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Select item 115506201.

High-fat-diet-induced hepatic insulin resistance per se attenuates murine de novo lipogenesis

Leigh Goedeke, Jordan W. Strober, Rebecca Suh, Lauren M. Paolella, Xiruo Li, Jillian C. Rogers, Max C. Petersen, Ali R. Nasiri, Gregori Casals, Mario Kahn, Gary W. Cline, Varman T. Samuel, Gerald I. Shulman, Daniel F. Vatner

iScience. 2024 Nov 15; 27(11): 111175. Published online 2024 Oct 15. doi: 10.1016/j.isci.2024.111175

PMCID:: PMC11550620

Abstract Article PDF–3.7M

Select item 115063242.

Cellular Profile of Subfornical Organ Insulin Receptors in Mice

Han-Rae Kim, Jin-Kwon Jeong, Colin N. Young

Biomolecules. 2024 Oct; 14(10): 1256. Published online 2024 Oct 4. doi: 10.3390/biom14101256

PMCID:: PMC11506324

Abstract Article PDF–3.5M

Select item 114885403.

Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis

Carlos G. Ardanaz, Aida de la Cruz, Paras S. Minhas, Nira Hernández-Martín, Miguel Ángel Pozo, M. Pilar Valdecantos, Ángela M. Valverde, Palmira Villa-Valverde, Marcos Elizalde-Horcada, Elena Puerta, María J. Ramírez, Jorge E. Ortega, Ainhoa Urbiola, Cristina Ederra, Mikel Ariz, Carlos Ortiz-de-Solórzano, Joaquín Fernández-Irigoyen, Enrique Santamaría, Gerard Karsenty, Jens C. Brüning, Maite Solas

Sci Adv. 2024 Oct 18; 10(42): eadp1115. Published online 2024 Oct 18. doi: 10.1126/sciadv.adp1115

PMCID:: PMC11488540

Abstract Article PDF–1.7M

Select item 114691434.

Fetuin-B Interacts With Insulin Receptor-β and Promotes Insulin Resistance in Retina Cells

Wenyi Zhang, Xin Wang, Shuwei Tian, Jianming Wang, Aiyi Zhou

Invest Ophthalmol Vis Sci. 2024 Oct; 65(12): 16. Published online 2024 Oct 9. doi: 10.1167/iovs.65.12.16

PMCID:: PMC11469143

Abstract Article PDF–2.7M

Select item 113519525.

Impact of Serotonin Transporter Absence on Brain Insulin Receptor Expression, Plasma Metabolome Changes, and ADHD-like Behavior in Mice fed a Western Diet

Daniel C. Anthony, Fay Probert, Anna Gorlova, Jenna Hebert, Daniel Radford-Smith, Zlata Nefedova, Aleksei Umriukhin, Andrey Nedorubov, Raymond Cespuglio, Boris Shulgin, Aleksey Lyundup, Klaus Peter Lesch, Tatyana Strekalova

Biomolecules. 2024 Aug; 14(8): 884. Published online 2024 Jul 23. doi: 10.3390/biom14080884

PMCID:: PMC11351952

Abstract Article PDF–5.4M

Select item 112601296.

Insulin receptor orchestrates kidney antibacterial defenses

Laura Schwartz, Aaron Simoni, Pearlly Yan, Kristin Salamon, Altan Turkoglu, Gabriela Vasquez Martinez, Diana Zepeda-Orozco, Tad Eichler, Xin Wang, John David Spencer

Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29): e2400666121. Published online 2024 Jul 8. doi: 10.1073/pnas.2400666121

PMCID:: PMC11260129

Abstract Article PDF–3.9M

Select item 111408637.

Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes

Kim Moorwood, Florentia M. Smith, Alastair S. Garfield, Andrew Ward

BMC Biol. 2024; 22: 127. Published online 2024 May 30. doi: 10.1186/s12915-024-01926-w

PMCID:: PMC11140863

Abstract Article PDF–6.8M

Select item 111215418.

Normal Ovarian Function in Subfertile Mouse with Amhr2-Cre-Driven Ablation of Insr and Igf1r

Jenna C. Douglas, Nikola Sekulovski, Madison R. Arreola, Yeongseok Oh, Kanako Hayashi, James A. MacLean, II

Genes (Basel) 2024 May; 15(5): 616. Published online 2024 May 12. doi: 10.3390/genes15050616

PMCID:: PMC11121541

Abstract Article PDF–7.1M

Select item 111083149.

Hepatitis B virus inhibits insulin receptor signaling and impairs liver regeneration via intracellular retention of the insulin receptor

Sebastian Robert Barthel, Regina Medvedev, Thekla Heinrich, Sarah Manon Büchner, Nadja Kettern, Eberhard Hildt

Cell Mol Life Sci. 2016 Nov; 73(21): 4121–4140. Published online 2016 May 7. doi: 10.1007/s00018-016-2259-1

PMCID:: PMC11108314

Abstract Article PDF–12M

Select item 1109437110.

Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection

Laura Schwartz, Kristin Salamon, Aaron Simoni, Tad Eichler, Ashley R. Jackson, Matthew Murtha, Brian Becknell, Andrew Kauffman, Sarah Linn-Peirano, Natalie Holdsworth, Vidhi Tyagi, Hancong Tang, Steve Rust, Hanna Cortado, Irina Zabbarova, Anthony Kanai, John David Spencer

Cell Rep. Author manuscript; available in PMC 2024 May 15.

