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Select item 114057191.

CMG helicase disassembly is essential and driven by two pathways in budding yeast

Cristian Polo Rivera, Tom D Deegan, Karim P M Labib

EMBO J. 2024 Sep; 43(18): 3818–3845. Published online 2024 Jul 22. doi: 10.1038/s44318-024-00161-x

PMCID:: PMC11405719

Abstract Article PDF–6.9M

Select item 114053952.

A common mechanism for recruiting the Rrm3 and RTEL1 accessory helicases to the eukaryotic replisome

Ottavia Olson, Simone Pelliciari, Emma D Heron, Tom D Deegan

EMBO J. 2024 Sep; 43(18): 3846–3875. Published online 2024 Jul 22. doi: 10.1038/s44318-024-00168-4

PMCID:: PMC11405395

Abstract Article PDF–3.3M

Select item 111048493.

Characterization of the dimeric CMG/pre-initiation complex and its transition into DNA replication forks

Lu Liu, Yue Zhang, Jingjing Zhang, Jian-Hua Wang, Qinhong Cao, Zhen Li, Judith L. Campbell, Meng-Qiu Dong, Huiqiang Lou

Cell Mol Life Sci. 2020 Aug; 77(15): 3041–3058. Published online 2019 Nov 15. doi: 10.1007/s00018-019-03333-9

PMCID:: PMC11104849

Abstract Article PDF–9.1M

Select item 107001384.

The social and structural architecture of the yeast protein interactome

André C. Michaelis, Andreas-David Brunner, Maximilian Zwiebel, Florian Meier, Maximilian T. Strauss, Isabell Bludau, Matthias Mann

Nature. 2023; 624(7990): 192–200. Published online 2023 Nov 15. doi: 10.1038/s41586-023-06739-5

PMCID:: PMC10700138

Abstract Article PDF–20M

Select item 105115615.

Synergism between CMG helicase and leading strand DNA polymerase at replication fork

Zhichun Xu, Jianrong Feng, Daqi Yu, Yunjing Huo, Xiaohui Ma, Wai Hei Lam, Zheng Liu, Xiang David Li, Toyotaka Ishibashi, Shangyu Dang, Yuanliang Zhai

Nat Commun. 2023; 14: 5849. Published online 2023 Sep 20. doi: 10.1038/s41467-023-41506-0

PMCID:: PMC10511561

Abstract Article PDF–5.3M

Select item 102333686.

A systematic proximity ligation approach to studying protein‐substrate specificity identifies the substrate spectrum of the Ssh1 translocon

Nir Cohen, Naama Aviram, Maya Schuldiner

EMBO J. 2023 Jun; 42(11): e113385. Published online 2023 Apr 19. doi: 10.15252/embj.2022113385

PMCID:: PMC10233368

Abstract Article PDF–1.2M

Select item 92098117.

New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources

Stacia R Engel, Edith D Wong, Robert S Nash, Suzi Aleksander, Micheal Alexander, Eric Douglass, Kalpana Karra, Stuart R Miyasato, Matt Simison, Marek S Skrzypek, Shuai Weng, J Michael Cherry

Genetics. 2022 Apr; 220(4): iyab224. Published online 2021 Dec 13. doi: 10.1093/genetics/iyab224

PMCID:: PMC9209811

Abstract Article PDF–818K

Select item 86953828.

A conserved mechanism for regulating replisome disassembly in eukaryotes

Michael Jenkyn-Bedford, Morgan L. Jones, Yasemin Baris, Karim P. M. Labib, Giuseppe Cannone, Joseph T. P. Yeeles, Tom D. Deegan

Nature. 2021; 600(7890): 743–747. Published online 2021 Oct 26. doi: 10.1038/s41586-021-04145-3

PMCID:: PMC8695382

Abstract Article PDF–80M

Select item 77187519.

Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1

Elsbeth Sanders, Phoebe A. Nguyen, Cody M. Rogers, Matthew L. Bochman

G3 (Bethesda) 2020 Dec; 10(12): 4359–4368. Published online 2020 Oct 28. doi: 10.1534/g3.120.401709

PMCID:: PMC7718751

Abstract Article PDF–1.2M

Select item 746261110.

