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Items: 1 to 20 of 317

1.
Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch
Kristjan H. Gretarsson, Stephen Abini-Agbomson, Susan L. Gloor, Daniel N. Weinberg, Jamie L. McCuiston, Vishnu Udayakumar Sunitha Kumary, Allison R. Hickman, Varun Sahu, Rachel Lee, Xinjing Xu, Natalie Lipieta, Samuel Flashner, Oluwatobi A. Adeleke, Irina K. Popova, Hailey F. Taylor, Kelsey Noll, Carolina Lin Windham, Danielle N. Maryanski, Bryan J. Venters, Hiroshi Nakagawa, Michael-Christopher Keogh, Karim-Jean Armache, Chao Lu
Sci Adv. 2024 Aug 30; 10(35): eadp0975. Published online 2024 Aug 28. doi: 10.1126/sciadv.adp0975
PMCID:
PMC11352909
AbstractArticlePDF–5.2M
2.
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss
Hui Wang, Kimon Divaris, Bohu Pan, Xiaofei Li, Jong-Hyung Lim, Gundappa Saha, Marko Barovic, Danai Giannakou, Jonathan M. Korostoff, Yu Bing, Souvik Sen, Kevin Moss, Di Wu, James D. Beck, Christie M. Ballantyne, Pradeep Natarajan, Kari E. North, Mihai G. Netea, Triantafyllos Chavakis, George Hajishengallis
Cell. Author manuscript; available in PMC 2024 Jul 14.
Published in final edited form as: Cell. 2024 Jul 11; 187(14): 3690–3711.e19. Published online 2024 Jun 4. doi: 10.1016/j.cell.2024.05.003
PMCID:
PMC11246233
AbstractArticlePDF–3.0M
3.
Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2-V617F–positive myeloproliferative neoplasms
Marc Usart, Jan Stetka, Damien Luque Paz, Nils Hansen, Quentin Kimmerlin, Tiago Almeida Fonseca, Melissa Lock, Lucia Kubovcakova, Riikka Karjalainen, Hui Hao-Shen, Anastasiya Börsch, Athimed El Taher, Jessica Schulz, Jean-Christophe Leroux, Stefan Dirnhofer, Radek C. Skoda
Blood. 2024 Jun 13; 143(24): 2490–2503. Published online 2024 Mar 18. doi: 10.1182/blood.2023020270
PMCID:
PMC11208296
AbstractArticle
4.
Aortic disease and cardiomyopathy in patients with a novel DNMT3A gene variant causing Tatton-Brown–Rahman syndrome
Dovile Zebrauskiene, Egle Sadauskiene, Justas Dapkunas, Visvaldas Kairys, Joris Balciunas, Aleksandras Konovalovas, Ruta Masiuliene, Gunda Petraityte, Nomeda Valeviciene, Mindaugas Mataciunas, Jurate Barysiene, Violeta Mikstiene, Migle Tomkuviene, Egle Preiksaitiene
Clin Epigenetics. 2024; 16: 76. Published online 2024 Jun 6. doi: 10.1186/s13148-024-01686-y
PMCID:
PMC11157947
AbstractArticlePDF–5.2M
5.
Effect of DNMT3A R882H Hot Spot Mutations on DDX43 Promoter Methylation in Acute Myeloid Leukemia
Tahere Tabatabaei, Mohammad Reza Rezvany, Bahare Ghasemi, Farzane Vafaei, Masoumeh Kiani Zadeh, Farhad Zaker, Arash Salmaninejad
Biomed Res Int. 2024; 2024: 9625043. Published online 2024 May 21. doi: 10.1155/2024/9625043
PMCID:
PMC11132831
AbstractArticlePDF–909K
6.
DNMT3A Cooperates with YAP/TAZ to Drive Gallbladder Cancer Metastasis
Sunwang Xu, Zhiqing Yuan, Cen Jiang, Wei Chen, Qiwei Li, Tao Chen
Adv Sci (Weinh) 2024 Apr; 11(16): 2308531. Published online 2024 Feb 21. doi: 10.1002/advs.202308531
PMCID:
PMC11040361
AbstractArticlePDF–7.0M
7.
Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations
Jiuwei Lu, Yiran Guo, Jiekai Yin, Jianbin Chen, Yinsheng Wang, Gang Greg Wang, Jikui Song
Nat Commun. 2024; 15: 3111. Published online 2024 Apr 10. doi: 10.1038/s41467-024-47398-y
PMCID:
PMC11006857
AbstractArticlePDF–4.2M
8.
DNMT3A rs1550117 Polymorphism is Associated With Late-Onset Alzheimer’s Disease in a Chinese Population
Chen Ling, Dai Fangyu, Hu Wanhua, Chen Kelong, Wu zhimin, Zhang yuting, Zhou rong
Am J Alzheimers Dis Other Demen. 2016 May; 31(3): 278–281. Published online 2015 Sep 14. doi: 10.1177/1533317515603688
PMCID:
PMC10852886
AbstractArticlePDF–116K
9.
DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts
Mariana Shumliakivska, Guillermo Luxán, Inga Hemmerling, Marina Scheller, Xue Li, Carsten Müller-Tidow, Bianca Schuhmacher, Zhengwu Sun, Andreas Dendorfer, Alisa Debes, Simone-Franziska Glaser, Marion Muhly-Reinholz, Klara Kirschbaum, Jedrzej Hoffmann, Eike Nagel, Valentina O. Puntmann, Sebastian Cremer, Florian Leuschner, Wesley Tyler Abplanalp, David John, Andreas M. Zeiher, Stefanie Dimmeler
Nat Commun. 2024; 15: 606. Published online 2024 Jan 19. doi: 10.1038/s41467-023-43003-w
PMCID:
PMC10799021
AbstractArticlePDF–6.0M
10.
miR-4270 suppresses hepatocellular carcinoma progression by inhibiting DNMT3A-mediated methylation of HGFAC promoter
Qiang Zou, Shasha Cao
PeerJ. 2023; 11: e16566. Published online 2023 Dec 5. doi: 10.7717/peerj.16566
PMCID:
PMC10704985
AbstractArticlePDF–15M
11.
