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Select item 108937001.

Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson’s disease phenotypes in vivo and in cell models

Murni Tio, Rujing Wen, Cai Ning Choo, Jian Bin Tan, Aaron Chua, Bin Xiao, Jeyapriya Rajameenakshi Sundaram, Christine Hui Shan Chan, Eng-King Tan

J Biomed Sci. 2024; 31: 24. Published online 2024 Feb 23. doi: 10.1186/s12929-024-01010-z

PMCID:: PMC10893700

Abstract Article PDF–14M

Select item 105208722.

APOLLO, a testis-specific Drosophila ortholog of importin-4, mediates the loading of protamine-like protein Mst77F into sperm chromatin

Alexander V. Emelyanov, Daniel Barcenilla-Merino, Benjamin Loppin, Dmitry V. Fyodorov

J Biol Chem. 2023 Oct; 299(10): 105212. Published online 2023 Sep 2. doi: 10.1016/j.jbc.2023.105212

PMCID:: PMC10520872

Abstract Article PDF–1.5M

Select item 101057363.

Next-generation large-scale binary protein interaction network for Drosophila melanogaster

Hong-Wen Tang, Kerstin Spirohn, Yanhui Hu, Tong Hao, István A. Kovács, Yue Gao, Richard Binari, Donghui Yang-Zhou, Kenneth H. Wan, Joel S. Bader, Dawit Balcha, Wenting Bian, Benjamin W. Booth, Atina G. Coté, Steffi de Rouck, Alice Desbuleux, Kah Yong Goh, Dae-Kyum Kim, Jennifer J. Knapp, Wen Xing Lee, Irma Lemmens, Cathleen Li, Mian Li, Roujia Li, Hyobin Julianne Lim, Yifang Liu, Katja Luck, Dylan Markey, Carl Pollis, Sudharshan Rangarajan, Jonathan Rodiger, Sadie Schlabach, Yun Shen, Dayag Sheykhkarimli, Bridget TeeKing, Frederick P. Roth, Jan Tavernier, Michael A. Calderwood, David E. Hill, Susan E. Celniker, Marc Vidal, Norbert Perrimon, Stephanie E. Mohr

Nat Commun. 2023; 14: 2162. Published online 2023 Apr 15. doi: 10.1038/s41467-023-37876-0

PMCID:: PMC10105736

Abstract Article PDF–3.2M

Select item 84962774.

A cross-species approach for the identification of Drosophila male sterility genes

Kimihide Ibaraki, Mihoko Nakatsuka, Takashi Ohsako, Masahide Watanabe, Yu Miyazaki, Machi Shirakami, Timothy L Karr, Rikako Sanuki, Masatoshi Tomaru, Toshiyuki Takano-Shimizu-Kouno

G3 (Bethesda) 2021 Aug; 11(8): jkab183. Published online 2021 May 29. doi: 10.1093/g3journal/jkab183

PMCID:: PMC8496277

Abstract Article PDF–421K

Select item 81151795.

Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium

Elsayed Metwally, Guoli Zhao, Qifu Wang, Yong Q. Zhang

Cell Res. 2021 Apr; 31(4): 433–449. Published online 2020 Aug 26. doi: 10.1038/s41422-020-0388-4

PMCID:: PMC8115179

Abstract Article PDF–7.5M

Select item 77580516.

Autocrine insulin pathway signaling regulates actin dynamics in cell wound repair

Mitsutoshi Nakamura, Jeffrey M. Verboon, Tessa E. Allen, Maria Teresa Abreu-Blanco, Raymond Liu, Andrew N. M. Dominguez, Jeffrey J. Delrow, Susan M. Parkhurst

PLoS Genet. 2020 Dec; 16(12): e1009186. Published online 2020 Dec 11. doi: 10.1371/journal.pgen.1009186

PMCID:: PMC7758051

Abstract Article PDF–9.7M

Select item 74656837.

The Biochemistry of Cytoplasmic Incompatibility Caused by Endosymbiotic Bacteria

Hongli Chen, Mengwen Zhang, Mark Hochstrasser

Genes (Basel) 2020 Aug; 11(8): 852. Published online 2020 Jul 25. doi: 10.3390/genes11080852

PMCID:: PMC7465683

Abstract Article PDF–1.2M

Select item 72447608.

Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1

Wei Liu, Xiuying Duan, Lingna Xu, Weina Shang, Jiayao Zhao, Liquan Wang, Jian-Chiuan Li, Chun-Hong Chen, Jun-Ping Liu, Chao Tong

Cell Death Differ. 2020 Jun; 27(6): 2014–2029. Published online 2020 Jan 6. doi: 10.1038/s41418-019-0482-7

PMCID:: PMC7244760

Abstract Article PDF–13M

Select item 69615789.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 688114610.

The Wolbachia cytoplasmic incompatibility enzyme CidB targets nuclear import and protamine-histone exchange factors

John Frederick Beckmann, Gagan Deep Sharma, Luis Mendez, Hongli Chen, Mark Hochstrasser

eLife. 2019; 8: e50026. Published online 2019 Nov 27. doi: 10.7554/eLife.50026

PMCID:: PMC6881146

Abstract Article PDF–5.2M

Select item 675092611.

Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis

Jia Zhou, Lingna Xu, Xiuying Duan, Wei Liu, Xiaocui Zhao, Xi Wang, Weina Shang, Xuefei Fang, Huan Yang, Lijun Jia, Jian Bai, Jiayao Zhao, Liquan Wang, Chao Tong

Sci Adv. 2019 Sep; 5(9): eaax0365. Published online 2019 Sep 18. doi: 10.1126/sciadv.aax0365

PMCID:: PMC6750926

Abstract Article PDF–14M

Select item 651407312.

C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A

Thomas G. Moens, Teresa Niccoli, Katherine M. Wilson, Magda L. Atilano, Nicol Birsa, Lauren M. Gittings, Benedikt V. Holbling, Miranda C. Dyson, Annora Thoeng, Jacob Neeves, Idoia Glaria, Lu Yu, Julia Bussmann, Erik Storkebaum, Mercedes Pardo, Jyoti S. Choudhary, Pietro Fratta, Linda Partridge, Adrian M. Isaacs

Acta Neuropathol. 2019; 137(3): 487–500. Published online 2019 Jan 2. doi: 10.1007/s00401-018-1946-4

PMCID:: PMC6514073

Abstract Article PDF–2.1M

Select item 650653913.

Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila

Hagar Meltzer, Efrat Marom, Idan Alyagor, Oded Mayseless, Victoria Berkun, Netta Segal-Gilboa, Tamar Unger, David Luginbuhl, Oren Schuldiner

Nat Commun. 2019; 10: 2113. Published online 2019 May 8. doi: 10.1038/s41467-019-10140-0

PMCID:: PMC6506539

Abstract Article PDF–6.5M

Select item 646244114.

Calcium-Activated Calpain Specifically Cleaves Glutamate Receptor IIA But Not IIB at the Drosophila Neuromuscular Junction

Elsayed Metwally, Guoli Zhao, Wenhua Li, Qifu Wang, Yong Q. Zhang

J Neurosci. 2019 Apr 10; 39(15): 2776–2791. doi: 10.1523/JNEUROSCI.2213-17.2019

PMCID:: PMC6462441

Abstract Article PDF–5.0M

Select item 570780515.

Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Piero Sanfilippo, Jiayu Wen, Eric C. Lai

Genome Biol. 2017; 18: 229. Published online 2017 Nov 30. doi: 10.1186/s13059-017-1358-0

PMCID:: PMC5707805

Abstract Article PDF–3.2M

Select item 568900216.

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

Xiaochuan Liu, Jaime Freitas, Dinghai Zheng, Marta S. Oliveira, Mainul Hoque, Torcato Martins, Telmo Henriques, Bin Tian, Alexandra Moreira

RNA. 2017 Dec; 23(12): 1807–1816. doi: 10.1261/rna.062661.117

PMCID:: PMC5689002

Abstract Article PDF–4.0M

Select item 527052117.

The mRNA transportome of the BicD/Egl transport machinery

Paula Vazquez-Pianzola, Bogdan Schaller, Martino Colombo, Dirk Beuchle, Samuel Neuenschwander, Anne Marcil, Rémy Bruggmann, Beat Suter

RNA Biol. 2017; 14(1): 73–89. Published online 2016 Nov 1. doi: 10.1080/15476286.2016.1251542

PMCID:: PMC5270521

Abstract Article PDF–2.1M

Select item 523872418.

Thioredoxin-dependent disulfide bond reduction is required for protamine eviction from sperm chromatin

Alexander V. Emelyanov, Dmitry V. Fyodorov

Genes Dev. 2016 Dec 15; 30(24): 2651–2656. doi: 10.1101/gad.290916.116

PMCID:: PMC5238724

Abstract Article PDF–482K

Select item 512686419.

Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster

Punita Juneja, Andrew Quinn, Francis M. Jiggins

BMC Genomics. 2016; 17: 981. Published online 2016 Nov 28. doi: 10.1186/s12864-016-3333-7

PMCID:: PMC5126864

Abstract Article PDF–1.1M

Select item 507911120.

C9orf72 dipeptide repeats impair the assembly, dynamics and function of membrane-less organelles

Kyung-Ha Lee, Peipei Zhang, Hong Joo Kim, Diana Mitrea, Mohona Sarkar, Brian Freibaum, Jaclyn Cika, Maura Coughlin, James Messing, Amandine Molliex, Brian Maxwell, Nam Chul Kim, Jamshid Temirov, Jennifer Moore, Regina-Maria Kolaitis, Timothy Shaw, Bing Bai, Junmin Peng, Richard Kriwacki, J. Paul Taylor

Cell. Author manuscript; available in PMC 2017 Oct 20.

Published in final edited form as: Cell. 2016 Oct 20; 167(3): 774–788.e17. doi: 10.1016/j.cell.2016.10.002

PMCID:: PMC5079111

Abstract Article PDF–2.3M

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