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Items: 1 to 20 of 39

1.
ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection
Luis O. Correa-Medero, Shayna E. Jankowski, Hanna S. Hong, Nicholas D. Armas, Aditi I. Vijendra, Mack B. Reynolds, Garrett M. Fogo, Dominik Awad, Alexander T. Dils, Kantaro A. Inoki, Reid G. Williams, Annabelle M. Ye, Nadezhda Svezhova, Francisco Gomez-Rivera, Kathleen L. Collins, Mary X. O’Riordan, Thomas H. Sanderson, Costas A. Lyssiotis, Shannon A. Carty
Cell Rep. Author manuscript; available in PMC 2024 Jun 24.
Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114156. Published online 2024 Apr 29. doi: 10.1016/j.celrep.2024.114156
PMCID:
PMC11194752
AbstractArticlePDF–2.8M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex
Liangguang Leo Lin, Huilun Helen Wang, Brent Pederson, Xiaoqiong Wei, Mauricio Torres, You Lu, Zexin Jason Li, Xiaodan Liu, Hancheng Mao, Hui Wang, Linyao Elina Zhou, Zhen Zhao, Shengyi Sun, Ling Qi
Nat Commun. 2024; 15: 1440. Published online 2024 Feb 16. doi: 10.1038/s41467-024-45633-0
Correction in:
Nat Commun. 2024; 15: 3241.
PMCID:
PMC10873344
AbstractArticlePDF–7.3M
4.
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool
Yewei Ji, Yuan Luo, Yating Wu, Yao Sun, Lianfeng Zhao, Zhen Xue, Mengqi Sun, Xiaoqiong Wei, Zinan He, Shuangcheng Alivia Wu, Liangguang Leo Lin, You Lu, Lei Chang, Fei Chen, Siyu Chen, Wei Qian, Xiaoxi Xu, Shengnuo Chen, Dongli Pan, Zhangsen Zhou, Sheng Xia, Chih-Chi Andrew Hu, Tingbo Liang, Ling Qi
Nat Cell Biol. 2023; 25(5): 726–739. Published online 2023 May 4. doi: 10.1038/s41556-023-01138-4
PMCID:
PMC10185471
AbstractArticlePDF–22M
5.
Integration of ER protein quality control mechanisms defines β cell function and ER architecture
Neha Shrestha, Mauricio Torres, Jason Zhang, You Lu, Leena Haataja, Rachel B. Reinert, Jeffrey Knupp, Yu-Jie Chen, Gunes Parlakgul, Ana Paula Arruda, Billy Tsai, Peter Arvan, Ling Qi
J Clin Invest. 2023 Jan 3; 133(1): e163584. Published online 2023 Jan 3. doi: 10.1172/JCI163584
PMCID:
PMC9797341
AbstractArticlePDF–5.5M
6.
SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer
Asmita Bhattacharya, Juncheng Wei, Wenxin Song, Beixue Gao, Chunyan Tian, Shuangcheng Alivia Wu, Jian Wang, Ligong Chen, Deyu Fang, Ling Qi
iScience. 2022 Oct 21; 25(10): 105183. Published online 2022 Sep 24. doi: 10.1016/j.isci.2022.105183
PMCID:
PMC9550610
AbstractArticlePDF–6.4M
7.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
8.
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection
Xia Liu, Jingjing Yu, Longyong Xu, Katharine Umphred-Wilson, Fanglue Peng, Yao Ding, Brendan M Barton, Xiangdong Lv, Michael Y Zhao, Shengyi Sun, Yuning Hong, Ling Qi, Stanley Adoro, Xi Chen
eLife. 2021; 10: e69975. Published online 2021 Jul 9. doi: 10.7554/eLife.69975
PMCID:
PMC8315795
AbstractArticlePDF–3.1M
9.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
10.
Protein Quality Control Through Endoplasmic Reticulum-Associated Degradation Maintains Hematopoietic Stem Cell Identity and Niche Interactions
Longyong Xu, Xia Liu, Fanglue Peng, Weijie Zhang, Liting Zheng, Yao Ding, Tianpeng Gu, Kaosheng Lv, Jin Wang, Laura Ortinau, Tianyuan Hu, Xiangguo Shi, Guojun Shi, Ge Shang, Shengyi Sun, Takao Iwawaki, Yewei Ji, Wei Li, Jeffrey M. Rosen, Xiang H.-F. Zhang, Dongsu Park, Stanley Adoro, Andre Catic, Wei Tong, Ling Qi, Daisuke Nakada, Xi Chen
Nat Cell Biol. Author manuscript; available in PMC 2021 Mar 21.
