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Select item 112099351.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111366832.

The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory

MAHER KURDI, ALAA ALKHOTANI, ABDULRAHMAN SABBAGH, EYAD FAIZO, AHMED I. LARY, AHMED K. BAMAGA, MAJID ALMANSOURI, BADR HAFIZ, THAMER ALSHARIF, SALEH BAEESA

Oncol Res. 2024; 32(6): 1037–1045. Published online 2024 May 23. doi: 10.32604/or.2024.051112

PMCID:: PMC11136683

Abstract Article PDF–3.0M

Select item 111094833.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 111016264.

PRMT5-mediated methylation of STAT3 is required for lung cancer stem cell maintenance and tumour growth

Yoshinori Abe, Takumi Sano, Naoki Otsuka, Masashi Ogawa, Nobuyuki Tanaka

Commun Biol. 2024; 7: 593. Published online 2024 May 17. doi: 10.1038/s42003-024-06290-7

PMCID:: PMC11101626

Abstract Article PDF–1.4M

Select item 110932125.

SMYD4 monomethylates PRMT5 and forms a positive feedback loop to promote hepatocellular carcinoma progression

Zhenyu Zhou, Zheng Chen, Qianlei Zhou, Shiyu Meng, Juanyi Shi, Sintim Mui, Hai Jiang, Jianhong Lin, Gui He, Wenbin Li, Jianlong Zhang, Jie Wang, Chuanchao He, Yongcong Yan, Zhiyu Xiao

Cancer Sci. 2024 May; 115(5): 1587–1601. Published online 2024 Mar 4. doi: 10.1111/cas.16139

PMCID:: PMC11093212

Abstract Article PDF–68M

Select item 110871096.

Identification of protein methyltransferases 5 associated with ferroptosis and immune cell infiltration of head and neck squamous cell carcinoma

Xiaoyue Zhang, Qiang Liu, Lujuan Wang, Qiu Peng

Aging (Albany NY) 2024 Apr 30; 16(8): 7426–7436. Published online 2024 Apr 25. doi: 10.18632/aging.205768

PMCID:: PMC11087109

Abstract Article PDF–2.6M

Select item 110720217.

PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As₂O₃ by stabilizing oncoprotein PML-RARα

Xinping Huang, Yongfeng Yang, Dan Zhu, Yan Zhao, Min Wei, Ke Li, Hong-hu Zhu, Xiaofeng Zheng

Cell Mol Life Sci. 2022 Jun; 79(6): 319. Published online 2022 May 27. doi: 10.1007/s00018-022-04358-3

PMCID:: PMC11072021

Abstract Article PDF–9.5M

Select item 110204948.

CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA

Yunlu Liu, Hongyan Jiang, Keli Hu, Hui Zou, Weiguo Zhang, Jiangtao Liu, Xiaofei Jian

PLoS One. 2024; 19(4): e0298947. Published online 2024 Apr 16. doi: 10.1371/journal.pone.0298947

PMCID:: PMC11020494

Abstract Article PDF–4.3M

Select item 109321509.

Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2^low Adult T-Cell Leukemia/Lymphoma

Tomonaga Ichikawa, Akira Suekane, Shingo Nakahata, Hidekatsu Iha, Kazuya Shimoda, Takashi Murakami, Kazuhiro Morishita

Int J Mol Sci. 2024 Mar; 25(5): 2842. Published online 2024 Feb 29. doi: 10.3390/ijms25052842

PMCID:: PMC10932150

Abstract Article PDF–3.7M

Select item 1089748910.

The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions

Dimitriya H Garvanska, R Elias Alvarado, Filip Oskar Mundt, Richard Lindqvist, Josephine Kerzel Duel, Fabian Coscia, Emma Nilsson, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante, Dorothea R Morris, Michelle N Vu, Leah K Estes, Alyssa M McLeland, Jordyn Walker, Patricia A Crocquet-Valdes, Blanca Lopez Mendez, Kenneth S Plante, David H Walker, Melanie Bianca Weisser, Anna K Överby, Matthias Mann, Vineet D Menachery, Jakob Nilsson

EMBO Rep. 2024 Feb; 25(2): 902–926. Published online 2024 Jan 2. doi: 10.1038/s44319-023-00043-z

PMCID:: PMC10897489

Abstract Article PDF–8.2M

Select item 1071672211.

PRMT5 participates in B cell overactivation in patients with primary Sjogren's syndrome (pSS) through RSAD2‐mediated NF‐κB signaling

Hong Zhu, Jian Zheng, Yan Zhou, Tong Wu, Tiantian Zhu

Immun Inflamm Dis. 2023 Dec; 11(12): e1102. Published online 2023 Dec 13. doi: 10.1002/iid3.1102

PMCID:: PMC10716722

Abstract Article PDF–2.0M

Select item 1069046812.

MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression

Yan Sun, Xin Jin, Junpeng Meng, Feng Guo, Taoyu Chen, Xiaoyan Zhao, Heshui Wu, Dianyun Ren

EMBO J. 2023 Dec; 42(23): e114558. Published online 2023 Oct 31. doi: 10.15252/embj.2023114558

PMCID:: PMC10690468

Abstract Article PDF–17M

Select item 1062148313.

Antitumor Effects of PRMT5 Inhibition in Sarcomas

Stéphanie Verbeke, Aurélien Bourdon, Jean-Philippe Guegan, Laura Leroy, Vanessa Chaire, Elodie Richard, Alban Bessede, Antoine Italiano

Cancer Res Commun. 2023 Nov; 3(11): 2211–2220. Published online 2023 Nov 2. doi: 10.1158/2767-9764.CRC-23-0239

PMCID:: PMC10621483

Abstract Article PDF–7.1M

Select item 1057891514.

Epigenetic regulation of vascular smooth muscle cell phenotypic switch and neointimal formation by PRMT5

Ni Zhu, Zhi-Fu Guo, Kyosuke Kazama, Bing Yi, Nopprarat Tongmuang, Huijuan Yao, Ruifeng Yang, Chen Zhang, Yongwen Qin, Lin Han, Jianxin Sun

Cardiovasc Res. 2023 Aug; 119(12): 2244–2255. Published online 2023 Jul 24. doi: 10.1093/cvr/cvad110

PMCID:: PMC10578915

Abstract Article PDF–1.2M

Select item 1051721515.

PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma

Shelby L. Sloan, Fiona Brown, Mackenzie Long, Christoph Weigel, Shirsha Koirala, Ji-Hyun Chung, Betsy Pray, Lynda Villagomez, Claire Hinterschied, Anuvrat Sircar, JoBeth Helmig-Mason, Alexander Prouty, Eric Brooks, Youssef Youssef, Walter Hanel, Samir Parekh, Wing Keung Chan, Zhengming Chen, Rosa Lapalombella, Lalit Sehgal, Kris Vaddi, Peggy Scherle, Selina Chen-Kiang, Maurizio Di Liberto, Olivier Elemento, Cem Meydan, Jonathan Foox, Daniel Butler, Christopher E. Mason, Robert A. Baiocchi, Lapo Alinari

Blood. 2023 Sep 7; 142(10): 887–902. Published online 2023 Jun 5. doi: 10.1182/blood.2022019419

PMCID:: PMC10517215

Abstract Article

Select item 1050265716.

MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis

Debao Fang, Hao Hu, Kailiang Zhao, Aman Xu, Changjun Yu, Yong Zhu, Ning Yu, Bo Yao, Suyun Tang, Xianning Wu, Yide Mei

Adv Sci (Weinh) 2023 Sep; 10(26): 2303336. Published online 2023 Jul 12. doi: 10.1002/advs.202303336

PMCID:: PMC10502657

Abstract Article PDF–3.4M

Select item 1046961217.

High-sensitivity profiling of SARS-CoV-2 noncoding region–host protein interactome reveals the potential regulatory role of negative-sense viral RNA

Liuyiqi Jiang, Mu Xiao, Qing-Qing Liao, Luqian Zheng, Chunyan Li, Yuemei Liu, Bing Yang, Aiming Ren, Chao Jiang, Xin-Hua Feng

mSystems. 2023 Jul-Aug; 8(4): e00135-23. Published online 2023 Jun 14. doi: 10.1128/msystems.00135-23

PMCID:: PMC10469612

Abstract Article PDF–4.0M

Select item 1040088418.

PRMT5 triggers glucocorticoid-induced cell migration in triple-negative breast cancer

Lara Malik Noureddine, Julien Ablain, Ausra Surmieliova-Garnès, Julien Jacquemetton, Thuy Ha Pham, Elisabetta Marangoni, Anne Schnitzler, Ivan Bieche, Bassam Badran, Olivier Trédan, Nader Hussein, Muriel Le Romancer, Coralie Poulard

Life Sci Alliance. 2023 Oct; 6(10): e202302009. Published online 2023 Aug 3. doi: 10.26508/lsa.202302009

PMCID:: PMC10400884

Abstract Article PDF–3.5M

Select item 1039866019.

C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains

Julia Jülg, Dieter Edbauer, Christian Behrends

EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895

PMCID:: PMC10398660

Abstract Article PDF–2.4M

Select item 1037397920.

PRMT5 facilitates angiogenesis and EMT via HIF-1α/VEGFR/Akt signaling axis in lung cancer

Yonghua Zheng, Huaxia Ji, Wulin Yi, Zhanjun Chen, Xiaobiao Hu, Jie Zhou, Yang Wang, Xiao Zheng

Aging (Albany NY) 2023 Jul 15; 15(13): 6163–6178. Published online 2023 Jul 3. doi: 10.18632/aging.204826

PMCID:: PMC10373979

Abstract Article PDF–1.6M

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