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Select item 115588001.

Glucocorticoid excess alters metabolic rate and substrate utilisation via 11β-HSD1

Samuel R Heaselgrave, Silke Heising, Stuart A Morgan, David M Carthwright, Michael Sagmeister, Rowan S Hardy, Craig L Doig, Nicholas Morton, Kostas Tsintzas, Gareth G Lavery

J Endocrinol. 2024 Nov 1; 263(2): e240205. Prepublished online 2024 Sep 20. Published online 2024 Oct 28. doi: 10.1530/JOE-24-0205

PMCID:: PMC11558800

Abstract Article PDF–3.2M

Select item 114499082.

Targeting osteoblastic 11β-HSD1 to combat high-fat diet-induced bone loss and obesity

Chuanxin Zhong, Nanxi Li, Shengzheng Wang, Dijie Li, Zhihua Yang, Lin Du, Guangxin Huang, Haitian Li, Wing Sze Yeung, Shan He, Shuting Ma, Zhuqian Wang, Hewen Jiang, Huarui Zhang, Zhanghao Li, Xiaoxin Wen, Song Xue, Xiaohui Tao, Haorui Li, Duoli Xie, Yihao Zhang, Zefeng Chen, Junqin Wang, Jianfeng Yan, Zhengming Liang, Zongkang Zhang, Zhigang Zhong, Zeting Wu, Chao Wan, Chao Liang, Luyao Wang, Sifan Yu, Yuan Ma, Yuanyuan Yu, Fangfei Li, Yang Chen, Baoting Zhang, Aiping Lyu, Fuzeng Ren, Hong Zhou, Jin Liu, Ge Zhang

Nat Commun. 2024; 15: 8588. Published online 2024 Oct 4. doi: 10.1038/s41467-024-52965-4

PMCID:: PMC11449908

Abstract Article PDF–3.1M

Select item 113014253.

Deletion of Hsd11b1 suppresses caloric restriction-induced bone marrow adiposity in male but not female mice

Andrea Lovdel, Karla J Suchacki, Fiona Roberts, Richard J Sulston, Robert J Wallace, Benjamin J Thomas, Rachel M B Bell, Iris Pruñonosa Cervera, Gavin J Macpherson, Nicholas M Morton, Natalie Z M Homer, Karen E Chapman, William P Cawthorn

J Endocrinol. 2024 Aug 1; 262(2): e240072. Prepublished online 2024 May 28. Published online 2024 Jun 24. doi: 10.1530/JOE-24-0072

PMCID:: PMC11301425

Abstract Article PDF–2.5M

Select item 111388434.

Human and rodent type 1 11β-hydroxysteroid dehydrogenases are 7β-hydroxycholesterol dehydrogenases involved in oxysterol metabolism

M. Hult, B. Elleby, N. Shafqat, S. Svensson, A. Rane, H. Jörnvall, L. Abrahmsen, U. Oppermann

Cell Mol Life Sci. 2004 Apr; 61(7-8): 992–999. doi: 10.1007/s00018-003-3476-y

PMCID:: PMC11138843

Abstract Article PDF–218K

Select item 106264525.

Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice

Verena M. Merk, Truong San Phan, Alice Wiedmann, Rowan S. Hardy, Gareth G. Lavery, Thomas Brunner

Front Immunol. 2023; 14: 1252874. Published online 2023 Oct 23. doi: 10.3389/fimmu.2023.1252874

PMCID:: PMC10626452

Abstract Article PDF–6.1M

Select item 106165066.

G6PC1 and G6PC2 Influence Glucose-6-Phosphate Flux but not 11β-Hydroxysteroid Dehydrogenase Type 1 Activity

Emily M. Hawes, Kayla A. Boortz, James K. Oeser, Margaret L. O’Rourke, Richard M. O’Brien

J Mol Endocrinol. Author manuscript; available in PMC 2024 Nov 1.

Published in final edited form as: J Mol Endocrinol. 2023 Nov 1; 71(4): e230070. Published online 2023 Oct 18. doi: 10.1530/JME-23-0070

PMCID:: PMC10616506

Abstract Article PDF–1005K

Select item 103675507.

11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling

Hanwen Li, Sihan Hu, Runze Wu, Hongyou Zhou, Kai Zhang, Ke Li, Wenzheng Lin, Qin Shi, Hao Chen, Shan Lv

Int J Biol Sci. 2023; 19(11): 3628–3639. Published online 2023 Jul 15. doi: 10.7150/ijbs.82933

PMCID:: PMC10367550

Abstract Article PDF–8.3M

Select item 102444608.

Hyperglycemia-activated 11β-hydroxysteroid dehydrogenase type 1 increases endoplasmic reticulum stress and skin barrier dysfunction

Young Bin Lee, Hyun Jee Hwang, Eunjung Kim, Sung Ha Lim, Choon Hee Chung, Eung Ho Choi

Sci Rep. 2023; 13: 9206. Published online 2023 Jun 6. doi: 10.1038/s41598-023-36294-y

PMCID:: PMC10244460

Abstract Article PDF–4.3M

Select item 101724639.

Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS

Rahul Y. Mahida, Siân Lax, Christopher R. Bassford, Aaron Scott, Dhruv Parekh, Rowan S. Hardy, Babu Naidu, Michael A. Matthay, Paul M. Stewart, Mark C. Cooper, Gavin D. Perkins, David R. Thickett

Front Immunol. 2023; 14: 1159831. Published online 2023 Apr 27. doi: 10.3389/fimmu.2023.1159831

PMCID:: PMC10172463

Abstract Article PDF–3.5M

Select item 1002708210.

