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Items: 1 to 20 of 32

1.
Knockout mice with pituitary malformations help identify human cases of hypopituitarism
Julian Martinez-Mayer, Michelle L. Brinkmeier, Sean P. O’Connell, Arnold Ukagwu, Marcelo A. Marti, Mirta Miras, Maria V. Forclaz, Maria G. Benzrihen, Leonard Y. M. Cheung, Sally A. Camper, Buffy S. Ellsworth, Lori T. Raetzman, Maria I. Pérez-Millán, Shannon W. Davis
Genome Med. 2024; 16: 75. Published online 2024 May 31. doi: 10.1186/s13073-024-01347-y
PMCID:
PMC11140907
AbstractArticlePDF–4.4M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response
Wenjuan Ma, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Ahad Khalilnezhad, Miho Kataoka, Yuichiro Arima, Yosuke Tanaka, Shigeru Yanagi, Terumasa Umemoto, Toshio Suda
EMBO J. 2024 Feb; 43(3): 339–361. Published online 2024 Jan 18. doi: 10.1038/s44318-024-00029-0
PMCID:
PMC10897143
AbstractArticlePDF–6.2M
4.
PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity
Rui Liu, Lin-Wen Zeng, Hui-Fang Li, Jun-Ge Shi, Bo Zhong, Hong-Bing Shu, Shu Li
Cell Res. 2023 Dec; 33(12): 923–939. Published online 2023 Nov 6. doi: 10.1038/s41422-023-00890-4
PMCID:
PMC10709454
AbstractArticlePDF–4.4M
5.
MARCH5 promotes STING pathway activation by suppressing polymer formation of oxidized STING
Kyungpyo Son, Seokhwan Jeong, Eunchong Eom, Dohyeong Kwon, Suk‐Jo Kang
EMBO Rep. 2023 Dec; 24(12): e57496. Published online 2023 Nov 2. doi: 10.15252/embr.202357496
PMCID:
PMC10702817
AbstractArticlePDF–1.9M
6.
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation
Yeon‐Ji Park, Niranjan Dodantenna, Yonghyeon Kim, Tae‐Hwan Kim, Ho‐Soo Lee, Young‐Suk Yoo, June Heo, Jae‐Ho Lee, Myung‐Hee Kwon, Ho Chul Kang, Jong‐Soo Lee, Hyeseong Cho
EMBO J. 2023 Oct; 42(19): e113481. Published online 2023 Aug 14. doi: 10.15252/embj.2023113481
PMCID:
PMC10548170
AbstractArticlePDF–1.8M
7.
Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker
Georgina E. T. Blake, Xiaohui Zhao, Hong wa Yung, Graham J. Burton, Anne C. Ferguson-Smith, Russell S. Hamilton, Erica D. Watson
Nat Commun. 2021; 12: 3714. Published online 2021 Jun 17. doi: 10.1038/s41467-021-24036-5
PMCID:
PMC8211854
AbstractArticlePDF–1.9M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
Keisuke Takeda, Aoi Uda, Mikihiro Mitsubori, Shun Nagashima, Hiroko Iwasaki, Naoki Ito, Isshin Shiiba, Satoshi Ishido, Masaaki Matsuoka, Ryoko Inatome, Shigeru Yanagi
Commun Biol. 2021; 4: 192. Published online 2021 Feb 12. doi: 10.1038/s42003-021-01720-2
PMCID:
PMC7881000
AbstractArticlePDF–5.6M
10.
MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress
Shun Nagashima, Keisuke Takeda, Nobuhiko Ohno, Satoshi Ishido, Motohide Aoki, Yurika Saitoh, Takumi Takada, Takeshi Tokuyama, Ayumu Sugiura, Toshifumi Fukuda, Nobuko Matsushita, Ryoko Inatome, Shigeru Yanagi
Life Sci Alliance. 2019 Aug; 2(4): e201900308. Published online 2019 Aug 15. doi: 10.26508/lsa.201900308
PMCID:
PMC6696985
AbstractArticlePDF–2.8M
11.
MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites
Keisuke Takeda, Shun Nagashima, Isshin Shiiba, Aoi Uda, Takeshi Tokuyama, Naoki Ito, Toshifumi Fukuda, Nobuko Matsushita, Satoshi Ishido, Takao Iwawaki, Takashi Uehara, Ryoko Inatome, Shigeru Yanagi
EMBO J. 2019 Aug 1; 38(15): e100999. Published online 2019 Jun 13. doi: 10.15252/embj.2018100999
PMCID:
PMC6669929
AbstractArticlePDF–1.8M
12.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
13.
The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes
Simon T. Bond, Sarah C. Moody, Yingying Liu, Mete Civelek, Claudio J. Villanueva, Paul Gregorevic, Bronwyn A. Kingwell, Andrea L. Hevener, Aldons J. Lusis, Darren C. Henstridge, Anna C. Calkin, Brian G. Drew
Am J Physiol Endocrinol Metab. 2019 Feb 1; 316(2): E293–E304. Published online 2018 Dec 4. doi: 10.1152/ajpendo.00394.2018
PMCID:
PMC6397360
AbstractArticle
14.
Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each
Afzal M. Dogar, Ramona Pauchard-Batschulat, Barbara Grisoni-Neupert, Larry Richman, Alexandra Paillusson, Sylvain Pradervand, Otto Hagenbüchle, Giovanna Ambrosini, Christoph D. Schmid, Philipp Bucher, Lukas C. Kühn
PLoS One. 2018; 13(11): e0206823. Published online 2018 Nov 12. doi: 10.1371/journal.pone.0206823
PMCID:
PMC6231638
AbstractArticlePDF–3.8M
15.
MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival
Y-Y Park, O T K Nguyen, H Kang, H Cho
Cell Death Dis. 2014 Apr; 5(4): e1172. Published online 2014 Apr 10. doi: 10.1038/cddis.2014.142
PMCID:
PMC5424118
AbstractArticlePDF–3.7M
16.
Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry
Devin K. Schweppe, Juan D. Chavez, Chi Fung Lee, Arianne Caudal, Shane E. Kruse, Rudy Stuppard, David J. Marcinek, Gerald S. Shadel, Rong Tian, James E. Bruce
Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7): 1732–1737. Published online 2017 Jan 27. doi: 10.1073/pnas.1617220114
PMCID:
PMC5321032
AbstractArticlePDF–1.1M
17.
The mitochondrial ubiquitin ligase plays an anti‐apoptotic role in cardiomyocytes by regulating mitochondrial fission
Jing Wang, Lynn H. H. Aung, Bellur S. Prabhakar, Peifeng Li
J Cell Mol Med. 2016 Dec; 20(12): 2278–2288. Published online 2016 Jul 22. doi: 10.1111/jcmm.12914
PMCID:
PMC5134389
AbstractArticlePDF–959K
18.
The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling
Young-Suk Yoo, Yong-Yea Park, Jae-Hoon Kim, Hyeseon Cho, Song-Hee Kim, Ho-Soo Lee, Tae-Hwan Kim, You Sun Kim, Youngsoo Lee, Chul-Joong Kim, Jae U Jung, Jong-Soo Lee, Hyeseong Cho
Nat Commun. 2015; 6: 7910. Published online 2015 Aug 6. doi: 10.1038/ncomms8910
PMCID:
PMC4918326
AbstractArticlePDF–2.1M
19.
Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling
Hao Gu, Qidong Li, Shan Huang, Weiguang Lu, Fangyuan Cheng, Ping Gao, Chen Wang, Lin Miao, Yide Mei, Mian Wu
Nat Commun. 2015; 6: 7112. Published online 2015 Jun 2. doi: 10.1038/ncomms8112
PMCID:
PMC4458872
AbstractArticlePDF–2.0M
20.
Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt
Jernej Murn, Kathi Zarnack, Yawei J. Yang, Omer Durak, Elisabeth A. Murphy, Sihem Cheloufi, Dilenny M. Gonzalez, Marianna Teplova, Tomaž Curk, Johannes Zuber, Dinshaw J. Patel, Jernej Ule, Nicholas M. Luscombe, Li-Huei Tsai, Christopher A. Walsh, Yang Shi
Genes Dev. 2015 Mar 1; 29(5): 501–512. doi: 10.1101/gad.258483.115
PMCID:
PMC4358403
AbstractArticlePDF–1.4M

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