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Items: 1 to 20 of 223

1.
Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development
Christiane Grammer, Julia A. Komorowska, Jeremy B. Swann
iScience. 2024 Jul 19; 27(7): 110258. Published online 2024 Jun 13. doi: 10.1016/j.isci.2024.110258
PMCID:
PMC11261450
AbstractArticlePDF–11M
2.
VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis
Melissa M. Wolf, Matthew Z. Madden, Emily N. Arner, Jackie E. Bader, Xiang Ye, Logan Vlach, Megan L. Tigue, Madelyn D. Landis, Patrick B. Jonker, Zaid Hatem, KayLee K. Steiner, Dakim K. Gaines, Bradley I. Reinfeld, Emma S. Hathaway, Fuxue Xin, M. Noor Tantawy, Scott M. Haake, Eric Jonasch, Alexander Muir, Vivian L. Weiss, Kathryn E. Beckermann, W. Kimryn Rathmell, Jeffrey C. Rathmell
J Clin Invest. 2024 Apr 15; 134(8): e173934. Published online 2024 Apr 15. doi: 10.1172/JCI173934
PMCID:
PMC11014672
AbstractArticlePDF–9.8M
3.
VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas
Hyemin Lee, Li Zhuang, Boyi Gan
J Clin Invest. 2024 Apr 15; 134(8): e179560. Published online 2024 Apr 15. doi: 10.1172/JCI179560
PMCID:
PMC11014664
AbstractArticlePDF–606K
4.
Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors
Adam Myszczyszyn, Oliver Popp, Severine Kunz, Anje Sporbert, Simone Jung, Louis C. Penning, Annika Fendler, Philipp Mertins, Walter Birchmeier
PLoS One. 2024; 19(3): e0282938. Published online 2024 Mar 21. doi: 10.1371/journal.pone.0282938
PMCID:
PMC10957084
AbstractArticlePDF–4.7M
5.
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
Tao Zhang, Daichao Xu, Jianping Liu, Min Wang, Li-Juan Duan, Min Liu, Huyan Meng, Yuan Zhuang, Huibing Wang, Yingnan Wang, Mingming Lv, Zhengyi Zhang, Jia Hu, Linyu Shi, Rui Guo, Xingxing Xie, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu, Fabin Dang, Dongxian Guan, Cong Jiang, Xiaoming Dai, Hiroyuki Inuzuka, Peiqiang Yan, Jingchao Wang, Mrigya Babuta, Gewei Lian, Zhenbo Tu, Ji Miao, Gyongyi Szabo, Guo-Hua Fong, Antoine E. Karnoub, Yu-Ru Lee, Lifeng Pan, William G. Kaelin, Jr., Junying Yuan, Wenyi Wei
Nat Cell Biol. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Nat Cell Biol. 2023 Jul; 25(7): 950–962. Published online 2023 Jul 3. doi: 10.1038/s41556-023-01170-4
PMCID:
PMC10617019
AbstractArticlePDF–8.3M
6.
Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease
Wenyan Hao, Hongxian Zhang, Peng Hong, Xin Zhang, Xuyang Zhao, Lulin Ma, Xiaoyan Qiu, Hao Ping, Dan Lu, Yuxin Yin
Cell Death Dis. 2023 Oct; 14(10): 680. Published online 2023 Oct 13. doi: 10.1038/s41419-023-06185-1
PMCID:
PMC10575931
AbstractArticlePDF–8.2M
7.
Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease
Madlen Kunke, Hannah Knöfler, Eileen Dahlke, Luis Zanon Rodriguez, Martina Böttner, Alexey Larionov, Makhabbat Saudenova, Gerrit M. Ohrenschall, Magdalena Westermann, Stefan Porubsky, Joana P. Bernardes, Robert Häsler, Jean-Luc Magnin, Hermann Koepsell, François Jouret, Franziska Theilig
Cell Death Dis. 2023 Aug; 14(8): 562. Published online 2023 Aug 26. doi: 10.1038/s41419-023-06074-7
PMCID:
PMC10457389
AbstractArticlePDF–6.2M
8.
