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Select item 111930601.

Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of mitochondrial integrity and Parkin-mediated mitophagy

Yingmei Zhang, Rongjun Zou, Miyesaier Abudureyimu, Qiong Liu, Jipeng Ma, Haixia Xu, Wei Yu, Jian Yang, Jianguo Jia, Sanli Qian, Haichang Wang, Yang Yang, Xin Wang, Xiaoping Fan, Jun Ren

J Mol Cell Biol. 2023 Sep; 15(9): mjad056. Published online 2023 Sep 28. doi: 10.1093/jmcb/mjad056

Correction in:: J Mol Cell Biol. 2024 Sep 4

PMCID:: PMC11193060

Abstract Article PDF–5.7M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108885873.

Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection

Lung-An Hsu, Yung-Hsin Yeh, Chi-Jen Chang, Wei-Jan Chen, Hsin-Yi Tsai, Gwo-Jyh Chang

Int J Mol Sci. 2024 Feb; 25(4): 2186. Published online 2024 Feb 11. doi: 10.3390/ijms25042186

PMCID:: PMC10888587

Abstract Article PDF–1.8M

Select item 107317784.

ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING pathway

Haoran Liu, Qin Hu, Ke Ren, Pengxin Wu, Yang Wang, Chuanzhu Lv

Mol Med. 2023; 29: 171. Published online 2023 Dec 20. doi: 10.1186/s10020-023-00769-5

PMCID:: PMC10731778

Abstract Article PDF–13M

Select item 107119175.

Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis

Yuru Chen, Jiazheng Sun, Jiazhou Liu, Yuxian Wei, Xiaoyu Wang, Huiying Fang, Huimin Du, Jing Huang, Qin Li, Guosheng Ren, Xiaoyi Wang, Hongzhong Li

J Immunother Cancer. 2023; 11(12): e007487. Published online 2023 Dec 8. doi: 10.1136/jitc-2023-007487

PMCID:: PMC10711917

Abstract Article PDF–3.7M

Select item 105200616.

A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators

Yi-Cheng Chang, Hsiao-Lin Lee, Wenjin Yang, Meng-Lun Hsieh, Cai-Cin Liu, Tung-Yuan Lee, Jing-Yong Huang, Jiun-Yi Nong, Fu-An Li, Hsiao-Li Chuang, Zhi-Zhong Ding, Wei-Lun Su, Li-Yun Chueh, Yi-Ting Tsai, Che-Hong Chen, Daria Mochly-Rosen, Lee-Ming Chuang

Nat Commun. 2023; 14: 5971. Published online 2023 Sep 25. doi: 10.1038/s41467-023-41570-6

PMCID:: PMC10520061

Abstract Article PDF–13M

Select item 105055757.

乙醛脱氢酶2改善急性肺损伤小鼠的肺内皮屏障及维持线粒体动力学平衡

王丽娅, 田美惠, 李蓉, 吴越, 王莎莎, 吕恒, 刘忠义, 于影

Nan Fang Yi Ke Da Xue Xue Bao. 2023 Aug 20; 43(8): 1388–1395. Chinese. doi: 10.12122/j.issn.1673-4254.2023.08.16

PMCID:: PMC10505575

Abstract Article PDF–2.7M

Select item 102977968.

SGLT2i ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant

Hongchao Guo, Xuan Yu, Yu Liu, David T Paik, Johanne Marie Justesen, Mark Chandy, James W Jahng, Tiejun Zhang, Weijun Wu, Freeborn Rwere, Shane Rui Zhao, Suman Pokhrel, Rabindra Shivnaraine, Souhrid Mukherjee, Daniel J Simon, Amit Manhas, Angela Zhang, Che-Hong Chen, Manuel A Rivas, Eric R Gross, Daria Mochly-Rosen, Joseph C Wu

Sci Transl Med. Author manuscript; available in PMC 2023 Jun 27.

Published in final edited form as: Sci Transl Med. 2023 Jan 25; 15(680): eabp9952. Published online 2023 Jan 25. doi: 10.1126/scitranslmed.abp9952

PMCID:: PMC10297796

Abstract Article PDF–2.7M

Select item 102444069.

A Common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice

An-Sheng Lee, Yen-Ling Sung, Szu-Hua Pan, Kuo-Tzu Sung, Cheng-Huang Su, Shiao-Li Ding, Ying-Jui Lu, Chin-Ling Hsieh, Yun-Fang Chen, Chuan-Chuan Liu, Wei-Yu Chen, Xuan-Ren Chen, Fa-Po Chung, Shih-Wei Wang, Che-Hong Chen, Daria Mochly-Rosen, Chung-Lieh Hung, Hung-I Yeh, Shien-Fong Lin

Commun Biol. 2023; 6: 610. Published online 2023 Jun 6. doi: 10.1038/s42003-023-04985-x

PMCID:: PMC10244406

Abstract Article PDF–8.0M

Select item 1010698710.

p53 protects against alcoholic fatty liver disease via ALDH2 inhibition

Pengbo Yao, Zhenxi Zhang, Hongchao Liu, Peng Jiang, Wei Li, Wenjing Du

EMBO J. 2023 Apr; 42(8): e112304. Published online 2023 Feb 24. doi: 10.15252/embj.2022112304

PMCID:: PMC10106987

Abstract Article PDF–16M

Select item 1010175011.

