PMC Links for GEO Profiles (Select 42613619) - PMC

Select item 99759471.

Structural mechanism of CRL4‐instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor

Vu Thuy Khanh Le‐Trilling, Sofia Banchenko, Darius Paydar, Pia Madeleine Leipe, Lukas Binting, Simon Lauer, Andrea Graziadei, Robin Klingen, Christine Gotthold, Jörg Bürger, Thilo Bracht, Barbara Sitek, Robert Jan Lebbink, Anna Malyshkina, Thorsten Mielke, Juri Rappsilber, Christian MT Spahn, Sebastian Voigt, Mirko Trilling, David Schwefel

EMBO J. 2023 Mar; 42(5): e112351. Published online 2023 Feb 10. doi: 10.15252/embj.2022112351

PMCID:: PMC9975947

Abstract Article PDF–6.2M

Select item 74053852.

A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses

Yuxin Wang, Qiaoling Song, Wei Huang, Yuxi Lin, Xin Wang, Chenyao Wang, Belinda Willard, Chenyang Zhao, Jing Nan, Elise Holvey-Bates, Zhuoya Wang, Derek Taylor, Jinbo Yang, George R. Stark

Cell Res. 2021 Feb; 31(2): 206–218. Published online 2020 Aug 5. doi: 10.1038/s41422-020-0386-6

PMCID:: PMC7405385

Abstract Article PDF–4.3M

Select item 70719123.

Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection

Heidi J. Elsaesser, Mahmood Mohtashami, Ivan Osokine, Laura M. Snell, Cameron R. Cunningham, Giselle M. Boukhaled, Dorian B. McGavern, Juan Carlos Zúñiga-Pflücker, David G. Brooks

Proc Natl Acad Sci U S A. 2020 Mar 10; 117(10): 5420–5429. Published online 2020 Feb 24. doi: 10.1073/pnas.1913776117

PMCID:: PMC7071912

Abstract Article PDF–2.8M

Select item 66001884.

Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus Tropism

Lisa Miorin, Maudry Laurent-Rolle, Giuseppe Pisanelli, Pierre Hendrick Co, Randy A. Albrecht, Adolfo García-Sastre, Juliet Morrison

J Virol. 2019 Jul 15; 93(14): e00151-19. Prepublished online 2019 May 1. Published online 2019 Jun 28. doi: 10.1128/JVI.00151-19

PMCID:: PMC6600188

Abstract Article PDF–2.2M

Select item 64980565.

Species-Specific Pathogenicity of Severe Fever with Thrombocytopenia Syndrome Virus Is Determined by Anti-STAT2 Activity of NSs

Rokusuke Yoshikawa, Saori Sakabe, Shuzo Urata, Jiro Yasuda

J Virol. 2019 May 15; 93(10): e02226-18. Prepublished online 2019 Feb 27. Published online 2019 May 1. doi: 10.1128/JVI.02226-18

PMCID:: PMC6498056

Abstract Article PDF–2.0M

Select item 61781356.

STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection

Radha Gopal, Benjamin Lee, Kevin J. McHugh, Helen E. Rich, Krishnaveni Ramanan, Sivanarayana Mandalapu, Michelle E. Clay, Philip J. Seger, Richard I. Enelow, Michelle L. Manni, Keven M. Robinson, Javier Rangel-Moreno, John F. Alcorn

Front Immunol. 2018; 9: 2151. Published online 2018 Sep 25. doi: 10.3389/fimmu.2018.02151

PMCID:: PMC6178135

Abstract Article PDF–4.6M

Select item 60267327.

STAT2-Dependent Immune Responses Ensure Host Survival despite the Presence of a Potent Viral Antagonist

Vu Thuy Khanh Le-Trilling, Kerstin Wohlgemuth, Meike U. Rückborn, Andreja Jagnjic, Fabienne Maaßen, Lejla Timmer, Benjamin Katschinski, Mirko Trilling

J Virol. 2018 Jul 15; 92(14): e00296-18. Prepublished online 2018 May 9. Published online 2018 Jun 29. doi: 10.1128/JVI.00296-18

PMCID:: PMC6026732

Abstract Article PDF–2.7M

Select item 59535598.

An immunocompetent mouse model of Zika virus infection

Matthew J. Gorman, Elizabeth A. Caine, Konstantin Zaitsev, Matthew C. Begley, James Weger-Lucarelli, Melissa B. Uccellini, Shashank Tripathi, Juliet Morrison, Boyd L. Yount, Kenneth H. Dinnon, III, Claudia Rückert, Michael C. Young, Zhe Zhu, Shelly J. Robertson, Kristin L. McNally, Jing Ye, Bin Cao, Indira U. Mysorekar, Gregory D. Ebel, Ralph S. Baric, Sonja M. Best, Maxim N. Artyomov, Adolfo Garcia-Sastre, Michael S. Diamond

Cell Host Microbe. Author manuscript; available in PMC 2019 May 9.