Published in final edited form as: Nat Cell Biol. 2020 Oct; 22(10): 1162–1169. Published online 2020 Sep 21. doi: 10.1038/s41556-020-00581-x
PMCID:
PMC7888538
AbstractArticlePDF–2.7M
11.
ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity
Lu Liu, Ayaka Inoki, Kelly Fan, Fengbiao Mao, Guojun Shi, Xi Jin, Meiling Zhao, Gina Ney, Morgan Jones, Shengyi Sun, Yali Dou, Ken Inoki, Ling Qi, Qing Li
Blood. 2020 Dec 24; 136(26): 2975–2986. Prepublished online 2020 Nov 4. doi: 10.1182/blood.2020007975
PMCID:
PMC7770563
AbstractArticle
12.
Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling
Neha Shrestha, Tongyu Liu, Yewei Ji, Rachel B. Reinert, Mauricio Torres, Xin Li, Maria Zhang, Chih-Hang Anthony Tang, Chih-Chi Andrew Hu, Chengyang Liu, Ali Naji, Ming Liu, Jiandie D. Lin, Sander Kersten, Peter Arvan, Ling Qi
J Clin Invest. 2020 Jul 1; 130(7): 3499–3510. Published online 2020 May 26. doi: 10.1172/JCI134874
PMCID:
PMC7324191
AbstractArticlePDF–18M
13.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
14.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
15.
Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH
Asmita Bhattacharya, Shengyi Sun, Heting Wang, Ming Liu, Qiaoming Long, Lei Yin, Sander Kersten, Kezhong Zhang, Ling Qi
EMBO J. 2018 Nov 15; 37(22): e99277. Published online 2018 Nov 2. doi: 10.15252/embj.201899277
PMCID:
PMC6236331
AbstractArticlePDF–4.1M
16.
Inflammation arising from obesity reduces taste bud abundance and inhibits renewal
Andrew Kaufman, Ezen Choo, Anna Koh, Robin Dando
PLoS Biol. 2018 Mar; 16(3): e2001959. Published online 2018 Mar 20. doi: 10.1371/journal.pbio.2001959
PMCID:
PMC5860696
AbstractArticlePDF–5.1M
17.
Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age-associated obesity
Geun Hyang Kim, Guojun Shi, Diane R.M. Somlo, Leena Haataja, Soobin Song, Qiaoming Long, Eduardo A. Nillni, Malcolm J. Low, Peter Arvan, Martin G. Myers, Jr., Ling Qi
J Clin Invest. 2018 Mar 1; 128(3): 1125–1140. Published online 2018 Feb 19. doi: 10.1172/JCI96420
PMCID:
PMC5824855
AbstractArticlePDF–21M
18.
ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis
Guojun Shi, Diane R.M. Somlo, Geun Hyang Kim, Cristina Prescianotto-Baschong, Shengyi Sun, Nicole Beuret, Qiaoming Long, Jonas Rutishauser, Peter Arvan, Martin Spiess, Ling Qi
J Clin Invest. 2017 Oct 2; 127(10): 3897–3912. Published online 2017 Sep 18. doi: 10.1172/JCI94771
PMCID:
PMC5617659
AbstractArticlePDF–19M
19.
Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus
Daniel G. Bichet, Yoann Lussier
J Clin Invest. 2017 Oct 2; 127(10): 3591–3593. Published online 2017 Sep 18. doi: 10.1172/JCI96839
PMCID:
PMC5617649
AbstractArticlePDF–1.8M
20.
Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling
Ioannis Serafimidis, Eva Rodriguez-Aznar, Mathias Lesche, Kazuaki Yoshioka, Yoh Takuwa, Andreas Dahl, Duojia Pan, Anthony Gavalas
PLoS Biol. 2017 Mar; 15(3): e2000949. Published online 2017 Mar 1. doi: 10.1371/journal.pbio.2000949
PMCID:
PMC5331964
AbstractArticlePDF–5.1M

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