Methylation signatures in clinically variable syndromic disorders: a familial DNMT3A variant in two adults with Tatton-Brown–Rahman syndrome
Candy Kumps, Erika D’haenens, Jennifer Kerkhof, Haley McConkey, Marielle Alders, Bekim Sadikovic, Olivier M. Vanakker
Eur J Hum Genet. 2023 Dec; 31(12): 1350–1354. Published online 2023 Sep 22. doi: 10.1038/s41431-023-01459-w
PMCID:
PMC10689817
ArticlePDF–1017K
12.
An updated meta-analysis investigating the association between DNMTs gene polymorphism andgastric cancer risk
Yu-Long Zhang, Yu-Wei Wang, Ming-Jie He, Jian-Lan Chang
PLoS One. 2023; 18(10): e0293466. Published online 2023 Oct 25. doi: 10.1371/journal.pone.0293466
PMCID:
PMC10599511
AbstractArticlePDF–1.3M
13.
Identification of Cell Type-Specific Effects of DNMT3A Mutations on Relapse in Acute Myeloid Leukemia
Seo-Gyeong Bae, Hyeoung-Joon Kim, Mi Yeon Kim, Dennis Dong Hwan Kim, So-I Shin, Jae-Sook Ahn, Jihwan Park
Mol Cells. 2023 Oct 31; 46(10): 611–626. Published online 2023 Sep 27. doi: 10.14348/molcells.2023.0093
PMCID:
PMC10590706
AbstractArticlePDF–8.5M
14.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
15.
Familial Clonal Hematopoiesis in a Long Telomere Syndrome
Emily A. DeBoy, Michael G. Tassia, Kristen E. Schratz, Stephanie M. Yan, Zoe L. Cosner, Emily J. McNally, Dustin L. Gable, Zhimin Xiang, David B. Lombard, Emmanuel S. Antonarakis, Christopher D. Gocke, Rajiv C. McCoy, Mary Armanios
N Engl J Med. Author manuscript; available in PMC 2023 Dec 29.
Published in final edited form as: N Engl J Med. 2023 Jun 29; 388(26): 2422–2433. Published online 2023 May 4. doi: 10.1056/NEJMoa2300503
PMCID:
PMC10501156
AbstractArticlePDF–1.9M
16.
DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming
Xuejiao Yang, Xiao Wang, Ying Yang, Zhiyang Li, Yunshuo Chen, Siqi Shang, Yueying Wang
J Transl Med. 2023; 21: 481. Published online 2023 Jul 18. doi: 10.1186/s12967-023-04323-z
PMCID:
PMC10355022
AbstractArticlePDF–8.2M
17.
DNMT3A-coordinated splicing governs the stem state switch toward differentiation in embryonic and hematopoietic stem cells
Raghav Ramabadran, Jarey H. Wang, Jaime M. Reyes, Anna G. Guzman, Sinjini Gupta, Carina Rosas, Lorenzo Brunetti, Michael C. Gundry, Ayala Tovy, Hali Long, Tianpeng Gu, Sean M. Cullen, Siddhartha Tyagi, Danielle Rux, Jean J. Kim, Steven M. Kornblau, Michael Kyba, Fabio Stossi, Rachel E. Rau, Koichi Takahashi, Thomas F. Westbrook, Margaret A. Goodell
Nat Cell Biol. Author manuscript; available in PMC 2023 Oct 6.
Published in final edited form as: Nat Cell Biol. 2023 Apr; 25(4): 528–539. Published online 2023 Apr 6. doi: 10.1038/s41556-023-01109-9
PMCID:
PMC10337578
AbstractArticlePDF–3.7M
18.
Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway
Lakshmi Reddy Palam, Baskar Ramdas, Katelyn Pickerell, Santhosh Kumar Pasupuleti, Rahul Kanumuri, Annamaria Cesarano, Megan Szymanski, Bryce Selman, Utpal P. Dave, George Sandusky, Fabiana Perna, Sophie Paczesny, Reuben Kapur
JCI Insight. 2023 May 8; 8(9): e163864. Published online 2023 May 8. doi: 10.1172/jci.insight.163864
PMCID:
PMC10243813
AbstractArticlePDF–22M
19.
The impact of DNMT3A variant allele frequency and two different comutations on patients with de novo cytogenetically normal acute myeloid leukemia
Xian Chen, Chuchu Tian, Zhuanghui Hao, Lingang Pan, Minglin Hong, Wei Wei, Daniel Muteb Muyey, Hongwei Wang, Xiuhua Chen
Cancer Med. 2023 May; 12(9): 10340–10350. Published online 2023 Mar 13. doi: 10.1002/cam4.5764
PMCID:
PMC10225240
AbstractArticlePDF–3.1M
20.
MiR-532-3p inhibited the methylation of SOCS2 to suppress the progression of PC by targeting DNMT3A
Kaiqiong Wang, Dongwei Gong, Xin Qiao, Jinfang Zheng
Life Sci Alliance. 2023 May; 6(5): e202201703. Published online 2023 Apr 21. doi: 10.26508/lsa.202201703
PMCID:
PMC10128082
AbstractArticlePDF–4.9M

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