Resting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF‐1α
Abigaelle Pelletier, Eric Nelius, Zheng Fan, Ekaterina Khatchatourova, Abdiel Alvarado‐Diaz, Jingyi He, Ewelina Krzywinska, Michal Sobecki, Shunmugam Nagarajan, Yann Kerdiles, Joachim Fandrey, Dagmar Gotthardt, Veronika Sexl, Katrien de Bock, Christian Stockmann
EMBO Rep. 2023 Jun; 24(6): e56156. Published online 2023 Mar 29. doi: 10.15252/embr.202256156
PMCID:
PMC10240188
AbstractArticlePDF–2.1M
9.
Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism
Jie Shen, Qian Zha, Qian-hua Yang, Yue-qian Zhou, Xiao Liang, Ying-jie Chen, Gui-xia Qi, Xiao-jin Zhang, Wen-bing Yao, Xiang-dong Gao, Song Chen
Acta Pharmacol Sin. 2023 May; 44(5): 940–953. Published online 2022 Nov 10. doi: 10.1038/s41401-022-01014-1
PMCID:
PMC10104824
AbstractArticlePDF–6.3M
10.
The von Hippel-Lindau Tumor Suppressor Gene Mutations Modulate Lipocalin-2 Expression in Ferroptotic-Inflammatory Pathways
Chan-Yen Kuo, Po-Chun Hsieh, Valeria Chiu, Chou-Chin Lan, Kuo-Cheng Lu
Oxid Med Cell Longev. 2023; 2023: 7736638. Published online 2023 Jan 21. doi: 10.1155/2023/7736638
PMCID:
PMC9884170
AbstractArticlePDF–2.3M
11.
ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma
Philipp Seidel, Anne Rubarth, Kyra Zodel, Asin Peighambari, Felix Neumann, Yannick Federkiel, Hsin Huang, Rouven Hoefflin, Mojca Adlesic, Christian Witt, David J. Hoffmann, Patrick Metzger, Ralph K. Lindemann, Frank T. Zenke, Christoph Schell, Melanie Boerries, Dominik von Elverfeldt, Wilfried Reichardt, Marie Follo, Joachim Albers, Ian J. Frew
JCI Insight. 2022 Dec 22; 7(24): e156087. Published online 2022 Dec 22. doi: 10.1172/jci.insight.156087
PMCID:
PMC9869969
AbstractArticlePDF–3.4M
12.
A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle
Xun Wang, Yuemeng Jia, Jiawei Zhao, Nicholas P. Lesner, Cameron J. Menezes, Spencer D. Shelton, Siva Sai Krishna Venigalla, Jian Xu, Chunyu Cai, Prashant Mishra
J Clin Invest. 2022 Dec 1; 132(23): e161638. Published online 2022 Dec 1. doi: 10.1172/JCI161638
PMCID:
PMC9711883
AbstractArticlePDF–56M
13.
IL6 and CCL18 Mediate Cross-talk between VHL-Deficient Kidney Cells and Macrophages during Development of Renal Cell Carcinoma
Thi-Ngoc Nguyen, Hieu-Huy Nguyen-Tran, Chen-Yun Chen, Tien Hsu
Cancer Res. 2022 Aug 3; 82(15): 2716–2733. Published online 2022 Jun 6. doi: 10.1158/0008-5472.CAN-21-3749
PMCID:
PMC9662868
AbstractArticlePDF–3.3M
14.
HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection
Ruining Liu, Victoria Muliadi, Wenjun Mou, Hanxiong Li, Juan Yuan, Johan Holmberg, Benedict J. Chambers, Nadeem Ullah, Jakob Wurth, Mohammad Alzrigat, Susanne Schlisio, Berit Carow, Lars Gunnar Larsson, Martin E. Rottenberg
Nat Commun. 2022; 13: 5093. Published online 2022 Sep 5. doi: 10.1038/s41467-022-32639-9
Correction in:
Nat Commun. 2022; 13: 6545.
