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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 100942822.

Mouse Models with SGLT2 Mutations: Toward Understanding the Role of SGLT2 beyond Glucose Reabsorption

Keiko Unno, Kyoko Taguchi, Yoshiichi Takagi, Tadashi Hase, Shinichi Meguro, Yoriyuki Nakamura

Int J Mol Sci. 2023 Apr; 24(7): 6278. Published online 2023 Mar 27. doi: 10.3390/ijms24076278

PMCID:: PMC10094282

Abstract Article PDF–447K

Select item 100701153.

Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2

Mitsunori Fujino, Naoki Morito, Takuto Hayashi, Masami Ojima, Shun Ishibashi, Akihiro Kuno, Seizo Koshiba, Kunihiro Yamagata, Satoru Takahashi

JCI Insight. 2023 Mar 22; 8(6): e163306. Published online 2023 Mar 22. doi: 10.1172/jci.insight.163306

PMCID:: PMC10070115

Abstract Article PDF–14M

Select item 92237854.

Col4a3^-/- Mice on Balb/C Background Have Less Severe Cardiorespiratory Phenotype and SGLT2 Over-Expression Compared to 129x1/SvJ and C57Bl/6 Backgrounds

Camila I. Irion, Monique Williams, Jose Condor Capcha, Trevor Eisenberg, Guerline Lambert, Lauro M. Takeuchi, Grace Seo, Keyvan Yousefi, Rosemeire Kanashiro-Takeuchi, Keith A. Webster, Karen C. Young, Joshua M. Hare, Lina A. Shehadeh

Int J Mol Sci. 2022 Jun; 23(12): 6674. Published online 2022 Jun 15. doi: 10.3390/ijms23126674

PMCID:: PMC9223785

Abstract Article PDF–7.7M

Select item 91266785.

circ_000166/miR-296 Aggravates the Process of Diabetic Renal Fibrosis by Regulating the SGLT2 Signaling Pathway in Renal Tubular Epithelial Cells

Sheng Chen

Dis Markers. 2022; 2022: 6103086. Published online 2022 May 16. doi: 10.1155/2022/6103086

PMCID:: PMC9126678

Abstract Article PDF–2.3M

Select item 82009666.

Characteristics of Ventricular Electrophysiological Substrates in Metabolic Mice Treated with Empagliflozin

Shih-Jie Jhuo, I-Hsin Liu, Wei-Chung Tasi, Te-Wu Chou, Yi-Hsiung Lin, Bin-Nan Wu, Kun-Tai Lee, Wen-Ter Lai

Int J Mol Sci. 2021 Jun; 22(11): 6105. Published online 2021 Jun 5. doi: 10.3390/ijms22116105

PMCID:: PMC8200966

Abstract Article PDF–4.4M

Select item 76993427.

SGLT2 Inhibition by Intraperitoneal Dapagliflozin Mitigates Peritoneal Fibrosis and Ultrafiltration Failure in a Mouse Model of Chronic Peritoneal Exposure to High-Glucose Dialysate

Michael S. Balzer, Song Rong, Johannes Nordlohne, Jan D. Zemtsovski, Sonja Schmidt, Britta Stapel, Maria Bartosova, Sibylle von Vietinghoff, Hermann Haller, Claus P. Schmitt, Nelli Shushakova

Biomolecules. 2020 Nov; 10(11): 1573. Published online 2020 Nov 19. doi: 10.3390/biom10111573

PMCID:: PMC7699342

Abstract Article PDF–4.0M

Select item 75895918.

Sodium-Glucose Co-Transporter 2 Inhibitors Correct Metabolic Maladaptation of Proximal Tubular Epithelial Cells in High-Glucose Conditions

Kohsuke Shirakawa, Motoaki Sano

Int J Mol Sci. 2020 Oct; 21(20): 7676. Published online 2020 Oct 16. doi: 10.3390/ijms21207676

PMCID:: PMC7589591

Abstract Article PDF–4.6M

Select item 75870019.

Sodium/glucose cotransporter 2 is expressed in choroid plexus epithelial cells and ependymal cells in human and mouse brains

Yoichi Chiba, Yasunori Sugiyama, Nozomu Nishi, Wakako Nonaka, Ryuta Murakami, Masaki Ueno

Neuropathology. 2020 Oct; 40(5): 482–491. Published online 2020 Jun 2. doi: 10.1111/neup.12665

PMCID:: PMC7587001

Abstract Article PDF–17M

Select item 755465610.

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

Heeyoung Chae, Robert Augustin, Eva Gatineau, Eric Mayoux, Mohammed Bensellam, Nancy Antoine, Firas Khattab, Bao-Khanh Lai, Davide Brusa, Birgit Stierstorfer, Holger Klein, Bilal Singh, Lucie Ruiz, Michael Pieper, Michael Mark, Pedro L. Herrera, Fiona M. Gribble, Frank Reimann, Anne Wojtusciszyn, Christophe Broca, Nano Rita, Lorenzo Piemonti, Patrick Gilon

Mol Metab. 2020 Dec; 42: 101071. Published online 2020 Sep 5. doi: 10.1016/j.molmet.2020.101071

PMCID:: PMC7554656

Abstract Article PDF–5.0M

Select item 743287211.

