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Select item 107554981.

Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion

Chun-Guang Guo, Rui Sun, Xiao Wang, Ye Yuan, Yan Xu, Shihan Li, Xueting Sun, Jue Wang, Xinli Hu, Tiannan Guo, Xiao-Wei Chen, Rui-Ping Xiao, Xiuqin Zhang

Mol Metab. 2024 Jan; 79: 101847. Published online 2023 Nov 30. doi: 10.1016/j.molmet.2023.101847

PMCID:: PMC10755498

Abstract Article PDF–3.6M

Select item 106833542.

hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner

Weijie Hao, Zhimin Chen, Jingzhi Tang, Ru Yang, Wei-Qiang Gao, Huiming Xu

J Transl Med. 2023; 21: 861. Published online 2023 Nov 28. doi: 10.1186/s12967-023-04704-4

PMCID:: PMC10683354

Abstract Article PDF–4.8M

Select item 105820453.

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization

Toshiharu Onodera, May-Yun Wang, Joseph M. Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S. Balzer, Dae-Seok Kim, Xuenan Sun, Yu A. An, Bianca C. Field, Charlotte Lee, Ei-ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M. Kusminski, Ruth Gordillo, Laurent Gautron, Denise K. Marciano, Ming Chang Hu, Shawn C. Burgess, Katalin Susztak, Orson W. Moe, Philipp E. Scherer

Nat Commun. 2023; 14: 6531. Published online 2023 Oct 17. doi: 10.1038/s41467-023-42188-4

PMCID:: PMC10582045

Abstract Article PDF–4.6M

Select item 104001094.

PCK1 Protects against Mitoribosomal Defects in Diabetic Nephropathy in Mouse Models

Kazuhiro Hasegawa, Yusuke Sakamaki, Masanori Tamaki, Shu Wakino

J Am Soc Nephrol. 2023 Aug; 34(8): 1343–1365. Published online 2023 May 18. doi: 10.1681/ASN.0000000000000156

PMCID:: PMC10400109

Abstract Article

Select item 103133625.

Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression

Dongmei Gou, Rui Liu, Xiaoqun Shan, Haijun Deng, Chang Chen, Jin Xiang, Yi Liu, Qingzhu Gao, Zhi Li, Ailong Huang, Kai Wang, Ni Tang

J Clin Invest. 2023 Jul 3; 133(13): e161713. Published online 2023 Jul 3. doi: 10.1172/JCI161713

PMCID:: PMC10313362

Abstract Article PDF–26M

Select item 102402086.

Hepatic ZBTB22 promotes hyperglycemia and insulin resistance via PEPCK1‐driven gluconeogenesis

Naihua Liu, Xiaoying Yang, Jingyi Guo, Lei Zhang, Shangyi Huang, Jiabing Chen, Jiawen Huang, Yingjian Chen, Tianqi Cui, Yi Zheng, Tianyao Li, Kaijia Tang, Yadi Zhong, Siwei Duan, Lili Yu, Ying Tang, Dayong Zheng, Huafeng Pan, Yong Gao

EMBO Rep. 2023 Jun; 24(6): e56390. Published online 2023 May 8. doi: 10.15252/embr.202256390

PMCID:: PMC10240208

Abstract Article PDF–15M

Select item 102297437.

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN

Kaini Zhang, Chen Yang, Xin Zhou, Jin Liang, Jianjin Guo, Min Li, Yi Zhang, Shulin Shao, Peng Sun, Kai Li, Jingjing Huang, Fang Chen, Xiubin Liang, Dongming Su

Cell Mol Life Sci. 2023 Jun; 80(6): 168. Published online 2023 May 30. doi: 10.1007/s00018-023-04820-w

PMCID:: PMC10229743

Abstract Article PDF–2.9M

Select item 102024778.

PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells

Thomas Verissimo, Delal Dalga, Grégoire Arnoux, Imene Sakhi, Anna Faivre, Hannah Auwerx, Soline Bourgeois, Deborah Paolucci, Quentin Gex, Joseph M. Rutkowski, David Legouis, Carsten A. Wagner, Andrew M. Hall, Sophie de Seigneux

Am J Physiol Renal Physiol. 2023 Jun 1; 324(6): F532–F543. Published online 2023 Apr 27. doi: 10.1152/ajprenal.00038.2023

PMCID:: PMC10202477

Abstract Article

Select item 100150959.

Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Qian Ye, Yi Liu, Guiji Zhang, Haijun Deng, Xiaojun Wang, Lin Tuo, Chang Chen, Xuanming Pan, Kang Wu, Jiangao Fan, Qin Pan, Kai Wang, Ailong Huang, Ni Tang

Nat Commun. 2023; 14: 1402. Published online 2023 Mar 14. doi: 10.1038/s41467-023-37142-3

PMCID:: PMC10015095

Abstract Article PDF–4.2M

Select item 979914310.

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice

Ferrol I. Rome, Gregory L. Shobert, William C. Voigt, David B. Stagg, Patrycja Puchalska, Shawn C. Burgess, Peter A. Crawford, Curtis C. Hughey

Am J Physiol Endocrinol Metab. 2023 Jan 1; 324(1): E9–E23. Published online 2022 Nov 9. doi: 10.1152/ajpendo.00222.2022

PMCID:: PMC9799143

Abstract Article

Select item 968745511.

