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Select item 113794741.

LXR-dependent enhancer activation regulates the temporal organization of the liver’s response to refeeding leading to lipogenic gene overshoot

Noga Korenfeld, Tali Gorbonos, Maria C. Romero Florian, Dan Rotaro, Dana Goldberg, Talia Radushkevitz-Frishman, Meital Charni-Natan, Meirav Bar-Shimon, Carolyn L. Cummins, Ido Goldstein

PLoS Biol. 2024 Sep; 22(9): e3002735. Published online 2024 Sep 12. doi: 10.1371/journal.pbio.3002735

PMCID:: PMC11379474

Abstract Article PDF–3.4M

Select item 109508042.

Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis

Brian Kleiboeker, Anyuan He, Min Tan, Dongliang Lu, Donghua Hu, Xuejing Liu, Parniyan Goodarzi, Fong-Fu Hsu, Babak Razani, Clay F. Semenkovich, Irfan J. Lodhi

Mol Metab. 2024 Apr; 82: 101913. Published online 2024 Mar 7. doi: 10.1016/j.molmet.2024.101913

PMCID:: PMC10950804

Abstract Article PDF–4.3M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108002694.

Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages

Ruiyi Zhang, Yifei Dong, Yang Liu, Dorsa Moezzi, Samira Ghorbani, Reza Mirzaei, Brian M Lozinski, Jeff F Dunn, V Wee Yong, Mengzhou Xue

Stroke Vasc Neurol. 2023 Dec; 8(6): 486–502. Published online 2023 May 3. doi: 10.1136/svn-2023-002331

PMCID:: PMC10800269

Abstract Article PDF–9.0M

Select item 107852425.

Ginsenoside F2 Restrains Hepatic Steatosis and Inflammation by Altering the Binding Affinity of Liver X Receptor Coregulators

Kyurae Kim, Myung-Ho Kim, Ji In Kang, Jong-In Baek, Byeong-Min Jeon, Ho Min Kim, Sun-Chang Kim, Won-Il Jeong

J Ginseng Res. 2024 Jan; 48(1): 89–97. Published online 2023 Oct 27. doi: 10.1016/j.jgr.2023.10.001

PMCID:: PMC10785242

Abstract Article PDF–5.7M

Select item 99928186.

Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1

Jiyeon Kim, Haeseung Lee, Jeong-Eun Lee, Garam Choi, Hayeon Chung, Daehong Kim, Min Jung Park, Yong Seok Gye, Kwang-Soo Shin, Chang-Yuil Kang, Seung-Ki Kwok, Yeonseok Chung

Proc Natl Acad Sci U S A. 2023 Feb 28; 120(9): e2213793120. Published online 2023 Feb 21. doi: 10.1073/pnas.2213793120

PMCID:: PMC9992818

Abstract Article PDF–1.1M

Select item 99263107.

Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages

Suzanne A.E. van Wouw, Marlene van den Berg, Maroua El Ouraoui, Amber Meurs, Jenina Kingma, Roelof Ottenhoff, Melanie Loix, Marten A. Hoeksema, Koen Prange, Gerard Pasterkamp, Jerome J.A. Hendriks, Jeroen F.J. Bogie, Jan B. van Klinken, Frederic M. Vaz, Aldo Jongejan, Menno P.J. de Winther, Noam Zelcer

J Lipid Res. 2023 Feb; 64(2): 100325. Published online 2022 Dec 31. doi: 10.1016/j.jlr.2022.100325

PMCID:: PMC9926310

Abstract Article PDF–2.6M

Select item 91624998.

Myeloid LXR deficiency induces inflammatory gene expression in foamy macrophages and accelerates atherosclerosis

Kaori Endo-Umeda, Eunyoung Kim, David G. Thomas, Wenli Liu, Huijuan Dou, Mustafa Yalcinkaya, Sandra Abramowicz, Tong Xiao, Per Antonson, Jan-Åke Gustafsson, Makoto Makishima, Muredach P. Reilly, Nan Wang, Alan R. Tall

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Jun; 42(6): 719–731. Published online 2022 Apr 28. doi: 10.1161/ATVBAHA.122.317583

PMCID:: PMC9162499

Abstract Article PDF–2.2M

Select item 89562709.

Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor

Jean Personnaz, Enzo Piccolo, Alizée Dortignac, Jason S. Iacovoni, Jérôme Mariette, Vincent Rocher, Arnaud Polizzi, Aurélie Batut, Simon Deleruyelle, Lucas Bourdens, Océane Delos, Lucie Combes-Soia, Romain Paccoud, Elsa Moreau, Frédéric Martins, Thomas Clouaire, Fadila Benhamed, Alexandra Montagner, Walter Wahli, Robert F. Schwabe, Armelle Yart, Isabelle Castan-Laurell, Justine Bertrand-Michel, Odile Burlet-Schiltz, Catherine Postic, Pierre-Damien Denechaud, Cédric Moro, Gaelle Legube, Chih-Hao Lee, Hervé Guillou, Philippe Valet, Cédric Dray, Jean-Philippe Pradère

Sci Adv. 2022 Mar; 8(12): eabg9055. Published online 2022 Mar 25. doi: 10.1126/sciadv.abg9055

PMCID:: PMC8956270

Abstract Article PDF–3.7M

Select item 880307610.

Krüppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development

Huilun Wang, Yanhong Guo, Haocheng Lu, Yonghong Luo, Wenting Hu, Wenying Liang, Minerva T Garcia-Barrio, Lin Chang, Anna Schwendeman, Jifeng Zhang, Y Eugene Chen

Cardiovasc Res. 2022 Feb; 118(2): 475–488. Published online 2021 Feb 4. doi: 10.1093/cvr/cvab027

PMCID:: PMC8803076

Abstract Article PDF–2.1M

Select item 860496511.

Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice

Kaori Endo-Umeda, Hiroyuki Nakashima, Shigeyuki Uno, Shota Toyoshima, Naoki Umeda, Shihoko Komine-Aizawa, Shuhji Seki, Makoto Makishima

Sci Rep. 2021; 11: 22595. Published online 2021 Nov 19. doi: 10.1038/s41598-021-02062-z

PMCID:: PMC8604965

Abstract Article PDF–4.8M

Select item 848801612.

SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1

Chaoyu Zhu, Menghao Huang, Hyeong-Geug Kim, Kushan Chowdhury, Jing Gao, Sheng Liu, Jun Wan, Li Wei, X. Charlie Dong

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2021 Dec 1; 1867(12): 166249. Published online 2021 Aug 21. doi: 10.1016/j.bbadis.2021.166249

PMCID:: PMC8488016

Abstract Article PDF–1.4M

Select item 842716613.

Myeloid-Derived Suppressive Cells Deficient in Liver X Receptor α Protected From Autoimmune Hepatitis

Bo Li, Min Lian, Yikang Li, Qiwei Qian, Jun Zhang, Qiaoyan Liu, Ruqi Tang, Xiong Ma

Front Immunol. 2021; 12: 732102. Published online 2021 Aug 26. doi: 10.3389/fimmu.2021.732102

PMCID:: PMC8427166

Abstract Article PDF–5.5M

Select item 835041214.

Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα

Jessica Kain, Xiaolong Wei, Nihal A. Reddy, Andrew J. Price, Claire Woods, Irina M. Bochkis

Mol Metab. 2021 Nov; 53: 101291. Published online 2021 Jul 8. doi: 10.1016/j.molmet.2021.101291

PMCID:: PMC8350412

Abstract Article PDF–6.8M

Select item 832241415.

Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression

Huang Huang, Xiaoping Wu, Dongwei Meng, Yizhou Feng, Lan Zhou, Zhenyu Liu, Shupei Tang, Xueqin Li, Yi Cao, Haiyang He, Zhunyi Xie, Jingbo Zhang, Yongwen Chen, Tingting Zhao, Yuzhang Wu, Xinyuan Zhou

Cell Mol Immunol. 2021 Aug; 18(8): 1969–1980. Published online 2020 Sep 22. doi: 10.1038/s41423-020-00546-y

PMCID:: PMC8322414

Abstract Article PDF–2.2M

Select item 830162016.

Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation

Takuya Ishikiriyama, Hiroyuki Nakashima, Kaori Endo-Umeda, Masahiro Nakashima, Seigo Ito, Manabu Kinoshita, Masami Ikarashi, Makoto Makishima, Shuhji Seki

PLoS One. 2021; 16(7): e0254886. Published online 2021 Jul 23. doi: 10.1371/journal.pone.0254886

PMCID:: PMC8301620

Abstract Article PDF–1.9M

Select item 819038417.

Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages

Cristina M. Ramírez, Marta Torrecilla-Parra, Virginia Pardo-Marqués, Mario Fernández de-Frutos, Ana Pérez-García, Carlos Tabraue, Juan Vladimir de la Rosa, Patricia Martín-Rodriguez, Mercedes Díaz-Sarmiento, Uxue Nuñez, Marta C. Orizaola, Paqui G. Través, Marta Camps, Lisardo Boscá, Antonio Castrillo

Front Endocrinol (Lausanne) 2021; 12: 635923. Published online 2021 May 27. doi: 10.3389/fendo.2021.635923

PMCID:: PMC8190384

Abstract Article PDF–10M

Select item 799793018.

Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice

Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Mélanie Mahé, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Inés Pineda-Torra, Edward A. Fisher, Michael J. Garabedian

Commun Biol. 2021; 4: 420. Published online 2021 Mar 26. doi: 10.1038/s42003-021-01925-5

PMCID:: PMC7997930

Abstract Article PDF–6.8M

Select item 793877019.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 792563220.

Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXRα-Mediated Macrophage Phagocytosis

Peng Wang, Xingjiang Mu, Hongyan Zhao, Yutian Li, Lu Wang, Vivian Wolfe, Shu-Nan Cui, Xiaohong Wang, Tianqing Peng, Basilia Zingarelli, Chunting Wang, Guo-Chang Fan

Front Immunol. 2021; 12: 647070. Published online 2021 Feb 17. doi: 10.3389/fimmu.2021.647070

PMCID:: PMC7925632

Abstract Article PDF–4.0M

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