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Select item 114322331.

The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site

Yoshinao Kubo, Manya Bakatumana Hans, Taisuke Nakamura, Hideki Hayashi

Int J Mol Sci. 2024 Sep; 25(18): 9987. Published online 2024 Sep 16. doi: 10.3390/ijms25189987

PMCID:: PMC11432233

Abstract Article PDF–3.0M

Select item 114252832.

Furin Egress from the TGN is Regulated by Membrane‐Associated RING‐CH Finger (MARCHF) Proteins and Ubiquitin‐Specific Protease 32 (USP32) via Nondegradable K33‐Polyubiquitination

Wenqiang Su, Iqbal Ahmad, You Wu, Lijie Tang, Ilyas Khan, Bowei Ye, Jie Liang, Sunan Li, Yong‐Hui Zheng

Adv Sci (Weinh) 2024 Sep; 11(35): 2403732. Published online 2024 Jul 19. doi: 10.1002/advs.202403732

PMCID:: PMC11425283

Abstract Article PDF–6.1M

Select item 109913783.

Novel genetic association of the Furin gene polymorphism rs1981458 with COVID-19 severity among Indian populations

Rudra Kumar Pandey, Anshika Srivastava, Rahul Kumar Mishra, Prajjval Pratap Singh, Gyaneshwer Chaubey

Sci Rep. 2024; 14: 7822. Published online 2024 Apr 3. doi: 10.1038/s41598-024-54607-7

Correction in:: Sci Rep. 2024; 14: 9523.

PMCID:: PMC10991378

Abstract Article PDF–3.5M

Select item 109902774.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 109420365.

Pathological changes in oral epithelium and the expression of SARS-CoV-2 entry receptors, ACE2 and furin

Osnat Grinstein-Koren, Michal Lusthaus, Hilla Tabibian-Keissar, Ilana Kaplan, Amos Buchner, Ron Ilatov, Marilena Vered, Ayelet Zlotogorski-Hurvitz

PLoS One. 2024; 19(3): e0300269. Published online 2024 Mar 15. doi: 10.1371/journal.pone.0300269

PMCID:: PMC10942036

Abstract Article PDF–2.2M

Select item 105719656.

An Overview of the Role of Furin in Type 2 Diabetes

Sulaiman K. Marafie, Fahd Al-Mulla

Cells. 2023 Oct; 12(19): 2407. Published online 2023 Oct 5. doi: 10.3390/cells12192407

PMCID:: PMC10571965

Abstract Article PDF–613K

Select item 103410587.

Allele-Specific Epigenetic Regulation of FURIN Expression at a Coronary Artery Disease Susceptibility Locus

Wei Yang, Junjun Cao, David G. McVey, Shu Ye

Cells. 2023 Jul; 12(13): 1681. Published online 2023 Jun 21. doi: 10.3390/cells12131681

PMCID:: PMC10341058

Abstract Article PDF–4.2M

Select item 103238958.

Overexpression of the pro‐protein convertase furin predicts prognosis and promotes papillary thyroid carcinoma progression and metastasis through RAF/MEK signaling

Pratheesh Kumar Poyil, Abdul K. Siraj, Divya Padmaja, Sandeep Kumar Parvathareddy, Roxanne Diaz, Saravanan Thangavel, Rafia Begum, Wael Haqawi, Falah Hassan Al‐Mohanna, Saif S. Al‐Sobhi, Fouad Al‐Dayel, Khawla S. Al‐Kuraya

Mol Oncol. 2023 Jul; 17(7): 1324–1342. Published online 2023 Feb 27. doi: 10.1002/1878-0261.13396

PMCID:: PMC10323895

Abstract Article PDF–6.4M

Select item 102178349.

