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Items: 1 to 20 of 84

1.
TNF-ɑ induces mitochondrial dysfunction to drive NLRP3/Caspase-1/GSDMD-mediated pyroptosis in MCF-7 cells
Kexin Gao, Yancui Liu, Cheng Sun, Ying Wang, Hongrong Bao, Guoyang Liu, Jinrui Ou, Ping Sun
Sci Rep. 2024; 14: 25880. Published online 2024 Oct 29. doi: 10.1038/s41598-024-76997-4
PMCID:
PMC11519391
AbstractArticlePDF–2.5M
2.
Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion
Wen Chen, Shuangfeng Chen, Chenghua Yan, Yaguang Zhang, Ronghua Zhang, Min Chen, Shufen Zhong, Weiguo Fan, Songling Zhu, Danyan Zhang, Xiao Lu, Jia Zhang, Yuying Huang, Lin Zhu, Xuezhen Li, Dawei Lv, Yadong Fu, Houkun Iv, Zhiyang Ling, Liyan Ma, Hai Jiang, Gang Long, Jinfang Zhu, Dong Wu, Bin Wu, Bing Sun
Nat Immunol. Author manuscript; available in PMC 2024 Aug 26.
Published in final edited form as: Nat Immunol. 2022 Jul; 23(7): 1021–1030. Published online 2022 Jul 6. doi: 10.1038/s41590-022-01255-6
PMCID:
PMC11345751
AbstractArticlePDF–4.7M
3.
Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis
Fangyuan Chen, Shuyu Li, Min Liu, Cheng Qian, Zhiyin Shang, Xu Song, Wei Jiang, Chuantao Tu
Cell Mol Life Sci. 2024 Dec; 81(1): 295. Published online 2024 Jul 9. doi: 10.1007/s00018-024-05328-7
PMCID:
PMC11335218
AbstractArticlePDF–3.0M
4.
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D
Gang Du, Liam B. Healy, Liron David, Caitlin Walker, Tarick J. El-Baba, Corinne A. Lutomski, Byoungsook Goh, Bowen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R. Luo, Jonathan C. Kagan, Sungwhan F. Oh, Carol V. Robinson, Judy Lieberman, Hao Wu
Nature. Author manuscript; available in PMC 2024 Dec 1.
Published in final edited form as: Nature. 2024 Jun; 630(8016): 437–446. Published online 2024 Apr 10. doi: 10.1038/s41586-024-07373-5
PMCID:
PMC11283288
AbstractArticlePDF–7.9M
5.
Gut microbiota-mediated activation of GSDMD ignites colorectal tumorigenesis
Ju Chen, Neha Singh, Xiaoyang Ye, Eileen Victoria Theune, Kepeng Wang
Cancer Gene Ther. 2024; 31(7): 1007–1017. Published online 2024 Jun 19. doi: 10.1038/s41417-024-00796-2
PMCID:
PMC11257976
AbstractArticlePDF–3.9M
6.
P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis
Lei Chen, Yi Liu, Shaoyu Yue, Hui Wang, Jia Chen, Wenming Ma, Wenlong Xu, Muyang Xu, Ziqi Chen, Xianguo Chen, Li Zhang, Chaozhao Liang
Int J Biol Sci. 2024; 20(9): 3393–3411. Published online 2024 Jun 11. doi: 10.7150/ijbs.94704
PMCID:
PMC11234205
AbstractArticlePDF–15M
7.
Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis
Jiani Shen, Feng Li, Xu Han, Dongying Fu, Yiping Xu, Changjian Zhu, Zhou Liang, Ziwen Tang, Ruilin Zheng, Xinrong Hu, Ruoni Lin, Qiaoqiao Pei, Jing Nie, Ning Luo, Xiaoyan Li, Wei Chen, Haiping Mao, Yi Zhou, Xueqing Yu
Cell Commun Signal. 2024; 22: 308. Published online 2024 Jun 3. doi: 10.1186/s12964-024-01681-z
PMCID:
PMC11149269
AbstractArticlePDF–10M
8.
Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis
Xing-Nian Zhou, Quan Zhang, Hong Peng, Yu-Jie Qin, Yu-Hong Liu, Lu Wang, Ming-Liang Cheng, Xin-Hua Luo, Hong Li
World J Gastroenterol. 2024 Mar 21; 30(11): 1588–1608. Published online 2024 Mar 21. doi: 10.3748/wjg.v30.i11.1588
PMCID:
PMC11008418
AbstractArticlePDF–18M
9.
