu, Jinhe Guo, Peiqiang Yan, Fangtao Chi, Tao Zhang, Hiroyuki Inuzuka, John M. Asara, Ping Wang, Jianping Guo, Wenyi Wei

Nat Metab. Author manuscript; available in PMC 2024 May 6.

Published in final edited form as: Nat Metab. 2023 Feb; 5(2): 265–276. Published online 2023 Feb 2. doi: 10.1038/s42255-022-00732-4

PMCID:: PMC11070849

Abstract Article PDF–5.4M

Select item 110477865.

SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression

Tingting Lv, Xiude Fan, Chang He, Suwei Zhu, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu, Ruihua Shi, Qin He

Redox Biol. 2024 Jun; 72: 103159. Published online 2024 Apr 16. doi: 10.1016/j.redox.2024.103159

PMCID:: PMC11047786

Abstract Article PDF–22M

Select item 107941126.

Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1

Nazma Malik, Bibiana I. Ferreira, Pablo E. Hollstein, Stephanie D. Curtis, Elijah Trefts, Sammy Weiser Novak, Jingting Yu, Rebecca Gilson, Kristina Hellberg, Lingjing Fang, Arlo Sheridan, Nasun Hah, Gerald S. Shadel, Uri Manor, Reuben J. Shaw

Science. Author manuscript; available in PMC 2024 Jan 18.

Published in final edited form as: Science. 2023 Apr 21; 380(6642): eabj5559. Published online 2023 Apr 21. doi: 10.1126/science.abj5559

PMCID:: PMC10794112

Abstract Article PDF–3.3M

Select item 107903877.

NUSAP1 promotes pancreatic ductal adenocarcinoma progression by drives the epithelial-mesenchymal transition and reduces AMPK phosphorylation

Yuan Liu, Rong Tang, Qing-Cai Meng, Si Shi, Jin Xu, Xian-Jun Yu, Bo Zhang, Wei Wang

BMC Cancer. 2024; 24: 87. Published online 2024 Jan 16. doi: 10.1186/s12885-024-11842-5

PMCID:: PMC10790387

Abstract Article PDF–9.6M

Select item 106290858.

Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA

Anthony Yan-Tang Wu, Ponarulselvam Sekar, Duen-Yi Huang, Shu-Hao Hsu, Chi-Ming Chan, Wan-Wan Lin

J Biomed Sci. 2023; 30: 91. Published online 2023 Nov 7. doi: 10.1186/s12929-023-00978-4

PMCID:: PMC10629085

Abstract Article PDF–2.9M

Select item 105997499.

PLCL1 suppresses tumour progression by regulating AMPK/mTOR-mediated autophagy in renal cell carcinoma

Zhou Pan, Jing Huang, Huajie Song, Yusha Xiao, Ting Liu, Yan Zeng, Hengcheng Zhu, Kang Yang

Aging (Albany NY) 2023 Oct 15; 15(19): 10407–10427. Published online 2023 Oct 6. doi: 10.18632/aging.205085

PMCID:: PMC10599749

Abstract Article PDF–2.6M

Select item 1057763510.

A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress

Weiwei Jiang, Mengyao Zhang, Chuan Gao, Chaojun Yan, Ronghui Gao, Ziwei He, Xin Wei, Jingjing Xiong, Zilun Ruan, Qian Yang, Jinpeng Li, Qifang Li, Ziyi Zhong, Mengna Zhang, Qianqian Yuan, Hankun Hu, Shuang Wang, Ming‐Ming Hu, Cheguo Cai, Gao‐Song Wu, Chao Jiang, Ya‐Lin Zhang, Chen‐Song Zhang, Jing Zhang

EMBO J. 2023 Oct; 42(20): e113743. Published online 2023 Sep 4. doi: 10.15252/embj.2023113743

PMCID:: PMC10577635

Abstract Article PDF–3.8M

Select item 1056882011.

DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy

Ning Wu, Jinzhong Ji, Xiaoqin Gou, Pan Hu, Yao Cheng, Yuhang Liu, Yuanying Wang, Qilong Zhang, Li Zuo

Virol J. 2023; 20: 231. Published online 2023 Oct 11. doi: 10.1186/s12985-023-02166-0

PMCID:: PMC10568820

Abstract Article PDF–2.1M

Select item 1047848712.

Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer

Shuyong Yu, Ruisha Tu, Zhaowei Chen, Jian Song, Ping Li, Feixiang Hu, Guihong Yuan, Ronglin Zhang, Yini Li

BMC Med Genomics. 2023; 16: 209. Published online 2023 Sep 5. doi: 10.1186/s12920-023-01645-1

PMCID:: PMC10478487

Abstract Article PDF–5.1M

Select item 1041006213.

Sex and age differences in AMPK phosphorylation, mitochondrial homeostasis, and inflammation in hearts from inflammatory cardiomyopathy patients

Maria Luisa Barcena, Greta Tonini, Natalie Haritonow, Pavelas Breiter, Hendrik Milting, Istvan Baczko, Ursula Müller‐Werdan, Yury Ladilov, Vera Regitz‐Zagrosek

Aging Cell. 2023 Aug; 22(8): e13894. Published online 2023 Jun 26. doi: 10.1111/acel.13894

PMCID:: PMC10410062

Abstract Article PDF–2.1M

Select item 1028085714.

METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression

Wei Wei, Zhong-Yuan Zhang, Bin Shi, Yike Cai, Hou-Shun Zhang, Chun-Lei Sun, Yun-Fei Fei, Wen Zhong, Shuang Zhang, Chen Wang, Bing He, Guan-Min Jiang, Hao Wang

J Exp Clin Cancer Res. 2023; 42: 151. Published online 2023 Jun 20. doi: 10.1186/s13046-023-02732-y

Correction in:: J Exp Clin Cancer Res. 2024; 43: 26.

PMCID:: PMC10280857

Abstract Article PDF–12M

Select item 1023742215.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1021835316.

JAC4 Inhibits EGFR-Driven Lung Adenocarcinoma Growth and Metastasis through CTBP1-Mediated JWA/AMPK/NEDD4L/EGFR Axis

Kun Ding, Xuqian Jiang, Zhangding Wang, Lu Zou, Jiahua Cui, Xiong Li, Chuanjun Shu, Aiping Li, Jianwei Zhou

Int J Mol Sci. 2023 May; 24(10): 8794. Published online 2023 May 15. doi: 10.3390/ijms24108794

PMCID:: PMC10218353

Abstract Article PDF–19M

Select item 1015364917.

Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

Liping Xie, Yanmei Yuan, Simiao Xu, Sijia Lu, Jinyang Gu, Yanping Wang, Yibing Wang, Xianjing Zhang, Suzhen Chen, Jian Li, Junxi Lu, Honglin Sun, Ruixiang Hu, Hailong Piao, Wen Wang, Cunchuan Wang, Jing Wang, Na Li, Morris F. White, Liu Han, Weiping Jia, Ji Miao, Junli Liu

Cell Rep. Author manuscript; available in PMC 2023 May 2.

Published in final edited form as: Cell Rep. 2022 Oct 18; 41(3): 111498. doi: 10.1016/j.celrep.2022.111498

PMCID:: PMC10153649

Abstract Article PDF–1.6M

Select item 1011932218.

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

Lei Chen, Wenjing Zhang, Dan Chen, Quan Yang, Siwen Sun, Zhenwei Dai, Zhengzheng Li, Xuemei Liang, Chaoqun Chen, Yuexia Jiao, Lili Zhi, Lianmei Zhao, Jinrui Zhang, Xuefeng Liu, Jinyao Zhao, Man Li, Yang Wang, Yangfan Qi

Signal Transduct Target Ther. 2023; 8: 159. Published online 2023 Apr 21. doi: 10.1038/s41392-023-01367-x

PMCID:: PMC10119322

Abstract Article PDF–7.7M

Select item 1007290619.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1007041820.

AMPK phosphorylates and stabilises copper transporter 1 to synergise metformin and copper chelator for breast cancer therapy

Xiaomei Zhang, Qiwei Jiang, Yaqing Su, Lang Bu, Zicheng Sun, Xueji Wu, Bing Gao, Lei Wang, Ying Lin, Wei Xie, Jianping Guo

Br J Cancer. 2023 Apr 12; 128(8): 1452–1465. Published online 2023 Feb 17. doi: 10.1038/s41416-022-02127-4

PMCID:: PMC10070418

Abstract Article PDF–2.8M

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