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Select item 109815241.

Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krüpple-like factor 4 deacetylation

Jin Zhang, Chenzhong Xu, Xiaolong Tang, Shimin Sun, Siqi Liu, Langmei Yang, Yuqin Chen, Qifeng Yang, Tong-You Wade Wei, Xiaojing Wu, Jian Wang, Chen Wang, Xiaosong Yan, Lei Yang, Yanqin Niu, Deming Gou, John Y J Shyy, Baohua Liu

Cardiovasc Res. 2024 Mar; 120(4): 403–416. Published online 2024 Jan 10. doi: 10.1093/cvr/cvae011

PMCID:: PMC10981524

Abstract Article PDF–1.8M

Select item 108230652.

Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice

Yufei Wei, Xinhuan Wang, Zhihua Ma, Pan Xiang, Gaoao Liu, Bin Yin, Lin Hou, Pengcheng Shu, Wei Liu, Xiaozhong Peng

iScience. 2024 Feb 16; 27(2): 108706. Published online 2023 Dec 9. doi: 10.1016/j.isci.2023.108706

PMCID:: PMC10823065

Abstract Article PDF–8.1M

Select item 103302393.

The Mitochondrial Unfolded Protein Response Regulates Hippocampal Neural Stem Cell Aging

Chih Ling Wang, Rika Ohkubo, Wei-Chieh Mu, Wei Chen, Jiang Lan Fan, Zehan Song, Ayane Maruichi, Peter H. Sudmant, Angela O. Pisco, Dena B. Dubal, Na Ji, Danica Chen

Cell Metab. Author manuscript; available in PMC 2024 Jun 6.

Published in final edited form as: Cell Metab. 2023 Jun 6; 35(6): 996–1008.e7. Published online 2023 May 4. doi: 10.1016/j.cmet.2023.04.012

PMCID:: PMC10330239

Abstract Article PDF–2.8M

Select item 98251204.

The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease

Rika Ohkubo, Wei-Chieh Mu, Chih-Ling Wang, Zehan Song, Marine Barthez, Yifei Wang, Nathaniel Mitchener, Rasul Abdullayev, Yeong Rim Lee, Yuze Ma, Megan Curtin, Suraj Srinivasan, Xingjia Zhang, Fanghan Yang, Peter H. Sudmant, Angela Oliveira Pisco, Norma Neff, Cole M. Haynes, Danica Chen

Cell Rep. Author manuscript; available in PMC 2023 Jan 7.

Published in final edited form as: Cell Rep. 2022 Dec 13; 41(11): 111803. doi: 10.1016/j.celrep.2022.111803

PMCID:: PMC9825120

Abstract Article PDF–3.2M

Select item 97447495.

SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

Tatsuya Yoshizawa, Yoshifumi Sato, Shihab U. Sobuz, Tomoya Mizumoto, Tomonori Tsuyama, Md. Fazlul Karim, Keishi Miyata, Masayoshi Tasaki, Masaya Yamazaki, Yuichi Kariba, Norie Araki, Eiichi Araki, Shingo Kajimura, Yuichi Oike, Thomas Braun, Eva Bober, Johan Auwerx, Kazuya Yamagata

Nat Commun. 2022; 13: 7439. Published online 2022 Dec 12. doi: 10.1038/s41467-022-35219-z

PMCID:: PMC9744749

Abstract Article PDF–3.1M

Select item 96884836.

SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice

Tomoya Mizumoto, Tatsuya Yoshizawa, Yoshifumi Sato, Takaaki Ito, Tomonori Tsuyama, Akiko Satoh, Satoshi Araki, Kenichi Tsujita, Masaru Tamura, Yuichi Oike, Kazuya Yamagata

Cells. 2022 Nov; 11(22): 3609. Published online 2022 Nov 15. doi: 10.3390/cells11223609

PMCID:: PMC9688483

Abstract Article PDF–2.6M

Select item 89193337.

