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Items: 1 to 20 of 128

1.
Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors
Ahmed H. Ghobashi, Rosie Lanzloth, Christopher A. Ladaika, Ashiq Masood, Heather M. O’Hagan
Cancers (Basel) 2024 Jun; 16(11): 2040. Published online 2024 May 28. doi: 10.3390/cancers16112040
PMCID:
PMC11171101
AbstractArticlePDF–9.3M
2.
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
Peter M. K. Westcott, Francesc Muyas, Haley Hauck, Olivia C. Smith, Nathan J. Sacks, Zackery A. Ely, Alex M. Jaeger, William M. Rideout, III, Daniel Zhang, Arjun Bhutkar, Mary C. Beytagh, David A. Canner, Grissel C. Jaramillo, Roderick T. Bronson, Santiago Naranjo, Abbey Jin, J. J. Patten, Amanda M. Cruz, Sean-Luc Shanahan, Isidro Cortes-Ciriano, Tyler Jacks
Nat Genet. 2023; 55(10): 1686–1695. Published online 2023 Sep 14. doi: 10.1038/s41588-023-01499-4
PMCID:
PMC10562252
AbstractArticlePDF–18M
3.
Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer
Yurong Song, Travis D. Kerr, Chelsea Sanders, Lisheng Dai, Shaneen S. Baxter, Brandon Somerville, Ryan N. Baugher, Stephanie D. Mellott, Todd B. Young, Heidi E. Lawhorn, Teri M. Plona, Bingfang Xu, Lei Wei, Qiang Hu, Song Liu, Alan Hutson, Baktiar Karim, Sandra Burkett, Simone Difilippantonio, Ligia Pinto, Johannes Gebert, Matthias Kloor, Steven M. Lipkin, Shizuko Sei, Robert H. Shoemaker
Front Oncol. 2023; 13: 1223915. Published online 2023 Sep 8. doi: 10.3389/fonc.2023.1223915
PMCID:
PMC10516605
AbstractArticlePDF–8.3M
4.
Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation
Guia Cerretelli, Ying Zhou, Mike F. Müller, David J. Adams, Mark J. Arends
Dis Model Mech. 2023 Aug 1; 16(8): dmm050240. Published online 2023 Jul 31. doi: 10.1242/dmm.050240
PMCID:
PMC10417510
AbstractArticle
5.
Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model
J Gebert, O Gelincik, M Oezcan-Wahlbrink, JD Marshall, A Hernandez-Sanchez, K Urban, M Long, E Cortes, E Tosti, EM Katzenmaier, Y Song, A Elsaadi, N Deng, E Vilar, V Fuchs, N Nelius, Yuan, A Ahadova, S Sei, RH Shoemaker, A Umar, L Wei, S Liu, P Bork, W Edelmann, M von Knebel Doeberitz, SM Lipkin, M Kloor
Gastroenterology. Author manuscript; available in PMC 2023 May 15.
Published in final edited form as: Gastroenterology. 2021 Oct; 161(4): 1288–1302.e13. Published online 2021 Jul 2. doi: 10.1053/j.gastro.2021.06.073
Correction in:
Gastroenterology. 2021 Oct 14
PMCID:
PMC10184299
AbstractArticlePDF–1.9M
6.
NAD+ repletion with niacin counteracts cancer cachexia
Marc Beltrà, Noora Pöllänen, Claudia Fornelli, Kialiina Tonttila, Myriam Y. Hsu, Sandra Zampieri, Lucia Moletta, Samantha Corrà, Paolo E. Porporato, Riikka Kivelä, Carlo Viscomi, Marco Sandri, Juha J. Hulmi, Roberta Sartori, Eija Pirinen, Fabio Penna
Nat Commun. 2023; 14: 1849. Published online 2023 Apr 3. doi: 10.1038/s41467-023-37595-6
PMCID:
PMC10070388
AbstractArticlePDF–4.6M
7.
Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding
Susanne R Bruekner, Wietske Pieters, Alexander Fish, A Manuel Liaci, Serge Scheffers, Emily Rayner, Daphne Kaldenbach, Lisa Drost, Marleen Dekker, Sandrine van Hees-Stuivenberg, Elly Delzenne-Goette, Charlotte de Konink, Hellen Houlleberghs, Hendrikus Jan Dubbink, Abeer AlSaegh, Niels de Wind, Friedrich Förster, Hein te Riele, Titia K Sixma
Nucleic Acids Res. 2023 Feb 22; 51(3): 1173–1188. Published online 2023 Jan 30. doi: 10.1093/nar/gkad015
PMCID:
PMC9943660
AbstractArticlePDF–5.2M
8.
Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination
Emily Sible, Mary Attaway, Giuseppe Fiorica, Genesis Michel, Jayanta Chaudhuri, Bao Q. Vuong
J Immunol. 2023 Feb 15; 210(4): 369–376. Published online 2023 Jan 4. doi: 10.4049/jimmunol.2200590
PMCID:
PMC9915862
AbstractArticlePDF–822K
9.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
10.
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
Yuqing Feng, Conglei Li, Jessica A. Stewart, Philip Barbulescu, Noé Seija Desivo, Alejandro Álvarez-Quilón, Rossanna C. Pezo, Madusha L. W. Perera, Katherine Chan, Amy Hin Yan Tong, Rukshana Mohamad-Ramshan, Maribel Berru, Diana Nakib, Gavin Li, Gholam Ali Kardar, James R. Carlyle, Jason Moffat, Daniel Durocher, Javier M. Di Noia, Ashok S. Bhagwat, Alberto Martin
Nature. Author manuscript; available in PMC 2022 Aug 30.
Published in final edited form as: Nature. 2021 Dec; 600(7888): 324–328. Published online 2021 Nov 24. doi: 10.1038/s41586-021-04144-4
PMCID:
PMC9425297
AbstractArticlePDF–4.9M
11.
Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer
Elena Tosti, Ana S. Almeida, Tam T.T. Tran, Mariel Barbachan e Silva, Pilib Ó. Broin, Robert Dubin, Ken Chen, Amanda P. Beck, Andrew S. Mclellan, Eduardo Vilar, Aaron Golden, Paul W. O’Toole, Winfried Edelmann
Cell Mol Gastroenterol Hepatol. 2022; 14(3): 693–717. Published online 2022 Jun 7. doi: 10.1016/j.jcmgh.2022.05.010
PMCID:
PMC9421583
AbstractArticlePDF–7.1M
12.
Ethanol‐induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome
Guia Cerretelli, Ying Zhou, Mike F Müller, David J Adams, Mark J Arends
J Pathol. 2021 Dec; 255(4): 464–474. Published online 2021 Oct 13. doi: 10.1002/path.5796
PMCID:
PMC9291843
AbstractArticlePDF–19M
13.
DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis
Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun
Blood. 2021 Dec 9; 138(23): 2360–2371. doi: 10.1182/blood.2021011247
PMCID:
PMC8832461
AbstractArticle
14.
Lactobacillus rhamnosus GG Orchestrates an Antitumor Immune Response
Joshua A. Owens, Bejan J. Saeedi, Crystal R. Naudin, Sarah Hunter-Chang, Maria E. Barbian, Richard U. Eboka, Lauren Askew, Trevor M. Darby, Brian S. Robinson, Rheinallt M. Jones
Cell Mol Gastroenterol Hepatol. 2021; 12(4): 1311–1327. Published online 2021 Jun 7. doi: 10.1016/j.jcmgh.2021.06.001
PMCID:
PMC8463873
AbstractArticlePDF–6.6M
15.
