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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 93530382.

NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis

Fangji Yang, Wenxiong Xu, Lina Wu, Luo Yang, Shu Zhu, Lu Wang, Wenbin Wu, Yuzhen Zhang, Yutian Chong, Liang Peng

Front Endocrinol (Lausanne) 2022; 13: 898750. Published online 2022 Jul 22. doi: 10.3389/fendo.2022.898750

PMCID:: PMC9353038

Abstract Article PDF–8.4M

Select item 91858113.

Sodium⁺/taurocholate cotransporting polypeptide as target therapy for liver fibrosis

Ahmad Salhab, Johnny Amer, Yinying Lu, Rifaat Safadi

Gut. 2022 Jul; 71(7): 1373–1385. Published online 2021 Jul 15. doi: 10.1136/gutjnl-2020-323345

PMCID:: PMC9185811

Abstract Article PDF–5.6M

Select item 78513444.

NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings

Fengfeng Mao, Meng-Xuan Wang, Xinfeng Hou, Zhongmin Zhou, Yan-Yan Yan, Ling-Juan Fang, Zexi Tan, Wei-Yuan Fang, Teng Liu, Wenhui He, Cong Li, Xin-Bao Xie, Shi-Qi Lu, Jianhua Sui, Fengchao Wang, Jun Han, Jian-She Wang, Wenhui Li

Cell Mol Gastroenterol Hepatol. 2021; 11(3): 831–839. Published online 2020 Sep 9. doi: 10.1016/j.jcmgh.2020.09.001

PMCID:: PMC7851344

Article PDF–4.1M

Select item 66827325.

Increased sulfation of bile acids in mice and human subjects with sodium taurocholate cotransporting polypeptide deficiency

Fengfeng Mao, Teng Liu, Xinfeng Hou, Hanqing Zhao, Wenhui He, Cong Li, Zhiyi Jing, Jianhua Sui, Fengchao Wang, Xiaohui Liu, Jun Han, Christoph H. Borchers, Jian-She Wang, Wenhui Li

J Biol Chem. 2019 Aug 2; 294(31): 11853–11862. Published online 2019 Jun 14. doi: 10.1074/jbc.RA118.007179

PMCID:: PMC6682732

Abstract Article PDF–2.4M

Select item 66755496.

NTCP deficiency in mice protects against obesity and hepatosteatosis

Joanne M. Donkers, Sander Kooijman, Davor Slijepcevic, Roni F. Kunst, Reinout L.P. Roscam Abbing, Lizette Haazen, Dirk R. de Waart, Johannes H.M. Levels, Kristina Schoonjans, Patrick C.N. Rensen, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf

JCI Insight. 2019 Jul 25; 4(14): e127197. Published online 2019 Jul 25. doi: 10.1172/jci.insight.127197

PMCID:: PMC6675549

Abstract Article PDF–3.6M

Select item 56987077.

Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice

Davor Slijepcevic, Reinout L.P. Roscam Abbing, Takeshi Katafuchi, Antje Blank, Joanne M. Donkers, Stéphanie van Hoppe, Dirk. R. de Waart, Dagmar Tolenaars, Jonathan H.M. van der Meer, Manon Wildenberg, Ulrich Beuers, Ronald P.J. Oude Elferink, Alfred H. Schinkel, Stan F.J. van de Graaf

Hepatology. 2017 Nov; 66(5): 1631–1643. Published online 2017 Sep 29. doi: 10.1002/hep.29251

PMCID:: PMC5698707

Abstract Article PDF–791K

Select item 49188448.

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders

Jessica M. Ferrell, Shannon Boehme, Feng Li, John Y. L. Chiang

J Lipid Res. 2016 Jul; 57(7): 1144–1154. doi: 10.1194/jlr.M064709

PMCID:: PMC4918844

Abstract Article PDF–1.3M

Select item 46574689.

Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na⁺-taurocholate cotransporting polypeptide knockout mice

Davor Slijepcevic, Christina Kaufman, Catharina GK Wichers, Eduardo H Gilglioni, Florian A Lempp, Suzanne Duijst, Dirk R de Waart, Ronald PJ Oude Elferink, Walter Mier, Bruno Stieger, Ulrich Beuers, Stephan Urban, Stan FJ van de Graaf

Hepatology. 2015 Jul; 62(1): 207–219. Published online 2015 May 8. doi: 10.1002/hep.27694

PMCID:: PMC4657468

Abstract Article PDF–856K

Select item 459181110.

