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Select item 111949651.

Deciphering the role of KLRB1: a novel prognostic indicator in hepatocellular carcinoma

Siting Fang, Yinglu Zhou

BMC Gastroenterol. 2024; 24: 210. Published online 2024 Jun 24. doi: 10.1186/s12876-024-03299-4

PMCID:: PMC11194965

Abstract Article PDF–5.8M

Select item 111165392.

Down-regulation of KLRB1 is associated with increased cell growth, metastasis, poor prognosis, as well as a dysfunctional immune microenvironment in LUAD

Jiu-Ling Chen, Chuang-Yan Wu, Xiang-Yu Luo, Xue-Ying Wang, Fang-Ming Wang, Xin Huang, Wei Yuan, Qiang Guo

Sci Rep. 2024; 14: 11782. Published online 2024 May 23. doi: 10.1038/s41598-024-60414-x

PMCID:: PMC11116539

Abstract Article PDF–11M

Select item 110181933.

A comprehensive analysis of the KLRB1 expression and its clinical implication in testicular germ cell tumors: A review

Luyu Li, Yaorui Hu, Xiao Li, Baojun Ju

Medicine (Baltimore) 2024 Apr 12; 103(15): e37688. Published online 2024 Apr 12. doi: 10.1097/MD.0000000000037688

PMCID:: PMC11018193

Abstract Article PDF–3.3M

Select item 107927024.

Immune checkpoint CD161/LLT1‐associated immunological landscape and diagnostic value in oral squamous cell carcinoma

Xinyang Hu, Yuexin Dong, Shixin Xie, Yuxian Song, Chenhang Yu, Yijia He, Zhiyong Wang, Qingang Hu, Yanhong Ni, Liang Ding

J Pathol Clin Res. 2024 Mar; 10(2): e353. Published online 2024 Jan 17. doi: 10.1002/cjp2.353

PMCID:: PMC10792702

Abstract Article PDF–53M

Select item 107133945.

Inhibiting KLRB1 expression is associated with impairing cancer immunity and leading to cancer progression and poor prognosis in breast invasive carcinoma patients

Jin-Rong He, Dan Li, Qun-Xian Zhang, Tao Liu, Yu Ding, Chuang-Yan Wu, Shan-Shan Chen, Jiu-Ling Chen

Aging (Albany NY) 2023 Nov 30; 15(22): 13265–13286. Published online 2023 Nov 20. doi: 10.18632/aging.205239

PMCID:: PMC10713394

Abstract Article PDF–2.6M

Select item 102420916.

SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis

Marzena Lenart, Magdalena Górecka, Michal Bochenek, Emilia Barreto-Duran, Artur Szczepański, Adrianna Gałuszka-Bulaga, Natalia Mazur-Panasiuk, Kazimierz Węglarczyk, Andżelika Siwiec-Koźlik, Mariusz Korkosz, Paweł P. Łabaj, Monika Baj-Krzyworzeka, Maciej Siedlar, Krzysztof Pyrc

Front Immunol. 2023; 14: 1123155. Published online 2023 May 23. doi: 10.3389/fimmu.2023.1123155

PMCID:: PMC10242091

Abstract Article PDF–5.1M

Select item 99756697.

CD161 Characterizes an Inflamed Subset of Cytotoxic T Lymphocytes Associated with Prolonged Survival in Human Papillomavirus–Driven Oropharyngeal Cancer

Ye Wei, Tingting Xu, Chong Li, Xin Zhou, Wei Qian, Chunying Shen, Qifeng Wang, Xing Xing, Xiaomin Ou, Xiayun He, Hongmei Yin, Chaosu Hu, Yu Wang, Qinghai Ji, Fengtao Su, Xueguan Lu

Cancer Immunol Res. 2023 Mar 1; 11(3): 306–319. Published online 2023 Jan 12. doi: 10.1158/2326-6066.CIR-22-0454

PMCID:: PMC9975669

Abstract Article PDF–15M

Select item 88541858.

