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Select item 88809191.

TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes

Adiel Cohen, Emese Pataki, Martin Kupiec, Ronit Weisman

PLoS Genet. 2022 Feb; 18(2): e1010061. Published online 2022 Feb 14. doi: 10.1371/journal.pgen.1010061

PMCID:: PMC8880919

Abstract Article PDF–2.1M

Select item 76609252.

TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8^AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast

Emese Pataki, Luba Simhaev, Hamutal Engel, Adiel Cohen, Martin Kupiec, Ronit Weisman

PLoS Genet. 2020 Nov; 16(11): e1009196. Published online 2020 Nov 2. doi: 10.1371/journal.pgen.1009196

PMCID:: PMC7660925

Abstract Article PDF–3.4M

Select item 68029643.

TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium

Karen Baker, Irene A Gyamfi, Gregory I Mashanov, Justin E Molloy, Michael A Geeves, Daniel P Mulvihill

eLife. 2019; 8: e51150. Published online 2019 Sep 30. doi: 10.7554/eLife.51150

PMCID:: PMC6802964

Abstract Article PDF–2.6M

Select item 57097624.

TORC1 and TORC2 converge to regulate the SAGA co‐activator in response to nutrient availability

Thomas Laboucarié, Dylane Detilleux, Ricard A Rodriguez‐Mias, Céline Faux, Yves Romeo, Mirita Franz‐Wachtel, Karsten Krug, Boris Maček, Judit Villén, Janni Petersen, Dominique Helmlinger

EMBO Rep. 2017 Dec; 18(12): 2197–2218. Published online 2017 Oct 27. doi: 10.15252/embr.201744942

PMCID:: PMC5709762

Abstract Article PDF–1.4M

Select item 53546055.

A central role for TOR signalling in a yeast model for juvenile CLN3 disease

Michael E. Bond, Rachel Brown, Charalampos Rallis, Jürg Bähler, Sara E. Mole

Microb Cell. 2015 Dec 7; 2(12): 466–480. Published online 2015 Nov 11. doi: 10.15698/mic2015.12.241

PMCID:: PMC5354605

Abstract Article PDF–2.1M

Select item 53405276.

Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

Hisashi Tatebe, Shinichi Murayama, Toshiya Yonekura, Tomoyuki Hatano, David Richter, Tomomi Furuya, Saori Kataoka, Kyoko Furuita, Chojiro Kojima, Kazuhiro Shiozaki

eLife. 2017; 6: e19594. Published online 2017 Mar 7. doi: 10.7554/eLife.19594

PMCID:: PMC5340527

Abstract Article PDF–1.8M

Select item 52667907.

A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast

Ruth Martín, Marina Portantier, Nathalia Chica, Mari Nyquist-Andersen, Juan Mata, Sandra Lopez-Aviles

Curr Biol. 2017 Jan 23; 27(2): 175–188. doi: 10.1016/j.cub.2016.11.037

PMCID:: PMC5266790

Abstract Article

Select item 51203298.

Multiple crosstalk between TOR and the cell integrity MAPK signaling pathway in fission yeast

Marisa Madrid, Beatriz Vázquez-Marín, Alejandro Franco, Teresa Soto, Jero Vicente-Soler, Mariano Gacto, José Cansado

Sci Rep. 2016; 6: 37515. Published online 2016 Nov 23. doi: 10.1038/srep37515

PMCID:: PMC5120329

Abstract Article PDF–5.7M

Select item 49583059.

TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis

Karen Baker, Sara Kirkham, Lenka Halova, Jane Atkin, Mirita Franz-Wachtel, David Cobley, Karsten Krug, Boris Maček, Daniel P. Mulvihill, Janni Petersen

J Cell Sci. 2016 Jul 1; 129(13): 2613–2624. doi: 10.1242/jcs.190124

PMCID:: PMC4958305

Abstract Article

Select item 486149910.

Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress

Adiel Cohen, Martin Kupiec, Ronit Weisman

J Biol Chem. 2016 Apr 22; 291(17): 9371–9381. Published online 2016 Feb 24. doi: 10.1074/jbc.M115.705251

PMCID:: PMC4861499

Abstract Article PDF–1.4M

Select item 482123611.

Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2

Wei Du, Gabriella M. Forte, Duncan Smith, Janni Petersen

Open Biol. 2016 Mar; 6(3): 150189. Published online 2016 Mar 2. doi: 10.1098/rsob.150189

PMCID:: PMC4821236

Abstract Article PDF–1.0M

Select item 461245012.

Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose

Tomoyuki Hatano, Susumu Morigasaki, Hisashi Tatebe, Kyoko Ikeda, Kazuhiro Shiozaki

Cell Cycle. 2015 Mar 15; 14(6): 848–856. Published online 2015 Jan 15. doi: 10.1080/15384101.2014.1000215

PMCID:: PMC4612450

Abstract Article PDF–516K

Select item 411813113.

Glucose Activates TORC2-Gad8 Protein via Positive Regulation of the cAMP/cAMP-dependent Protein Kinase A (PKA) Pathway and Negative Regulation of the Pmk1 Protein-Mitogen-activated Protein Kinase Pathway

Adiel Cohen, Martin Kupiec, Ronit Weisman

J Biol Chem. 2014 Aug 1; 289(31): 21727–21737. Published online 2014 Jun 13. doi: 10.1074/jbc.M114.573824

PMCID:: PMC4118131

Abstract Article PDF–1.1M

Select item 402381814.

Isp7 Is a Novel Regulator of Amino Acid Uptake in the TOR Signaling Pathway

Dana Laor, Adiel Cohen, Metsada Pasmanik-Chor, Varda Oron-Karni, Martin Kupiec, Ronit Weisman

Mol Cell Biol. 2014 Mar; 34(5): 794–806. doi: 10.1128/MCB.01473-13

Correction in:: Mol Cell Biol. 2014 Apr; 34(8): 1535.

PMCID:: PMC4023818

Abstract Article PDF–1.8M

Select item 384092815.

Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition

Lenka Hálová, Wei Du, Sara Kirkham, Duncan L. Smith, Janni Petersen

J Cell Biol. 2013 Nov 25; 203(4): 595–604. doi: 10.1083/jcb.201305103

PMCID:: PMC3840928

Abstract Article PDF–2.6M

Select item 377824216.

Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries

Jiyong Wang, Xavier Tadeo, Haitong Hou, Patricia G. Tu, James Thompson, John R. Yates, III, Songtao Jia

Genes Dev. 2013 Sep 1; 27(17): 1886–1902. doi: 10.1101/gad.221010.113

PMCID:: PMC3778242

Abstract Article PDF–1.8M

Select item 370767117.

TORC2 Is Required to Maintain Genome Stability during S Phase in Fission Yeast

Miriam Schonbrun, Masha Kolesnikov, Martin Kupiec, Ronit Weisman

J Biol Chem. 2013 Jul 5; 288(27): 19649–19660. Published online 2013 May 23. doi: 10.1074/jbc.M113.464974

PMCID:: PMC3707671

Abstract Article PDF–2.0M

Select item 350723118.

TORC2 and the AGC kinase Gad8 regulate phosphorylation of the ribosomal protein S6 in fission yeast

Wei Du, Lenka Hálová, Sara Kirkham, Jane Atkin, Janni Petersen

Biol Open. 2012 Sep 15; 1(9): 884–888. Published online 2012 Jul 17. doi: 10.1242/bio.20122022

PMCID:: PMC3507231

Abstract Article PDF–475K

Select item 338063619.

Hierarchical modularity and the evolution of genetic interactomes across species

Colm J. Ryan, Assen Roguev, Kristin Patrick, Jiewei Xu, Harlizawati Jahari, Zongtian Tong, Pedro Beltrao, Michael Shales, Hong Qu, Sean R. Collins, Joseph I. Kliegman, Lingli Jiang, Dwight Kuo, Elena Tosti, Hyun-Soo Kim, Winfried Edelmann, Michael-Christopher Keogh, Derek Greene, Chao Tang, Pádraig Cunningham, Kevan M. Shokat, Gerard Cagney, J. Peter Svensson, Christine Guthrie, Peter J. Espenshade, Trey Ideker, Nevan J. Krogan

Mol Cell. Author manuscript; available in PMC 2013 Jun 8.

Published in final edited form as: Mol Cell. 2012 Jun 8; 46(5): 691–704. doi: 10.1016/j.molcel.2012.05.028

PMCID:: PMC3380636

Abstract Article PDF–2.1M

Select item 300832320.

Rab-family GTPase regulates TOR complex 2 signaling in fission yeast

Hisashi Tatebe, Susumu Morigasaki, Shinichi Murayama, Cui Tracy Zeng, Kazuhiro Shiozaki

Curr Biol. Author manuscript; available in PMC 2011 Nov 23.

Published in final edited form as: Curr Biol. 2010 Nov 23; 20(22): 1975–1982. Published online 2010 Oct 28. doi: 10.1016/j.cub.2010.10.026

PMCID:: PMC3008323

Abstract Article PDF–1.5M

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