Mutation in Sodium-Glucose Cotransporter 2 Results in Down-Regulation of Amyloid Beta (A4) Precursor-Like Protein 1 in Young Age, Which May Lead to Poor Memory Retention in Old Age

Keiko Unno, Yoshiichi Takagi, Tomokazu Konishi, Mitsuhiro Suzuki, Akiyuki Miyake, Takumi Kurotaki, Tadashi Hase, Shinichi Meguro, Atsuyoshi Shimada, Sanae Hasegawa-Ishii, Monira Pervin, Kyoko Taguchi, Yoriyuki Nakamura

Int J Mol Sci. 2020 Aug; 21(15): 5579. Published online 2020 Aug 4. doi: 10.3390/ijms21155579

PMCID:: PMC7432872

Abstract Article PDF–1.1M

Select item 733631912.

Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice

Lakshini Y Herat, Natalie C Ward, Aaron L Magno, Elizabeth P Rakoczy, Marcio G Kiuchi, Markus P Schlaich, Vance B Matthews

World J Gastroenterol. 2020 Jun 21; 26(23): 3225–3235. Published online 2020 Jun 21. doi: 10.3748/wjg.v26.i23.3225

PMCID:: PMC7336319

Abstract Article PDF–7.9M

Select item 729433213.

Gene knockout of the Na⁺-glucose cotransporter SGLT2 in a murine model of acute kidney injury induced by ischemia-reperfusion

Josselin Nespoux, Rohit Patel, Haiyan Zhang, Winnie Huang, Brent Freeman, Paul W. Sanders, Young Chul Kim, Volker Vallon

Am J Physiol Renal Physiol. 2020 May 1; 318(5): F1100–F1112. Published online 2020 Mar 2. doi: 10.1152/ajprenal.00607.2019

PMCID:: PMC7294332

Abstract Article

Select item 721206114.

No direct effect of sodium-glucose transporter-2 (SGLT2) activity on glucagon secretion

Rune E. Kuhre, Seyed M. Ghiasi, Alice E. Adriaenssens, Nicolai J. Wewer Albrechtsen, Daniel B. Andersen, Alexander Aivazidis, Lihua Chen, Thomas Mandrup-Poulsen, Cathrine Ørskov, Fiona M. Gribble, Frank Reimann, Nils Wierup, Björn Tyrberg, Jens J. Holst

Diabetologia. Author manuscript; available in PMC 2020 May 11.

Published in final edited form as: Diabetologia. 2019 Jun 1; 62(6): 1011–1023. Published online 2019 Mar 22. doi: 10.1007/s00125-019-4849-6

PMCID:: PMC7212061

Abstract Article PDF–2.1M

Select item 705954915.

Genetic ablation of SGLT2 function in mice impairs tissue mineral density but does not affect fracture resistance of bone

Kathryn M. Thrailkill, R. Clay Bunn, Sasidhar Uppuganti, Philip Ray, Kate Garrett, Iuliana Popescu, Jacquelyn S. Pennings, John L. Fowlkes, Jeffry S. Nyman

Bone. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: Bone. 2020 Apr; 133: 115254. Published online 2020 Jan 25. doi: 10.1016/j.bone.2020.115254

PMCID:: PMC7059549

Abstract Article PDF–839K

Select item 682881516.

β-catenin regulates the formation of multiple nephron segments in the mouse kidney

Patrick Deacon, Charles W. Concodora, Eunah Chung, Joo-Seop Park

Sci Rep. 2019; 9: 15915. Published online 2019 Nov 4. doi: 10.1038/s41598-019-52255-w

PMCID:: PMC6828815

Abstract Article PDF–3.3M

Select item 645951017.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 638319418.

SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1

Aleksandra Novikov, Yiling Fu, Winnie Huang, Brent Freeman, Rohit Patel, Charlotte van Ginkel, Hermann Koepsell, Meinrad Busslinger, Akira Onishi, Josselin Nespoux, Volker Vallon

Am J Physiol Renal Physiol. 2019 Jan 1; 316(1): F173–F185. Published online 2018 Nov 14. doi: 10.1152/ajprenal.00462.2018

PMCID:: PMC6383194

Abstract Article

Select item 632980619.

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Elisa Vergari, Jakob G. Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J. B. Briant, Margarita V. Chibalina, Fiona M. Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J. G. Rorsman, Ioannis I. Spiliotis, Andrei Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman

Nat Commun. 2019; 10: 139. Published online 2019 Jan 11. doi: 10.1038/s41467-018-08193-8

PMCID:: PMC6329806

Abstract Article PDF–985K

Select item 593153120.

High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection

Hiroyuki Umino, Kazuhiro Hasegawa, Hitoshi Minakuchi, Hirokazu Muraoka, Takahisa Kawaguchi, Takeshi Kanda, Hirobumi Tokuyama, Shu Wakino, Hiroshi Itoh

Sci Rep. 2018; 8: 6791. Published online 2018 May 1. doi: 10.1038/s41598-018-25054-y

PMCID:: PMC5931531

Abstract Article PDF–2.4M

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