PMCID:
PMC9445005
AbstractArticlePDF–5.7M
15.
Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity
Jihye Han, Qingqing Wan, Goo-Young Seo, Kenneth Kim, Sarah el Baghdady, Jee H. Lee, Mitchell Kronenberg, Yun-Cai Liu
J Exp Med. 2022 Jun 6; 219(6): e20211985. Published online 2022 May 9. doi: 10.1084/jem.20211985
PMCID:
PMC9093746
AbstractArticlePDF–7.2M
16.
Endothelial Reprogramming Stimulated by Oncostatin M Promotes Inflammation and Tumorigenesis in VHL-Deficient Kidney Tissue
Hieu-Huy Nguyen-Tran, Thi-Ngoc Nguyen, Chen-Yun Chen, Tien Hsu
Cancer Res. 2021 Oct 1; 81(19): 5060–5073. Published online 2021 Jul 23. doi: 10.1158/0008-5472.CAN-21-0345
PMCID:
PMC8974431
AbstractArticlePDF–3.1M
17.
Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes
Yosuke Harada, Tomohisa Sujino, Kentaro Miyamoto, Ena Nomura, Yusuke Yoshimatsu, Shun Tanemoto, Satoko Umeda, Keiko Ono, Yohei Mikami, Nobuhiro Nakamoto, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Tuneo Ikenoue, Atsushi Hirao, Yoshiaki Kubota, Takanori Kanai
iScience. 2022 Apr 15; 25(4): 104021. Published online 2022 Mar 4. doi: 10.1016/j.isci.2022.104021
PMCID:
PMC8933710
AbstractArticlePDF–3.3M
18.
Deletion of Vhl in Dmp1-Expressing Cells Causes Microenvironmental Impairment of B Cell Lymphopoiesis
Betsabel Chicana, Nastaran Abbasizadeh, Christian Burns, Hanna Taglinao, Joel A. Spencer, Jennifer O. Manilay
Front Immunol. 2022; 13: 780945. Published online 2022 Feb 16. doi: 10.3389/fimmu.2022.780945
PMCID:
PMC8889104
AbstractArticlePDF–10M
19.
The impact of hypoxia on B cells in COVID-19
Prasanti Kotagiri, Federica Mescia, Aimee L. Hanson, Lorinda Turner, Laura Bergamaschi, Ana Peñalver, Nathan Richoz, Stephen D. Moore, Brian M. Ortmann, Benjamin J. Dunmore, Michael D. Morgan, Zewen Kelvin Tuong, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Berthold Göttgens, Mark Toshner, Christoph Hess, Patrick. H. Maxwell, Menna. R. Clatworthy, James A. Nathan, John R. Bradley, Paul A. Lyons, Natalie Burrows, Kenneth G.C. Smith
EBioMedicine. 2022 Mar; 77: 103878. Published online 2022 Feb 19. doi: 10.1016/j.ebiom.2022.103878
PMCID:
PMC8856886
AbstractArticlePDF–1.9M
20.
In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells
Bonnie Huang, James D. Phelan, Silvia Preite, Julio Gomez-Rodriguez, Kristoffer H. Johansen, Hirofumi Shibata, Arthur L. Shaffer, III, Qin Xu, Brendan Jeffrey, Martha Kirby, Stacie Anderson, Yandan Yang, Selamawit Gossa, Dorian B. McGavern, Louis M. Staudt, Pamela L. Schwartzberg
Nat Commun. 2022; 13: 805. Published online 2022 Feb 10. doi: 10.1038/s41467-022-28378-6
PMCID:
PMC8831505
AbstractArticlePDF–4.7M

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