PCSK3 Overexpression in Sjögren’s Syndrome Patients May Be Regulated by rs4932178 SNP in Its Promoter Region and Correlates with IFN-γ Gene Expression

Andrea Latini, Giada De Benedittis, Serena Colafrancesco, Carlo Perricone, Giuseppe Novelli, Lucia Novelli, Roberta Priori, Cinzia Ciccacci, Paola Borgiani

Genes (Basel) 2023 May; 14(5): 981. Published online 2023 Apr 26. doi: 10.3390/genes14050981

PMCID:: PMC10217834

Abstract Article PDF–621K

Select item 1003890110.

Proteolytic Activation of Human-specific Olduvai Domains by the Furin Protease

Ashley Pacheco, Aaron Issaian, Jonathan Davis, Nathan Anderson, Travis Nemkov, Natasia Paukovich, Morkos A. Henen, Beat Vögeli, James M. Sikela, Kirk Hansen

Int J Biol Macromol. Author manuscript; available in PMC 2024 Apr 15.

Published in final edited form as: Int J Biol Macromol. 2023 Apr 15; 234: 123041. Published online 2022 Dec 26. doi: 10.1016/j.ijbiomac.2022.12.260

PMCID:: PMC10038901

Abstract Article PDF–641K

Select item 966446811.

Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice

Ilaria Coppola, Bas Brouwers, Leanne Walker, Ceyhun Alar, Sandra Meulemans, Anne White, Bruno Ramos-Molina, John W.M. Creemers

Mol Metab. 2022 Dec; 66: 101627. Published online 2022 Oct 29. doi: 10.1016/j.molmet.2022.101627

PMCID:: PMC9664468

Abstract Article PDF–1.4M

Select item 944993212.

Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2

Gang Xu, Yezi Wu, Tongyang Xiao, Furong Qi, Lujie Fan, Shengyuan Zhang, Jian Zhou, Yanhua He, Xiang Gao, Hongxiang Zeng, Yunfei Li, Zheng Zhang

Signal Transduct Target Ther. 2022; 7: 312. Published online 2022 Sep 7. doi: 10.1038/s41392-022-01156-y

PMCID:: PMC9449932

Abstract Article PDF–5.2M

Select item 943393813.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 926261414.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 923162315.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 910523516.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 908862617.

FURIN gene variants (rs6224/rs4702) as potential markers of death and cardiovascular traits in severe COVID‐19

Eliecer Coto, Guillermo M. Albaiceta, Laura Amado‐Rodríguez, Marta García‐Clemente, Elías Cuesta‐Llavona, Daniel Vázquez‐Coto, Belén Alonso, Sara Iglesias, Santiago Melón, Marta E. Alvarez‐Argüelles, José A. Boga, Susana Rojo‐Alba, Sergio Pérez‐Oliveira, Victoria Alvarez, Juan Gómez

J Med Virol. 2022 Aug; 94(8): 3589–3595. Published online 2022 Apr 12. doi: 10.1002/jmv.27748

PMCID:: PMC9088626

Abstract Article PDF–935K

Select item 904494618.

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David N. Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Etienne Decroly, Tram NQ Pham, Éric A. Cohen, Nabil G. Seidah

J Virol. 2022 Apr; 96(8): e00128-22. Published online 2022 Mar 28. doi: 10.1128/jvi.00128-22

Correction in:: J Virol. 2022 Jul; 96(13): e00745-22.

PMCID:: PMC9044946

Abstract Article PDF–4.9M

Select item 903755419.

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy

Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell

Autophagy. 2022; 18(4): 829–840. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1960116

PMCID:: PMC9037554

Abstract Article PDF–4.1M

Select item 899079320.

FURIN Promoter Methylation Predicts the Risk of Incident Diabetes: A Prospective Analysis in the Gusu Cohort

Yan He, Yinan Li, Jianan Zhang, Linan Chen, Jing Li, Min Zhang, Qiu Zhang, Ying Lu, Jun Jiang, Xiaolong Zhang, Jianwei Hu, Yi Ding, Mingzhi Zhang, Hao Peng

Front Endocrinol (Lausanne) 2022; 13: 873012. Published online 2022 Mar 25. doi: 10.3389/fendo.2022.873012