The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells
Prashant V. Bommi, Charles M. Bowen, Laura Reyes-Uribe, Wenhui Wu, Hiroyuki Katayama, Pedro Rocha, Edwin R. Parra, Alejandro Francisco-Cruz, Zuhal Ozcan, Elena Tosti, Jason A. Willis, Hong Wu, Melissa W. Taggart, Jared K. Burks, Patrick M. Lynch, Winfried Edelmann, Paul Scheet, Ignacio I. Wistuba, Krishna M. Sinha, Samir M. Hanash, Eduardo Vilar
Cancer Res. Author manuscript; available in PMC 2021 Nov 15.
Published in final edited form as: Cancer Res. 2021 May 15; 81(10): 2760–2773. Published online 2021 Mar 18. doi: 10.1158/0008-5472.CAN-20-2896
PMCID:
PMC8318201
AbstractArticlePDF–2.0M
16.
How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse
Felix Hofmann, Torsten Thalheim, Karen Rother, Marianne Quaas, Christiane Kerner, Jens Przybilla, Gabriela Aust, Joerg Galle
Int J Mol Sci. 2021 Jul; 22(14): 7345. Published online 2021 Jul 8. doi: 10.3390/ijms22147345
PMCID:
PMC8305140
AbstractArticlePDF–3.2M
17.
The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer
Eva Pastille, Marie-Hélène Wasmer, Alexandra Adamczyk, Vivian P. Vu, Lukas F. Mager, Nhi Ngo Thi Phuong, Vittoria Palmieri, Cedric Simillion, Wiebke Hansen, Stefan Kasper, Martin Schuler, Beat Muggli, Kathy D. McCoy, Jan Buer, Inti Zlobec, Astrid M. Westendorf, Philippe Krebs
Mucosal Immunol. 2019; 12(4): 990–1003. Published online 2019 Jun 5. doi: 10.1038/s41385-019-0176-y
PMCID:
PMC7746527
AbstractArticlePDF–3.5M
18.
Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models
Amaia Martinez-Usatorre, Ece Kadioglu, Gael Boivin, Chiara Cianciaruso, Alan Guichard, Bruno Torchia, Nadine Zangger, Sina Nassiri, Ioanna Keklikoglou, Martina Schmittnaegel, Carola H. Ries, Etienne Meylan, Michele De Palma
Sci Transl Med. Author manuscript; available in PMC 2022 Feb 11.
Published in final edited form as: Sci Transl Med. 2021 Aug 11; 13(606): eabd1616. Published online 2021 Aug 11. doi: 10.1126/scitranslmed.abd1616
PMCID:
PMC7612153
AbstractArticlePDF–3.9M
19.
Mechanistic insight into crossing over during mouse meiosis
Shaun E. Peterson, Scott Keeney, Maria Jasin
Mol Cell. Author manuscript; available in PMC 2021 Jun 18.
Published in final edited form as: Mol Cell. 2020 Jun 18; 78(6): 1252–1263.e3. Published online 2020 May 1. doi: 10.1016/j.molcel.2020.04.009
PMCID:
PMC7454200
AbstractArticlePDF–4.0M
20.
Proteome instability is a therapeutic vulnerability in mismatch repair deficient cancer
Daniel J McGrail, Jeannine Garnett, Jun Yin, Hui Dai, David J.H. Shih, Truong Nguyen Anh Lam, Yang Li, Chaoyang Sun, Yongsheng Li, Rosemarie Schmandt, Ji Yuan Wu, Limei Hu, Yulong Liang, Guang Peng, Eric Jonasch, David Menter, Melinda S. Yates, Scott Kopetz, Karen Lu, Russell Broaddus, Gordon B. Mills, Nidhi Sahni, Shiaw-Yih Lin
Cancer Cell. Author manuscript; available in PMC 2021 Mar 16.
Published in final edited form as: Cancer Cell. 2020 Mar 16; 37(3): 371–386.e12. Published online 2020 Feb 27. doi: 10.1016/j.ccell.2020.01.011
PMCID:
PMC7337255
AbstractArticlePDF–3.5M

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