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Select item 115214101.

MDM2 Is Essential to Maintain the Homeostasis of Epithelial Cells by Targeting p53

Su Wang, Shufen Zhong, Ying Huang, Songling Zhu, Shuangfeng Chen, Ran Wang, Sonam Wangmo, Bo Peng, Houkun Lv, Jichao Yang, Liyan Ma, Zhiyang Ling, Yaguang Zhang, Pengfei Sui, Bing Sun

J Innate Immun. 2024 Jan-Dec; 16(1): 397–412. Published online 2024 Aug 12. doi: 10.1159/000539824

PMCID:: PMC11521410

Abstract Article PDF–3.0M

Select item 113515882.

Ribosomal Protein S4 X-Linked as a Novel Modulator of MDM2 Stability by Suppressing MDM2 Auto-Ubiquitination and SCF Complex-Mediated Ubiquitination

Satsuki Ryu, Hiroki Nakashima, Yuka Tanaka, Risa Mukai, Yasuhiro Ishihara, Takashi Tominaga, Takayuki Ohshima

Biomolecules. 2024 Aug; 14(8): 885. Published online 2024 Jul 23. doi: 10.3390/biom14080885

PMCID:: PMC11351588

Abstract Article PDF–1.7M

Select item 112062213.

CRL4^DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development

Xiao-Ran Han, Naoya Sasaki, Sarah C. Jackson, Pu Wang, Zhijun Li, Matthew D. Smith, Ling Xie, Xian Chen, Yanping Zhang, William F. Marzluff, Yue Xiong

Sci Adv. 2020 Dec; 6(51): eabd6078. Published online 2020 Dec 18. doi: 10.1126/sciadv.abd6078

PMCID:: PMC11206221

Abstract Article PDF–2.7M

Select item 111596774.

Association of TP53 and MDM2 polymorphisms with survival in bladder cancer patients treated with chemoradiotherapy

Asano Shinohara, Shigeru Sakano, Yuji Hinoda, Jun Nishijima, Yoshihisa Kawai, Taku Misumi, Kazuhiro Nagao, Takahiko Hara, Hideyasu Matsuyama

Cancer Sci. 2009 Dec; 100(12): 2376–2382. Published online 2009 Aug 27. doi: 10.1111/j.1349-7006.2009.01331.x

PMCID:: PMC11159677

Abstract Article PDF–200K

Select item 111592185.

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2

Chihiro Ohtsubo, Daisuke Shiokawa, Masami Kodama, Christian Gaiddon, Hitoshi Nakagama, Aart G. Jochemsen, Yoichi Taya, Koji Okamoto

Cancer Sci. 2009 Jul; 100(7): 1291–1299. Published online 2009 Apr 15. doi: 10.1111/j.1349-7006.2009.01180.x

PMCID:: PMC11159218

Abstract Article PDF–3.5M

Select item 111481846.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 110219687.

FOXO1 promotes cancer cell growth through MDM2-mediated p53 degradation

Haruki Tomiyasu, Makoto Habara, Shunsuke Hanaki, Yuki Sato, Yosei Miki, Midori Shimada

J Biol Chem. 2024 Apr; 300(4): 107209. Published online 2024 Mar 21. doi: 10.1016/j.jbc.2024.107209

PMCID:: PMC11021968

Abstract Article PDF–1.7M

Select item 109922668.

Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery

Michihisa Kono, Takumi Kumai, Ryusuke Hayashi, Hidekiyo Yamaki, Hiroki Komatsuda, Risa Wakisaka, Toshihiro Nagato, Takayuki Ohkuri, Akemi Kosaka, Kenzo Ohara, Kan Kishibe, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Esteban Celis, Hiroya Kobayashi, Yasuaki Harabuchi

Cancer Immunol Immunother. 2021 Dec; 70(12): 3421–3434. Published online 2021 Apr 18. doi: 10.1007/s00262-021-02940-5

PMCID:: PMC10992266

Abstract Article PDF–1.4M

Select item 108893559.

Association of MDM2 Overexpression in Ameloblastomas with MDM2 Amplification and BRAF^V600E Expression

Konstantinos I. Tosios, Eleni-Marina Kalogirou, Ioannis G. Koutlas

Int J Mol Sci. 2024 Feb; 25(4): 2238. Published online 2024 Feb 13. doi: 10.3390/ijms25042238

PMCID:: PMC10889355

Abstract Article PDF–10M

Select item 1080618810.

MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner

Jianfeng Shu, Jinni Jiang, Xiaofang Wang, Xuejie Yang, Guofang Zhao, Ting Cai

Cell Death Dis. 2024 Jan; 15(1): 83. Published online 2024 Jan 23. doi: 10.1038/s41419-024-06474-3

Correction in:: Cell Death Dis. 2024 May; 15(5): 320.

PMCID:: PMC10806188

Abstract Article PDF–7.3M

Select item 1078258511.

TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression

Yu Zhang, Zhenlin Huang, Keqiang Li, Guoqing Xie, Yuankang Feng, Zihao Wang, Ningyang Li, Ruoyang Liu, Yinghui Ding, Jun Wang, Jinjian Yang, Zhankui Jia

J Exp Clin Cancer Res. 2024; 43: 16. Published online 2024 Jan 11. doi: 10.1186/s13046-023-02920-w

PMCID:: PMC10782585

Abstract Article PDF–11M

Select item 1078146012.

SRSF7 downregulation induces cellular senescence through generation of MDM2 variants

Jiwon Hong, Seongki Min, Gyesoon Yoon, Su Bin Lim

Aging (Albany NY) 2023 Dec 31; 15(24): 14591–14606. Published online 2023 Dec 29. doi: 10.18632/aging.205420

PMCID:: PMC10781460

Abstract Article PDF–2.2M

Select item 1071280913.

Association of rs1570360 and rs2010963 in VEGF and rs2279744 in the MDM2 gene with Recurrent Implantation Failure in Iranian Women

Mehdi Elmi, Pegah Ghandil, Masoud Hemadi, Maryam Tahmasebi Birgani, Alihossein Saberi

JBRA Assist Reprod. 2023 Jul-Sep; 27(3): 342–347. doi: 10.5935/1518-0557.20220062

PMCID:: PMC10712809

Abstract Article PDF–203K

Select item 1070022114.

MDM2 amplification is rare in gastric cancer

Samir Abdullazade, Hans-Michael Behrens, Sandra Krüger, Jochen Haag, Christoph Röcken

Virchows Arch. 2023; 483(6): 795–807. Published online 2023 Oct 11. doi: 10.1007/s00428-023-03674-8

PMCID:: PMC10700221

Abstract Article PDF–1.4M

Select item 1063707215.

ZNF500 abolishes breast cancer proliferation and sensitizes chemotherapy by stabilizing P53 via competing with MDM2

Xiaowen Ma, Mingwei Fan, Kaibo Yang, Yuanyuan Wang, Ran Hu, Mengyao Guan, Yuekang Hou, Jiao Ying, Ning Deng, Qingchang Li, Guiyang Jiang, Yong Zhang, Xiupeng Zhang

Cancer Sci. 2023 Nov; 114(11): 4237–4251. Published online 2023 Sep 12. doi: 10.1111/cas.15947

PMCID:: PMC10637072

Abstract Article PDF–22M

Select item 1050265716.

MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis

Debao Fang, Hao Hu, Kailiang Zhao, Aman Xu, Changjun Yu, Yong Zhu, Ning Yu, Bo Yao, Suyun Tang, Xianning Wu, Yide Mei

Adv Sci (Weinh) 2023 Sep; 10(26): 2303336. Published online 2023 Jul 12. doi: 10.1002/advs.202303336

PMCID:: PMC10502657

Abstract Article PDF–3.4M

Select item 1042584917.

LncRNA NRON promotes tumorigenesis by enhancing MDM2 activity toward tumor suppressor substrates

Qiannan Guo, Yihui Li, Yunmei Zhang, Liping Shen, Huayue Lin, Jianing Chen, Erwei Song, Man‐Li Luo

EMBO J. 2023 Aug; 42(16): e112414. Published online 2023 Jun 29. doi: 10.15252/embj.2022112414

PMCID:: PMC10425849

Abstract Article PDF–18M

Select item 1036458618.

New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4

Salomé Araujo‐Abad, Bruno Rizzuti, Adrián Villamarin‐Ortiz, David Pantoja‐Uceda, Celia M. Moreno‐Gonzalez, Olga Abian, Adrián Velazquez‐Campoy, José L. Neira, Camino de Juan Romero

Protein Sci. 2023 Aug; 32(8): e4723. Published online 2023 Aug 1. doi: 10.1002/pro.4723

PMCID:: PMC10364586

Abstract Article PDF–7.4M

Select item 1034981419.

miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia

Han Zhong Pei, Zhiyong Peng, Xiaomei Zhuang, Xiaobo Wang, Bo Lu, Yao Guo, Yuming Zhao, Dengyang Zhang, Yunjun Xiao, Tianshun Gao, Liuting Yu, Chunxiao He, Shunjie Wu, Suk-Hwan Baek, Zhizhuang Joe Zhao, Xiaojun Xu, Yun Chen

Cell Death Discov. 2023; 9: 249. Published online 2023 Jul 15. doi: 10.1038/s41420-023-01537-4

PMCID:: PMC10349814

Abstract Article PDF–3.6M

Select item 1033388420.

Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions

Johanna Kliche, Dimitriya Hristoforova Garvanska, Leandro Simonetti, Dilip Badgujar, Doreen Dobritzsch, Jakob Nilsson, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2023 Jul; 19(7): e11164. Published online 2023 May 23. doi: 10.15252/msb.202211164

PMCID:: PMC10333884

Abstract Article PDF–5.0M

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