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Items: 1 to 20 of 301

1.
The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness
Xingxing Zhu, Yue Wu, Yanfeng Li, Xian Zhou, Jens O. Watzlawik, Yin Maggie Chen, Ariel L. Raybuck, Daniel D. Billadeau, Virginia Smith Shapiro, Wolfdieter Springer, Jie Sun, Mark R. Boothby, Hu Zeng
Nat Commun. 2024; 15: 10163. Published online 2024 Nov 23. doi: 10.1038/s41467-024-54344-5
PMCID:
PMC11585635
AbstractArticlePDF–5.8M
2.
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Daizhao Deng, Xianming Liu, Wenlan Huang, Sirui Yuan, Genming Liu, Shanshan Ai, Yijie Fu, Haokun Xu, Xinyi Zhang, Shihai Li, Song Xu, Xiaochun Bai, Yue Zhang
Bone Res. 2024; 12: 49. Published online 2024 Aug 28. doi: 10.1038/s41413-024-00360-6
PMCID:
PMC11358419
AbstractArticlePDF–4.5M
3.
Reprogramming Tumor-Associated Macrophages to Outcompete Endovascular Endothelial Progenitor Cells and Suppress Tumor Neoangiogenesis
Mytrang H. Do, Wei Shi, Liangliang Ji, Erik Ladewig, Xian Zhang, Raghvendra M. Srivastava, Kristelle J. Capistrano, Chaucie Edwards, Isha Malik, Briana G. Nixon, Efstathios G. Stamatiades, Ming Liu, Shun Li, Peng Li, Chun Chou, Ke Xu, Ting-Wei Hsu, Xinxin Wang, Timothy A. Chan, Christina S. Leslie, Ming O. Li
Immunity. Author manuscript; available in PMC 2024 Nov 14.
Published in final edited form as: Immunity. 2023 Nov 14; 56(11): 2555–2569.e5. doi: 10.1016/j.immuni.2023.10.010
PMCID:
PMC11284818
AbstractArticlePDF–3.8M
4.
Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter
Jason A Iskarpatyoti, Jianling Shi, Mathew A Abraham, Abhay P S Rathore, Yuxuan Miao, Soman N Abraham
Cell Rep. Author manuscript; available in PMC 2024 Jul 2.
Published in final edited form as: Cell Rep. 2022 Sep 27; 40(13): 111346. doi: 10.1016/j.celrep.2022.111346
PMCID:
PMC11218746
AbstractArticlePDF–1.8M
5.
The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling
Meng Xie, Markéta Kaiser, Yaakov Gershtein, Daniela Schnyder, Ruslan Deviatiiarov, Guzel Gazizova, Elena Shagimardanova, Tomáš Zikmund, Greet Kerckhofs, Evgeny Ivashkin, Dominyka Batkovskyte, Phillip T. Newton, Olov Andersson, Kaj Fried, Oleg Gusev, Hugo Zeberg, Jozef Kaiser, Igor Adameyko, Andrei S. Chagin
Nat Commun. 2024; 15: 2367. Published online 2024 Mar 26. doi: 10.1038/s41467-024-46030-3
PMCID:
PMC10965948
AbstractArticlePDF–9.9M
6.
Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss
Erin R Cullen, Mona Safari, Isabelle Mittelstadt, Matthew C Weston
eLife. 2024; 12: RP91323. Published online 2024 Mar 6. doi: 10.7554/eLife.91323
PMCID:
PMC10942640
AbstractArticlePDF–13M
7.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
8.
Reprogramming tumour-associated macrophages to outcompete cancer cells
Xian Zhang, Shun Li, Isha Malik, Mytrang H. Do, Liangliang Ji, Chun Chou, Wei Shi, Kristelle J. Capistrano, Jing Zhang, Ting-Wei Hsu, Briana G. Nixon, Ke Xu, Xinxin Wang, Andrea Ballabio, Laura S. Schmidt, W. Marston Linehan, Ming O. Li
Nature. Author manuscript; available in PMC 2023 Dec 14.
Published in final edited form as: Nature. 2023 Jul; 619(7970): 616–623. Published online 2023 Jun 28. doi: 10.1038/s41586-023-06256-5
PMCID:
PMC10719927
AbstractArticlePDF–5.6M
9.
Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
Thao DV Le, Dianxin Liu, Gai-Linn K Besing, Ritika Raghavan, Blair J Ellis, Ryan P Ceddia, Sheila Collins, Julio E Ayala
eLife. 2023; 12: e80944. Published online 2023 Nov 6. doi: 10.7554/eLife.80944
PMCID:
PMC10691799
AbstractArticlePDF–1.7M
10.
mTORC1-selective activation of translation elongation promotes disease progression in chronic lymphocytic leukemia
Natasha Malik, Jodie Hay, Hassan N. B. Almuhanna, Karen M. Dunn, Jamie Lees, Jennifer Cassels, Jiatian Li, Rinako Nakagawa, Owen J. Sansom, Alison M. Michie
Leukemia. 2023; 37(12): 2414–2425. Published online 2023 Sep 29. doi: 10.1038/s41375-023-02043-3
PMCID:
PMC10681897
AbstractArticlePDF–4.8M
11.
mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction
Gabriel O. de Souza, Pryscila D. S. Teixeira, Niels O. S. Câmara, Jose Donato, Jr.
Cells. 2023 Oct; 12(20): 2442. Published online 2023 Oct 12. doi: 10.3390/cells12202442
PMCID:
PMC10605346
AbstractArticlePDF–8.1M
12.
Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung
Kelly Kersten, Ran You, Sophia Liang, Kevin M. Tharp, Joshua Pollack, Valerie M. Weaver, Matthew F. Krummel, Mark B. Headley
Cell Rep. Author manuscript; available in PMC 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112582. Published online 2023 May 31. doi: 10.1016/j.celrep.2023.112582
PMCID:
PMC10592447
AbstractArticlePDF–1.1M
13.
Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve
Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylène Brunelle, Nicolas Gévry, Bruce D. Murphy
Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2220849120. Published online 2023 Jul 26. doi: 10.1073/pnas.2220849120
PMCID:
PMC10410717
AbstractArticlePDF–3.9M
14.
Raptor levels are critical for β-cell adaptation to a high-fat diet in male mice
Manuel Blandino-Rosano, Ruy Andrade Louzada, Joao Pedro Werneck-De-Castro, Camila Lubaczeuski, Joana Almaça, Markus A. Rüegg, Michael N. Hall, Gil Leibowitz, Ernesto Bernal-Mizrachi
Mol Metab. 2023 Sep; 75: 101769. Published online 2023 Jul 7. doi: 10.1016/j.molmet.2023.101769
PMCID:
PMC10391668
AbstractArticlePDF–2.6M
15.
mTORC2–NDRG1–CDC42 axis couples fasting to mitochondrial fission
Nuria Martinez-Lopez, Pamela Mattar, Miriam Toledo, Henrietta Bains, Manu Kalyani, Marie Louise Aoun, Mridul Sharma, Laura Beth J. McIntire, Leslie Gunther-Cummins, Frank P. Macaluso, Jennifer T. Aguilan, Simone Sidoli, Mathieu Bourdenx, Rajat Singh
Nat Cell Biol. 2023; 25(7): 989–1003. Published online 2023 Jun 29. doi: 10.1038/s41556-023-01163-3
PMCID:
PMC10344787
AbstractArticlePDF–23M
16.
TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse Model
Meng Ye, Yuanyuan Hu, Bowen Zhao, Qianxue Mou, Yueqi Ni, Jing Luo, Lu Li, Hong Zhang, Yin Zhao
Invest Ophthalmol Vis Sci. 2023 Jul; 64(10): 1. Published online 2023 Jul 3. doi: 10.1167/iovs.64.10.1
PMCID:
PMC10324417
AbstractArticlePDF–5.1M
17.
mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons
François-Xavier Michon, Isabel Laplante, Anthony Bosson, Richard Robitaille, Jean-Claude Lacaille
Mol Brain. 2023; 16: 55. Published online 2023 Jul 3. doi: 10.1186/s13041-023-01042-w
PMCID:
PMC10318662
AbstractArticlePDF–3.8M
18.
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Cell Rep. Author manuscript; available in PMC 2023 Jun 30.
Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112529. Published online 2023 May 17. doi: 10.1016/j.celrep.2023.112529
PMCID:
PMC10312392
AbstractArticlePDF–3.8M
19.
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility
Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao
Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5
PMCID:
PMC10307852
AbstractArticlePDF–8.8M
20.
Natural γδT17 cell development and functional acquisition is governed by the mTORC2-c-Maf-controlled mitochondrial fission pathway
Yunke Wang, Hui Qin, Yihua Cai, Xu Chen, Hong Li, Diego Elias Montoya-Durango, Chuanlin Ding, Xiaoling Hu, Julia H. Chariker, Harshini Sarojini, Sufan Chien, Eric C. Rouchka, Huang-Ge Zhang, Jie Zheng, Fuming Qiu, Jun Yan
iScience. 2023 May 19; 26(5): 106630. Published online 2023 Apr 10. doi: 10.1016/j.isci.2023.106630
PMCID:
PMC10182300
AbstractArticlePDF–8.7M

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