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Select item 110950801.

MHC class II antigen presentation by tumoral lymphatics is required for tumor specific signature and suppressive functions of Tregs

Anastasia O. Gkountidi, Laure Garnier, Juan Dubrot, Julien Angelillo, Guillaume Harlé, Dale Brighouse, Ludovic J. Wrobel, Robert Pick, Christoph Scheiermann, Melody A. Swartz, Stéphanie Hugues

Cancer Immunol Res. Author manuscript; available in PMC 2024 May 15.

Published in final edited form as: Cancer Immunol Res. 2021 Jul; 9(7): 748–764. Published online 2021 May 5. doi: 10.1158/2326-6066.CIR-20-0784

PMCID:: PMC11095080

Abstract Article PDF–3.0M

Select item 110563192.

Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Jonathan Serody, Benjamin Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li

Nat Cancer. 2024; 5(4): 601–624. Published online 2024 Feb 27. doi: 10.1038/s43018-024-00736-x

PMCID:: PMC11056319

Abstract Article PDF–33M

Select item 110250163.

Bone marrow plasma cells require P2rX4 to sense extracellular ATP

Masaki Ishikawa, Zainul S. Hasanali, Yongge Zhao, Arundhoti Das, Marieke Lavaert, Carly J. Roman, Jennifer Londregan, David Allman, Avinash Bhandoola

Nature. Author manuscript; available in PMC 2024 Apr 18.

Published in final edited form as: Nature. 2024 Feb; 626(8001): 1102–1107. Published online 2024 Feb 14. doi: 10.1038/s41586-024-07047-2

PMCID:: PMC11025016

Abstract Article PDF–5.5M

Select item 109399724.

HLA-DQ8 Supports Development of Insulitis Mediated By Insulin-Reactive Human TCR-Transgenic T-cells In NOD Mice

Jeremy J. Racine, Adel Misherghi, Jennifer R. Dwyer, Richard Maser, Elvira Forte, Olivia Bedard, Susanne Sattler, Alberto Pugliese, Laurie Landry, Colleen Elso, Maki Nakayama, Stuart Mannering, Nadia Rosenthal, David V. Serreze

J Immunol. Author manuscript; available in PMC 2024 Dec 15.

Published in final edited form as: J Immunol. 2023 Dec 15; 211(12): 1792–1805. doi: 10.4049/jimmunol.2300303

PMCID:: PMC10939972

Abstract Article PDF–1.6M

Select item 108808165.

Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer

Maria Zagorulya, Leon Yim, Duncan M. Morgan, Austin Edwards, Elen Torres-Mejia, Noor Momin, Chloe V. McCreery, Izabella L. Zamora, Brendan L. Horton, James G. Fox, K. Dane Wittrup, J. Christopher Love, Stefani Spranger

Immunity. Author manuscript; available in PMC 2024 Feb 21.

Published in final edited form as: Immunity. 2023 Feb 14; 56(2): 386–405.e10. Published online 2023 Feb 2. doi: 10.1016/j.immuni.2023.01.010

PMCID:: PMC10880816

Abstract Article PDF–3.2M

Select item 108797146.

Dendritic cells overcome Cre/Lox induced gene deficiency by siphoning cytosolic material from surrounding cells

Christopher H. Herbst, Aurélie Bouteau, Evelin J. Menykő, Zhen Qin, Ervin Gyenge, Qingtai Su, Vincent Cooper, Neil A. Mabbott, Botond Z. Igyártó

iScience. 2024 Mar 15; 27(3): 109119. Published online 2024 Feb 6. doi: 10.1016/j.isci.2024.109119

PMCID:: PMC10879714

Abstract Article PDF–5.1M

Select item 108523437.

Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice

Emily E. Whitaker, Neal E. Mecum, Riley C. Cott, Diana J. Goode

PLoS One. 2024; 19(2): e0298396. Published online 2024 Feb 8. doi: 10.1371/journal.pone.0298396

PMCID:: PMC10852343

Abstract Article PDF–4.5M

Select item 108367698.