Aldehyde Dehydrogenase 2 Ameliorates LPS-Induced Acute Kidney Injury through Detoxification of 4-HNE and Suppression of the MAPK Pathway

Jifu Jin, Rebecca Suchi Chang, Sujuan Xu, Guang Xia, Jennifer Ming Jen Wong, Yi Fang, Ping Jia, Xiaoqiang Ding

J Immunol Res. 2023; 2023: 5513507. Published online 2023 Apr 6. doi: 10.1155/2023/5513507

PMCID:: PMC10101750

Abstract Article PDF–3.7M

Select item 1004078812.

ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock

Ying Zhang, Ying Lv, Qingju Zhang, Xingfang Wang, Qi Han, Yan Liang, Simeng He, Qiuhuan Yuan, Jiaqi Zheng, Changchang Xu, Xiangxin Zhang, Zichen Wang, Huaxiang Yu, Li Xue, Jiali Wang, Feng Xu, Jiaojiao Pang, Yuguo Chen

Front Pharmacol. 2023; 14: 1125866. Published online 2023 Mar 13. doi: 10.3389/fphar.2023.1125866

PMCID:: PMC10040788

Abstract Article PDF–5.5M

Select item 997426113.

Aldehyde Dehydrogenase 2 Protects the Kidney from Ischemia–Reperfusion Injury by Suppressing the IκBα/NF-κB/IL-17C Pathway

Yiwen Chen, Yan Xiong, Jun Luo, Qianchao Hu, Jianan Lan, Yongkang Zou, Qin Ma, Hanlin Yao, Zhongzhong Liu, Zibiao Zhong, Qifa Ye

Oxid Med Cell Longev. 2023; 2023: 2264030. Published online 2023 Feb 21. doi: 10.1155/2023/2264030

PMCID:: PMC9974261

Abstract Article PDF–4.8M

Select item 992494514.

Chronic alcohol metabolism results in DNA repair infidelity and cell cycle‐induced senescence in neurons

Jacquelyne Ka‐Li Sun, Deng Wu, Genper Chi‐Ngai Wong, Tsun‐Ming Lau, Meigui Yang, Ronald P. Hart, Kin‐Ming Kwan, Ho Yin Edwin Chan, Hei‐Man Chow

Aging Cell. 2023 Feb; 22(2): e13772. Published online 2023 Jan 23. doi: 10.1111/acel.13772

PMCID:: PMC9924945

Abstract Article PDF–69M

Select item 987841215.

ALDH2通过线粒体融合与裂变减轻脂多糖诱导的脑微血管内皮细胞屏障的损伤

王莎莎, 吕恒, 王丽娅, 田美惠, 高洁, 刘忠义, 王佳慧, 于影

Nan Fang Yi Ke Da Xue Xue Bao. 2022 Dec 20; 42(12): 1882–1888. Chinese. doi: 10.12122/j.issn.1673-4254.2022.12.18

PMCID:: PMC9878412

Abstract Article PDF–1.3M

Select item 986004216.

Aldehyde dehydrogenase 2 alleviates mitochondrial dysfunction by promoting PGC-1α-mediated biogenesis in acute kidney injury

Jiaying Li, Xiaoxiao Shi, Zhixin Chen, Jiatong Xu, Ruohuan Zhao, Yuhao Liu, Yubing Wen, Limeng Chen

Cell Death Dis. 2023 Jan; 14(1): 45. Published online 2023 Jan 20. doi: 10.1038/s41419-023-05557-x

PMCID:: PMC9860042

Abstract Article PDF–6.9M

Select item 979290917.

ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis

Wiramon Rungratanawanich, Yuhong Lin, Xin Wang, Toshihiro Kawamoto, Saravana Babu Chidambaram, Byoung-Joon Song

Redox Biol. 2023 Feb; 59: 102577. Published online 2022 Dec 13. doi: 10.1016/j.redox.2022.102577

PMCID:: PMC9792909

Abstract Article PDF–13M

Select item 956351218.

ALDH₂ knockout protects against aortic dissection

Chentao Luo, Bing Zhou, Yong Cui, Zhifang Liu, Shuwei Wang

BMC Cardiovasc Disord. 2022; 22: 443. Published online 2022 Oct 13. doi: 10.1186/s12872-022-02874-5

PMCID:: PMC9563512

Abstract Article PDF–1.5M

Select item 948193319.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 932175020.

Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice

Qinfeng Hu, Hang Chen, Cheng Shen, Beijian Zhang, Xinyu Weng, Xiaolei Sun, Jin Liu, Zhen Dong, Kai Hu, Junbo Ge, Aijun Sun

Alcohol Clin Exp Res. 2022 May; 46(5): 707–723. Published online 2022 Apr 20. doi: 10.1111/acer.14811

PMCID:: PMC9321750

Abstract Article PDF–41M

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