Published in final edited form as: Cell Host Microbe. 2018 May 9; 23(5): 672–685.e6. doi: 10.1016/j.chom.2018.04.003

PMCID:: PMC5953559

Abstract Article PDF–1.7M

Select item 58087339.

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission

Rojeen Shahni, Catherine M. Cale, Glenn Anderson, Laura D. Osellame, Sophie Hambleton, Thomas S. Jacques, Yehani Wedatilake, Jan-Willem Taanman, Emma Chan, Waseem Qasim, Vincent Plagnol, Annapurna Chalasani, Michael R. Duchen, Kimberly C. Gilmour, Shamima Rahman

Brain. 2015 Oct; 138(10): 2834–2846. Published online 2015 Jun 30. doi: 10.1093/brain/awv182

PMCID:: PMC5808733

Abstract Article PDF–1.4M

Select item 537364310.

A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses

Shashank Tripathi, Vinod R. M. T. Balasubramaniam, Julia A. Brown, Ignacio Mena, Alesha Grant, Susana V. Bardina, Kevin Maringer, Megan C. Schwarz, Ana M. Maestre, Marion Sourisseau, Randy A. Albrecht, Florian Krammer, Matthew J. Evans, Ana Fernandez-Sesma, Jean K. Lim, Adolfo García-Sastre

PLoS Pathog. 2017 Mar; 13(3): e1006258. Published online 2017 Mar 9. doi: 10.1371/journal.ppat.1006258

PMCID:: PMC5373643

Abstract Article PDF–2.3M

Select item 508058911.

Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling

Sajith Nair, Pradeep Bist, Neha Dikshit, Manoj N Krishnan

Sci Rep. 2016; 6: 36179. Published online 2016 Oct 26. doi: 10.1038/srep36179

PMCID:: PMC5080589

Abstract Article PDF–2.4M

Select item 454728512.

Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness

Pil Soo Sung, HyeonJoo Cheon, Chung Hwan Cho, Seon-Hui Hong, Do Youn Park, Hyung-Il Seo, Su-Hyung Park, Seung Kew Yoon, George R. Stark, Eui-Cheol Shin

Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33): 10443–10448. Published online 2015 Jul 27. doi: 10.1073/pnas.1513341112

PMCID:: PMC4547285

Abstract Article PDF–1.5M

Select item 405627513.

TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways

Jun Xu, Philip W. Zoltick, Ana M. Gamero, Stefania Gallucci

J Leukoc Biol. 2014 Jul; 96(1): 93–103. doi: 10.1189/jlb.2A0713-393RR

PMCID:: PMC4056275

Abstract Article

Select item 405444914.

IRF7-Dependent Type I Interferon Production Induces Lethal Immune-Mediated Disease in STAT1 Knockout Mice Infected with Lymphocytic Choriomeningitis Virus

Wen Li, Markus J. Hofer, So Ri Jung, Sue-Ling Lim, Iain L. Campbell

J Virol. 2014 Jul; 88(13): 7578–7588. doi: 10.1128/JVI.03117-13

PMCID:: PMC4054449

Abstract Article PDF–2.9M

Select item 358198615.

STAT2 deficiency and susceptibility to viral illness in humans

Sophie Hambleton, Stephen Goodbourn, Dan F. Young, Paul Dickinson, Siti M. B. Mohamad, Manoj Valappil, Naomi McGovern, Andrew J. Cant, Scott J. Hackett, Peter Ghazal, Neil V. Morgan, Richard E. Randall

Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8): 3053–3058. Published online 2013 Feb 7. doi: 10.1073/pnas.1220098110

PMCID:: PMC3581986

Abstract Article PDF–601K

Select item 331042916.

Mouse STAT2 Restricts Early Dengue Virus Replication

Joseph Ashour, Juliet Morrison, Maudry Laurent-Rolle, Alan Belicha-Villanueva, Courtney Ray Plumlee, Dabeiba Bernal-Rubio, Kate Williams, Eva Harris, Ana Fernandez-Sesma, Christian Schindler, Adolfo García-Sastre

Cell Host Microbe. Author manuscript; available in PMC 2012 Mar 22.

Published in final edited form as: Cell Host Microbe. 2010 Nov 18; 8(5): 410–421. doi: 10.1016/j.chom.2010.10.007