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    Items: 1 to 20 of 137

    1.
    ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance
    Cheol-Jung Lee, Heejung Lee, Seo Ree Kim, Soo-Bin Nam, Ga-Eun Lee, Kyeong Eun Yang, Guk Jin Lee, Sang Hoon Chun, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Sung-Jun Cho, Yong-Yeon Cho
    Cell Death Dis. 2024 Apr; 15(4): 274. Published online 2024 Apr 17. doi: 10.1038/s41419-024-06647-0
    PMCID:
    PMC11024157
    AbstractArticlePDF–5.2M
    2.
    CSN6‐SPOP‐HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation
    Kai Li, Jiayu Zhang, Haiwen Lyu, Jinneng Yang, Wenxia Wei, Yuzhi Wang, Haidan Luo, Yijing Zhang, Xin Jiang, Hairong Yi, Mengan Wang, Caiyun Zhang, Kang Wu, Lishi Xiao, Weijie Wen, Hui Xu, Guolin Li, Yunle Wan, Fang Yang, Runxiang Yang, Xinhui Fu, Baifu Qin, Zhongguo Zhou, Haipeng Zhang, Mong‐Hong Lee
    Adv Sci (Weinh) 2024 Apr; 11(14): 2306827. Published online 2024 Feb 2. doi: 10.1002/advs.202306827
    PMCID:
    PMC11005689
    AbstractArticlePDF–9.1M
    3.
    BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma
    Zongdong Yu, Xiang Wu, Jie Zhu, Huan Yan, Yuxuan Li, Hui Zhang, Yeling Zhong, Man Lin, Ganghui Ye, Xinming Li, Jiabei Jin, Kailang Li, Jie Wang, Hui Zhuang, Ting Lin, Jian He, Changjiang Lu, Zeping Xu, Xie Zhang, Hong Li, Xiaofeng Jin
    Cell Mol Life Sci. 2024 Dec; 81(1): 82. Published online 2024 Feb 10. doi: 10.1007/s00018-024-05144-z
    PMCID:
    PMC10858942
    AbstractArticlePDF–17M
    4.
    Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP
    Nafiseh Sabri, Matthew J. Cuneo, Melissa R. Marzahn, Jihun Lee, Jill J. Bouchard, Ömer Güllülü, Sivaraja Vaithiyalingam, Madeleine B. Borgia, Jeremy Schmit, Tanja Mittag
    J Biol Chem. 2023 Dec; 299(12): 105427. Published online 2023 Nov 4. doi: 10.1016/j.jbc.2023.105427
    PMCID:
    PMC10696467
    AbstractArticlePDF–5.1M
    5.
    Ubiquitin E3 ligase SPOP is a host negative regulator of enterovirus 71-encoded 2A protease
    Lichao Zang, Xinyu Yang, Yan Chen, Fan Huang, Yukang Yuan, Xiangjie Chen, Yibo Zuo, Ying Miao, Jin Gu, Hui Guo, Wenxin Xia, Yang Peng, Mengyuan Tang, Ziwei Huang, Yangyang Wang, Jinhong Ma, Jingting Jiang, Wei Zhou, Hui Zheng, Weifeng Shi
    J Virol. 2023 Oct; 97(10): e00786-23. Published online 2023 Oct 5. doi: 10.1128/jvi.00786-23
    PMCID:
    PMC10617436
    AbstractArticlePDF–2.6M
    6.
    Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ERα axis
    Yidong Ge, Jiabei Jin, Gun Chen, Jinyun Li, Meng Ye, Xiaofeng Jin
    Cell Commun Signal. 2023; 21: 303. Published online 2023 Oct 30. doi: 10.1186/s12964-023-01342-7
    PMCID:
    PMC10614411
    AbstractArticlePDF–6.8M
    7.
    SPOP targets the immune transcription factor IRF1 for proteasomal degradation
    Irene Schwartz, Milica Vunjak, Valentina Budroni, Adriana Cantoran García, Marialaura Mastrovito, Adrian Soderholm, Matthias Hinterndorfer, Melanie de Almeida, Kathrin Hacker, Jingkui Wang, Kimon Froussios, Julian Jude, Thomas Decker, Johannes Zuber, Gijs A Versteeg
    eLife. 2023; 12: e89951. Published online 2023 Aug 25. doi: 10.7554/eLife.89951
    PMCID:
    PMC10491434
    AbstractArticlePDF–4.3M
    8.
    Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners
    Awa Diop, Paola Pietrangeli, Caterina Nardella, Valeria Pennacchietti, Livia Pagano, Angelo Toto, Mariana Di Felice, Sara Di Matteo, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni
    Int J Mol Sci. 2023 Jun; 24(12): 10138. Published online 2023 Jun 14. doi: 10.3390/ijms241210138
    PMCID:
    PMC10298926
    AbstractArticlePDF–1.1M
    9.
    TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks
    Jian Ma, Yingke Zhou, Penglin Pan, Haixin Yu, Zixi Wang, Lei Lily Li, Bing Wang, Yuqian Yan, Yunqian Pan, Qi Ye, Tianjie Liu, Xiaoyu Feng, Shan Xu, Ke Wang, Xinyang Wang, Yanlin Jian, Bohan Ma, Yizeng Fan, Yang Gao, Haojie Huang, Lei Li
    Nat Commun. 2023; 14: 1810. Published online 2023 Mar 31. doi: 10.1038/s41467-023-37499-5
    PMCID:
    PMC10066190
    AbstractArticlePDF–5.6M
    10.
    Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations
    F Emil Thomasen, Matthew J Cuneo, Tanja Mittag, Kresten Lindorff-Larsen
    eLife. 2023; 12: e84147. Published online 2023 Mar 1. doi: 10.7554/eLife.84147
    PMCID:
    PMC9998093
    AbstractArticlePDF–6.1M
    11.
    SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1–PD-L1 axis
    Kun Gao, Qing Shi, Ye Gu, Wanqi Yang, Yuanlong He, Zeheng Lv, Yan Ding, Wenxin Cao, Chenji Wang, Xiaoping Wan
    Cell Death Differ. 2023 Feb; 30(2): 475–487. Published online 2022 Dec 8. doi: 10.1038/s41418-022-01097-7
    PMCID:
    PMC9950446
    AbstractArticlePDF–4.9M
    12.
    SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF
    Kai Feng, Qing Shi, Dongyue Jiao, Yingji Chen, Wanqi Yang, Ke Su, Yalan Wang, Yan Huang, Pingzhao Zhang, Yao Li, Chenji Wang
    Cell Biosci. 2022; 12: 211. Published online 2022 Dec 30. doi: 10.1186/s13578-022-00950-z
    PMCID:
    PMC9805134
    AbstractArticlePDF–9.4M
    13.
    Speckle-type POZ protein could play a potential inhibitory role in human renal cell carcinoma
    Zhi Chen, Zuan Li, Chunlin Li, Bingcai Li, Haojian Wang, Deyong Nong, Ximing Li, Guihai Huang, Junhao Lin, Wei Li
    BMC Cancer. 2022; 22: 1277. Published online 2022 Dec 7. doi: 10.1186/s12885-022-10340-w
    PMCID:
    PMC9727862
    AbstractArticlePDF–2.9M
    14.
    SPOP in Cancer: Phenomena, Mechanisms and Its Role in Therapeutic Implications
    Xiaojuan Yang, Qing Zhu
    Genes (Basel) 2022 Nov; 13(11): 2051. Published online 2022 Nov 7. doi: 10.3390/genes13112051
    PMCID:
    PMC9690554
    AbstractArticlePDF–2.3M
    15.
    CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein
    Min Dong, Min Qian, Zhengyi Ruan
    J Immunother Cancer. 2022; 10(10): e005270. Published online 2022 Oct 5. doi: 10.1136/jitc-2022-005270
    Correction in:
    J Immunother Cancer. 2023; 11(12): e005270corr1.
    PMCID:
    PMC9535172
    AbstractArticlePDF–10M
    16.
    The speckle-type POZ protein (SPOP) inhibits breast cancer malignancy by destabilizing TWIST1
    Chunli Wei, Yun Liu, Xiaoyan Liu, Jingliang Cheng, Jiewen Fu, Xiuli Xiao, Robb E. Moses, Xiaotao Li, Junjiang Fu
    Cell Death Discov. 2022; 8: 389. Published online 2022 Sep 17. doi: 10.1038/s41420-022-01182-3
    PMCID:
    PMC9482615
    AbstractArticlePDF–3.0M
    17.
    Enhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer
    Kun Gao, Qing Shi, Yajuan Liu, Chenji Wang
    Autophagy. 2022; 18(8): 2013–2015. Published online 2022 Apr 19. doi: 10.1080/15548627.2022.2062873
    PMCID:
    PMC9450965
    AbstractArticlePDF–353K
    18.
    SPOP promotes cervical cancer progression by inducing the movement of PD-1 away from PD-L1 in spatial localization
    Jiangchun Wu, Yong Wu, Qinhao Guo, Siyu chen, Simin Wang, Xiaohua Wu, Jun Zhu, Xingzhu Ju
    J Transl Med. 2022; 20: 384. Published online 2022 Aug 30. doi: 10.1186/s12967-022-03574-6
    PMCID:
    PMC9429754
    AbstractArticlePDF–3.6M
    19.
    ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression
    Yizeng Fan, Tao Hou, Weichao Dan, Yasheng Zhu, Bo Liu, Yi Wei, Zixi Wang, Yang Gao, Jin Zeng, Lei Li
    Cell Death Differ. 2022 Aug; 29(8): 1611–1624. Published online 2022 Feb 22. doi: 10.1038/s41418-022-00951-y
    PMCID:
    PMC9345960
    AbstractArticlePDF–5.6M
    20.
    GLI3 is stabilized by SPOP mutations and promotes castration resistance via functional cooperation with androgen receptor in prostate cancer
    Marieke Burleson, Janice J. Deng, Tai Qin, Thu Minh Duong, Yuqian Yan, Xiang Gu, Debodipta Das, Acarizia Easley, Michael A. Liss, P. Renee Yew, Roble Bedolla, Addanki Pratap Kumar, Tim Hui-Ming Huang, Yi Zou, Yidong Chen, Chun-Liang Chen, Haojie Huang, Lu-Zhe Sun, Thomas G. Boyer
    Mol Cancer Res. Author manuscript; available in PMC 2022 Jul 6.
    Published in final edited form as: Mol Cancer Res. 2022 Jan; 20(1): 62–76. Published online 2021 Oct 5. doi: 10.1158/1541-7786.MCR-21-0108
    PMCID:
    PMC9258906
    AbstractArticlePDF–3.2M

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