11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD

Justine M. Webster, Kelsy Waaijenberg, Wouter R. P. H. van de Worp, Marco C. J. M. Kelders, Sara Lambrichts, Claire Martin, Frank Verhaegen, Brent Van der Heyden, Charlotte Smith, Gareth G. Lavery, Annemie M. W. J. Schols, Rowan S. Hardy, Ramon C. J. Langen

Am J Physiol Lung Cell Mol Physiol. 2023 Apr 1; 324(4): L400–L412. Published online 2023 Feb 21. doi: 10.1152/ajplung.00009.2022

PMCID:: PMC10027082

Abstract Article

Select item 957808811.

11β-HSD1 contributes to age-related metabolic decline in male mice

Stuart A Morgan, Laura L Gathercole, Zaki K Hassan-Smith, Jeremy Tomlinson, Paul M Stewart, Gareth G Lavery

J Endocrinol. 2022 Dec 1; 255(3): 117–129. Published online 2022 Oct 7. doi: 10.1530/JOE-22-0169

PMCID:: PMC9578088

Abstract Article PDF–1.0M

Select item 955683712.

Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

Elina Akalestou, Livia Lopez-Noriega, Ioannis Christakis, Ming Hu, Alexander D. Miras, Isabelle Leclerc, Guy A. Rutter

Front Endocrinol (Lausanne) 2022; 13: 1020576. Published online 2022 Sep 29. doi: 10.3389/fendo.2022.1020576

PMCID:: PMC9556837

Abstract Article PDF–6.7M

Select item 932773713.

Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice

Esteban Salazar-Petres, Daniela Pereira-Carvalho, Jorge Lopez-Tello, Amanda Nancy Sferruzzi-Perri

Biol Reprod. 2022 Jun; 106(6): 1292–1311. Published online 2022 Mar 16. doi: 10.1093/biolre/ioac056

PMCID:: PMC9327737

Abstract Article PDF–3.0M

Select item 913490814.

The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1

Mengliang Hu, Tingting Han, Qiyu Pan, Dongsheng Ni, Fengyi Gao, Liying Wang, Hangjiang Ren, Xiaoyi Zhang, Haoyun Jiao, Yuefeng Wang, Dapeng Dai, Yong Man, Weiqing Tang, Yue Sun, Wei Li, Jian Li, Guoping Li

Int J Biol Sci. 2022; 18(8): 3107–3121. Published online 2022 Apr 30. doi: 10.7150/ijbs.42376

PMCID:: PMC9134908

Abstract Article PDF–3.2M

Select item 879007215.

Enhanced Angiogenesis by 11βHSD1 Blockage Is Insufficient to Improve Reperfusion Following Hindlimb Ischaemia

Junxi Wu, Eileen Miller, Callam Davidson, Brian R. Walker, Patrick W. F. Hadoke

Front Cardiovasc Med. 2021; 8: 795823. Published online 2022 Jan 12. doi: 10.3389/fcvm.2021.795823

PMCID:: PMC8790072

Abstract Article PDF–1.3M

Select item 849232616.

Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization

Yan Yin, Meade E. Haller, Sangappa B. Chadchan, Ramakrishna Kommagani, Liang Ma

JCI Insight. 2021 Sep 8; 6(17): e150254. Published online 2021 Sep 8. doi: 10.1172/jci.insight.150254

PMCID:: PMC8492326

Abstract Article PDF–3.4M

Select item 819857917.

Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin

Beom Jun Kim, Noo Ri Lee, Chung Hyeok Lee, Young Bin Lee, Sung Jay Choe, Solam Lee, Hyun Jee Hwang, Eunjung Kim, Gareth G. Lavery, Kyong-Oh Shin, Kyungho Park, Eung Ho Choi

Int J Mol Sci. 2021 Jun; 22(11): 5750. Published online 2021 May 27. doi: 10.3390/ijms22115750

PMCID:: PMC8198579

Abstract Article PDF–2.1M

Select item 781563718.

Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids

Chloe Fenton, Claire Martin, Rachel Jones, Adam Croft, Joana Campos, Amy J Naylor, Angela E Taylor, Myriam Chimen, Mark Cooper, Gareth G Lavery, Karim Raza, Rowan S Hardy

Ann Rheum Dis. 2021 Feb; 80(2): 250–260. Published online 2020 Nov 8. doi: 10.1136/annrheumdis-2020-218493

PMCID:: PMC7815637

Abstract Article PDF–9.1M

Select item 767886419.

Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis

Noo Ri Lee, Beom Jun Kim, Chung Hyeok Lee, Young Bin Lee, Solam Lee, Hyun Jee Hwang, Eunjung Kim, Sung Hee Kim, Min-Geol Lee, Sang Eun Lee, Gareth G. Lavery, Eung Ho Choi

Sci Rep. 2020; 10: 20237. Published online 2020 Nov 19. doi: 10.1038/s41598-020-77281-x

PMCID:: PMC7678864

Abstract Article PDF–3.3M

Select item 667315120.

Enhanced Hippocampal Long-Term Potentiation and Spatial Learning in Aged 11β-Hydroxysteroid Dehydrogenase Type 1 Knock-Out Mice

Joyce L. W. Yau, Kara M. McNair, June Noble, David Brownstein, Carina Hibberd, Nik Morton, John J. Mullins, Richard G. M. Morris, Stuart Cobb, Jonathan R. Seckl

J Neurosci. 2007 Sep 26; 27(39): 10487–10496. doi: 10.1523/JNEUROSCI.2190-07.2007

PMCID:: PMC6673151

Abstract Article PDF–458K

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