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Items: 1 to 20 of 215

1.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
2.
Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan
Robert Nakayama, Yasunori Sato, Mitsuko Masutani, Hideki Ogino, Fumihiko Nakatani, Hirokazu Chuman, Yasuo Beppu, Hideo Morioka, Hiroo Yabe, Hiroshi Hirose, Haruhiko Sugimura, Hiromi Sakamoto, Tsutomu Ohta, Yoshiaki Toyama, Teruhiko Yoshida, Akira Kawai
Cancer Sci. 2008 Feb; 99(2): 333–339. Published online 2008 Feb 6. doi: 10.1111/j.1349-7006.2007.00692.x
PMCID:
PMC11159914
AbstractArticlePDF–155K
3.
WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases
Jung-Hoon Yoon, Karthi Sellamuthu, Louise Prakash, Satya Prakash
Genes Dev. 2024 Mar 1; 38(5-6): 213–232. doi: 10.1101/gad.351410.123
PMCID:
PMC11065173
AbstractArticlePDF–1.7M
4.
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR
Dali Zong, Natasha C. Koussa, James A. Cornwell, Ajith V. Pankajam, Michael J. Kruhlak, Nancy Wong, Raj Chari, Steven D. Cappell, André Nussenzweig
Genes Dev. 2023 Oct 1; 37(19-20): 913–928. doi: 10.1101/gad.351085.123
PMCID:
PMC10691471
AbstractArticlePDF–4.0M
5.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
6.
Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt
J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706
PMCID:
PMC10243116
AbstractArticlePDF–13M
7.
Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma
Xi-Ya Li, Ji-Chuan Wu, Ping Liu, Zi-Juan Li, Yong Wang, Bing-Yi Chen, Cheng-Long Hu, Ming-Yue Fei, Peng-Cheng Yu, Yi-Lun Jiang, Chun-Hui Xu, Bin-He Chang, Xin-Chi Chen, Li-Juan Zong, Jia-Ying Zhang, Ying Fang, Xiao-Jian Sun, Kai Xue, Li Wang, Shu-Bei Chen, Shi-Yu Jiang, Ai-ling Gui, Ling Yang, Juan J. Gu, Bao-Hua Yu, Qun-ling Zhang, Lan Wang
Leukemia. 2023; 37(1): 164–177. Published online 2022 Nov 9. doi: 10.1038/s41375-022-01747-2
PMCID:
PMC9883169
AbstractArticlePDF–6.6M
8.
Werner syndrome protein works as a dimer for unwinding and replication fork regression
Soochul Shin, Kwangbeom Hyun, Jinwoo Lee, Dongwon Joo, Tomasz Kulikowicz, Vilhelm A Bohr, Jaehoon Kim, Sungchul Hohng
Nucleic Acids Res. 2023 Jan 11; 51(1): 337–348. Published online 2022 Dec 30. doi: 10.1093/nar/gkac1200
PMCID:
PMC9841404
AbstractArticlePDF–2.2M
9.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation
Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang
Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005
PMCID:
PMC9772558
AbstractArticlePDF–8.2M
10.
The in vivo Interaction Landscape of Histones H3.1 and H3.3
Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins
Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411
PMCID:
PMC9540345
AbstractArticlePDF–3.9M
11.
WRN Rescues Replication Forks Compromised by a BRCA2 Deficiency: Predictions for How Inhibition of a Helicase that Suppresses Premature Aging Tilts the Balance to Fork Demise and Chromosomal Instability in Cancer
Arindam Datta, Robert M. Brosh, Jr.
Bioessays. Author manuscript; available in PMC 2023 Aug 1.
Published in final edited form as: Bioessays. 2022 Aug; 44(8): e2200057. Published online 2022 Jun 25. doi: 10.1002/bies.202200057
PMCID:
PMC9527950
AbstractArticlePDF–692K
12.
Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB
Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan
EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698
PMCID:
PMC9433938
AbstractArticlePDF–9.3M
13.
The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis
Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi
Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y
PMCID:
PMC9343455
AbstractArticlePDF–3.7M
14.
Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling
Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser
Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151
PMCID:
PMC9105235
AbstractArticlePDF–5.8M
15.
Repeat expansions confer WRN dependence in microsatellite-unstable cancers
Niek van Wietmarschen, Sriram Sridharan, William J. Nathan, Anthony Tubbs, Edmond M. Chan, Elsa Callen, Wei Wu, Frida Belinky, Veenu Tripathi, Nancy Wong, Kyla Foster, Javad Noorbakhsh, Kiran Garimella, Abimael Cruz-Migoni, Joshua A. Sommers, Yongqing Huang, Ashir A. Borah, Jonathan T. Smith, Jeremie Kalfon, Nikolas Kesten, Kasper Fugger, Robert L. Walker, Egor Dolzhenko, Michael A. Eberle, Bruce E. Hayward, Karen Usdin, Catherine H. Freudenreich, Robert M. Brosh, Jr, Stephen C. West, Peter J. McHugh, Paul S. Meltzer, Adam J. Bass, André Nussenzweig
Nature. Author manuscript; available in PMC 2022 Mar 11.
Published in final edited form as: Nature. 2020 Oct; 586(7828): 292–298. Published online 2020 Sep 30. doi: 10.1038/s41586-020-2769-8
PMCID:
PMC8916167
AbstractArticlePDF–4.2M
16.
R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1
Veronica Marabitti, Pasquale Valenzisi, Giorgia Lillo, Eva Malacaria, Valentina Palermo, Pietro Pichierri, Annapaola Franchitto
Int J Mol Sci. 2022 Feb; 23(3): 1547. Published online 2022 Jan 28. doi: 10.3390/ijms23031547
PMCID:
PMC8836129
AbstractArticlePDF–1.4M
17.
Characterization of Stress Responses in a Drosophila Model of Werner Syndrome
Derek G. Epiney, Charlotte Salameh, Deirdre Cassidy, Luhan T. Zhou, Joshua Kruithof, Rolan Milutinović, Tomas S. Andreani, Aaron E. Schirmer, Elyse Bolterstein
Biomolecules. 2021 Dec; 11(12): 1868. Published online 2021 Dec 12. doi: 10.3390/biom11121868
PMCID:
PMC8699552
AbstractArticlePDF–1.7M
18.
WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
Arindam Datta, Kajal Biswas, Joshua A. Sommers, Haley Thompson, Sanket Awate, Claudia M. Nicolae, Tanay Thakar, George-Lucian Moldovan, Robert H. Shoemaker, Shyam K. Sharan, Robert M. Brosh, Jr
Nat Commun. 2021; 12: 6561. Published online 2021 Nov 12. doi: 10.1038/s41467-021-26811-w
PMCID:
PMC8590011
AbstractArticlePDF–6.8M
19.
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim
Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6
PMCID:
PMC8566473
AbstractArticlePDF–2.7M
20.
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo
Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396
PMCID:
PMC8552907
AbstractArticlePDF–3.9M

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