TR4 worsen urosepsis by regulating GSDMD
Huan Wang, Shibin Zhu, Zhenwei Zhou, Zhenghui Wang, Wei Zhuang, Dingwei Xue, Zeyi Lu, Qiming Zheng, Lifeng Ding, Liangliang Ren, Wenqing Luo, Ruyue Wang, Guangju Ge, Liqun Xia, Gonghui Li, Haiyang Wu
Eur J Med Res. 2024; 29: 151. Published online 2024 Mar 1. doi: 10.1186/s40001-024-01742-6
PMCID:
PMC10908015
AbstractArticlePDF–6.5M
10.
Structural insights into cytokine cleavage by inflammatory caspase-4
Pascal Devant, Ying Dong, Julian Mintseris, Weiyi Ma, Steven P. Gygi, Hao Wu, Jonathan C. Kagan
Nature. Author manuscript; available in PMC 2024 Jun 1.
Published in final edited form as: Nature. 2023 Dec; 624(7991): 451–459. Published online 2023 Nov 22. doi: 10.1038/s41586-023-06751-9
Correction in:
Nature. 2024 Jan 3
PMCID:
PMC10807405
AbstractArticlePDF–6.9M
11.
GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis
Yi Zhong, Taoyuan Huang, Xiaoli Li, Peiyi Luo, Bingjun Zhang
PeerJ. 2024; 12: e16768. Published online 2024 Jan 16. doi: 10.7717/peerj.16768
PMCID:
PMC10798152
AbstractArticlePDF–19M
12.
O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
Fan Yu, Zhen Zhang, Yiping Leng, Alex F. Chen
Inflamm Res. 2024; 73(1): 5–17. Published online 2023 Nov 14. doi: 10.1007/s00011-023-01812-1
PMCID:
PMC10776498
AbstractArticlePDF–1.7M
13.
Pyroptosis inhibiting nanobodies block Gasdermin D pore formation
Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking, Lisa D. J. Schiffelers, Florian I. Schmidt, Matthias Geyer
Nat Commun. 2023; 14: 7923. Published online 2023 Dec 1. doi: 10.1038/s41467-023-43707-z
PMCID:
PMC10692205
AbstractArticlePDF–2.7M
14.
System analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma
Shixin Zhao, Yongkang Zhu, Hengdeng Liu, Xuefeng He, Julin Xie
J Transl Med. 2023; 21: 801. Published online 2023 Nov 10. doi: 10.1186/s12967-023-04513-9
PMCID:
PMC10636830
AbstractArticlePDF–9.8M
15.
Expression and significance of effector proteins NLRP3 and gasdermin D N-terminal protein in the pyrolysis pathway in breast cancer
Ligao Wu, Xia Wu, Jinjie Liu, Yuanli Huang, Qing Zhu
Medicine (Baltimore) 2023 Oct 6; 102(40): e35440. Published online 2023 Oct 6. doi: 10.1097/MD.0000000000035440
PMCID:
PMC10552993
AbstractArticlePDF–683K
16.
Gasdermin D (GSDMD) Is Upregulated in Psoriatic Skin—A New Potential Link in the Pathogenesis of Psoriasis
Julia Nowowiejska, Anna Baran, Justyna Magdalena Hermanowicz, Anna Pryczynicz, Beata Sieklucka, Dariusz Pawlak, Iwona Flisiak
Int J Mol Sci. 2023 Sep; 24(17): 13047. Published online 2023 Aug 22. doi: 10.3390/ijms241713047
PMCID:
PMC10488204
AbstractArticlePDF–4.0M
17.
Gasdermin D Plays an Oncogenic Role in Glioma and Correlates to an Immunosuppressive Microenvironment
Mengyuan Li, Ping Jiang, Shuhua Wei, Yuhan Yang, Liting Xiong, Junjie Wang, Chunxiao Li
Biomolecules. 2023 Jun; 13(6): 904. Published online 2023 May 29. doi: 10.3390/biom13060904
PMCID:
PMC10295969
AbstractArticlePDF–11M
18.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
19.
Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors
Zhen Dai, Wan-Cong Liu, Xiao-Yi Chen, Xiao Wang, Jun-Long Li, Xiang Zhang
Front Immunol. 2023; 14: 1178662. Published online 2023 May 18. doi: 10.3389/fimmu.2023.1178662
PMCID:
PMC10232970
AbstractArticlePDF–2.3M
20.
Copy number variation of gasdermin D gene is associated with atrial fibrillation-related thromboembolic stroke
Pang-Shuo Huang, Jen-Fang Cheng, Guan-Wei Li, Eric Y Chuang, Jien-Jiun Chen, Fu-Chun Chiu, Cho-Kai Wu, Yi-Chih Wang, Juey-Jen Hwang, Chia-Ti Tsai
Europace. 2023 May; 25(5): euad103. Published online 2023 Apr 21. doi: 10.1093/europace/euad103
PMCID:
PMC10228625
AbstractArticlePDF–355K

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