Maternal Calorie Restriction Induces a Transcriptional Cytoprotective Response in Embryonic Liver Partially Dependent on Nrf2

George I. Habeos, Fotini Filippopoulou, Evagelia E. Habeos, Electra Kalaitzopoulou, Marianna Skipitari, Polyxeni Papadea, George Lagoumintzis, Athanasios Niarchos, Christos D. Georgiou, Dionysios V. Chartoumpekis

Antioxidants (Basel) 2022 Nov; 11(11): 2274. Published online 2022 Nov 17. doi: 10.3390/antiox11112274

PMCID:: PMC9687455

Abstract Article PDF–2.0M

Select item 938646412.

The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation

Ziyi Song, Alus M. Xiaoli, Youlei Li, Gerile Siqin, Tian Wu, Randy Strich, Jeffrey E. Pessin, Fajun Yang

Mol Metab. 2022 Oct; 64: 101548. Published online 2022 Jul 19. doi: 10.1016/j.molmet.2022.101548

PMCID:: PMC9386464

Abstract Article PDF–6.6M

Select item 938238913.

Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism

Patrycja A Jazwiec, Violet S Patterson, Tatiane A Ribeiro, Erica Yeo, Katherine M Kennedy, Paulo C F Mathias, Jim J Petrik, Deborah M Sloboda

Biol Reprod. 2022 Aug; 107(2): 574–589. Published online 2022 Apr 4. doi: 10.1093/biolre/ioac066

PMCID:: PMC9382389

Abstract Article PDF–1.7M

Select item 867762414.

O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis

Rui Liu, Dongmei Gou, Jin Xiang, Xuanming Pan, Qingzhu Gao, Peng Zhou, Yi Liu, Jie Hu, Kai Wang, Ni Tang

Oncogene. 2021; 40(50): 6707–6719. Published online 2021 Oct 14. doi: 10.1038/s41388-021-02058-z

PMCID:: PMC8677624

Abstract Article PDF–6.5M

Select item 863973115.

Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα

Ozren Stojanović, Jordi Altirriba, Dorothée Rigo, Martina Spiljar, Emilien Evrard, Benedek Roska, Salvatore Fabbiano, Nicola Zamboni, Pierre Maechler, Françoise Rohner-Jeanrenaud, Mirko Trajkovski

Nat Commun. 2021; 12: 7031. Published online 2021 Dec 2. doi: 10.1038/s41467-021-27133-7

PMCID:: PMC8639731

Abstract Article PDF–2.6M

Select item 826247916.

Multitissue ²H/¹³C flux analysis reveals reciprocal upregulation of renal gluconeogenesis in hepatic PEPCK-C–knockout mice

Mohsin Rahim, Clinton M. Hasenour, Tomasz K. Bednarski, Curtis C. Hughey, David H. Wasserman, Jamey D. Young

JCI Insight. 2021 Jun 22; 6(12): e149278. Published online 2021 Jun 22. doi: 10.1172/jci.insight.149278

PMCID:: PMC8262479

Abstract Article PDF–1.3M

Select item 826247317.

Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation

Jin Xiang, Chang Chen, Rui Liu, Dongmei Gou, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang, Kai Wang, Ni Tang

J Clin Invest. 2021 Apr 15; 131(8): e144703. Published online 2021 Apr 15. doi: 10.1172/JCI144703

PMCID:: PMC8262473

Abstract Article PDF–17M

Select item 723504818.

TFEB regulates murine liver cell fate during development and regeneration

Nunzia Pastore, Tuong Huynh, Niculin J. Herz, Alessia Calcagni’, Tiemo J. Klisch, Lorenzo Brunetti, Kangho Ho Kim, Marco De Giorgi, Ayrea Hurley, Annamaria Carissimo, Margherita Mutarelli, Niya Aleksieva, Luca D’Orsi, William R. Lagor, David D. Moore, Carmine Settembre, Milton J. Finegold, Stuart J. Forbes, Andrea Ballabio

Nat Commun. 2020; 11: 2461. Published online 2020 May 18. doi: 10.1038/s41467-020-16300-x

PMCID:: PMC7235048

Abstract Article PDF–8.7M

Select item 700306619.

Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation

Panagiota Karagianni, Panagiotis Moulos, Dominic Schmidt, Duncan T. Odom, Iannis Talianidis

Cell Rep. 2020 Feb 4; 30(5): 1319–1328.e6. Published online 2019 Feb 4. doi: 10.1016/j.celrep.2020.01.006

PMCID:: PMC7003066

Abstract Article

Select item 662242620.

Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation

Kasey Cargill, Shelby L. Hemker, Andrew Clugston, Anjana Murali, Elina Mukherjee, Jiao Liu, Daniel Bushnell, Andrew J. Bodnar, Zubaida Saifudeen, Jacqueline Ho, Carlton M. Bates, Dennis Kostka, Eric S. Goetzman, Sunder Sims-Lucas

J Am Soc Nephrol. 2019 Jul; 30(7): 1192–1205. Published online 2019 May 29. doi: 10.1681/ASN.2018111170

PMCID:: PMC6622426

Abstract Article

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