Regulation of Plasma Membrane Localization of the Na⁺-Taurocholate Cotransporting Polypeptide (Ntcp) by Hyperosmolarity and Tauroursodeoxycholate

Annika Sommerfeld, Patrick G. K. Mayer, Miriam Cantore, Dieter Häussinger

J Biol Chem. 2015 Oct 2; 290(40): 24237–24254. Published online 2015 Aug 25. doi: 10.1074/jbc.M115.666883

Correction in:: J Biol Chem. 2016 Jul 22; 291(30): 15908.

PMCID:: PMC4591811

Abstract Article PDF–4.1M

Select item 451912911.

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis

Jun Hamazaki, Shoshiro Hirayama, Shigeo Murata

PLoS Genet. 2015 Jul; 11(7): e1005401. Published online 2015 Jul 29. doi: 10.1371/journal.pgen.1005401

PMCID:: PMC4519129

Abstract Article PDF–11M

Select item 447452812.

The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3′ processing

Ken-ichiro Abe, Ryoma Yamamoto, Vedran Franke, Minjun Cao, Yutaka Suzuki, Masataka G Suzuki, Kristian Vlahovicek, Petr Svoboda, Richard M Schultz, Fugaku Aoki

EMBO J. 2015 Jun 3; 34(11): 1523–1537. Published online 2015 Apr 20. doi: 10.15252/embj.201490648

PMCID:: PMC4474528

Abstract Article PDF–1.5M

Select item 370018513.

Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide

Huan Yan, Bo Peng, Wenhui He, Guocai Zhong, Yonghe Qi, Bijie Ren, Zhenchao Gao, Zhiyi Jing, Mei Song, Guangwei Xu, Jianhua Sui, Wenhui Li

J Virol. 2013 Jul; 87(14): 7977–7991. doi: 10.1128/JVI.03540-12

PMCID:: PMC3700185

Abstract Article PDF–9.1M

Select item 354363214.

The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis

Nathan J. Cherrington, Teresa E. Estrada, Harrison A. Frisk, Mark J. Canet, Rhiannon N. Hardwick, Bohuslav Dvorak, Katie Lux, Melissa D. Halpern

Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1; 304(1): G48–G56. Published online 2012 Nov 1. doi: 10.1152/ajpgi.00317.2012

PMCID:: PMC3543632

Abstract Article

Select item 335531215.

RNA-Seq Reveals Different mRNA Abundance of Transporters and Their Alternative Transcript Isoforms During Liver Development

Julia Yue Cui, Sumedha S. Gunewardena, Byunggil Yoo, Jie Liu, Helen J. Renaud, Hong Lu, Xiao-bo Zhong, Curtis D. Klaassen

Toxicol Sci. 2012 Jun; 127(2): 592–608. Published online 2012 Mar 27. doi: 10.1093/toxsci/kfs107

PMCID:: PMC3355312

Abstract Article PDF–1.1M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253417.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 279491918.

Generation of mouse conditional and null alleles of the type III sodium-dependent phosphate cotransporter PiT-1

Maria H Festing, Mei Y Speer, Hsueh-Ying Yang, Cecilia M Giachelli

Genesis. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Genesis. 2009 Dec; 47(12): 858–863. doi: 10.1002/dvg.20577

PMCID:: PMC2794919

Abstract Article PDF–190K

Select item 274081119.

Regulation of hepatic bile acid transporters Ntcp and Bsep expression

Xingguo Cheng, David Buckley, Curtis D. Klaassen

Biochem Pharmacol. Author manuscript; available in PMC 2009 Sep 9.

Published in final edited form as: Biochem Pharmacol. 2007 Dec 3; 74(11): 1665–1676. Published online 2007 Aug 19. doi: 10.1016/j.bcp.2007.08.014

PMCID:: PMC2740811

Abstract Article PDF–540K

Select item 273982820.

Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice

Iván L. Csanaky, Lauren M. Aleksunes, Yuji Tanaka, Curtis D. Klaassen

Am J Physiol Gastrointest Liver Physiol. 2009 Sep; 297(3): G419–G433. Published online 2009 Jun 4. doi: 10.1152/ajpgi.90728.2008

PMCID:: PMC2739828

Abstract Article

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