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Items: 1 to 20 of 356

1.
RhoA-LIMK Signaling Axis Reveals Rostral-Caudal Plane and Spatial Dysregulation in the Brain of Alzheimer’s Disease Mouse Models
Shayan Nik Akhtar, Qun Lu
J Alzheimers Dis. Author manuscript; available in PMC 2024 Jul 24.
Published in final edited form as: J Alzheimers Dis. 2023; 95(4): 1643–1656. doi: 10.3233/JAD-230408
PMCID:
PMC11268434
AbstractArticlePDF–3.3M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Microglia maintain structural integrity during fetal brain morphogenesis
Akindé René Lawrence, Alice Canzi, Cécile Bridlance, Nicolas Olivié, Claire Lansonneur, Clarissa Catale, Lara Pizzamiglio, Benoit Kloeckner, Aymeric Silvin, David A.D. Munro, Aurélien Fortoul, Davide Boido, Feriel Zehani, Hugues Cartonnet, Sarah Viguier, Guillaume Oller, Paola Squarzoni, Adrien Candat, Julie Helft, Cécile Allet, Francoise Watrin, Jean-Bernard Manent, Pierre Paoletti, Denis Thieffry, Laura Cantini, Clare Pridans, Josef Priller, Antoinette Gélot, Paolo Giacobini, Luisa Ciobanu, Florent Ginhoux, Morgane Sonia Thion, Ludmilla Lokmane, Sonia Garel
Cell. 2024 Feb 15; 187(4): 962–980.e19. doi: 10.1016/j.cell.2024.01.012
PMCID:
PMC10869139
AbstractArticle
4.
RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
Antje Schaefer, Richard G. Hodge, Haisheng Zhang, G. Aaron Hobbs, Julien Dilly, Minh Huynh, Craig M. Goodwin, Feifei Zhang, J. Nathaniel Diehl, Mariaelena Pierobon, Elisa Baldelli, Sehrish Javaid, Karson Guthrie, Naim U. Rashid, Emanuel F. Petricoin, Adrienne D. Cox, William C. Hahn, Andrew J. Aguirre, Adam J. Bass, Channing J. Der
Sci Signal. Author manuscript; available in PMC 2024 Jan 16.
Published in final edited form as: Sci Signal. 2023 Dec 19; 16(816): eadg5289. Published online 2023 Dec 19. doi: 10.1126/scisignal.adg5289
PMCID:
PMC10791543
AbstractArticlePDF–2.3M
5.
USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice
Lenka Schorova, Nathalie Bedard, Anouar Khayachi, Hung-Hsiang Ho, Joao Bolivar-Pedroso, Julie Huynh, Mikaela Piccirelli, Yifei Wang, Marie Plourde, Wen Luo, Esther del Cid-Pellitero, Irina Shlaifer, María José Castellanos-Montiel, Ziqi Yu, Dulce Valeria Carrillo Valenzuela, María Lacalle-Aurioles, Anita Kriz, Yihong Ye, Thomas M. Durcan, Simon S. Wing
NPJ Parkinsons Dis. 2023; 9: 157. Published online 2023 Nov 28. doi: 10.1038/s41531-023-00601-1
PMCID:
PMC10684503
AbstractArticlePDF–13M
6.
RhoA Promotes Synovial Proliferation and Bone Erosion in Rheumatoid Arthritis through Wnt/PCP Pathway
Ning Chen, Chao-Yue Diao, Xin Huang, Wei-Xing Tan, Ya-Bing Chen, Xin-Yu Qian, Jie Gao, Dong-Bao Zhao
Mediators Inflamm. 2023; 2023: 5057009. Published online 2023 Nov 1. doi: 10.1155/2023/5057009
PMCID:
PMC10667059
AbstractArticlePDF–6.3M
7.
PFTK1 kinase regulates axogenesis during development via RhoA activation
Yasmilde Rodríguez González, Fatemeh Kamkar, Paymaan Jafar-nejad, Suzi Wang, Dianbo Qu, Leticia Sanchez Alvarez, Dina Hawari, Margaret Sonnenfeld, Ruth S. Slack, Paul R. Albert, David S. Park, Alvin Joselin
BMC Biol. 2023; 21: 240. Published online 2023 Oct 31. doi: 10.1186/s12915-023-01732-w
PMCID:
PMC10617079
AbstractArticlePDF–9.3M
8.
RhoA balances microglial reactivity and survival during neuroinflammation
Renato Socodato, Artur Rodrigues-Santos, Joana Tedim-Moreira, Tiago O. Almeida, Teresa Canedo, Camila C. Portugal, João B. Relvas
Cell Death Dis. 2023 Oct; 14(10): 690. Published online 2023 Oct 20. doi: 10.1038/s41419-023-06217-w
Correction in:
Cell Death Dis. 2023 Dec; 14(12): 808.
PMCID:
PMC10589285
AbstractArticlePDF–6.0M
9.
RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice
Samuel Y. Ng, Leon Brown, Kristen Stevenson, Tiffany deSouza, Jon C. Aster, Abner Louissaint, Jr, David M. Weinstock
Blood. 2018 Aug 30; 132(9): 935–947. Published online 2020 Nov 7. doi: 10.1182/blood-2017-11-818617
PMCID:
PMC10251505
AbstractArticle
10.
RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
Jirong Wang, Chengyun Xu, Jing Zhang, Yizhong Bao, Ying Tang, Xiaoling Lv, Bo Ma, Ximei Wu, Genxiang Mao
Mol Med. 2023; 29: 49. Published online 2023 Apr 5. doi: 10.1186/s10020-023-00638-1
Correction in:
Mol Med. 2023; 29: 102.