Drp1 regulates transcription of ribosomal protein genes in embryonic hearts

Qiancong Zhao, Shun Yan, Jin Lu, Danitra J. Parker, Huiying Wu, Qianchuang Sun, David K. Crossman, Shanrun Liu, Qin Wang, Hiromi Sesaki, Kasturi Mitra, Kexiang Liu, Kai Jiao

J Cell Sci. 2022 Feb 15; 135(4): jcs258956. Published online 2022 Feb 21. doi: 10.1242/jcs.258956

PMCID:: PMC8919333

Abstract Article

Select item 89104588.

Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury

Andrea Sánchez-Navarro, Miguel Ángel Martínez-Rojas, Adrián Albarrán-Godinez, Rosalba Pérez-Villalva, Johan Auwerx, Abigail de la Cruz, Lilia G. Noriega, Florencia Rosetti, Norma A. Bobadilla

Int J Mol Sci. 2022 Mar; 23(5): 2573. Published online 2022 Feb 25. doi: 10.3390/ijms23052573

PMCID:: PMC8910458

Abstract Article PDF–2.8M

Select item 86780729.

Sirtuin 7 Regulates Nitric Oxide Production and Apoptosis to Promote Mycobacterial Clearance in Macrophages

Su Zhang, Yaya Liu, Xuefeng Zhou, Min Ou, Guohui Xiao, Fang Li, Zhongyuan Wang, Zhaoqin Wang, Lei Liu, Guoliang Zhang

Front Immunol. 2021; 12: 779235. Published online 2021 Dec 3. doi: 10.3389/fimmu.2021.779235

PMCID:: PMC8678072

Abstract Article PDF–6.3M

Select item 849411010.

SIRT7 promotes chromosome synapsis during prophase I of female meiosis

Berta N. Vazquez, Cecilia S. Blengini, Yurdiana Hernandez, Lourdes Serrano, Karen Schindler

Chromosoma. Author manuscript; available in PMC 2021 Oct 6.

Published in final edited form as: Chromosoma. 2019 Sep; 128(3): 369–383. Published online 2019 Jun 29. doi: 10.1007/s00412-019-00713-9

PMCID:: PMC8494110

Abstract Article PDF–2.5M

Select item 809734911.

SIRT7 modulates the stability and activity of the renal K‐Cl cotransporter KCC4 through deacetylation

Lilia G Noriega, Zesergio Melo, Renuga D Rajaram, Adriana Mercado, Armando R Tovar, Laura A Velazquez‐Villegas, María Castañeda‐Bueno, Yazmín Reyes‐López, Dongryeol Ryu, Lorena Rojas‐Vega, German Magaña‐Avila, Adriana M López‐Barradas, Mariana Sánchez‐Hernández, Anne Debonneville, Alain Doucet, Lydie Cheval, Nimbe Torres, Johan Auwerx, Olivier Staub, Gerardo Gamba

EMBO Rep. 2021 May 5; 22(5): e50766. Published online 2021 Mar 22. doi: 10.15252/embr.202050766

PMCID:: PMC8097349

Abstract Article PDF–2.2M

Select item 793877012.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 786515013.

SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress

Alessandro Ianni, Poonam Kumari, Shahriar Tarighi, Nicolas G. Simonet, Daniela Popescu, Stefan Guenther, Soraya Hölper, Andreas Schmidt, Christian Smolka, Shijing Yue, Marcus Krüger, Claudia Fiorillo, Alejandro Vaquero, Eva Bober, Thomas Braun

Proc Natl Acad Sci U S A. 2021 Feb 2; 118(5): e2015339118. Published online 2021 Jan 25. doi: 10.1073/pnas.2015339118

PMCID:: PMC7865150

Abstract Article PDF–2.4M

Select item 750732514.

SIRT7 activates quiescent hair follicle stem cells to ensure hair growth in mice

Guo Li, Xiaolong Tang, Shuping Zhang, Meiling Jin, Ming Wang, Zhili Deng, Zuojun Liu, Minxian Qian, Wei Shi, Zimei Wang, Hongfu Xie, Ji Li, Baohua Liu

EMBO J. 2020 Sep 15; 39(18): e104365. Published online 2020 Jul 21. doi: 10.15252/embj.2019104365

PMCID:: PMC7507325

Abstract Article PDF–7.9M

Select item 738515815.

