PMC Links for GEO Profiles (Select 47193642) - PMC

Select item 97795531.

Novel p.G250A Mutation Associated with Chronic Pancreatitis Highlights Misfolding-Prone Region in Carboxypeptidase A1 (CPA1)

Máté Sándor, Franziska G. Thiel, Margit Schmid, Alexandra Demcsák, Nataly C. Morales Granda, Balázs Csaba Németh, Sandor Vajda, André Hoerning, Miklós Sahin-Tóth

Int J Mol Sci. 2022 Dec; 23(24): 15463. Published online 2022 Dec 7. doi: 10.3390/ijms232415463

PMCID:: PMC9779553

Abstract Article PDF–1.7M

Select item 88602212.

Carboxypeptidase A1 (CPA1) Immunohistochemistry Is Highly Sensitive and Specific for Acinar Cell Carcinoma (ACC) of the Pancreas

Ria Uhlig, Hendrina Contreras, Sören Weidemann, Natalia Gorbokon, Anne Menz, Franziska Büscheck, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Christoph Fraune, Katharina Möller, Christian Bernreuther, Patrick Lebok, Guido Sauter, Waldemar Wilczak, Jakob Izbicki, Daniel Perez, Jörg Schrader, Stefan Steurer, Eike Burandt, Rainer Krech, David Dum, Till Krech, Andreas Marx, Ronald Simon, Sarah Minner, Frank Jacobsen, Till S. Clauditz

Am J Surg Pathol. 2022 Jan; 46(1): 97–104. Published online 2021 Oct 21. doi: 10.1097/PAS.0000000000001817

PMCID:: PMC8860221

Abstract Article PDF–433K

Select item 88106743.

Endoplasmic stress-inducing variants in CPB1 and CPA1 and risk of pancreatic cancer; a case-control study and meta-analysis

Makoto Kawamoto, Shiro Kohi, Toshiya Abe, Mohamad Dbouk, Anne Macgregor-Das, Chiho Koi, Ki-Byung Song, Michael Borges, Ryo Sugimine, Daniel Laheru, Ralph H. Hruban, Nicholas Roberts, Alison P. Klein, Michael Goggins

Int J Cancer. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Int J Cancer. 2022 Apr 1; 150(7): 1123–1133. Published online 2021 Dec 6. doi: 10.1002/ijc.33883

PMCID:: PMC8810674

Abstract Article PDF–1.1M

Select item 59390874.

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer

Koji Tamura, Jun Yu, Tatsuo Hata, Masaya Suenaga, Koji Shindo, Toshiya Abe, Anne MacGregor-Das, Michael Borges, Christopher L. Wolfgang, Matthew J. Weiss, Jin He, Marcia Irene Canto, Gloria M. Petersen, Steven Gallinger, Sapna Syngal, Randall E. Brand, Anil Rustgi, Sara H. Olson, Elena Stoffel, Michele L. Cote, George Zogopoulos, James B. Potash, Fernando S. Goes, Richard W. McCombie, Peter P. Zandi, Mehdi Pirooznia, Melissa Kramer, Jennifer Parla, James R. Eshleman, Nicholas J. Roberts, Ralph H. Hruban, Alison Patricia Klein, Michael Goggins

Proc Natl Acad Sci U S A. 2018 May 1; 115(18): 4767–4772. Published online 2018 Apr 18. doi: 10.1073/pnas.1720588115

PMCID:: PMC5939087

Abstract Article PDF–746K

Select item 55428455.

No Significant Enrichment of Rare Functionally Defective CPA1 Variants in a Large Chinese Idiopathic Chronic Pancreatitis Cohort

Hao Wu, Dai-Zhan Zhou, Dorottya Berki, Andrea Geisz, Wen-Bin Zou, Xiao-Tian Sun, Liang-Hao Hu, Zhen-Hua Zhao, An-Jing Zhao, Lin He, David N. Cooper, Claude Férec, Jian-Min Chen, Zhao-Shen Li, Miklós Sahin-Tóth, Zhuan Liao

Hum Mutat. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Hum Mutat. 2017 Aug; 38(8): 959–963. Published online 2017 May 30. doi: 10.1002/humu.23254

PMCID:: PMC5542845

Abstract Article PDF–321K

Select item 50161656.

Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2

András Szabó, Claudia Pilsak, Melinda Bence, Heiko Witt, Miklós Sahin-Tóth

J Biol Chem. 2016 Aug 19; 291(34): 17706–17716. Published online 2016 Jun 29. doi: 10.1074/jbc.M116.743237

PMCID:: PMC5016165

Abstract Article PDF–1.5M

Select item 39094997.