Published in final edited form as: Cell Rep. 2024 Apr 23; 43(4): 114007. Published online 2024 Mar 21. doi: 10.1016/j.celrep.2024.114007

PMCID:: PMC11094371

Abstract Article PDF–2.5M

Select item 1088149011.

Insulin and IGF-1 have both overlapping and distinct effects on CD4⁺ T cell mitochondria, metabolism, and function

Kaitlin Kiernan, Yazan Alwarawrah, Amanda G. Nichols, Keiko Danzaki, Nancie J. MacIver

Sci Rep. 2024; 14: 4331. Published online 2024 Feb 21. doi: 10.1038/s41598-024-54836-w

PMCID:: PMC10881490

Abstract Article PDF–1.7M

Select item 1084687112.

Differential roles of insulin receptor in adipocyte progenitor cells in mice

Yexian Yuan, Zuoxiao Shi, Shaolei Xiong, Ruoci Hu, Qing Song, Zhenyuan Song, Sang-Ging Ong, Yuwei Jiang

Mol Cell Endocrinol. Author manuscript; available in PMC 2024 Feb 6.

Published in final edited form as: Mol Cell Endocrinol. 2023 Aug 1; 573: 111968. Published online 2023 May 25. doi: 10.1016/j.mce.2023.111968

PMCID:: PMC10846871

Abstract Article PDF–4.1M

Select item 1071051813.

Astrocytic insulin receptor controls circadian behavior via dopamine signaling in a sexually dimorphic manner

Antía González-Vila, María Luengo-Mateos, María Silveira-Loureiro, Pablo Garrido-Gil, Nataliia Ohinska, Marco González-Domínguez, Jose Luis Labandeira-García, Cristina García-Cáceres, Miguel López, Olga Barca-Mayo

Nat Commun. 2023; 14: 8175. Published online 2023 Dec 9. doi: 10.1038/s41467-023-44039-8

PMCID:: PMC10710518

Abstract Article PDF–4.2M

Select item 1065806614.

MAD2-Dependent Insulin Receptor Endocytosis Regulates Metabolic Homeostasis

Junhee Park, Catherine Hall, Brandon Hubbard, Traci LaMoia, Rafael Gaspar, Ali Nasiri, Fang Li, Hanrui Zhang, Jiyeon Kim, Rebecca A. Haeusler, Domenico Accili, Gerald I. Shulman, Hongtao Yu, Eunhee Choi

Diabetes. 2023 Dec; 72(12): 1781–1794. Published online 2023 Sep 19. doi: 10.2337/db23-0314

PMCID:: PMC10658066

Abstract Article PDF–26M

Select item 1062130215.

Hippocampus Insulin Receptors Regulate Episodic and Spatial Memory Through Excitatory/Inhibitory Balance

Cai-Yan Xue, Tian Gao, E Mao, Zhen-Zhen Kou, Ling Dong, Feng Gao

ASN Neuro. 2023 Jan-Dec; 15: 17590914231206657. Published online 2023 Oct 31. doi: 10.1177/17590914231206657

PMCID:: PMC10621302

Abstract Article PDF–4.0M

Select item 1052896416.

Genetic activation of glycolysis in osteoblasts preserves bone mass in type I diabetes

Xing Ji, Rebecca Seeley, Ke Li, Fangfang Song, Xueyang Liao, Chao Song, Marco Angelozzi, Arianna Valeri, Tyler Marmo, Wen-Chih Lee, Yu Shi, Fanxin Long

Cell Chem Biol. Author manuscript; available in PMC 2024 Sep 21.

Published in final edited form as: Cell Chem Biol. 2023 Sep 21; 30(9): 1053–1063.e5. Published online 2023 Aug 9. doi: 10.1016/j.chembiol.2023.07.003

PMCID:: PMC10528964

Abstract Article PDF–2.3M

Select item 1036202317.

Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model

Marcos David Munoz, Alexa Zamudio, Maximilian McCann, Victoria Gil, Pingwen Xu, Chong Wee Liew

Sci Rep. 2023; 13: 11808. Published online 2023 Jul 21. doi: 10.1038/s41598-023-37482-6

PMCID:: PMC10362023

Abstract Article PDF–5.1M

Select item 1027280018.

Ghrelin does not impact the blunted counterregulatory response to recurrent hypoglycemia in mice

Kripa Shankar, Salil Varshney, Deepali Gupta, Bharath K. Mani, Sherri Osborne-Lawrence, Nathan P. Metzger, Corine P. Richard, Jeffrey M. Zigman

Front Endocrinol (Lausanne) 2023; 14: 1181856. Published online 2023 Jun 2. doi: 10.3389/fendo.2023.1181856

PMCID:: PMC10272800

Abstract Article PDF–2.2M

Select item 1024513719.

The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice

Yan Wang, Roger Lopez-Bellido, Xiaojiao Huo, Annemieke Kavelaars, Michael J. Galko

Biol Open. 2023 Jun 15; 12(6): bio059864. Published online 2023 Jun 1. doi: 10.1242/bio.059864

PMCID:: PMC10245137

Abstract Article PDF–3.3M

Select item 1021413420.

Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model

Wenqiang Chen, Qian Huang, Ekaterina Katie Lazdon, Antonio Gomes, Marisa Wong, Emily Stephens, Tabitha Grace Royal, Dan Frenkel, Weikang Cai, C. Ronald Kahn

Proc Natl Acad Sci U S A. 2023 May 23; 120(21): e2220684120. Published online 2023 May 15. doi: 10.1073/pnas.2220684120

PMCID:: PMC10214134

Abstract Article PDF–2.0M

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