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Select item 111576721.

High expression of DEC2 distinguishes chondroblastic osteosarcoma and promotes tumour growth by activating the VEGFC/VEGFR2 signalling pathway

Maimaitiaili Tuerxun, Xu Zheng, Jun Xu, Quanjun Yang, Ting Yuan, Changqing Zhang, Shumin Zhou

J Cell Mol Med. 2024 Jun; 28(11): e18462. Published online 2024 Jun 7. doi: 10.1111/jcmm.18462

PMCID:: PMC11157672

Abstract Article PDF–54M

Select item 109177802.

BHLHE40/41 regulate microglia and peripheral macrophage responses associated with Alzheimer’s disease and other disorders of lipid-rich tissues

Anna Podleśny-Drabiniok, Gloriia Novikova, Yiyuan Liu, Josefine Dunst, Rose Temizer, Chiara Giannarelli, Samuele Marro, Taras Kreslavsky, Edoardo Marcora, Alison Mary Goate

Nat Commun. 2024; 15: 2058. Published online 2024 Mar 6. doi: 10.1038/s41467-024-46315-7

PMCID:: PMC10917780

Abstract Article PDF–4.5M

Select item 103809483.

Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development

Tatsuhiko Furukawa, Kentaro Mimami, Toshiyuki Nagata, Masatasu Yamamoto, Masami Sato, Akihide Tanimoto

Int J Mol Sci. 2023 Jul; 24(14): 11731. Published online 2023 Jul 21. doi: 10.3390/ijms241411731

PMCID:: PMC10380948

Abstract Article PDF–598K

Select item 85840414.

BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma

Toshiyuki Nagata, Kentaro Minami, Masatatsu Yamamoto, Tsubasa Hiraki, Masashi Idogawa, Katsumi Fujimoto, Shun Kageyama, Kazuhiro Tabata, Kohichi Kawahara, Kazuhiro Ueda, Ryuji Ikeda, Yukio Kato, Masaaki Komatsu, Akihide Tanimoto, Tatsuhiko Furukawa, Masami Sato

Int J Mol Sci. 2021 Nov; 22(21): 11509. Published online 2021 Oct 26. doi: 10.3390/ijms222111509

PMCID:: PMC8584041

Abstract Article PDF–7.0M

Select item 85087645.

The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation

Xingzhi Wang, Fuyuki Sato, Keiji Tanimoto, Niveda Rajeshwaran, Lakshmi Thangavelu, Makoto Makishima, Ujjal K. Bhawal

Int J Mol Sci. 2021 Oct; 22(19): 10349. Published online 2021 Sep 26. doi: 10.3390/ijms221910349

PMCID:: PMC8508764

Abstract Article PDF–747K

Select item 81208376.

Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma

Xiao Yang, Jia-shun Wu, Mao Li, Wei-long Zhang, Xiao-lei Gao, Hao-fan Wang, Xiang-hua Yu, Xin Pang, Mei Zhang, Xin-hua Liang, Ya-ling Tang

J Exp Clin Cancer Res. 2021; 40: 169. Published online 2021 May 14. doi: 10.1186/s13046-021-01956-0

PMCID:: PMC8120837

Abstract Article PDF–10M

Select item 80090487.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 76869578.

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41

Kimberly L. Carey, Geraldine L.C. Paulus, Lingfei Wang, Dale R. Balce, Jessica W. Luo, Phil Bergman, Ianina C. Ferder, Lingjia Kong, Nicole Renaud, Shantanu Singh, Maria Kost-Alimova, Beat Nyfeler, Kara G. Lassen, Herbert W. Virgin, Ramnik J. Xavier

Cell Rep. Author manuscript; available in PMC 2020 Nov 25.

Published in final edited form as: Cell Rep. 2020 Nov 10; 33(6): 108371. doi: 10.1016/j.celrep.2020.108371

PMCID:: PMC7686957

Abstract Article PDF–1.6M

Select item 75694339.

DEC2 Serves as Potential Tumor Suppressor in Breast Carcinoma

Wentong Fang, Qian Li, Min Wang, Mingjie Zheng, Huirong Xu

Dis Markers. 2020; 2020: 6053154. Published online 2020 Oct 10. doi: 10.1155/2020/6053154

PMCID:: PMC7569433

Abstract Article PDF–2.2M

Select item 717131110.

BHLHE41 suppresses MCF‐7 cell invasion via MAPK/JNK pathway

Di Zhang, Qin Zheng, Chen Wang, Na Zhao, Yang Liu, Enhua Wang

J Cell Mol Med. 2020 Apr; 24(7): 4001–4010. Published online 2020 Feb 19. doi: 10.1111/jcmm.15033

PMCID:: PMC7171311

Abstract Article PDF–1.4M

Select item 641240011.