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

Tom D Deegan, Progya P Mukherjee, Ryo Fujisawa, Cristian Polo Rivera, Karim Labib

eLife. 2020; 9: e60371. Published online 2020 Aug 17. doi: 10.7554/eLife.60371

PMCID:: PMC7462611

Abstract Article PDF–4.9M

Select item 706972711.

The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress

Marco Fumasoni, Andrew W Murray

eLife. 2020; 9: e51963. Published online 2020 Feb 11. doi: 10.7554/eLife.51963

PMCID:: PMC7069727

Abstract Article PDF–4.6M

Select item 703406212.

Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability

Rowin Appanah, Emma Claire Lones, Umberto Aiello, Domenico Libri, Giacomo De Piccoli

Cell Rep. 2020 Feb 18; 30(7): 2094–2105.e9. Published online 2020 Feb 18. doi: 10.1016/j.celrep.2020.01.087

PMCID:: PMC7034062

Abstract Article

Select item 689951813.

In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast

Progya P. Mukherjee, Karim P.M. Labib

Cell Rep. 2019 Sep 10; 28(11): 2777–2783.e4. Published online 2019 Sep 10. doi: 10.1016/j.celrep.2019.08.026

PMCID:: PMC6899518

Abstract Article

Select item 680000514.

Ctf4 organizes sister replisomes and Pol α into a replication factory

Zuanning Yuan, Roxana Georgescu, Ruda de Luna Almeida Santos, Daniel Zhang, Lin Bai, Nina Y Yao, Gongpu Zhao, Michael E O'Donnell, Huilin Li

eLife. 2019; 8: e47405. Published online 2019 Oct 7. doi: 10.7554/eLife.47405

PMCID:: PMC6800005

Abstract Article PDF–7.0M

Select item 670561415.

Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase

Michael R. Wasserman, Grant D. Schauer, Michael E. O’Donnell, Shixin Liu

Cell. Author manuscript; available in PMC 2020 Jul 25.

Published in final edited form as: Cell. 2019 Jul 25; 178(3): 600–611.e16. doi: 10.1016/j.cell.2019.06.032

PMCID:: PMC6705614

Abstract Article PDF–1.6M

Select item 633883416.

Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression

Ryan Mayle, Lance Langston, Kelly R. Molloy, Dan Zhang, Brian T. Chait, Michael E. O’Donnell

Proc Natl Acad Sci U S A. 2019 Jan 15; 116(3): 798–803. Published online 2018 Dec 31. doi: 10.1073/pnas.1819107116

PMCID:: PMC6338834

Abstract Article PDF–1.3M

Select item 616612817.

Histone H2A‐H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin

Cecile Evrin, Joseph D Maman, Aurora Diamante, Luca Pellegrini, Karim Labib

EMBO J. 2018 Oct 1; 37(19): e99021. Published online 2018 Aug 13. doi: 10.15252/embj.201899021

PMCID:: PMC6166128

Abstract Article PDF–1.5M

Select item 612564118.

Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae

Maria G Iacovella, Michael Bremang, Omer Basha, Luciano Giacò, Walter Carotenuto, Cristina Golfieri, Barnabas Szakal, Marianna Dal Maschio, Valentina Infantino, Galina V Beznoussenko, Chinnu R Joseph, Clara Visintin, Alexander A Mironov, Rosella Visintin, Dana Branzei, Sébastien Ferreira-Cerca, Esti Yeger-Lotem, Peter De Wulf

Nucleic Acids Res. 2018 Sep 6; 46(15): 7586–7611. Published online 2018 Jul 16. doi: 10.1093/nar/gky618

PMCID:: PMC6125641

Abstract Article PDF–5.7M

Select item 592252819.

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

Harley O’Connor Mount, Nicole M. Revie, Robert T. Todd, Kaitlin Anstett, Cathy Collins, Michael Costanzo, Charles Boone, Nicole Robbins, Anna Selmecki, Leah E. Cowen

PLoS Genet. 2018 Apr; 14(4): e1007319. Published online 2018 Apr 27. doi: 10.1371/journal.pgen.1007319