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Select item 113219651.

Identification and validation of tryptophan-related gene signatures to predict prognosis and immunotherapy response in lung adenocarcinoma reveals a critical role for PTTG1

Ziqiang Wang, Jing Zhang, Chao Zuo, Huili Chen, Luyao Wang, Yiluo Xie, Hongyu Ma, Shengping Min, Xiaojing Wang, Chaoqun Lian

Front Immunol. 2024; 15: 1386427. Published online 2024 Jul 31. doi: 10.3389/fimmu.2024.1386427

PMCID:: PMC11321965

Abstract Article PDF–22M

Select item 107070542.

SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma

Emanuela Teveroni, Fiorella Di Nicuolo, Edoardo Vergani, Alessandro Oliva, Emanuele Pierpaolo Vodola, Giada Bianchetti, Giuseppe Maulucci, Marco De Spirito, Tonia Cenci, Francesco Pierconti, Gaetano Gulino, Federica Iavarone, Andrea Urbani, Domenico Milardi, Alfredo Pontecorvi, Francesca Mancini

Int J Mol Sci. 2023 Dec; 24(23): 16891. Published online 2023 Nov 29. doi: 10.3390/ijms242316891

PMCID:: PMC10707054

Abstract Article PDF–2.9M

Select item 104258423.

Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5

Zuzana Hodáková, Irina Grishkovskaya, Hanna L Brunner, Derek L Bolhuis, Katarina Belačić, Alexander Schleiffer, Harald Kotisch, Nicholas G Brown, David Haselbach

EMBO J. 2023 Aug; 42(16): e113348. Published online 2023 Jul 6. doi: 10.15252/embj.2022113348

PMCID:: PMC10425842

Abstract Article PDF–3.0M

Select item 101976074.

Molecular mechanisms for activation of the 26S proteasome

Donghoon Lee, Yanan Zhu, Louis Colson, Xiaorong Wang, Siyi Chen, Emre Tkacik, Lan Huang, Qi Ouyang, Alfred L. Goldberg, Ying Lu

Version 1. bioRxiv. Preprint. 2023 May 10. doi: 10.1101/2023.05.09.540094

Published in:: Mol Cell. 2023 Aug 17; 83(16): 2959–2975.e7.

PMCID:: PMC10197607

Abstract Article

Select item 99338625.

Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor

Xiaofu Cao, Adnan Shami Shah, Ethan J. Sanford, Marcus B. Smolka, Jeremy M. Baskin

ACS Chem Biol. Author manuscript; available in PMC 2023 Sep 16.

Published in final edited form as: ACS Chem Biol. 2022 Sep 16; 17(9): 2605–2618. Published online 2022 Aug 11. doi: 10.1021/acschembio.2c00527

PMCID:: PMC9933862

Abstract Article PDF–2.5M

Select item 93035496.

The pituitary tumour‐transforming gene 1/delta‐like homologue 1 pathway plays a key role in liver fibrogenesis

Meritxell Perramón, Silvia Carvajal, Vedrana Reichenbach, Guillermo Fernández‐Varo, Loreto Boix, Laura Macias‐Muñoz, Pedro Melgar‐Lesmes, Jordi Bruix, Shlomo Melmed, Santiago Lamas, Wladimiro Jiménez

Liver Int. 2022 Mar; 42(3): 651–662. Published online 2022 Jan 30. doi: 10.1111/liv.15165

PMCID:: PMC9303549

Abstract Article PDF–1.5M

Select item 92412267.

Clinical significance and potential regulatory mechanism of overexpression of pituitary tumor-transforming gene transcription factor in bladder cancer

Jian-Di Li, Abdirahman Ahmed Farah, Zhi-Guang Huang, Gao-Qiang Zhai, Rui-Gong Wang, Jia-Lin Liu, Qin-Jie Wang, Guan-Lan Zhang, Zi-Long Lei, Yi-Wu Dang, Sheng-Hua Li

BMC Cancer. 2022; 22: 713. Published online 2022 Jun 29. doi: 10.1186/s12885-022-09810-y

PMCID:: PMC9241226

Abstract Article PDF–8.7M

Select item 91123498.

Examining the mechanistic relationship of APC/C^CDH1 and its interphase inhibitor EMI1

Derek L. Bolhuis, Raquel C. Martinez‐Chacin, Kaeli A. Welsh, Tatyana Bodrug, Liying Cui, Michael J. Emanuele, Nicholas G. Brown

Protein Sci. 2022 Jun; 31(6): e4324. Published online 2022 May 17. doi: 10.1002/pro.4324

PMCID:: PMC9112349

Abstract Article PDF–4.2M

Select item 91063039.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 901883510.

Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription

Sang Bae Lee, Luciano Garofano, Aram Ko, Fulvio D’Angelo, Brulinda Frangaj, Danika Sommer, Qiwen Gan, KyeongJin Kim, Timothy Cardozo, Antonio Iavarone, Anna Lasorella

Nat Commun. 2022; 13: 2089. Published online 2022 Apr 19. doi: 10.1038/s41467-022-29502-2

PMCID:: PMC9018835

Abstract Article PDF–2.1M

Select item 891539311.

miR-374c-5p regulates PTTG1 and inhibits cell growth and metastasis in hepatocellular carcinoma by regulating epithelial-mesenchymal transition

Gang Yang, Yongfu Xiog, Guan Wang, Weinan Li, Tao Tang, Ji Sun, Jingdong Li

Mol Med Rep. 2022 Apr; 25(4): 148. Published online 2022 Mar 1. doi: 10.3892/mmr.2022.12664

PMCID:: PMC8915393

Abstract Article PDF–6.6M

Select item 884216512.

CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system

Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629

PMCID:: PMC8842165

Abstract Article PDF–3.0M

Select item 880493313.

Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes

Kaeli A Welsh, Derek L Bolhuis, Anneroos E Nederstigt, Joshua Boyer, Brenda R S Temple, Thomas Bonacci, Li Gu, Alban Ordureau, J Wade Harper, Joshua P Steimel, Qi Zhang, Michael J Emanuele, Joseph S Harrison, Nicholas G Brown

EMBO J. 2022 Feb 1; 41(3): e108823. Published online 2021 Dec 23. doi: 10.15252/embj.2021108823

PMCID:: PMC8804933

Abstract Article PDF–3.8M

Select item 876907214.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 874173915.

APC7 Mediates Ubiquitin Signaling in Constitutive Heterochromatin in the Developing Mammalian Brain

Cole J. Ferguson, Olivia Urso, Tatyana Bodrug, Brandon M. Gassaway, Edmond R. Watson, Jesuraj R. Prabu, Pablo Lara-Gonzalez, Raquel C. Martinez-Chacin, Dennis Y. Wu, Karlla W. Brigatti, Erik G. Puffenberger, Cora M. Taylor, Barbara Haas-Givler, Robert N. Jinks, Kevin A. Strauss, Arshad Desai, Harrison W. Gabel, Steven P. Gygi, Brenda A. Schulman, Nicholas G. Brown, Azad Bonni

Mol Cell. Author manuscript; available in PMC 2023 Jan 6.

Published in final edited form as: Mol Cell. 2022 Jan 6; 82(1): 90–105.e13. Published online 2021 Dec 22. doi: 10.1016/j.molcel.2021.11.031

PMCID:: PMC8741739

Abstract Article PDF–4.4M

Select item 866666516.

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre

iScience. 2021 Dec 17; 24(12): 103538. Published online 2021 Dec 1. doi: 10.1016/j.isci.2021.103538

PMCID:: PMC8666665

Abstract Article PDF–3.2M

Select item 848276417.

Structural basis of human separase regulation by securin and Cdk1-cyclin B1

Jun Yu, Pierre Raia, Chloe M. Ghent, Tobias Raisch, Yashar Sadian, Simone Cavadini, Pramod M. Sabale, David Barford, Stefan Raunser, David O. Morgan, Andreas Boland

Nature. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Nature. 2021 Aug; 596(7870): 138–142. Published online 2021 Jul 21. doi: 10.1038/s41586-021-03764-0

PMCID:: PMC8482764

Abstract Article PDF–3.4M

Select item 844651418.

Signatures of Multi-Omics Reveal Distinct Tumor Immune Microenvironment Contributing to Immunotherapy in Lung Adenocarcinoma

Ziqi Huang, Baihui Li, Yan Guo, Lei Wu, Fan Kou, Lili Yang

Front Immunol. 2021; 12: 723172. Published online 2021 Sep 3. doi: 10.3389/fimmu.2021.723172

PMCID:: PMC8446514

Abstract Article PDF–9.3M

Select item 824353519.

Identification of hub genes associated with prognosis, diagnosis, immune infiltration and therapeutic drug in liver cancer by integrated analysis

Xinyi Lei, Miao Zhang, Bingsheng Guan, Qiang Chen, Zhiyong Dong, Cunchuan Wang

Hum Genomics. 2021; 15: 39. Published online 2021 Jun 29. doi: 10.1186/s40246-021-00341-4

PMCID:: PMC8243535

Abstract Article PDF–6.6M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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