NLGN4X TCR transgenic T cells to treat gliomas

Christoper Krämer, Michael Kilian, Yu-Chan Chih, Alexandros Kourtesakis, Dirk C Hoffmann, Tamara Boschert, Philipp Koopmann, Khwab Sanghvi, Alice De Roia, Stefanie Jung, Kristine Jähne, Bryan Day, Lenny D Shultz, Miriam Ratliff, Richard Harbottle, Edward W Green, Rainer Will, Wolfgang Wick, Michael Platten, Lukas Bunse

Neuro Oncol. 2024 Feb; 26(2): 266–278. Published online 2023 Sep 16. doi: 10.1093/neuonc/noad172

PMCID:: PMC10836769

Abstract Article PDF–3.4M

Select item 107621549.

MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation

Wenna Chi, Na Kang, Linlin Sheng, Sichen Liu, Lei Tao, Xizhi Cao, Ye Liu, Can Zhu, Yuming Zhang, Bolong Wu, Ruiqun Chen, Lili Cheng, Jing Wang, Xiaolin Sun, Xiaohui Liu, Haiteng Deng, Jinliang Yang, Zhanguo Li, Wanli Liu, Ligong Chen

Nat Commun. 2024; 15: 163. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44540-0

PMCID:: PMC10762154

Abstract Article PDF–3.1M

Select item 1064539010.

Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer

Peter Zanvit, Dewald van Dyk, Christine Fazenbaker, Kelly McGlinchey, Weichuan Luo, Jessica M. Pezold, John Meekin, Chien-ying Chang, Rosa A. Carrasco, Shannon Breen, Crystal Sao-Fong Cheung, Ariel Endlich-Frazier, Benjamin Clark, Nina J. Chu, Alessio Vantellini, Philip L. Martin, Clare E. Hoover, Kenesha Riley, Steve M. Sweet, David Chain, Yeoun Jin Kim, Eric Tu, Nathalie Harder, Sandrina Phipps, Melissa Damschroder, Ryan N. Gilbreth, Mark Cobbold, Gordon Moody, Emily E. Bosco

J Clin Invest. 2023 Nov 15; 133(22): e169655. Published online 2023 Nov 15. doi: 10.1172/JCI169655

PMCID:: PMC10645390

Abstract Article PDF–2.6M

Select item 1064295111.

Multimodal control of dendritic cell functions by nociceptors

Pavel Hanč, Rodrigo J. Gonzalez, Irina B. Mazo, Yidi Wang, Talley Lambert, Gloria Ortiz, Evan W. Miller, Ulrich H. von Andrian

Science. Author manuscript; available in PMC 2023 Nov 13.

Published in final edited form as: Science. 2023 Mar 31; 379(6639): eabm5658. Published online 2023 Mar 31. doi: 10.1126/science.abm5658

PMCID:: PMC10642951

Abstract Article PDF–2.7M

Select item 1062358112.

I-A^g7 β56/57 polymorphisms regulate non-cognate negative selection to CD4 T cell orchestrators of type-1 diabetes

Brian D. Stadinski, Sarah B. Cleveland, Michael A. Brehm, Dale L. Greiner, Priya G. Huseby, Eric S. Huseby

Nat Immunol. Author manuscript; available in PMC 2023 Nov 3.

Published in final edited form as: Nat Immunol. 2023 Apr; 24(4): 652–663. Published online 2023 Feb 20. doi: 10.1038/s41590-023-01441-0

PMCID:: PMC10623581

Abstract Article PDF–4.1M

Select item 1061589413.

Segmented filamentous bacteria–induced epithelial MHCII regulates cognate CD4⁺ IELs and epithelial turnover

Tomáš Brabec, Martin Schwarzer, Katarína Kováčová, Martina Dobešová, Dagmar Schierová, Jiří Březina, Iva Pacáková, Dagmar Šrůtková, Osher Ben-Nun, Yael Goldfarb, Iva Šplíchalová, Michal Kolář, Jakub Abramson, Dominik Filipp, Jan Dobeš

J Exp Med. 2024 Jan 1; 221(1): e20230194. Published online 2023 Oct 30. doi: 10.1084/jem.20230194

Correction in:: J Exp Med. 2024 Jan 1; 221(1): e2023019411132023c.

PMCID:: PMC10615894

Abstract Article PDF–7.7M

Select item 1053878714.

