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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107581042.

Elevated SLC40A1 impairs cardiac function and exacerbates mitochondrial dysfunction, oxidative stress, and apoptosis in ischemic myocardia

Renqian Feng, Di Wang, Tiantian Li, Xulin Liu, Tingwei Peng, Mingchuan Liu, Gaotong Ren, Haowei Xu, Haixia Luo, Denghui Lu, Bingchao Qi, Mingming Zhang, Yan Li

Int J Biol Sci. 2024; 20(2): 414–432. Published online 2024 Jan 1. doi: 10.7150/ijbs.89368

PMCID:: PMC10758104

Abstract Article PDF–13M

Select item 104618413.

Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation

Kazuyoshi Ohta, Masahiko Ito, Takeshi Chida, Kenji Nakashima, Satoshi Sakai, Yumi Kanegae, Hideya Kawasaki, Takuya Aoshima, Shuji Takabayashi, Hirotaka Takahashi, Kazuhito Kawata, Ikuo Shoji, Tatsuya Sawasaki, Takafumi Suda, Tetsuro Suzuki

PLoS Pathog. 2023 Aug; 19(8): e1011591. Published online 2023 Aug 16. doi: 10.1371/journal.ppat.1011591

PMCID:: PMC10461841

Abstract Article PDF–2.6M

Select item 99683544.

Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke

Huiwen Zheng, Xin Guo, Shaomeng Kang, Zhongda Li, Tian Tian, Jianhua Li, Fudi Wang, Peng Yu, Shiyang Chang, Yan-zhong Chang

Cell Death Dis. 2023 Feb; 14(2): 161. Published online 2023 Feb 25. doi: 10.1038/s41419-023-05688-1

PMCID:: PMC9968354

Abstract Article PDF–6.0M

Select item 97683565.

Macrophage ferroportin serves as a therapeutic target against bacteria-induced acute lung injury by promoting barrier restoration

Hanbin Wang, Congli Zeng, Gan Luo, Yaqi Sun, Jue Zhang, Zhipeng Xu, Yuqian Guo, Hui Ye, Jiali Mao, Shiyu Chen, Yan Zhang, Kai Zhang, Marcos F. Vidal Melo, Xiangming Fang

iScience. 2022 Dec 22; 25(12): 105698. Published online 2022 Dec 1. doi: 10.1016/j.isci.2022.105698

PMCID:: PMC9768356

Abstract Article PDF–6.8M

Select item 94626686.

In iron-deficient mouse pregnancies, erythroferrone contributes to iron mobilization for embryo erythropoiesis

Veena Sangkhae, Vivian Yu, Richard Coffey, Kimberly O. O’Brien, Tomas Ganz, Elizabeta Nemeth

Am J Hematol. Author manuscript; available in PMC 2023 Oct 1.

Published in final edited form as: Am J Hematol. 2022 Oct; 97(10): 1348–1358. Published online 2022 Aug 16. doi: 10.1002/ajh.26680

PMCID:: PMC9462668

Abstract Article PDF–1.9M

Select item 93434637.

Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells

Linhao You, Pan-Pan Yu, Tianyu Dong, Wenhuan Guo, Shiyang Chang, Bingjie Zheng, Yunzhe Ci, Fudi Wang, Peng Yu, Guofen Gao, Yan-Zhong Chang

Cell Death Dis. 2022 Aug; 13(8): 667. Published online 2022 Aug 1. doi: 10.1038/s41419-022-05043-w

PMCID:: PMC9343463

Abstract Article PDF–5.5M

Select item 90509128.

Minimal effect of conditional ferroportin KO in the neural retina implicates ferrous iron in retinal iron overload and degeneration

Yingrui Liu, Bailey Baumann, Ying Song, Kevin Zhang, Jacob K. Sterling, Samira Lakhal-Littleton, Zbynek Kozmik, Guanfang Su, Joshua L. Dunaief

Exp Eye Res. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Exp Eye Res. 2022 May; 218: 108988. Published online 2022 Feb 21. doi: 10.1016/j.exer.2022.108988

PMCID:: PMC9050912

Abstract Article PDF–808K

Select item 89406959.

Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin

Mark R. Hanudel, Brian Czaya, Shirley Wong, Maxime Rappaport, Shweta Namjoshi, Kristine Chua, Grace Jung, Victoria Gabayan, Bo Qiao, Elizabeta Nemeth, Tomas Ganz

Kidney Int. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Kidney Int. 2022 Apr; 101(4): 711–719. Published online 2021 Nov 25. doi: 10.1016/j.kint.2021.10.036

PMCID:: PMC8940695

Abstract Article PDF–819K

Select item 846179410.

Myeloid-specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice

Nathan C. Winn, Elysa M. Wolf, Matthew A. Cottam, Monica Bhanot, Alyssa H. Hasty

Am J Physiol Endocrinol Metab. 2021 Sep 1; 321(3): E376–E391. Published online 2021 Aug 2. doi: 10.1152/ajpendo.00116.2021

PMCID:: PMC8461794

Abstract Article

Select item 839490411.

RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation

Li Jiang, Jiaming Wang, Kai Wang, Hao Wang, Qian Wu, Cong Yang, Yingying Yu, Pu Ni, Yueyang Zhong, Zijun Song, Enjun Xie, Ronggui Hu, Junxia Min, Fudi Wang

Blood. 2021 Aug 26; 138(8): 689–705. Prepublished online 2021 Apr 25. doi: 10.1182/blood.2020008986

PMCID:: PMC8394904

Abstract Article

Select item 834918712.

Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk

De-Liang Zhang, Jian Wu, Binal N. Shah, Katja C. Greutélaers, Manik C. Ghosh, Hayden Ollivierre, Xin-zhuan Su, Philip E. Thuma, George Bedu-Addo, Frank P. Mockenhaupt, Victor R. Gordeuk, Tracey A. Rouault

Science. Author manuscript; available in PMC 2021 Aug 7.

Published in final edited form as: Science. 2018 Mar 30; 359(6383): 1520–1523. doi: 10.1126/science.aal2022

PMCID:: PMC8349187

Abstract Article PDF–1.0M

Select item 831323913.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 825156714.

Marginally reduced maternal hepatic and splenic ferroportin under severe nutritional iron deficiency in pregnancy maintains systemic iron supply

Rafał Mazgaj, Paweł Lipiński, Eunice Sindhuvi Edison, Aleksandra Bednarz, Robert Staroń, Olga Haberkiewicz, Małgorzata Lenartowicz, Ewa Smuda, Aneta Jończy, Rafał R. Starzyński

Am J Hematol. 2021 Jun 1; 96(6): 659–670. Published online 2021 Mar 26. doi: 10.1002/ajh.26152

PMCID:: PMC8251567

Abstract Article PDF–5.7M

Select item 823902215.

Decreased ferroportin in hepatocytes promotes macrophages polarize towards an M2-like phenotype and liver fibrosis

Chengyuan Cai, Danning Zeng, Qing Gao, Lei Ma, Bohang Zeng, Yi Zhou, He Wang

Sci Rep. 2021; 11: 13386. Published online 2021 Jun 28. doi: 10.1038/s41598-021-92839-z

PMCID:: PMC8239022

Abstract Article PDF–11M

Select item 816682816.

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

Wen-Dai Bao, Pei Pang, Xiao-Ting Zhou, Fan Hu, Wan Xiong, Kai Chen, Jing Wang, Fudi Wang, Dong Xie, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Wang-Xia Wang, Peter T. Nelson, Jian-Guo Chen, Youming Lu, Heng-Ye Man, Dan Liu, Ling-Qiang Zhu

Cell Death Differ. 2021 May; 28(5): 1548–1562. Published online 2021 Jan 4. doi: 10.1038/s41418-020-00685-9

Correction in:: Cell Death Differ. 2024 Aug; 31(8): 1099.

PMCID:: PMC8166828

Abstract Article PDF–4.5M

Select item 783863617.

Mild Attenuation of the Pulmonary Inflammatory Response in a Mouse Model of Hereditary Hemochromatosis Type 4

Oriana Marques, Joana Neves, Natalie K. Horvat, Sandro Altamura, Martina U. Muckenthaler

Front Physiol. 2020; 11: 589351. Published online 2021 Jan 13. doi: 10.3389/fphys.2020.589351

PMCID:: PMC7838636

Abstract Article PDF–2.4M

Select item 783375718.

Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin−ferroportin axis

Qifeng Deng, Sidi Yang, Lanqing Sun, Kedi Dong, Yuanyuan Li, Shuyan Wu, Rui Huang

Gut Microbes. 2021; 13(1): 1849996. Published online 2021 Jan 21. doi: 10.1080/19490976.2020.1849996

PMCID:: PMC7833757

Abstract Article PDF–4.1M

Select item 772457319.

Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing

Nicholas J. Bessman, Jacques R.R. Mathieu, Cyril Renassia, Lei Zhou, Thomas C. Fung, Keith C. Fernandez, Christine Austin, Jesper B. Moeller, Sara Zumerle, Sabine Louis, Sophie Vaulont, Nadim J. Ajami, Harry Sokol, Gregory G. Putzel, Tara Arvedson, Robbyn E. Sockolow, Samira Lakhal-Littleon, Suzanne M. Cloonan, Manish Arora, Carole Peyssonnaux, Gregory F. Sonnenberg

Science. Author manuscript; available in PMC 2021 Apr 10.

Published in final edited form as: Science. 2020 Apr 10; 368(6487): 186–189. doi: 10.1126/science.aau6481

PMCID:: PMC7724573

Abstract Article PDF–1.2M

Select item 751568720.

Fetal liver hepcidin secures iron stores in utero

Lara Kämmerer, Goran Mohammad, Magda Wolna, Peter A. Robbins, Samira Lakhal-Littleton

Blood. 2020 Sep 24; 136(13): 1549–1557. Prepublished online 2020 Jun 15. doi: 10.1182/blood.2019003907

PMCID:: PMC7515687

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