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Items: 1 to 20 of 46

1.
Familial chylomicronemia syndrome: case reports of siblings with deletions of the GPIHBP1 gene
Ka Young Kim, You Joung Heo, Jung Min Ko, Young Ah Lee, Choong Ho Shin, Chang Seok Ki, Yun Jeong Lee
BMC Endocr Disord. 2024; 24: 47. Published online 2024 Apr 15. doi: 10.1186/s12902-024-01574-9
PMCID:
PMC11017581
AbstractArticlePDF–1.1M
2.
The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing
Wenxin Song, Anne P. Beigneux, Thomas A. Weston, Kai Chen, Ye Yang, Le Phuong Nguyen, Paul Guagliardo, Hyesoo Jung, Anh P. Tran, Yiping Tu, Caitlyn Tran, Gabriel Birrane, Kazuya Miyashita, Katsuyuki Nakajima, Masami Murakami, Peter Tontonoz, Haibo Jiang, Michael Ploug, Loren G. Fong, Stephen G. Young
Proc Natl Acad Sci U S A. 2023 Oct 31; 120(44): e2313825120. Published online 2023 Oct 23. doi: 10.1073/pnas.2313825120
PMCID:
PMC10623010
AbstractArticlePDF–5.3M
3.
A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism
Stephen G. Young, Wenxin Song, Ye Yang, Gabriel Birrane, Haibo Jiang, Anne P. Beigneux, Michael Ploug, Loren G. Fong
Proc Natl Acad Sci U S A. 2022 Sep 6; 119(36): e2211136119. Published online 2022 Aug 29. doi: 10.1073/pnas.2211136119
PMCID:
PMC9457329
AbstractArticlePDF–1.9M
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
Chylomicronemia from GPIHBP1 autoantibodies
Kazuya Miyashita, Jens Lutz, Lisa C. Hudgins, Dana Toib, Ambika P. Ashraf, Wenxin Song, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
J Lipid Res. 2020 Nov; 61(11): 1365–1376. Published online 2020 Sep 18. doi: 10.1194/jlr.R120001116
PMCID:
PMC7604722
AbstractArticlePDF–1.5M
6.
Regulation of lipoprotein lipase-mediated lipolysis of triglycerides
Debapriya Basu, Ira J. Goldberg
Curr Opin Lipidol. Author manuscript; available in PMC 2020 Sep 8.
Published in final edited form as: Curr Opin Lipidol. 2020 Jun; 31(3): 154–160. doi: 10.1097/MOL.0000000000000676
PMCID:
PMC7478854
AbstractArticlePDF–306K
7.
A lipoprotein lipase–GPI-anchored high-density lipoprotein–binding protein 1 fusion lowers triglycerides in mice: Implications for managing familial chylomicronemia syndrome
Amitabh V. Nimonkar, Stephen Weldon, Kevin Godbout, Darrell Panza, Susan Hanrahan, Rose Cubbon, Fangmin Xu, John W. Trauger, Jiaping Gao, Andrei Voznesensky
J Biol Chem. 2020 Mar 6; 295(10): 2900–2912. Published online 2019 Oct 23. doi: 10.1074/jbc.RA119.011079
PMCID:
PMC7062184
AbstractArticlePDF–2.9M
8.
GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients
Xuchen Hu, Ken Matsumoto, Rachel S Jung, Thomas A Weston, Patrick J Heizer, Cuiwen He, Norma P Sandoval, Christopher M Allan, Yiping Tu, Harry V Vinters, Linda M Liau, Rochelle M Ellison, Jazmin E Morales, Lynn J Baufeld, Nicholas A Bayley, Liqun He, Christer Betsholtz, Anne P Beigneux, David A Nathanson, Holger Gerhardt, Stephen G Young, Loren G Fong, Haibo Jiang
eLife. 2019; 8: e47178. Published online 2019 Jun 6. doi: 10.7554/eLife.47178
PMCID:
PMC6594755
AbstractArticlePDF–13M
9.
Structure of lipoprotein lipase in complex with GPIHBP1
Rishi Arora, Amitabh V. Nimonkar, Daniel Baird, Chunhua Wang, Chun-Hao Chiu, Patricia A. Horton, Susan Hanrahan, Rose Cubbon, Stephen Weldon, William R. Tschantz, Sascha Mueller, Reto Brunner, Philipp Lehr, Peter Meier, Johannes Ottl, Andrei Voznesensky, Pramod Pandey, Thomas M. Smith, Aleksandar Stojanovic, Alec Flyer, Timothy E. Benson, Michael J. Romanowski, John W. Trauger
Proc Natl Acad Sci U S A. 2019 May 21; 116(21): 10360–10365. Published online 2019 May 9. doi: 10.1073/pnas.1820171116
PMCID:
PMC6534989
AbstractArticlePDF–1.4M
10.
An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner
Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Jazmin E. Morales, Eniko Sajti, Ty D. Troutman, Thomas L. Saunders, Darren A. Cusanovich, Anne P. Beigneux, Casey E. Romanoski, Loren G. Fong, Stephen G. Young
J Lipid Res. 2019 Apr; 60(4): 869–879. Published online 2018 Dec 31. doi: 10.1194/jlr.M091322
PMCID:
PMC6446700
AbstractArticlePDF–2.2M
11.
Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis
Gabriel Birrane, Anne P. Beigneux, Brian Dwyer, Bettina Strack-Logue, Kristian Kølby Kristensen, Omar L. Francone, Loren G. Fong, Haydyn D. T. Mertens, Clark Q. Pan, Michael Ploug, Stephen G. Young, Muthuraman Meiyappan
Proc Natl Acad Sci U S A. 2019 Jan 29; 116(5): 1723–1732. Published online 2018 Dec 17. doi: 10.1073/pnas.1817984116
PMCID:
PMC6358717
AbstractArticlePDF–2.3M
12.
Decreased GPIHBP1 protein levels in visceral adipose tissue partly underlie the hypertriglyceridemic phenotype in insulin resistance
R. Preethi Surendran, Shanti D. Udayyapan, Mercedes Clemente-Postigo, Stefan R. Havik, Alinda W. M. Schimmel, Fransisco Tinahones, Max Nieuwdorp, Geesje M. Dallinga-Thie
PLoS One. 2018; 13(11): e0205858. Published online 2018 Nov 8. doi: 10.1371/journal.pone.0205858
PMCID:
PMC6224034
AbstractArticlePDF–1.5M
13.
A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase
Kristian K. Kristensen, Søren Roi Midtgaard, Simon Mysling, Oleg Kovrov, Lars Bo Hansen, Nicholas Skar-Gislinge, Anne P. Beigneux, Birthe B. Kragelund, Gunilla Olivecrona, Stephen G. Young, Thomas J. D. Jørgensen, Loren G. Fong, Michael Ploug
Proc Natl Acad Sci U S A. 2018 Jun 26; 115(26): E6020–E6029. Published online 2018 Jun 13. doi: 10.1073/pnas.1806774115
PMCID:
PMC6042107
AbstractArticlePDF–2.0M
14.
Biochemical Analysis of the LPL Truncation Variant, LPLS447X Reveals Increased Lipoprotein Uptake
Cassandra K. Hayne, Michael J. Lafferty, Brian J. Eglinger, John P. Kane, Saskia B. Neher
Biochemistry. Author manuscript; available in PMC 2018 Mar 13.
Published in final edited form as: Biochemistry. 2017 Jan 24; 56(3): 525–533. Published online 2017 Jan 9. doi: 10.1021/acs.biochem.6b00945
PMCID:
PMC5848218
AbstractArticlePDF–1.9M
15.
Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL
Mikael Larsson, Christopher M. Allan, Rachel S. Jung, Patrick J. Heizer, Anne P. Beigneux, Stephen G. Young, Loren G. Fong
J Lipid Res. 2017 Sep; 58(9): 1893–1902. Published online 2017 Jul 10. doi: 10.1194/jlr.M078220
PMCID:
PMC5580902
AbstractArticlePDF–1013K
16.
GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia
Xuchen Hu, Geesje M. Dallinga-Thie, G. Kees Hovingh, Sandy Y. Chang, Norma P. Sandoval, Tiffany Ly P. Dang, Isamu Fukamachi, Kazuya Miyashita, Katsuyuki Nakajima, Masami Murakami, Loren G. Fong, Michael Ploug, Stephen G. Young, Anne P. Beigneux
J Clin Lipidol. Author manuscript; available in PMC 2018 Jul 1.
Published in final edited form as: J Clin Lipidol. 2017 Jul-Aug; 11(4): 964–971. Published online 2017 Jun 13. doi: 10.1016/j.jacl.2017.05.017
PMCID:
PMC5568906
AbstractArticlePDF–647K
17.
Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding
Christopher M. Allan, Cris J. Jung, Mikael Larsson, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Tiffany Ly P. Dang, Rachel S. Jung, Anne P. Beigneux, Pieter J. de Jong, Loren G. Fong, Stephen G. Young
J Lipid Res. 2017 Jul; 58(7): 1453–1461. Published online 2017 May 5. doi: 10.1194/jlr.M076943
PMCID:
PMC5496041
AbstractArticlePDF–1.7M
18.
Genetics of Triglycerides and the Risk of Atherosclerosis
Jacqueline S. Dron, Robert A. Hegele
Curr Atheroscler Rep. 2017; 19(7): 31. Published online 2017 May 23. doi: 10.1007/s11883-017-0667-9
PMCID:
PMC5440481
AbstractArticlePDF–353K
19.
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL
Xuchen Hu, Mark W. Sleeman, Kazuya Miyashita, MacRae F. Linton, Christopher M. Allan, Cuiwen He, Mikael Larsson, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Alaleh Mapar, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
J Lipid Res. 2017 Jan; 58(1): 208–215. Published online 2016 Dec 29. doi: 10.1194/jlr.M072462
PMCID:
PMC5234723
AbstractArticlePDF–1.5M
20.
The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding
Simon Mysling, Kristian Kølby Kristensen, Mikael Larsson, Oleg Kovrov, André Bensadouen, Thomas JD Jørgensen, Gunilla Olivecrona, Stephen G Young, Michael Ploug
eLife. 2016; 5: e20958. Published online 2016 Dec 8. doi: 10.7554/eLife.20958
PMCID:
PMC5148603
AbstractArticlePDF–2.5M

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