Interactions between B cells and T follicular regulatory cells enhance susceptibility to Brucella infection independent of the anti-Brucella humoral response

Alexis S. Dadelahi, Mostafa F. N. Abushahba, Bárbara Ponzilacqua-Silva, Catherine A. Chambers, Charles R. Moley, Carolyn A. Lacey, Alexander L. Dent, Jerod A. Skyberg

PLoS Pathog. 2023 Sep; 19(9): e1011672. Published online 2023 Sep 18. doi: 10.1371/journal.ppat.1011672

PMCID:: PMC10538787

Abstract Article PDF–2.7M

Select item 1053037215.

Intestinal Microbiota Controls Graft-versus-Host Disease Independent of Donor-Host Genetic Disparity

Motoko Koyama, Daniel S Hippe, Sujatha Srinivasan, Sean C Proll, Oriana Miltiadous, Naisi Li, Ping Zhang, Kathleen S Ensbey, Noah G Hoffman, Christine R Schmidt, Albert C Yeh, Simone A Minnie, Susan M Strenk, Tina L Fiedler, Namita Hattangady, Jacob Kowalsky, Willian M Grady, Mariapia A Degli-Esposti, Antiopi Varelias, Andrew D Clouston, Marcel R M van den Brink, Neelendu Dey, Timothy W Randolph, Kate A Markey, David N Fredricks, Geoffrey R Hill

Immunity. Author manuscript; available in PMC 2024 Aug 8.

Published in final edited form as: Immunity. 2023 Aug 8; 56(8): 1876–1893.e8. Published online 2023 Jul 21. doi: 10.1016/j.immuni.2023.06.024

PMCID:: PMC10530372

Abstract Article PDF–1.7M

Select item 1047627916.

Gut microbiota regulates blood‐cerebrospinal fluid barrier function and Aβ pathology

Junhua Xie, Arnout Bruggeman, Clint De Nolf, Charysse Vandendriessche, Griet Van Imschoot, Elien Van Wonterghem, Lars Vereecke, Roosmarijn E Vandenbroucke

EMBO J. 2023 Sep; 42(17): e111515. Published online 2023 Jul 10. doi: 10.15252/embj.2022111515

PMCID:: PMC10476279

Abstract Article PDF–20M

Select item 1039867117.

Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice

Ruben Gomez‐Gutierrez, Ujjayini Ghosh, Wai‐Ming Yau, Nazaret Gamez, Katherine Do, Carlos Kramm, Hamid Shirani, Laura Vegas‐Gomez, Jonathan Schulz, Ines Moreno‐Gonzalez, Antonia Gutierrez, K Peter R Nilsson, Robert Tycko, Claudio Soto, Rodrigo Morales

EMBO Rep. 2023 Aug; 24(8): e57003. Published online 2023 Jul 10. doi: 10.15252/embr.202357003

PMCID:: PMC10398671

Abstract Article PDF–4.4M

Select item 1038774118.

Impaired regulatory function of granzyme B-producing B cells against T cell inflammatory responses in lupus mice

Jimeng Xue, Liling Xu, Hua Zhong, Mingxin Bai, Xin Li, Ranran Yao, Ziye Wang, Zhen Zhao, Hongchao Li, Huaqun Zhu, Fanlei Hu, Yin Su

Lupus Sci Med. 2023; 10(2): e000974. Published online 2023 Jul 27. doi: 10.1136/lupus-2023-000974

PMCID:: PMC10387741

Abstract Article PDF–2.4M

Select item 1029321419.

Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease

A. M. Schonhoff, D. A. Figge, G. P. Williams, A. Jurkuvenaite, N. J. Gallups, G. M. Childers, J. M. Webster, D. G. Standaert, J. E. Goldman, A. S. Harms

Nat Commun. 2023; 14: 3754. Published online 2023 Jun 26. doi: 10.1038/s41467-023-39060-w

PMCID:: PMC10293214

Abstract Article PDF–11M

Select item 1028107620.

T helper 1 effector memory CD4⁺ T cells protect the skin from poxvirus infection

Jake C. Harbour, Mahmoud Abdelbary, John B. Schell, Samantha P. Fancher, Jack J. McLean, Taylen J. Nappi, Susan Liu, Timothy J. Nice, Zheng Xia, Klaus Früh, Jeffrey C. Nolz

Cell Rep. Author manuscript; available in PMC 2023 Jun 20.

Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112407. Published online 2023 Apr 21. doi: 10.1016/j.celrep.2023.112407

PMCID:: PMC10281076

Abstract Article PDF–3.6M

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