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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107901062.

Phospholipase C-ε defines a PACAP-stimulated pathway for secretion in the chromaffin cell

Xiaohuan Chen, Breanna L. Coffman, Rebecca L. Brindley, Jason D. Galpin, Christopher A. Ahern, Kevin P. M. Currie, Alan V. Smrcka, Daniel Axelrod, Arun Anantharam

J Neuroendocrinol. Author manuscript; available in PMC 2024 Jan 16.

Published in final edited form as: J Neuroendocrinol. 2023 Nov; 35(11): e13255. Published online 2023 Mar 27. doi: 10.1111/jne.13255

PMCID:: PMC10790106

Abstract Article PDF–2.4M

Select item 97446563.

Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection

Douglas K. Atchison, Christopher L. O’Connor, Kimber Converso-Baran, Ingrid L. Bergin, Hongyu Zhang, Yu Wang, John R. Hartman, Wenjun Ju, Alan V. Smrcka, Santhi K. Ganesh, Markus Bitzer

Am J Physiol Heart Circ Physiol. 2022 Dec 1; 323(6): H1376–H1387. Published online 2022 Nov 11. doi: 10.1152/ajpheart.00262.2022

PMCID:: PMC9744656

Abstract Article

Select item 79387704.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 72943385.

Hypertension induces glomerulosclerosis in phospholipase C-ε1 deficiency

Douglas K. Atchison, Christopher L. O’Connor, Rajasree Menon, Edgar A. Otto, Santhi K. Ganesh, Roger C. Wiggins, Alan V. Smrcka, Markus Bitzer

Am J Physiol Renal Physiol. 2020 May 1; 318(5): F1177–F1187. Published online 2020 Mar 30. doi: 10.1152/ajprenal.00541.2019

PMCID:: PMC7294338

Abstract Article

Select item 70663836.

PLCε1 suppresses tumor growth by regulating murine T cell mobilization

M. Strazza, K. Adam, A. V. Smrcka, S. Lerrer, A. Mor

Clin Exp Immunol. 2020 Apr; 200(1): 53–60. Published online 2020 Jan 9. doi: 10.1111/cei.13409

PMCID:: PMC7066383

Abstract Article PDF–604K

Select item 53543377.

The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons

Jiaqing Tong, Xiaojie Liu, Casey Vickstrom, Yan Li, Laikang Yu, Youming Lu, Alan V. Smrcka, Qing-Song Liu

J Neurosci. 2017 Mar 15; 37(11): 3030–3044. doi: 10.1523/JNEUROSCI.2810-16.2017

PMCID:: PMC5354337

Abstract Article PDF–3.3M

Select item 53475838.

PLCε1 regulates SDF-1α–induced lymphocyte adhesion and migration to sites of inflammation

Marianne Strazza, Inbar Azoulay-Alfaguter, Michael Peled, Alan V. Smrcka, Edward Y. Skolnik, Shekhar Srivastava, Adam Mor

Proc Natl Acad Sci U S A. 2017 Mar 7; 114(10): 2693–2698. Published online 2017 Feb 17. doi: 10.1073/pnas.1612900114

PMCID:: PMC5347583

Abstract Article PDF–1.2M

Select item 52432269.

Phospholipase C-ε signaling mediates endothelial cell inflammation and barrier disruption in acute lung injury

Kaiser M. Bijli, Fabeha Fazal, Spencer A. Slavin, Antony Leonard, Valerie Grose, William B. Alexander, Alan V. Smrcka, Arshad Rahman

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1; 311(2): L517–L524. Published online 2016 Jul 1. doi: 10.1152/ajplung.00069.2016

PMCID:: PMC5243226

Abstract Article

Select item 501594910.

Genome-Wide Association Mapping for Female Infertility in Inbred Mice

Ji-Long Liu, Tong-Song Wang, Miao Zhao

G3 (Bethesda) 2016 Sep; 6(9): 2929–2935. Published online 2016 Jul 21. doi: 10.1534/g3.116.031575

PMCID:: PMC5015949

Abstract Article PDF–1.5M

Select item 493344211.

Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells

Masahiro Wakita, Hironori Edamatsu, Mingzhen Li, Aki Emi, Sohei Kitazawa, Tohru Kataoka

J Biol Chem. 2016 Jun 10; 291(24): 12586–12600. Published online 2016 Apr 6. doi: 10.1074/jbc.M116.717561

PMCID:: PMC4933442

Abstract Article PDF–3.1M

Select item 481103312.

Phospholipase C Epsilon (PLCε) Induced TRPC6 Activation: A Common but Redundant Mechanism in Primary Podocytes

Hermann Kalwa, Ursula Storch, Jana Demleitner, Susanne Fiedler, Tim Mayer, Martina Kannler, Meike Fahlbusch, Holger Barth, Alan Smrcka, Friedhelm Hildebrandt, Thomas Gudermann, Alexander Dietrich

J Cell Physiol. Author manuscript; available in PMC 2016 Mar 29.

Published in final edited form as: J Cell Physiol. 2015 Jun; 230(6): 1389–1399. doi: 10.1002/jcp.24883

PMCID:: PMC4811033

Abstract Article PDF–816K

Select item 476899013.

Knockout of phospholipase Cε attenuates N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder tumorigenesis

TAIMAO JIANG, TAO LIU, LIN LI, ZHIJUN YANG, YUNFENG BAI, DONGYE LIU, CHUIZE KONG

Mol Med Rep. 2016 Mar; 13(3): 2039–2045. Published online 2016 Jan 12. doi: 10.3892/mmr.2016.4762

PMCID:: PMC4768990

Abstract Article PDF–1.3M

Select item 469457814.

Endocardial Brg1 disruption illustrates the developmental origins of semilunar valve disease

Brynn N. Akerberg, Maithri L. Sarangam, Kryn Stankunas

Dev Biol. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: Dev Biol. 2015 Nov 1; 407(1): 158–172. Published online 2015 Jun 20. doi: 10.1016/j.ydbio.2015.06.015

PMCID:: PMC4694578

Abstract Article PDF–4.8M

Select item 464633015.

Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras-associating Domains of Phospholipase Cϵ

Stephanie S. Dusaban, Maya T. Kunkel, Alan V. Smrcka, Joan Heller Brown

J Biol Chem. 2015 Oct 30; 290(44): 26776–26783. Published online 2015 Sep 8. doi: 10.1074/jbc.M115.676098

PMCID:: PMC4646330

Abstract Article PDF–1.5M

Select item 420033216.

Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke

Anouk Oldenburger, Wim Timens, Sophie Bos, Marieke Smit, Alan V. Smrcka, Anne-Coline Laurent, Junjun Cao, Machteld Hylkema, Herman Meurs, Harm Maarsingh, Frank Lezoualc'h, Martina Schmidt

FASEB J. 2014 Nov; 28(11): 4617–4628. doi: 10.1096/fj.13-248930