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Items: 1 to 20 of 36

1.
Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions
Jonathan M. Alektiar, Mengrou Shan, Megan D. Radyk, Li Zhang, Christopher J. Halbrook, Lin Lin, Carlos Espinoza, Ivan F. Mier, Brooke L. Lavoie, Lucie Salvatore, Marina Pasca di Magliano, Lewis C. Cantley, Jacob L. Mueller, Costas A. Lyssiotis
PLoS One. 2024; 19(6): e0303577. Published online 2024 Jun 6. doi: 10.1371/journal.pone.0303577
PMCID:
PMC11156412
AbstractArticlePDF–2.1M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and Induces Circulating Insulin and Leptin in Obese Female Mice
Frank A. Simmen, John Mark P. Pabona, Ahmed Al-Dwairi, Iad Alhallak, Maria Theresa E. Montales, Rosalia C. M. Simmen
Int J Mol Sci. 2023 Apr; 24(7): 6613. Published online 2023 Apr 1. doi: 10.3390/ijms24076613
PMCID:
PMC10095602
AbstractArticlePDF–3.6M
4.
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany
Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527
PMCID:
PMC9603860
AbstractArticlePDF–3.4M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA
Xiaoyun Liu, Yan Jiao, Yanhong Cao, Nan Deng, Yonghui Ma, Karen A. Hasty, Andrew Kang, Hong Chen, John M. Stuart, Weikuan Gu
BMC Immunol. 2016; 17: 25. Published online 2016 Aug 2. doi: 10.1186/s12865-016-0163-y
PMCID:
PMC4970213
AbstractArticlePDF–2.5M
7.
Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage
Ling Liu, Supriya Shah, Jing Fan, Junyoung O Park, Kathryn E Wellen, Joshua D Rabinowitz
Nat Chem Biol. Author manuscript; available in PMC 2017 May 1.
Published in final edited form as: Nat Chem Biol. 2016 May; 12(5): 345–352. Published online 2016 Mar 21. doi: 10.1038/nchembio.2047
PMCID:
PMC4891982
AbstractArticlePDF–1.0M
8.
Mutant KRAS associated malic enzyme 1 expression is a predictive marker for radiation therapy response in non-small cell lung cancer
Gaurab Chakrabarti
Radiat Oncol. 2015; 10: 145. Published online 2015 Jul 16. doi: 10.1186/s13014-015-0457-x
PMCID:
PMC4502640
AbstractArticlePDF–813K
9.
Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice
Ahmed Al-Dwairi, Adam R. Brown, John Mark P. Pabona, Trang H. Van, Hamdan Hamdan, Charles P. Mercado, Charles M. Quick, Patricia A. Wight, Rosalia C. M. Simmen, Frank A. Simmen
PLoS One. 2014; 9(11): e113058. Published online 2014 Nov 17. doi: 10.1371/journal.pone.0113058
PMCID:
PMC4234650
AbstractArticlePDF–1.9M
10.
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
Peng Jiang, Wenjing Du, Anthony Mancuso, Kathryn E. Wellen, Xiaolu Yang
Nature. Author manuscript; available in PMC 2013 Jul 31.
Published in final edited form as: Nature. 2013 Jan 31; 493(7434): 689–693. Published online 2013 Jan 13. doi: 10.1038/nature11776
PMCID:
PMC3561500
AbstractArticlePDF–901K
11.
Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice
Ahmed Al-Dwairi, John Mark P. Pabona, Rosalia C. M. Simmen, Frank A. Simmen
PLoS One. 2012; 7(10): e46716. Published online 2012 Oct 4. doi: 10.1371/journal.pone.0046716
PMCID:
PMC3464285
AbstractArticlePDF–1.8M
12.
