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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 80761852.

Functional modulation of phosphodiesterase-6 by calcium in mouse rod photoreceptors

Teemu Turunen, Ari Koskelainen

Sci Rep. 2021; 11: 8938. Published online 2021 Apr 26. doi: 10.1038/s41598-021-88140-8

PMCID:: PMC8076185

Article PDF–2.7M

Select item 80479823.

Retinal degeneration-3 protein promotes photoreceptor survival by suppressing activation of guanylyl cyclase rather than accelerating GMP recycling

Alexander M. Dizhoor, Elena V. Olshevskaya, Igor V. Peshenko

J Biol Chem. 2021 Jan-Jun; 296: 100362. Published online 2021 Feb 2. doi: 10.1016/j.jbc.2021.100362

PMCID:: PMC8047982

Article PDF–2.2M

Select item 78384184.

Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract

Rupalatha Maddala, Junyuan Gao, Richard T. Mathias, Tylor R. Lewis, Vadim Y. Arshavsky, Adriana Levine, Jonathan M. Backer, Anne R. Bresnick, Ponugoti V. Rao

Sci Rep. 2021; 11: 2203. Published online 2021 Jan 26. doi: 10.1038/s41598-021-81611-y

PMCID:: PMC7838418

Article PDF–6.5M

Select item 69812715.

GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress

Anna Plana-Bonamaisó, Santiago López-Begines, Jordi Andilla, María José Fidalgo, Pablo Loza-Alvarez, Josep María Estanyol, Pedro de la Villa, Ana Méndez

Cell Death Dis. 2020 Jan; 11(1): 62. Published online 2020 Jan 24. doi: 10.1038/s41419-020-2255-0

PMCID:: PMC6981271

Article PDF–6.7M

Select item 67464536.

Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness

Alexander M. Dizhoor, Elena V. Olshevskaya, Igor V. Peshenko

J Biol Chem. 2019 Sep 13; 294(37): 13729–13739. Published online 2019 Jul 25. doi: 10.1074/jbc.RA119.009948

PMCID:: PMC6746453

Article PDF–2.6M

Select item 63621717.

Determination of basal phosphodiesterase activity in mouse rod photoreceptors with cGMP clamp

Teemu T. Turunen, Ari Koskelainen

Sci Rep. 2019; 9: 1183. Published online 2019 Feb 4. doi: 10.1038/s41598-018-37661-w

PMCID:: PMC6362171

Article PDF–2.8M

Select item 63252588.

Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State

Shinya Sato, Beata Jastrzebska, Andreas Engel, Krzysztof Palczewski, Vladimir J. Kefalov

J Neurosci. 2019 Jan 9; 39(2): 212–223. doi: 10.1523/JNEUROSCI.1980-18.2018

PMCID:: PMC6325258

Article PDF–1.2M

Select item 62037709.

Investigating the Ca²⁺-dependent and Ca²⁺-independent mechanisms for mammalian cone light adaptation

Frans Vinberg, Vladimir J. Kefalov

Sci Rep. 2018; 8: 15864. Published online 2018 Oct 26. doi: 10.1038/s41598-018-34073-8

PMCID:: PMC6203770

Article PDF–2.6M

Select item 594998910.

Guanylate cyclase–activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors

Frans Vinberg, Igor V. Peshenko, Jeannie Chen, Alexander M. Dizhoor, Vladimir J. Kefalov

J Biol Chem. 2018 May 11; 293(19): 7457–7465. Published online 2018 Mar 16. doi: 10.1074/jbc.RA117.001574

PMCID:: PMC5949989

Article PDF–1.1M

Select item 586414811.

GUCY2D Cone–Rod Dystrophy-6 Is a “Phototransduction Disease” Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1

Shinya Sato, Igor V. Peshenko, Elena V. Olshevskaya, Vladimir J. Kefalov, Alexander M. Dizhoor

J Neurosci. 2018 Mar 21; 38(12): 2990–3000. doi: 10.1523/JNEUROSCI.2985-17.2018

PMCID:: PMC5864148

Article PDF–2.8M

Select item 581154012.

Molecular determinants of Guanylate Cyclase Activating Protein subcellular distribution in photoreceptor cells of the retina

Santiago López-Begines, Anna Plana-Bonamaisó, Ana Méndez

Sci Rep. 2018; 8: 2903. Published online 2018 Feb 13. doi: 10.1038/s41598-018-20893-1

PMCID:: PMC5811540

Article PDF–3.3M

Select item 530288313.

Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket

Wendy Wing Sze Yue, Rikard Frederiksen, Xiaozhi Ren, Dong-Gen Luo, Takahiro Yamashita, Yoshinori Shichida, M Carter Cornwall, King-Wai Yau

eLife. 2017; 6: e18492. Published online 2017 Feb 10. doi: 10.7554/eLife.18492

PMCID:: PMC5302883

Article PDF–1.8M

Select item 501670314.

Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein

Igor V. Peshenko, Elena V. Olshevskaya, Alexander M. Dizhoor

J Biol Chem. 2016 Sep 9; 291(37): 19713–19723. Published online 2016 Jul 28. doi: 10.1074/jbc.M116.742288

PMCID:: PMC5016703

Article PDF–2.9M

Select item 472989015.

Bicarbonate and Ca²⁺ Sensing Modulators Activate Photoreceptor ROS-GC1 Synergistically

Teresa Duda, Alexandre Pertzev, Clint L. Makino, Rameshwar K. Sharma

Front Mol Neurosci. 2016; 9: 5. Published online 2016 Jan 28. doi: 10.3389/fnmol.2016.00005

PMCID:: PMC4729890

Article PDF–1.1M

Select item 459550316.

EP4 Receptor–Associated Protein in Macrophages Ameliorates Colitis and Colitis-Associated Tumorigenesis

Masato Nakatsuji, Manabu Minami, Hiroshi Seno, Mika Yasui, Hideyuki Komekado, Sei Higuchi, Risako Fujikawa, Yuki Nakanishi, Akihisa Fukuda, Kenji Kawada, Yoshiharu Sakai, Toru Kita, Peter Libby, Hiroki Ikeuchi, Masayuki Yokode, Tsutomu Chiba

PLoS Genet. 2015 Oct; 11(10): e1005542. Published online 2015 Oct 6. doi: 10.1371/journal.pgen.1005542