LLT1-CD161 Interaction in Cancer: Promises and Challenges

Veronique M. Braud, Aïda Meghraoui-Kheddar, Roxane Elaldi, Luciana Petti, Claire Germain, Fabienne Anjuère

Front Immunol. 2022; 13: 847576. Published online 2022 Feb 4. doi: 10.3389/fimmu.2022.847576

PMCID:: PMC8854185

Abstract Article PDF–2.4M

Select item 88192999.

Clinical characterization and immunosuppressive regulation of CD161 (KLRB1) in glioma through 916 samples

Wang Di, Wenhua Fan, Fan Wu, Zhongfang Shi, Zhiliang Wang, Mingchen Yu, You Zhai, Yuanhao Chang, Changqing Pan, Guanzhang Li, Ulf Dietrich Kahlert, Wei Zhang

Cancer Sci. 2022 Feb; 113(2): 756–769. Published online 2021 Dec 24. doi: 10.1111/cas.15236

PMCID:: PMC8819299

Abstract Article PDF–3.3M

Select item 829955710.

A Pan-Cancer Analysis of CD161, a Potential New Immune Checkpoint

Xiaohan Zhou, Jun Du, Chengdong Liu, Hanyi Zeng, Yuting Chen, Li Liu, Dehua Wu

Front Immunol. 2021; 12: 688215. Published online 2021 Jul 9. doi: 10.3389/fimmu.2021.688215

PMCID:: PMC8299557

Abstract Article PDF–5.4M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 793577212.

Inhibitory CD161 Receptor Identified in Glioma-infiltrating T cells by Single Cell Analysis

Nathan D. Mathewson, Orr Ashenberg, Itay Tirosh, Simon Gritsch, Elizabeth M. Perez, Sascha Marx, Livnat Jerby-Arnon, Rony Chanoch-Myers, Toshiro Hara, Alyssa R. Richman, Yoshinaga Ito, Jason Pyrdol, Mirco Friedrich, Kathrin Schumann, Michael J. Poitras, Prafulla C. Gokhale, L. Nicolas Gonzalez Castro, Marni E. Shore, Christine M. Hebert, Brian Shaw, Heather L. Cahill, Matthew Drummond, Wubing Zhang, Olamide Olawoyin, Hiroaki Wakimoto, Orit Rozenblatt-Rosen, Priscilla K. Brastianos, X. Shirley Liu, Pamela S. Jones, Daniel P. Cahill, Matthew P. Frosch, David N. Louis, Gordon J. Freeman, Keith L. Ligon, Alexander Marson, E. Antonio Chiocca, David A. Reardon, Aviv Regev, Mario L. Suvà, Kai W. Wucherpfennig

Cell. Author manuscript; available in PMC 2022 Mar 4.

Published in final edited form as: Cell. 2021 Mar 4; 184(5): 1281–1298.e26. Published online 2021 Feb 15. doi: 10.1016/j.cell.2021.01.022

PMCID:: PMC7935772

Abstract Article PDF–3.5M

Select item 671540613.

CD161 contributes to prenatal immune suppression of IFN-γ–producing PLZF⁺ T cells

Joanna Halkias, Elze Rackaityte, Sara L. Hillman, Dvir Aran, Ventura F. Mendoza, Lucy R. Marshall, Tippi C. MacKenzie, Trevor D. Burt

J Clin Invest. 2019 Sep 3; 129(9): 3562–3577. Published online 2019 Jul 29. doi: 10.1172/JCI125957

PMCID:: PMC6715406

Abstract Article PDF–8.0M

Select item 590003214.

CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells

Ayako Kurioka, Cormac Cosgrove, Yannick Simoni, Bonnie van Wilgenburg, Alessandra Geremia, Sophia Björkander, Eva Sverremark-Ekström, Christine Thurnheer, Huldrych F. Günthard, Nina Khanna, The Swiss HIV Cohort Study, Oxford IBD Cohort Investigators, Lucy Jane Walker, Carolina V. Arancibia-Cárcamo, Evan W. Newell, Christian B. Willberg, Paul Klenerman

Front Immunol. 2018; 9: 486. Published online 2018 Apr 9. doi: 10.3389/fimmu.2018.00486

PMCID:: PMC5900032

Abstract Article PDF–6.5M

Select item 535658015.

Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction

Stephen O. Mathew, Pankaj Chaudhary, Sheila B. Powers, Jamboor K. Vishwanatha, Porunelloor A. Mathew

Oncotarget. 2016 Oct 18; 7(42): 68650–68661. Published online 2016 Sep 8. doi: 10.18632/oncotarget.11896

PMCID:: PMC5356580

Abstract Article PDF–3.5M

Select item 530182316.

A subset of virus-specific CD161⁺ T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in AML

Abdullah Alsuliman, Muharrem Muftuoglu, Ahmad Khoder, Yong-Oon Ahn, Rafet Basar, Michael R. Verneris, Pawel Muranski, A. John Barrett, Enli Liu, Li Li, Kate Stringaris, Darius Armstrong-James, Hila Shaim, Kayo Kondo, Nobuhiko Imahashi, Borje Andersson, David Marin, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani

Blood. 2017 Feb 9; 129(6): 740–758. Prepublished online 2016 Nov 7. doi: 10.1182/blood-2016-05-713347

PMCID:: PMC5301823

Abstract Article

Select item 476023517.

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation

Alba Llibre, Constantino López-Macías, Teresa Marafioti, Hema Mehta, Amy Partridge, Carina Kanzig, Felice Rivellese, Jacob D. Galson, Lucy J. Walker, Paul Milne, Rodney E. Phillips, Dominic F. Kelly, Gordon J. Freeman, Mohey Eldin El Shikh, Paul Klenerman, Christian B. Willberg

J Immunol. 2016 Mar 1; 196(5): 2085–2094. Published online 2016 Feb 1. doi: 10.4049/jimmunol.1502462

PMCID:: PMC4760235

Abstract Article PDF–2.0M

Select item 473293918.

CD161^int CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut

J.R. Fergusson, M.H. Hühn, L. Swadling, L.J. Walker, A. Kurioka, A. Llibre, A. Bertoletti, G. Holländer, E.W. Newell, M.M. Davis, E. Sverremark-Ekström, F. Powrie, S. Capone, A. Folgori, E. Barnes, C.B. Willberg, J.E. Ussher, P. Klenerman

Mucosal Immunol. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Mucosal Immunol. 2016 Mar; 9(2): 401–413. Published online 2015 Jul 29. doi: 10.1038/mi.2015.69

PMCID:: PMC4732939

Abstract Article PDF–2.1M

Select item 467231919.

Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells

Qianting Yang, Qian Xu, Qi Chen, Jin Li, Mingxia Zhang, Yi Cai, Haiying Liu, Yiping Zhou, Guofang Deng, Qunyi Deng, Boping Zhou, Hardy Kornfeld, Xinchun Chen

Sci Rep. 2015; 5: 17918. Published online 2015 Dec 8. doi: 10.1038/srep17918

PMCID:: PMC4672319

Abstract Article PDF–1.4M

Select item 455042520.

The c.503T>C Polymorphism in the Human KLRB1 Gene Alters Ligand Binding and Inhibitory Potential of CD161 Molecules

Sascha Rother, Joachim Hundrieser, Claudia Pokoyski, Sonja Kollrich, Katja Borns, Rainer Blasczyk, Daniel Poehnert, Jürgen Klempnauer, Reinhard Schwinzer

PLoS One. 2015; 10(8): e0135682. Published online 2015 Aug 26. doi: 10.1371/journal.pone.0135682

PMCID:: PMC4550425

Abstract Article PDF–1.7M

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