RAB-Like 2 Has an Essential Role in Male Fertility, Sperm Intra-Flagellar Transport, and Tail Assembly
Jennifer C. Y. Lo, Duangporn Jamsai, Anne E. O'Connor, Claire Borg, Brett J. Clark, James C. Whisstock, Mark C. Field, Vicki Adams, Tomomoto Ishikawa, R. John Aitken, Belinda Whittle, Christopher C. Goodnow, Christopher J. Ormandy, Moira K. O'Bryan
PLoS Genet. 2012 Oct; 8(10): e1002969. Published online 2012 Oct 4. doi: 10.1371/journal.pgen.1002969
PMCID:
PMC3464206
AbstractArticlePDF–1.8M
13.
Three-dimensional visualisation of testis cord morphogenesis, a novel tubulogenic mechanism in development
Alexander N. Combes, Emmanuelle Lesieur, Vincent R. Harley, Andrew H. Sinclair, Melissa H. Little, Dagmar Wilhelm, Peter Koopman
Dev Dyn. Author manuscript; available in PMC 2011 Oct 9.
Published in final edited form as: Dev Dyn. 2009 May; 238(5): 1033–1041. doi: 10.1002/dvdy.21925
PMCID:
PMC3189492
AbstractArticlePDF–2.5M
14.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
15.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
16.
Validation of Candidate Causal Genes for Abdominal Obesity Which Affect Shared Metabolic Pathways and Networks
Xia Yang, Joshua L. Deignan, Hongxiu Qi, Jun Zhu, Su Qian, Judy Zhong, Gevork Torosyan, Sana Majid, Brie Falkard, Robert R. Kleinhanz, Jenny Karlsson, Lawrence W. Castellani, Sheena Mumick, Kai Wang, Tao Xie, Michael Coon, Chunsheng Zhang, Daria Estrada-Smith, Charles R. Farber, Susanna S. Wang, Atila Van Nas, Anatole Ghazalpour, Bin Zhang, Douglas J. MacNeil, John R. Lamb, Katrina M. Dipple, Marc L. Reitman, Margarete Mehrabian, Pek Y. Lum, Eric E. Schadt, Aldons J. Lusis, Thomas A. Drake
Nat Genet. Author manuscript; available in PMC 2010 Mar 15.
Published in final edited form as: Nat Genet. 2009 Apr; 41(4): 415–423. Published online 2009 Mar 8. doi: 10.1038/ng.325
PMCID:
PMC2837947
AbstractArticlePDF–580K
17.
A mitochondrial protein compendium elucidates complex I disease biology
David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha
Cell. Author manuscript; available in PMC 2009 Nov 18.
Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016
PMCID:
PMC2778844
AbstractArticlePDF–1.2M
18.
Malic enzyme is present in mouse islets and modulates insulin secretion
Jianxiang Xu, Junying Han, Yun Shi Long, Jennifer Lock, Gordon C. Weir, Paul N. Epstein, Ye Qi Liu
Diabetologia. Author manuscript; available in PMC 2009 Nov 16.
Published in final edited form as: Diabetologia. 2008 Dec; 51(12): 2281–2289. Published online 2008 Sep 19. doi: 10.1007/s00125-008-1155-0
PMCID:
PMC2777632
AbstractArticlePDF–602K
19.
Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion
Emma Heart, Gary W. Cline, Leon P. Collis, Rebecca L. Pongratz, Joshua P. Gray, Peter J. S. Smith
Am J Physiol Endocrinol Metab. 2009 Jun; 296(6): E1354–E1362. Published online 2009 Mar 17. doi: 10.1152/ajpendo.90836.2008
PMCID:
PMC2692397
AbstractArticle
20.
Silencing of Cytosolic or Mitochondrial Isoforms of Malic Enzyme Has No Effect on Glucose-stimulated Insulin Secretion from Rodent Islets
Sarah M. Ronnebaum, Mette V. Jensen, Hans E. Hohmeier, Shawn C. Burgess, Yun-Ping Zhou, Su Qian, Douglas MacNeil, Andrew Howard, Nancy Thornberry, Olga Ilkayeva, Danhong Lu, A. Dean Sherry, Christopher B. Newgard
J Biol Chem. 2008 Oct 24; 283(43): 28909–28917. doi: 10.1074/jbc.M804665200
PMCID:
PMC2570884
AbstractArticlePDF–598K

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