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Select item 111896281.

Metabolic regulation of misfolded protein import into mitochondria

Yuhao Wang, Linhao Ruan, Jin Zhu, Xi Zhang, Alexander Chih-Chieh Chang, Alexis Tomaszewski, Rong Li

eLife. 2024; 12: RP87518. Published online 2024 Jun 20. doi: 10.7554/eLife.87518

PMCID:: PMC11189628

Abstract Article PDF–9.0M

Select item 108724772.

Protein interaction network revealed by quantitative proteomic analysis links TFIIB to multiple aspects of the transcription cycle

Michael J. O’Brien, Athar Ansari

Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2024 Jan 1; 1872(1): 140968. Published online 2023 Oct 19. doi: 10.1016/j.bbapap.2023.140968

PMCID:: PMC10872477

Abstract Article PDF–1.7M

Select item 107001383.

The social and structural architecture of the yeast protein interactome

André C. Michaelis, Andreas-David Brunner, Maximilian Zwiebel, Florian Meier, Maximilian T. Strauss, Isabell Bludau, Matthias Mann

Nature. 2023; 624(7990): 192–200. Published online 2023 Nov 15. doi: 10.1038/s41586-023-06739-5

PMCID:: PMC10700138

Abstract Article PDF–20M

Select item 106817314.

Two mitochondrial HMG-box proteins, Cim1 and Abf2, antagonistically regulate mtDNA copy number in Saccharomyces cerevisiae

Simon Schrott, Christof Osman

Nucleic Acids Res. 2023 Nov 27; 51(21): 11813–11835. Published online 2023 Oct 18. doi: 10.1093/nar/gkad849

PMCID:: PMC10681731

Abstract Article PDF–2.4M

Select item 103595005.

Differential sensitivity of the yeast Lon protease Pim1p to impaired mitochondrial respiration

Meredith B. Metzger, Jessica L. Scales, Garis A. Grant, Abigail E. Molnar, Jadranka Loncarek, Allan M. Weissman

J Biol Chem. 2023 Aug; 299(8): 104937. Published online 2023 Jun 16. doi: 10.1016/j.jbc.2023.104937

PMCID:: PMC10359500

Abstract Article PDF–2.8M

Select item 102977006.

The Hsp90 molecular chaperone governs client proteins by targeting intrinsically disordered regions

Janhavi A. Kolhe, Neethu L. Babu, Brian C. Freeman

Mol Cell. Author manuscript; available in PMC 2024 Jun 15.

Published in final edited form as: Mol Cell. 2023 Jun 15; 83(12): 2035–2044.e7. Published online 2023 Jun 8. doi: 10.1016/j.molcel.2023.05.021

PMCID:: PMC10297700

Abstract Article PDF–2.0M

Select item 102350867.

Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores

Ksenia Smurova, Michela Damizia, Carmela Irene, Stefania Stancari, Giovanna Berto, Giulia Perticari, Maria Giuseppina Iacovella, Ilaria D’Ambrosio, Maria Giubettini, Réginald Philippe, Chiara Baggio, Elisabetta Callegaro, Andrea Casagranda, Alessandro Corsini, Vincenzo Gentile Polese, Anna Ricci, Erik Dassi, Peter De Wulf

Nat Commun. 2023; 14: 3172. Published online 2023 Jun 1. doi: 10.1038/s41467-023-38920-9

PMCID:: PMC10235086

Abstract Article PDF–2.6M

Select item 96380288.

Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress

Michelle Harreman Lehner, Jane Walker, Kotryna Temcinaite, Anna Herlihy, Michael Taschner, Adam C. Berger, Anita H. Corbett, A. Barbara Dirac Svejstrup, Jesper Q. Svejstrup

Cell Rep. 2022 Oct 25; 41(4): 111536. Published online 2022 Oct 25. doi: 10.1016/j.celrep.2022.111536

PMCID:: PMC9638028

Abstract Article

Select item 96296219.

Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications

Nitika, Bo Zheng, Linhao Ruan, Jake T. Kline, Siddhi Omkar, Jacek Sikora, Mara Texeira Torres, Yuhao Wang, Jade E. Takakuwa, Romain Huguet, Cinzia Klemm, Verónica A. Segarra, Matthew J. Winters, Peter M. Pryciak, Peter H. Thorpe, Kazuo Tatebayashi, Rong Li, Luca Fornelli, Andrew W. Truman

PLoS Biol. 2022 Oct; 20(10): e3001839. Published online 2022 Oct 21. doi: 10.1371/journal.pbio.3001839

PMCID:: PMC9629621

Abstract Article PDF–3.4M

Select item 957451410.

Elucidation of the interaction proteome of mitochondrial chaperone Hsp78 highlights its role in protein aggregation during heat stress

Witold Jaworek, Marc Sylvester, Giovanna Cenini, Wolfgang Voos

J Biol Chem. 2022 Oct; 298(10): 102494. Published online 2022 Sep 15. doi: 10.1016/j.jbc.2022.102494

PMCID:: PMC9574514

Abstract Article PDF–1.9M

Select item 928602311.

Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion

Mark Mattingly, Chris Seidel, Sofía Muñoz, Yan Hao, Ying Zhang, Zhihui Wen, Laurence Florens, Frank Uhlmann, Jennifer L. Gerton

Curr Biol. 2022 Jul 11; 32(13): 2884–2896.e6. doi: 10.1016/j.cub.2022.05.019

PMCID:: PMC9286023

Abstract Article

Select item 920981112.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

Stacia R Engel, Edith D Wong, Robert S Nash, Suzi Aleksander, Micheal Alexander, Eric Douglass, Kalpana Karra, Stuart R Miyasato, Matt Simison, Marek S Skrzypek, Shuai Weng, J Michael Cherry

Genetics. 2022 Apr; 220(4): iyab224. Published online 2021 Dec 13. doi: 10.1093/genetics/iyab224

PMCID:: PMC9209811

Abstract Article PDF–818K

Select item 891329513.

Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements

Jie Yang, Albert S. Song, R. Luke Wiseman, Gabriel C. Lander

J Biol Chem. 2022 Mar; 298(3): 101694. Published online 2022 Feb 7. doi: 10.1016/j.jbc.2022.101694

PMCID:: PMC8913295

Abstract Article PDF–1.4M

Select item 880492914.

Oxidative stress protein Oxr1 promotes V‐ATPase holoenzyme disassembly in catalytic activity‐independent manner

Md. Murad Khan, Seowon Lee, Sergio Couoh‐Cardel, Rebecca A Oot, Hyunmin Kim, Stephan Wilkens, Soung‐Hun Roh

EMBO J. 2022 Feb 1; 41(3): e109360. Published online 2021 Dec 17. doi: 10.15252/embj.2021109360

PMCID:: PMC8804929

Abstract Article PDF–5.5M

Select item 740638115.

Solid-phase inclusion as a mechanism for regulating unfolded proteins in the mitochondrial matrix

Linhao Ruan, Joshua T. McNamara, Xi Zhang, Alexander Chih-Chieh Chang, Jin Zhu, Yi Dong, Gordon Sun, Amy Peterson, Chan Hyun Na, Rong Li

Sci Adv. 2020 Aug; 6(32): eabc7288. Published online 2020 Aug 5. doi: 10.1126/sciadv.abc7288

PMCID:: PMC7406381

Abstract Article PDF–1.9M

Select item 720207416.

Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1

Aylin Göke, Simon Schrott, Arda Mizrak, Vladislav Belyy, Christof Osman, Peter Walter

Mol Biol Cell. 2020 Mar 19; 31(7): 527–545. doi: 10.1091/mbc.E19-08-0470

PMCID:: PMC7202074

Abstract Article PDF–3.9M

Select item 678975417.

Phosphorylation of mitochondrial matrix proteins regulates their selective mitophagic degradation

Panagiota Kolitsida, Jianwen Zhou, Michal Rackiewicz, Vladimir Nolic, Jörn Dengjel, Hagai Abeliovich

Proc Natl Acad Sci U S A. 2019 Oct 8; 116(41): 20517–20527. Published online 2019 Sep 23. doi: 10.1073/pnas.1901759116

Correction in:: Proc Natl Acad Sci U S A. 2019 Nov 26; 116(48): 24374.

PMCID:: PMC6789754

Abstract Article PDF–1.4M

Select item 668908618.

The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range

Hannah Girstmair, Franziska Tippel, Abraham Lopez, Katarzyna Tych, Frank Stein, Per Haberkant, Philipp Werner Norbert Schmid, Dominic Helm, Matthias Rief, Michael Sattler, Johannes Buchner

Nat Commun. 2019; 10: 3626. Published online 2019 Aug 9. doi: 10.1038/s41467-019-11518-w

PMCID:: PMC6689086

Abstract Article PDF–2.3M

Select item 666992219.

Endosome and Golgi‐associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism

Oliver Schmidt, Yannick Weyer, Verena Baumann, Michael A Widerin, Sebastian Eising, Mihaela Angelova, Alexander Schleiffer, Leopold Kremser, Herbert Lindner, Matthias Peter, Florian Fröhlich, David Teis

EMBO J. 2019 Aug 1; 38(15): e101433. Published online 2019 May 27. doi: 10.15252/embj.2018101433

PMCID:: PMC6669922

Abstract Article PDF–2.8M

Select item 664889520.

Tsr4 and Nap1, two novel members of the ribosomal protein chaperOME

Ingrid Rössler, Julia Embacher, Benjamin Pillet, Guillaume Murat, Laura Liesinger, Jutta Hafner, Julia Judith Unterluggauer, Ruth Birner-Gruenberger, Dieter Kressler, Brigitte Pertschy

Nucleic Acids Res. 2019 Jul 26; 47(13): 6984–7002. Published online 2019 May 7. doi: 10.1093/nar/gkz317