Variants in CPA1 are strongly associated with early-onset chronic pancreatitis

Heiko Witt, Sebastian Beer, Jonas Rosendahl, Jian-Min Chen, Giriraj Ratan Chandak, Atsushi Masamune, Melinda Bence, Richárd Szmola, Grzegorz Oracz, Milan Macek, Jr, Eesh Bhatia, Sandra Steigenberger, Denise Lasher, Florence Bühler, Catherine Delaporte, Johanna Tebbing, Maren Ludwig, Claudia Pilsak, Karolin Saum, Peter Bugert, Emmanuelle Masson, Sumit Paliwal, Seema Bhaskar, Agnieszka Sobczynska-Tomaszewska, Daniel Bak, Ivan Balascak, Gourdas Choudhuri, D. Nageshwar Reddy, G. Venkat Rao, Varghese Thomas, Kiyoshi Kume, Eriko Nakano, Yoichi Kakuta, Tooru Shimosegawa, Lukasz Durko, András Szabó, Andrea Schnúr, Péter Hegyi, Zoltán Rakonczay, Jr, Roland Pfützer, Alexander Schneider, David Alexander Groneberg, Markus Braun, Hartmut Schmidt, Ulrike Witt, Helmut Friess, Hana Algül, Olfert Landt, Markus Schuelke, Renate Krüger, Bertram Wiedenmann, Frank Schmidt, Klaus-Peter Zimmer, Peter Kovacs, Michael Stumvoll, Matthias Blüher, Thomas Müller, Andreas Janecke, Niels Teich, Robert Grützmann, Hans-Ulrich Schulz, Joachim Mössner, Volker Keim, Matthias Löhr, Claude Férec, Miklós Sahin-Tóth

Nat Genet. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: Nat Genet. 2013 Oct; 45(10): 1216–1220. Published online 2013 Aug 18. doi: 10.1038/ng.2730

PMCID:: PMC3909499

Abstract Article PDF–689K

Select item 31780598.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 30234779.

Chymotrypsin C Is a Co-activator of Human Pancreatic Procarboxypeptidases A1 and A2

Richárd Szmola, Melinda Bence, Andrea Carpentieri, András Szabó, Catherine E. Costello, John Samuelson, Miklós Sahin-Tóth

J Biol Chem. 2011 Jan 21; 286(3): 1819–1827. Published online 2010 Nov 22. doi: 10.1074/jbc.M110.187369

PMCID:: PMC3023477

Abstract Article PDF–1.3M

Select item 288296110.

Human Chromosome 7: DNA Sequence and Biology

Stephen W. Scherer, Joseph Cheung, Jeffrey R. MacDonald, Lucy R. Osborne, Kazuhiko Nakabayashi, Jo-Anne Herbrick, Andrew R. Carson, Layla Parker-Katiraee, Jennifer Skaug, Razi Khaja, Junjun Zhang, Alexander K. Hudek, Martin Li, May Haddad, Gavin E. Duggan, Bridget A. Fernandez, Emiko Kanematsu, Simone Gentles, Constantine C. Christopoulos, Sanaa Choufani, Dorota Kwasnicka, Xiangqun H. Zheng, Zhongwu Lai, Deborah Nusskern, Qing Zhang, Zhiping Gu, Fu Lu, Susan Zeesman, Malgorzata J. Nowaczyk, Ikuko Teshima, David Chitayat, Cheryl Shuman, Rosanna Weksberg, Elaine H. Zackai, Theresa A. Grebe, Sarah R. Cox, Susan J. Kirkpatrick, Nazneen Rahman, Jan M. Friedman, Henry H. Q. Heng, Pier Giuseppe Pelicci, Francesco Lo-Coco, Elena Belloni, Lisa G. Shaffer, Barbara Pober, Cynthia C. Morton, James F. Gusella, Gail A. P. Bruns, Bruce R. Korf, Bradley J. Quade, Azra H. Ligon, Heather Ferguson, Anne W. Higgins, Natalia T. Leach, Steven R. Herrick, Emmanuelle Lemyre, Chantal G. Farra, Hyung-Goo Kim, Anne M. Summers, Karen W. Gripp, Wendy Roberts, Peter Szatmari, Elizabeth J. T. Winsor, Karl-Heinz Grzeschik, Ahmed Teebi, Berge A. Minassian, Juha Kere, Lluis Armengol, Miguel Angel Pujana, Xavier Estivill, Michael D. Wilson, Ben F. Koop, Sabrina Tosi, Gudrun E. Moore, Andrew P. Boright, Eitan Zlotorynski, Batsheva Kerem, Peter M. Kroisel, Erwin Petek, David G. Oscier, Sarah J. Mould, Hartmut Döhner, Konstanze Döhner, Johanna M. Rommens, John B. Vincent, J. Craig Venter, Peter W. Li, Richard J. Mural, Mark D. Adams, Lap-Chee Tsui

Science. Author manuscript; available in PMC 2010 Jun 9.

Published in final edited form as: Science. 2003 May 2; 300(5620): 767–772. Published online 2003 Apr 10. doi: 10.1126/science.1083423