PMCID:
PMC10077675
AbstractArticlePDF–3.2M
11.
RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy
Joanne Ern Chi Soh, Akio Shimizu, Md Rasel Molla, Dimitar P. Zankov, Le Kim Chi Nguyen, Mahbubur Rahman Khan, Wondwossen Wale Tesega, Si Chen, Misa Tojo, Yoshito Ito, Akira Sato, Masahito Hitosugi, Shigeru Miyagawa, Hisakazu Ogita
J Biol Chem. 2023 Mar; 299(3): 102993. Published online 2023 Feb 8. doi: 10.1016/j.jbc.2023.102993
PMCID:
PMC10020657
AbstractArticlePDF–6.6M
12.
Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation
Qi Cheng, Jing Wu, Yingqian Xia, Qing Cheng, Yinjuan Zhao, Peixiang Zhu, Wangling Zhang, Shihu Zhang, Lei Zhang, Yushan Yuan, Chaojun Li, Guiquan Chen, Bin Xue
Mol Brain. 2023; 16: 24. Published online 2023 Feb 13. doi: 10.1186/s13041-023-01010-4
PMCID:
PMC9923931
AbstractArticlePDF–8.3M
13.
ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells
Soichiro Suzuki, Fumiaki Ando, Sae Kitagawa, Yu Hara, Tamami Fujiki, Shintaro Mandai, Koichiro Susa, Takayasu Mori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Commun Biol. 2023; 6: 29. Published online 2023 Jan 11. doi: 10.1038/s42003-023-04416-x
PMCID:
PMC9834212
AbstractArticlePDF–11M
14.
WNT5A-RHOA signaling is a driver of tumorigenesis and represents a therapeutically actionable vulnerability in small cell lung cancer
Kee-Beom Kim, Dong-Wook Kim, Youngchul Kim, Jun Tang, Nicole Kirk, Yongyu Gan, Bongjun Kim, Bingliang Fang, Jae-Il Park, Yi Zheng, Kwon-Sik Park
Cancer Res. Author manuscript; available in PMC 2023 May 15.
Published in final edited form as: Cancer Res. 2022 Nov 15; 82(22): 4219–4233. doi: 10.1158/0008-5472.CAN-22-1170
PMCID:
PMC9669186
AbstractArticlePDF–3.6M
15.
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany
Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527
PMCID:
PMC9603860
AbstractArticlePDF–3.4M
16.
A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability
Sebastian H.J. Koochaki, Mikołaj Słabicki, Ryan Lumpkin, Charles Zou, Roger Belizaire, Eric S. Fischer, Benjamin L. Ebert
J Biol Chem. 2022 Oct; 298(10): 102484. Published online 2022 Sep 13. doi: 10.1016/j.jbc.2022.102484
PMCID:
PMC9574515
AbstractArticlePDF–1.8M
17.
Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity
Md Rasel Molla, Akio Shimizu, Masahiro Komeno, Nor Idayu A. Rahman, Joanne Ern Chi Soh, Le Kim Chi Nguyen, Mahbubur Rahman Khan, Wondwossen Wale Tesega, Si Chen, Xiaoling Pang, Miki Tanaka-Okamoto, Noriyuki Takashima, Akira Sato, Tomoaki Suzuki, Hisakazu Ogita
Commun Biol. 2022; 5: 1071. Published online 2022 Oct 7. doi: 10.1038/s42003-022-04042-z
PMCID:
PMC9546906
AbstractArticlePDF–5.3M
18.
TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells
Jessica W. Bertol, Shelby Johnston, Rabia Ahmed, Victoria K. Xie, Kelsea M. Hubka, Lissette Cruz, Larissa Nitschke, Marta Stetsiv, Jeremy P. Goering, Paul Nistor, Sally Lowell, Hanne Hoskens, Peter Claes, Seth M. Weinberg, Irfan Saadi, Mary C. Farach-Carson, Walid D. Fakhouri
Development. 2022 Aug 1; 149(15): dev200068. Published online 2022 Aug 8. doi: 10.1242/dev.200068
PMCID:
PMC9440756
AbstractArticle
19.
Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma
Jose R. Cortes, Ioan Filip, Robert Albero, Juan A. Patiño-Galindo, S. Aidan Quinn, Wen-Hsuan W. Lin, Anouchka P. Laurent, Bobby B. Shih, Jessie A. Brown, Anisha J. Cooke, Adam Mackey, Jonah Einson, Sakellarios Zairis, Alfredo Rivas-Delgado, Maria Antonella Laginestra, Stefano Pileri, Elias Campo, Govind Bhagat, Adolfo A. Ferrando, Raul Rabadan, Teresa Palomero
Cell Rep. Author manuscript; available in PMC 2022 May 2.
Published in final edited form as: Cell Rep. 2022 Apr 19; 39(3): 110695. doi: 10.1016/j.celrep.2022.110695
PMCID:
PMC9059228
AbstractArticlePDF–3.0M
20.
RhoA/ROCK2 signalling is enhanced by PDGF‐AA in fibro‐adipogenic progenitor cells: implications for Duchenne muscular dystrophy
Esther Fernández‐Simón, Xavier Suárez‐Calvet, Ana Carrasco‐Rozas, Patricia Piñol‐Jurado, Susana López‐Fernández, Gemma Pons, Joan Josep Bech Serra, Carolina de la Torre, Noemí de Luna, Eduard Gallardo, Jordi Díaz‐Manera
J Cachexia Sarcopenia Muscle. 2022 Apr; 13(2): 1373–1384. Published online 2022 Feb 7. doi: 10.1002/jcsm.12923
PMCID:
PMC8977967
AbstractArticlePDF–18M

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