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Items: 1 to 20 of 49

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Degradation of NLRP3 by p62‐dependent‐autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia
Dongyuan Zhang, Yu Zhang, Jirong Pan, Jingjing Cao, Xiuping Sun, Xianglei Li, Ling Zhang, Chuan Qin
CNS Neurosci Ther. 2023 Oct; 29(10): 2826–2842. Published online 2023 Apr 18. doi: 10.1111/cns.14219
PMCID:
PMC10493665
AbstractArticlePDF–29M
3.
Stress-induced pseudokinase TRB3 augments IL1β signaling by interacting with Flightless homolog 1
Sumati Gonuguntla, Rohan K. Humphrey, Akshita Gorantla, Ergeng Hao, Ulupi S. Jhala
J Biol Chem. 2023 Aug; 299(8): 104803. Published online 2023 May 11. doi: 10.1016/j.jbc.2023.104803
PMCID:
PMC10432976
AbstractArticlePDF–2.0M
4.
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility
Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao
Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5
PMCID:
PMC10307852
AbstractArticlePDF–8.8M
5.
A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy
Yasuhide Kuwabara, Allen J. York, Suh-Chin Lin, Michelle A. Sargent, Kelly M. Grimes, James P. Pirruccello, Jeffery D. Molkentin
Proc Natl Acad Sci U S A. 2023 May 9; 120(19): e2213696120. Published online 2023 May 1. doi: 10.1073/pnas.2213696120
PMCID:
PMC10175844
AbstractArticlePDF–1.3M
6.
Flightless I Negatively Regulates Macrophage Surface TLR4, Delays Early Inflammation, and Impedes Wound Healing
Stuart J. Mills, Parinaz Ahangar, Hannah M. Thomas, Benjamin R. Hofma, Rachael Z. Murray, Allison J. Cowin
Cells. 2022 Jul; 11(14): 2192. Published online 2022 Jul 13. doi: 10.3390/cells11142192
PMCID:
PMC9318993
AbstractArticlePDF–3.9M
7.
Flightless-I is a potential biomarker for the early detection of alcoholic liver disease
Jaime Arellanes-Robledo, Joseph Ibrahim, Karina Reyes-Gordillo, Ruchi Shah, Leslie Leckey, M. Raj Lakshman
Biochem Pharmacol. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: Biochem Pharmacol. 2021 Jan; 183: 114323. Published online 2020 Nov 7. doi: 10.1016/j.bcp.2020.114323
PMCID:
PMC8614159
AbstractArticlePDF–3.3M
8.
Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells
Gink N. Yang, Parinaz Ahangar, Xanthe L. Strudwick, Zlatko Kopecki, Allison J. Cowin
Int J Mol Sci. 2021 Aug; 22(15): 8235. Published online 2021 Jul 30. doi: 10.3390/ijms22158235
PMCID:
PMC8348627
AbstractArticlePDF–4.7M
9.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
10.
Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling
P. D. Arora, K. Nakajima, A. Nanda, A. Plaha, A. Wilde, D. B. Sacks, C. A. McCulloch
Mol Biol Cell. 2020 Jul 15; 31(15): 1595–1610. doi: 10.1091/mbc.E19-10-0554
PMCID:
PMC7521798
AbstractArticlePDF–4.7M
11.
Attenuation of Flightless I Increases Human Pericyte Proliferation, Migration and Angiogenic Functions and Improves Healing in Murine Diabetic Wounds
Hannah M Thomas, Parinaz Ahangar, Benjamin R Hofma, Xanthe L Strudwick, Robert Fitridge, Stuart J Mills, Allison J Cowin
Int J Mol Sci. 2020 Aug; 21(16): 5599. Published online 2020 Aug 5. doi: 10.3390/ijms21165599
PMCID:
PMC7460558
AbstractArticlePDF–3.7M
12.
Increasing the level of cytoskeletal protein Flightless I reduces adhesion formation in a murine digital flexor tendon model
Jessica E. Jackson, Zlatko Kopecki, Peter J. Anderson, Allison J. Cowin
J Orthop Surg Res. 2020; 15: 362. Published online 2020 Aug 27. doi: 10.1186/s13018-020-01889-y
PMCID:
PMC7450967
AbstractArticlePDF–2.4M
13.
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant
Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely
Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089
PMCID:
PMC7295033
AbstractArticlePDF–2.7M
14.
In vitro analysis of the effect of Flightless I on murine tenocyte cellular functions
Jessica E. Jackson, Zlatko Kopecki, Peter J. Anderson, Allison J. Cowin
J Orthop Surg Res. 2020; 15: 170. Published online 2020 May 12. doi: 10.1186/s13018-020-01692-9
PMCID:
PMC7216515
AbstractArticlePDF–2.5M
15.
Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran sulphate sodium-induced ulcerative colitis
Z. Kopecki, G. Yang, S. Treloar, S. Mashtoub, G. S. Howarth, A. G. Cummins, A. J. Cowin
Sci Rep. 2019; 9: 12792. Published online 2019 Sep 5. doi: 10.1038/s41598-019-49129-6
PMCID:
PMC6728368
AbstractArticlePDF–2.8M
16.
The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1
Samuel J. Carpentier, Minjian Ni, Jeffrey M. Duggan, Richard G. James, Brad T. Cookson, Jessica A. Hamerman
Sci Signal. Author manuscript; available in PMC 2019 Nov 14.
Published in final edited form as: Sci Signal. 2019 May 14; 12(581): eaau0615. Published online 2019 May 14. doi: 10.1126/scisignal.aau0615
PMCID:
PMC6604799
AbstractArticlePDF–1.9M
17.
Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner
Paul R. Evans, Kyle J. Gerber, Eric B. Dammer, Duc M. Duong, Devrishi Goswami, Daniel J. Lustberg, Juan Zou, Jenny J. Yang, Serena M. Dudek, Patrick R. Griffin, Nicholas T. Seyfried, John R. Hepler
J Proteome Res. Author manuscript; available in PMC 2019 Jun 7.
Published in final edited form as: J Proteome Res. 2018 Apr 6; 17(4): 1700–1711. Published online 2018 Mar 20. doi: 10.1021/acs.jproteome.8b00027
PMCID:
PMC6554723
AbstractArticlePDF–2.0M
18.
The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation
P. D. Arora, T. He, K. Ng, C. A. McCulloch
Mol Biol Cell. 2018 Oct 1; 29(20): 2481–2493. doi: 10.1091/mbc.E18-03-0147
PMCID:
PMC6233052
AbstractArticlePDF–2.1M
19.
A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies
David K. Breslow, Sascha Hoogendoorn, Adam R. Kopp, David W. Morgens, Brandon K. Vu, Margaret C. Kennedy, Kyuho Han, Amy Li, Gaelen T. Hess, Michael C. Bassik, James K. Chen, Maxence V. Nachury
Nat Genet. Author manuscript; available in PMC 2018 Aug 19.
Published in final edited form as: Nat Genet. 2018 Mar; 50(3): 460–471. Published online 2018 Feb 19. doi: 10.1038/s41588-018-0054-7
PMCID:
PMC5862771
AbstractArticlePDF–2.5M
20.
Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders
Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba
Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.
Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594
PMCID:
PMC5645082
AbstractArticlePDF–2.3M

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