SIRT7 deficiency suppresses inflammation, induces EndoMT, and increases vascular permeability in primary pulmonary endothelial cells

Anne E. Wyman, Trang T. T. Nguyen, Pratap Karki, Mohan E. Tulapurkar, Chen-Ou Zhang, Junghyun Kim, Theresa G. Feng, Abdoulaye J. Dabo, Nevins W. Todd, Irina G. Luzina, Patrick Geraghty, Robert F. Foronjy, Jeffrey D. Hasday, Anna A. Birukova, Sergei P. Atamas, Konstantin G. Birukov

Sci Rep. 2020; 10: 12497. Published online 2020 Jul 27. doi: 10.1038/s41598-020-69236-z

PMCID:: PMC7385158

Abstract Article PDF–2.4M

Select item 673586416.

SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina

Berta N Vazquez, Joshua K Thackray, Nicolas G Simonet, Sanjay Chahar, Noriko Kane-Goldsmith, Simon J Newkirk, Suman Lee, Jinchuan Xing, Michael P Verzi, Wenfeng An, Alejandro Vaquero, Jay A Tischfield, Lourdes Serrano

Nucleic Acids Res. 2019 Sep 5; 47(15): 7870–7885. Published online 2019 Jun 21. doi: 10.1093/nar/gkz519

PMCID:: PMC6735864

Abstract Article PDF–2.2M

Select item 637180417.

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

Hanzhi Luo, Wei-Chieh Mu, Rajendra Karki, Hou-Hsien Chiang, Mary Mohrin, Jiyung J. Shin, Rika Ohkubo, Keisuke Ito, Thirumala-Devi Kanneganti, Danica Chen

Cell Rep. Author manuscript; available in PMC 2019 Feb 12.

Published in final edited form as: Cell Rep. 2019 Jan 22; 26(4): 945–954.e4. doi: 10.1016/j.celrep.2018.12.101

PMCID:: PMC6371804

Abstract Article PDF–1.0M

Select item 613295418.

Sirt7 inhibits Sirt1-mediated activation of Suv39h1

Poonam Kumari, Daniela Popescu, Shijing Yue, Eva Bober, Alessandro Ianni, Thomas Braun

Cell Cycle. 2018; 17(12): 1403–1412. Published online 2018 Jul 25. doi: 10.1080/15384101.2018.1486166

PMCID:: PMC6132954

Abstract Article PDF–1.6M

Select item 611727819.

Roles of Nmnat1 in the survival of retinal progenitors through the regulation of pro-apoptotic gene expression via histone acetylation

Hiroshi Kuribayashi, Yukihiro Baba, Toshiro Iwagawa, Eisuke Arai, Akira Murakami, Sumiko Watanabe

Cell Death Dis. 2018 Sep; 9(9): 891. Published online 2018 Aug 30. doi: 10.1038/s41419-018-0907-0

PMCID:: PMC6117278

Abstract Article PDF–3.3M

Select item 605336920.

SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix

Masatoshi Fukuda, Tatsuya Yoshizawa, Md. Fazlul Karim, Shihab U. Sobuz, Wataru Korogi, Daiki Kobayasi, Hiroki Okanishi, Masayoshi Tasaki, Katsuhiko Ono, Tomohiro Sawa, Yoshifumi Sato, Mami Chirifu, Takeshi Masuda, Teruya Nakamura, Hironori Tanoue, Kazuhisa Nakashima, Yoshihiro Kobashigawa, Hiroshi Morioka, Eva Bober, Sumio Ohtsuki, Yuriko Yamagata, Yukio Ando, Yuichi Oike, Norie Araki, Shu Takeda, Hiroshi Mizuta, Kazuya Yamagata

Nat Commun. 2018; 9: 2833. Published online 2018 Jul 19. doi: 10.1038/s41467-018-05187-4

PMCID:: PMC6053369

Abstract Article PDF–2.0M

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