Overexpression of BHLHE41, correlated with DNA hypomethylation in 3′UTR region, promotes the growth of human clear cell renal cell carcinoma

Zhouji Shen, Ling Zhu, Chao Zhang, Xiaobo Cui, Jun Lu

Oncol Rep. 2019 Apr; 41(4): 2137–2147. Published online 2019 Feb 7. doi: 10.3892/or.2019.7004

PMCID:: PMC6412400

Abstract Article PDF–1.3M

Select item 613166312.

Correlation between DEC1/DEC2 and epithelial-mesenchymal transition in human prostate cancer PC-3 cells

Qiang Liu, Yunyan Wu, Hiroko Seino, Toshihiro Haga, Tadashi Yoshizawa, Satoko Morohashi, Hiroshi Kijima

Mol Med Rep. 2018 Oct; 18(4): 3859–3865. Published online 2018 Aug 9. doi: 10.3892/mmr.2018.9367

PMCID:: PMC6131663

Abstract Article PDF–1.6M

Select item 607643913.

The tumor suppressor CIC directly regulates MAPK pathway genes via histone deacetylation

Simon Weissmann, Paul A. Cloos, Simone Sidoli, Ole N. Jensen, Steven Pollard, Kristian Helin

Cancer Res. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Cancer Res. 2018 Aug 1; 78(15): 4114–4125. Published online 2018 May 29. doi: 10.1158/0008-5472.CAN-18-0342

PMCID:: PMC6076439

Abstract Article PDF–2.5M

Select item 591539114.

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

Akihiko Numata, Hui Si Kwok, Akira Kawasaki, Jia Li, Qi-Ling Zhou, Jon Kerry, Touati Benoukraf, Deepak Bararia, Feng Li, Erica Ballabio, Marta Tapia, Aniruddha J. Deshpande, Robert S. Welner, Ruud Delwel, Henry Yang, Thomas A. Milne, Reshma Taneja, Daniel G. Tenen

Nat Commun. 2018; 9: 1622. Published online 2018 Apr 24. doi: 10.1038/s41467-018-03854-0

PMCID:: PMC5915391

Abstract Article PDF–2.1M

Select item 587971515.

DEC2 modulates orexin expression and regulates sleep

Arisa Hirano, Pei-Ken Hsu, Luoying Zhang, Lijuan Xing, Thomas McMahon, Maya Yamazaki, Louis J. Ptáček, Ying-Hui Fu

Proc Natl Acad Sci U S A. 2018 Mar 27; 115(13): 3434–3439. Published online 2018 Mar 12. doi: 10.1073/pnas.1801693115

PMCID:: PMC5879715

Abstract Article PDF–913K

Select item 572808616.

Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation

Jeffrey D. Stevens, Eric H. Roalson, Michael K. Skinner

Differentiation. Author manuscript; available in PMC 2017 Dec 13.

Published in final edited form as: Differentiation. 2008 Nov; 76(9): 1006–1022. Published online 2008 Jun 4. doi: 10.1111/j.1432-0436.2008.00285.x

PMCID:: PMC5728086

Abstract Article PDF–2.4M

Select item 553643417.

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway

Steffen Grampp, Virginia Schmid, Rafik Salama, Victoria Lauer, Franziska Kranz, James L. Platt, James Smythies, Hani Choudhry, Margarete Goppelt-Struebe, Peter J. Ratcliffe, David R. Mole, Johannes Schödel

PLoS Genet. 2017 Jul; 13(7): e1006872. Published online 2017 Jul 17. doi: 10.1371/journal.pgen.1006872

PMCID:: PMC5536434

Abstract Article PDF–3.8M

Select item 511775318.

Basic helix-loop-helix transcription factor DEC2 functions as an anti-apoptotic factor during paclitaxel-induced apoptosis in human prostate cancer cells

Qiang Liu, Yunyan Wu, Tadashi Yoshizawa, Xu Yan, Satoko Morohashi, Hiroko Seino, Yukio Kato, Hiroshi Kijima

Int J Mol Med. 2016 Dec; 38(6): 1727–1733. Published online 2016 Nov 8. doi: 10.3892/ijmm.2016.2798

PMCID:: PMC5117753

Abstract Article PDF–1.0M

Select item 494105519.

Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

Pierre Bigot, Leandro M. Colli, Mitchell J. Machiela, Lea Jessop, Timothy A. Myers, Julie Carrouget, Sarah Wagner, David Roberson, Caroline Eymerit, Daniel Henrion, Stephen J. Chanock

Nat Commun. 2016; 7: 12098. Published online 2016 Jul 7. doi: 10.1038/ncomms12098